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  1. Article: Editorial: The Effect of the COVID-19 Pandemic on Cancer Patients and Healthcare.

    Silvestris, Nicola / Brunetti, Oronzo / Galvano, Antonio / Russo, Antonio / Apolone, Giovanni

    Frontiers in oncology

    2022  Volume 12, Page(s) 859903

    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.859903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID Vaccination in Cancer Patients: What Vaccination Priority Strategies Should There Be?

    Silvestris, Nicola / Brunetti, Oronzo / Bernardini, Renato / Cinieri, Saverio

    Frontiers in oncology

    2021  Volume 11, Page(s) 641388

    Language English
    Publishing date 2021-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.641388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HSV1 microRNAs in glioblastoma development: an in silico study.

    Abdoli Shadbad, Mahdi / Hemmat, Nima / Abdoli Shadbad, Mahla / Brunetti, Oronzo / Silvestris, Nicola / Baradaran, Behzad

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 27

    Abstract: Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings highlighted the significance of viral microRNAs (miRs) in regulating post-transcriptional mRNA expression in various human conditions. Although HSV1 encodes viral ... ...

    Abstract Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings highlighted the significance of viral microRNAs (miRs) in regulating post-transcriptional mRNA expression in various human conditions. Although HSV1 encodes viral miRs and affects the central nervous system, no study investigated the roles of HSV1-encoding miRs in GBM development. This study applied in silico approaches to investigate whether HSV1-encoding miRs are involved in GBM development and, if so, how they regulate tumor-suppressive/oncogenes expression in GBM. This study leveraged bioinformatics approaches to identify the potential effect of HSV1 miRs in GBM development. The GSE158284, GSE153679, and GSE182109 datasets were analyzed to identify differentially expressed genes in GBM tissues and cell lines using the limma package in the R software. The GSE182109 dataset was analyzed to determine gene expression at the single-cell levels using the Seurat package in the R software. The TCGA-GTEX, GDSC, CTRP, immunogenetic, and enrichment analyses were performed to study the impact of identified viral HSV1 miRs targets in GBM development. hsv1-miR-H6-3p is upregulated in GBM and can be responsible for EPB41L1 and SH3PXD2A downregulation in GBM tissues. Also, hsv1-miR-H1-5p is upregulated in GBM and can decrease the expression of MELK, FZD2, NOVA1, TMEM97, PTPRZ1, and PDGFC in GBM development. The single-cell RNA sequencing analyses have demonstrated that MELK, FZD2, NOVA1, TMEM97, PTPRZ1, and PDGFC are expressed in astrocytes residing in the GBM microenvironment. This study provides novel insights into the potential roles of HSV1 miRs in GBM pathogenesis and offers a reference for further studies on the significance of HSV1 miRs in GBM development.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Glioblastoma/pathology ; Brain Neoplasms/pathology ; Cell Line ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/metabolism ; RNA-Binding Proteins/metabolism ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Proliferation ; Tumor Microenvironment ; Protein Serine-Threonine Kinases/metabolism ; Receptor-Like Protein Tyrosine Phosphatases, Class 5/metabolism
    Chemical Substances MicroRNAs ; RNA-Binding Proteins ; MELK protein, human (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; PTPRZ1 protein, human (EC 3.1.3.48) ; Receptor-Like Protein Tyrosine Phosphatases, Class 5 (EC 3.1.3.48)
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45249-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: HSV1 microRNAs in glioblastoma development

    Mahdi Abdoli Shadbad / Nima Hemmat / Mahla Abdoli Shadbad / Oronzo Brunetti / Nicola Silvestris / Behzad Baradaran

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    an in silico study

    2024  Volume 12

    Abstract: Abstract Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings highlighted the significance of viral microRNAs (miRs) in regulating post-transcriptional mRNA expression in various human conditions. Although HSV1 ... ...

    Abstract Abstract Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings highlighted the significance of viral microRNAs (miRs) in regulating post-transcriptional mRNA expression in various human conditions. Although HSV1 encodes viral miRs and affects the central nervous system, no study investigated the roles of HSV1-encoding miRs in GBM development. This study applied in silico approaches to investigate whether HSV1-encoding miRs are involved in GBM development and, if so, how they regulate tumor-suppressive/oncogenes expression in GBM. This study leveraged bioinformatics approaches to identify the potential effect of HSV1 miRs in GBM development. The GSE158284, GSE153679, and GSE182109 datasets were analyzed to identify differentially expressed genes in GBM tissues and cell lines using the limma package in the R software. The GSE182109 dataset was analyzed to determine gene expression at the single-cell levels using the Seurat package in the R software. The TCGA-GTEX, GDSC, CTRP, immunogenetic, and enrichment analyses were performed to study the impact of identified viral HSV1 miRs targets in GBM development. hsv1-miR-H6-3p is upregulated in GBM and can be responsible for EPB41L1 and SH3PXD2A downregulation in GBM tissues. Also, hsv1-miR-H1-5p is upregulated in GBM and can decrease the expression of MELK, FZD2, NOVA1, TMEM97, PTPRZ1, and PDGFC in GBM development. The single-cell RNA sequencing analyses have demonstrated that MELK, FZD2, NOVA1, TMEM97, PTPRZ1, and PDGFC are expressed in astrocytes residing in the GBM microenvironment. This study provides novel insights into the potential roles of HSV1 miRs in GBM pathogenesis and offers a reference for further studies on the significance of HSV1 miRs in GBM development.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Is it Time for a Therapeutic Algorithm in Resected Pancreatic Ductal Adenocarcinoma?

    Brunetti, Oronzo / Silvestris, Nicola

    Pancreas

    2019  Volume 49, Issue 1, Page(s) e11

    MeSH term(s) Algorithms ; Antineoplastic Combined Chemotherapy Protocols ; Carcinoma, Pancreatic Ductal ; Deoxycytidine/analogs & derivatives ; Humans ; Pancreatic Neoplasms
    Chemical Substances Deoxycytidine (0W860991D6) ; gemcitabine (B76N6SBZ8R)
    Language English
    Publishing date 2019-12-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000001449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 Infection in Cancer Patients: How Can Oncologists Deal With These Patients?

    Brunetti, Oronzo / Derakhshani, Afshin / Baradaran, Behzad / Galvano, Antonio / Russo, Antonio / Silvestris, Nicola

    Frontiers in oncology

    2020  Volume 10, Page(s) 734

    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: On the Management of Drug Interactions in the Course of Concomitant Treatments for COVID-19 and Antineoplastic Agents.

    Silvestris, Nicola / Munafò, Antonio / Brunetti, Oronzo / Burgaletto, Chiara / Scucces, Luisa / Bernardini, Renato

    Frontiers in oncology

    2020  Volume 10, Page(s) 1340

    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.01340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Basis and Advances in Clinical Application of Cytomegalovirus-Specific Cytotoxic T Cell Immunotherapy for Glioblastoma Multiforme.

    Daei Sorkhabi, Amin / Sarkesh, Aila / Saeedi, Hossein / Marofi, Faroogh / Ghaebi, Mahnaz / Silvestris, Nicola / Baradaran, Behzad / Brunetti, Oronzo

    Frontiers in oncology

    2022  Volume 12, Page(s) 818447

    Abstract: A high percentage of malignant gliomas are infected by human cytomegalovirus (HCMV), and the endogenous expression of HCMV genes and their products are found in these tumors. HCMV antigen expression and its implications in gliomagenesis have emerged as a ...

    Abstract A high percentage of malignant gliomas are infected by human cytomegalovirus (HCMV), and the endogenous expression of HCMV genes and their products are found in these tumors. HCMV antigen expression and its implications in gliomagenesis have emerged as a promising target for adoptive cellular immunotherapy (ACT) strategies in glioblastoma multiforme (GB) patients. Since antigen-specific T cells in the tumor microenvironments lack efficient anti-tumor immune response due to the immunosuppressive nature of glioblastoma, CMV-specific ACT relies on
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.818447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Lights and Shadows on Managing Immune Checkpoint Inhibitors in Oncology during the COVID-19 Era.

    Burgaletto, Chiara / Brunetti, Oronzo / Munafò, Antonio / Bernardini, Renato / Silvestris, Nicola / Cantarella, Giuseppina / Argentiero, Antonella

    Cancers

    2021  Volume 13, Issue 8

    Abstract: Since the start of the global spread of coronavirus disease (COVID-19) pandemic, cancer patients were identified as a specifically susceptible subgroup of the patient population. Several reports have shown that cancer patients have an increased risk of ... ...

    Abstract Since the start of the global spread of coronavirus disease (COVID-19) pandemic, cancer patients were identified as a specifically susceptible subgroup of the patient population. Several reports have shown that cancer patients have an increased risk of both contracting the infection and of experiencing a more severe disease course, with a rapidly evolving picture associated with higher mortality. The assumption of cancer patients as "COVID-19 vulnerable" has led, irretrievably, to profound changes in the decision making of oncological treatments. Potential justifications for such concerns encompass the cancer-dependent suppression of the immune response, as well as the influence of administration of systemic anticancer treatments, including chemotherapy and immunotherapy. Nevertheless, to date, it is not clear whether the use of immune checkpoint inhibitors (ICIs) in cancer patients is safe, given their modulating effects on the immune system, or that they may rather conceal detrimental consequences. Theoretically, on the one hand, ICIs may enhance the immunological control of viral infections through their immunostimulating mechanisms; on the other hand, they could contribute to the hyper-inflammatory phase of COVID-19, worsening its clinical outcomes. In this study, we report the foremost clinical observations on the safety of ICI administration in cancer patients affected by COVID-19.
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13081906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mapping the landscape of immunonutrition and cancer research: a comprehensive bibliometric analysis on behalf of NutriOnc Research Group.

    De Felice, Francesca / Cattaneo, Carlo G / Poto, Gianmario E / Antropoli, Carmine / Brillantino, Antonio / Carbone, Ludovico / Brunetti, Oronzo / De Luca, Raffaele / Desideri, Isacco / Incorvaia, Lorena / La Mendola, Roberta / Marmorino, Federica / Parini, Dario / Rodriquenz, Maria G / Salvestrini, Viola / Sebastiani, Federica / Polom, Karol / Marano, Luigi

    International journal of surgery (London, England)

    2024  Volume 110, Issue 1, Page(s) 395–405

    Abstract: The ongoing global health challenge of cancer is driving the pursuit of innovative avenues for prevention, treatment, and enhanced outcomes. The convergence of nutrition and immune modulation, known as immunonutrition, is ready to act as a catalyst for ... ...

    Abstract The ongoing global health challenge of cancer is driving the pursuit of innovative avenues for prevention, treatment, and enhanced outcomes. The convergence of nutrition and immune modulation, known as immunonutrition, is ready to act as a catalyst for transformative change in cancer research and therapy. Our study employs a bibliometric analysis to uncover the evolving trends within immunonutrition and cancer research across the past 25 years. Bibliometric data, including authors, journals, affiliations, and countries, were analyzed using the Bibliometrix R package. Clustering algorithms were applied to keywords to identify thematic areas and their evolution. A total of 489 documents were analyzed, showing an annual growth rate of 8.7%, with a collaboration index of 5.41, highlighting comprehensive multidisciplinary involvement within this landscape. Core authors demonstrated sustained productivity, while occasional authors indicated widespread interest. The Medical University of Warsaw led in institutional contributions. Country-wise, Italy, France, and the USA emerged as forerunners in fostering research productivity. Key journals like 'Clinical Nutrition' served as beacons, emphasizing the multidimensional nature of this topic. The analysis highlighted growing research output and several collaborations, indicating the importance of immunoenriched nutrition in cancer treatment. The interplay of core authors and diversified engagement harmoniously accentuates the cross-disciplinary nature of this burgeoning field. International collaboration facilitated knowledge exchange. Prominent documents shaped the field, emphasizing the significance of nutritional interventions. Thematic clusters revealed varied focuses, including pharmaconutrients, surgical approaches, inflammation, and specific cancers. The expanding research output suggests further development, particularly in exploring immunoenriched nutrition's impact on cancer types and patient populations. The multidisciplinary nature and international collaborations enhance the field's progress. Gaps in research underscore the need for original studies and personalized approaches. This study guides future research, informing evidence-based nutritional interventions and advancing cancer care practices.
    MeSH term(s) Humans ; Immunonutrition Diet ; Algorithms ; Bibliometrics ; Cluster Analysis ; France ; Neoplasms/therapy
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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