LIVIVO - Search results -

Search results

Result 1 - 10 of total 48

Search options

Article ; Online: Recidivism in Switzerland: the influence of custodial sanctions.

Gonçalves, Leonel Cunha / Baggio, Stéphanie / Weber, Michael / Urwyler, Thierry / Noll, Thomas / Singh, Jay P / Rossegger, Astrid / Endrass, Jérôme

Swiss medical weekly

2021 Volume 151, Page(s) w20462

Abstract: Aims of the study: Although many studies have investigated the influence of personal characteristics on recidivism, knowledge about the impact of correctional policies remains limited. The present study adds to this debate by investigating the effect of ...

Abstract	Aims of the study: Although many studies have investigated the influence of personal characteristics on recidivism, knowledge about the impact of correctional policies remains limited. The present study adds to this debate by investigating the effect of the dualistic system of custodial sanctions in Switzerland over time. Specifically, we: (1) tested the influence that different types of custodial sanctions – sentences (offering regular prison treatment) and measures (offering crime-related rehabilitation programmes) – have on reconviction rates; and (2) forecasted future reconviction rates to estimate their value in the year 2020. Methods: National level data from the Swiss Federal Statistical Office were collected, including 3-year reconviction rates after release from custody and the number of persons serving custodial sentences and measures. A time series framework was used for the analyses, which included data available from 1988 to 2013 (n = 26 years). Results: The number of persons serving custodial sentences had no effect on recidivism (p = 0.582); however, a higher number of persons serving custodial measures was significantly associated with a decrease in recidivism (p = 0.003). For the year 2020, a reconviction rate of 28% (range 23–33%) was predicted. Conclusions: Custodial measures seem to be associated with a reduction in recidivism. However, owing to the indeterminate time associated with some custodial measures, often at the cost of the prisoners’ rights and the criminal justice system, future studies are needed to determine the optimal serving time for custodial measures.
MeSH term(s)	Humans ; Prisoners ; Recidivism/prevention & control ; Switzerland
Language	English
Publishing date	2021-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2021.20462
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.152: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: COVID-19 Inmate Risk Appraisal (CIRA): development and validation of a screening tool to assess COVID-19 vulnerability in prisons.

Gonçalves, Leonel Cunha / Baggio, Stéphanie / Weber, Michael / Gétaz, Laurent / Wolff, Hans / Singh, Jay / Naegeli, Andreas / Rossegger, Astrid / Endrass, Jérôme

Swiss medical weekly

2021 Volume 151, Page(s) w20471

Abstract: Objectives: To develop and validate a screening tool designed to identify detained people at increased risk for COVID-19 mortality, the COVID-19 Inmate Risk Appraisal (CIRA).: Design: Cross-sectional study with a representative sample (development) ... ...

Abstract	Objectives: To develop and validate a screening tool designed to identify detained people at increased risk for COVID-19 mortality, the COVID-19 Inmate Risk Appraisal (CIRA). Design: Cross-sectional study with a representative sample (development) and a case-control sample (validation). Setting: The two largest Swiss prisons. Participants: (1) Development sample: all male persons detained in Pöschwies, Zurich (n = 365); (2) Validation sample: case-control sample of male persons detained in Champ-Dollon, Geneva (n = 192, matching 1:3 for participants at risk for severe course of COVID-19 and participants without risk factors). Main outcome measures: The CIRA combined seven risk factors identified by the World Health Organization and the Swiss Federal Office of Public Health as predictive of severe COVID-19 to derive an absolute risk increase in mortality rate: Age ≥60 years, cardiovascular disease, diabetes, hypertension, chronic respiratory disease, immunodeficiency and cancer. Results: Based on the development sample, we proposed a three-level classification: average (<3.7), elevated (3.7-5.7) and high (>5.7) risk. In the validation sample, the CIRA identified all individuals identified as vulnerable by national recommendations (having at least one risk factor). The category “elevated risk” maximised sensitivity (1) and specificity (0.97). The CIRA had even higher capacity in discriminating individuals vulnerable according to clinical evaluation (a four-level risk categorisation based on a consensus of medical staff). The category “elevated risk” maximised sensitivity and specificity (both 1). When considering the individuals classified as extremely high risk by medical staff, the category “high risk” had a high discriminatory capacity (sensitivity =0.89, specificity =0.97). Conclusions: The CIRA scores have a high discriminative ability and will be important in custodial settings to support decisions and prioritise actions using a standardised valid assessment method. However, as knowledge on risk factors for COVID-19 mortality is still limited, the CIRA may be considered preliminary. Underlying data will be updated regularly on the website (http://www.prison-research.com), where the CIRA algorithm is freely available.
MeSH term(s)	Adult ; Aged ; COVID-19/etiology ; COVID-19/prevention & control ; Case-Control Studies ; Cross-Sectional Studies ; Decision Support Techniques ; Female ; Humans ; Male ; Mass Screening/methods ; Mass Screening/standards ; Middle Aged ; Prisoners/statistics & numerical data ; Prisons ; Reproducibility of Results ; Risk Assessment/methods ; Risk Assessment/standards ; Risk Factors ; SARS-CoV-2 ; Sensitivity and Specificity ; Switzerland
Language	English
Publishing date	2021-02-08
Publishing country	Switzerland
Document type	Journal Article ; Validation Study
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2021.20471
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.152: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: COVID-19 fears and preventive behaviors among prison staff

da Cunha Gonçalves, Leonel / Baggio, Stéphanie / Schnyder, Nina / Zaballa, Maria-Eugenia / Baysson, Hélène / Guessous, Idris / Rossegger, Astrid / Endrass, Jérôme / Wolff, Hans / Stringhini, Silvia / Gétaz, Laurent

Victims & Offenders

2023 Volume 18, Issue 4, Page(s) 673–690

Abstract: This study focused on COVID-19 preventive behaviors and fears among prison staff members after the first wave of the pandemic. Cross-sectional data from 171 participants were collected in Switzerland. The level of fears (58.5%) and protective behaviors ( ... ...

Title translation	COVID-19 Ängste und präventive Verhaltensweisen unter Gefängnispersonal
Abstract	This study focused on COVID-19 preventive behaviors and fears among prison staff members after the first wave of the pandemic. Cross-sectional data from 171 participants were collected in Switzerland. The level of fears (58.5%) and protective behaviors (100%) were high. Correctional officers adhered less to preventive measures than other staff members (p = .001). Fears were related to a reduction of social contacts (p = .006) and worries about physical health was related to preventive behaviors in general (p = .006). There is a need to raise prison staff awareness regarding their vulnerability to the SARS-CoV-2 in order to improve the effectiveness of health campaigns in prison settings. Special attention should be given to correctional officers.
Keywords	COVID-19 ; Corrections Officers ; Fear ; Furcht ; Gefängnispersonal ; Gesundheitsverhalten ; Health Behavior ; Justizvollzugsbeamtinnen und Justizvollzugsbeamte ; Pandemics ; Pandemie ; Prevention ; Preventive Health Behavior ; Prison Personnel ; Prävention ; Präventives Gesundheitsverhalten
Language	English
Document type	Article
ISSN	1556-4886
ISSN	1556-4886
DOI	10.1080/15564886.2022.2041518
Database	PSYNDEX

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ablation of sensory nerves favours melanoma progression.

Prazeres, Pedro H D M / Leonel, Caroline / Silva, Walison N / Rocha, Beatriz G S / Santos, Gabryella S P / Costa, Alinne C / Picoli, Caroline C / Sena, Isadora F G / Gonçalves, William A / Vieira, Mariana S / Costa, Pedro A C / Campos, Leda M C C / Lopes, Miriam T P / Costa, Marcos R / Resende, Rodrigo R / Cunha, Thiago M / Mintz, Akiva / Birbrair, Alexander

Journal of cellular and molecular medicine

2020 Volume 24, Issue 17, Page(s) 9574–9589

Abstract: The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment restricts the ... ...

Abstract	The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment restricts the design of effective treatments. Nerves have been reported to contribute to the growth and maintenance of numerous tissues. The effects of sensory innervations on tumour growth remain unclear. Here, by using state-of-the-art techniques, including Cre/loxP technologies, confocal microscopy, in vivo-tracing and chemical denervation, we revealed the presence of sensory nerves infiltrating within the melanoma microenvironment, and affecting cancer progression. Strikingly, melanoma growth in vivo was accelerated following genetic ablation or chemical denervation of sensory nerves. In humans, a retrospective analysis of melanoma patients revealed that increased expression of genes related to sensory nerves in tumours was associated with better clinical outcomes. These findings suggest that sensory innervations counteract melanoma progression. The emerging knowledge from this research provides a novel target in the tumour microenvironment for therapeutic benefit in cancer patients.
MeSH term(s)	Animals ; Cell Communication/physiology ; Cell Line, Tumor ; Disease Progression ; Humans ; Melanoma/pathology ; Mice ; Mice, Inbred C57BL ; Retrospective Studies ; Sensory Receptor Cells/pathology ; Skin Neoplasms/pathology ; Tumor Microenvironment
Keywords	covid19
Language	English
Publishing date	2020-07-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.15381
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5752: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Unraveling the link between maltreatment and juvenile antisocial behavior

Braga, Teresa / Goncalves, Leonel Cunha / Basto-Pereira, Miguel / Maia, Angela

Aggression and Violent Behavior

A meta-analysis of prospective longitudinal studies

2017 Volume 33, Page(s) 37–50

Abstract: Examined the relationship between maltreatment and juvenile antisocial behaviors in a meta-analysis of prospective longitudinal studies. A total of 33 studies, including 23,973 youth (mean age for measure of maltreatment 15 years) with 69 effect sizes ... ...

Title translation	Den Zusammenhang zwischen Misshandlung und jugendlichem unsozialem Verhalten aufdecken: Eine Meta-Analyse prospektiver Längsschnittstudien
Abstract	Examined the relationship between maltreatment and juvenile antisocial behaviors in a meta-analysis of prospective longitudinal studies. A total of 33 studies, including 23,973 youth (mean age for measure of maltreatment 15 years) with 69 effect sizes were included in the final analysis. Results indicated an increased risk of juvenile delinquency in maltreated youth. Physical and sexual abuse were more strongly associated with aggressive behaviors, while neglect seemed more strongly related to general antisocial acts. Limitations of the meta-analysis, including the small sample size were discussed. Future research directions, to advance knowledge on the etiological mechanisms involved and to prevent adverse antisocial consequences of maltreatment were suggested.
Keywords	Aggressionsverhalten ; Aggressive Behavior ; Antisocial Behavior ; Child Abuse ; Child Neglect ; Dissoziales Verhalten ; Etiology ; Jugendliche Delinquenz ; Juvenile Delinquency ; Kindesmisshandlung ; Kindesvernachlässigung ; Körperliche Misshandlung ; Physical Abuse ; Risikofaktoren ; Risk Factors ; Sexual Abuse ; Sexueller Missbrauch ; Ätiologie
Language	English
Document type	Article
ZDB-ID	2019312-9
ISSN	1873-6335 ; 1359-1789
ISSN (online)	1873-6335
ISSN	1359-1789
DOI	10.1016/j.avb.2017.01.006
Database	PSYNDEX

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Ablation of sensory nerves favours melanoma progression

J. cell. mol. med

Abstract	The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment restricts the design of effective treatments. Nerves have been reported to contribute to the growth and maintenance of numerous tissues. The effects of sensory innervations on tumour growth remain unclear. Here, by using state-of-the-art techniques, including Cre/loxP technologies, confocal microscopy, in vivo-tracing and chemical denervation, we revealed the presence of sensory nerves infiltrating within the melanoma microenvironment, and affecting cancer progression. Strikingly, melanoma growth in vivo was accelerated following genetic ablation or chemical denervation of sensory nerves. In humans, a retrospective analysis of melanoma patients revealed that increased expression of genes related to sensory nerves in tumours was associated with better clinical outcomes. These findings suggest that sensory innervations counteract melanoma progression. The emerging knowledge from this research provides a novel target in the tumour microenvironment for therapeutic benefit in cancer patients.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32691511
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil.

Giovanetti, Marta / Slavov, Svetoslav Nanev / Fonseca, Vagner / Wilkinson, Eduan / Tegally, Houriiyah / Patané, José Salvatore Leister / Viala, Vincent Louis / San, Emmanuel James / Rodrigues, Evandra Strazza / Santos, Elaine Vieira / Aburjaile, Flavia / Xavier, Joilson / Fritsch, Hegger / Adelino, Talita Emile Ribeiro / Pereira, Felicidade / Leal, Arabela / Iani, Felipe Campos de Melo / de Carvalho Pereira, Glauco / Vazquez, Cynthia /

Sanabria, Gladys Mercedes Estigarribia / Oliveira, Elaine Cristina de / Demarchi, Luiz / Croda, Julio / Dos Santos Bezerra, Rafael / Paola Oliveira de Lima, Loyze / Martins, Antonio Jorge / Renata Dos Santos Barros, Claudia / Marqueze, Elaine Cristina / de Souza Todao Bernardino, Jardelina / Moretti, Debora Botequio / Brassaloti, Ricardo Augusto / de Lello Rocha Campos Cassano, Raquel / Mariani, Pilar Drummond Sampaio Corrêa / Kitajima, João Paulo / Santos, Bibiana / Proto-Siqueira, Rodrigo / Cantarelli, Vlademir Vicente / Tosta, Stephane / Nardy, Vanessa Brandão / Reboredo de Oliveira da Silva, Luciana / Gómez, Marcela Kelly Astete / Lima, Jaqueline Gomes / Ribeiro, Adriana Aparecida / Guimarães, Natália Rocha / Watanabe, Luiz Takao / Barbosa Da Silva, Luana / da Silva Ferreira, Raquel / da Penha, Mara Patricia F / Ortega, María José / de la Fuente, Andrea Gómez / Villalba, Shirley / Torales, Juan / Gamarra, María Liz / Aquino, Carolina / Figueredo, Gloria Patricia Martínez / Fava, Wellington Santos / Motta-Castro, Ana Rita C / Venturini, James / do Vale Leone de Oliveira, Sandra Maria / Gonçalves, Crhistinne Cavalheiro Maymone / do Carmo Debur Rossa, Maria / Becker, Guilherme Nardi / Giacomini, Mayra Presibella / Marques, Nelson Quallio / Riediger, Irina Nastassja / Raboni, Sonia / Mattoso, Gabriela / Cataneo, Allan D / Zanluca, Camila / Duarte Dos Santos, Claudia N / Assato, Patricia Akemi / Allan da Silva da Costa, Felipe / Poleti, Mirele Daiana / Lesbon, Jessika Cristina Chagas / Mattos, Elisangela Chicaroni / Banho, Cecilia Artico / Sacchetto, Lívia / Moraes, Marília Mazzi / Grotto, Rejane Maria Tommasini / Souza-Neto, Jayme A / Nogueira, Maurício Lacerda / Fukumasu, Heidge / Coutinho, Luiz Lehmann / Calado, Rodrigo Tocantins / Neto, Raul Machado / Bispo de Filippis, Ana Maria / Venancio da Cunha, Rivaldo / Freitas, Carla / Peterka, Cassio Roberto Leonel / de Fátima Rangel Fernandes, Cássia / Navegantes, Wildo / do Carmo Said, Rodrigo Fabiano / Campelo de A E Melo, Carlos F / Almiron, Maria / Lourenço, José / de Oliveira, Tulio / Holmes, Edward C / Haddad, Ricardo / Sampaio, Sandra Coccuzzo / Elias, Maria Carolina / Kashima, Simone / Junior de Alcantara, Luiz Carlos / Covas, Dimas Tadeu

Nature microbiology

2022 Volume 7, Issue 9, Page(s) 1490–1500

Abstract: The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre of the pandemic. SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, but important gaps remain in our understanding of virus ... ...

Abstract	The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an epicentre of the pandemic. SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, but important gaps remain in our understanding of virus transmission dynamics at a national scale. We use 17,135 near-complete genomes sampled from 27 Brazilian states and bordering country Paraguay. From March to November 2020, we detected co-circulation of multiple viral lineages that were linked to multiple importations (predominantly from Europe). After November 2020, we detected large, local transmission clusters within the country. In the absence of effective restriction measures, the epidemic progressed, and in January 2021 there was emergence and onward spread, both within and abroad, of variants of concern and variants under monitoring, including Gamma (P.1) and Zeta (P.2). We also characterized a genomic overview of the epidemic in Paraguay and detected evidence of importation of SARS-CoV-2 ancestor lineages and variants of concern from Brazil. Our findings show that genomic surveillance in Brazil enabled assessment of the real-time spread of emerging SARS-CoV-2 variants.
MeSH term(s)	Brazil ; COVID-19 ; Genomics ; Humans ; SARS-CoV-2
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-022-01191-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Genomic epidemiology reveals the impact of national and international restrictions measures on the SARS-CoV-2 epidemic in Brazil.

Giovanetti, Marta / Slavov, Svetoslav Nanev / Fonseca, Vagner / Wilkinson, Eduan / Tegally, Houriiyah / Patané, José Salvatore Leister / Viala, Vincent Louis / San, James Emmanuel / Rodrigues, Evandra Strazza / Santos, Elaine Vieira / Aburjaile, Flavia / Xavier, Joilson / Fritsch, Hegger / Adelino, Talita Emile Ribeiro / Pereira, Felicidade / Leal, Arabela / de Melo Iani, Felipe Campos / de Carvalho Pereira, Glauco / Vazquez, Cynthia /

Mercedes Estigarribia Sanabria, Gladys / de Oliveira, Elaine Cristina / Demarchi, Luiz / Croda, Julio / Dos Santos Bezerra, Rafael / de Lima, Loyze Paola Oliveira / Martins, Antonio Jorge / Dos Santos Barros, Claudia Renata / Marqueze, Elaine Cristina / de Souza Todao Bernardino, Jardelina / Moretti, Debora Botequio / Brassaloti, Ricardo Augusto / de Lello Rocha Campos Cassano, Raquel / Mariani, Pilar Drummond Sampaio Corrêa / Kitajima, João Paulo / Santos, Bibiana / Proto-Siqueira, Rodrigo / Cantarelli, Vlademir Vicente / Tosta, Stephane / Nardy, Vanessa Brandão / de Oliveira da Silva, Luciana Reboredo / Kelly Astete Gómez, Marcela / Lima, Jaqueline Gomes / Ribeiro, Adriana Aparecida / Guimarães, Natália Rocha / Watanabe, Luiz Takao / Da Silva, Luana Barbosa / da Silva Ferreira, Raquel / da Penha, Mara Patricia F / Ortega, María José / de la Fuente, Andrea Gómez / Villalba, Shirley / Torales, Juan / Gamarra, María Liz / Aquino, Carolina / Martínez Figueredo, Gloria Patricia / Fava, Wellington Santos / Motta-Castro, Ana Rita C / Venturini, James / de Oliveira, Sandra Maria do Vale Leone / Gonçalves, Crhistinne Cavalheiro Maymone / do Carmo Debur Rossa, Maria / Becker, Guilherme Nardi / Presibella, Mayra Marinho / Marques, Nelson Quallio / Riediger, Irina Nastassja / Raboni, Sonia / Coelho, Gabriela Mattoso / Cataneo, Allan Henrique Depieri / Zanluca, Camila / Dos Santos, Claudia N Duarte / Assato, Patricia Akemi / da Costa, Felipe Allan da Silva / Poleti, Mirele Daiana / Lesbon, Jessika Cristina Chagas / Mattos, Elisangela Chicaroni / Banho, Cecilia Artico / Sacchetto, Lívia / Moraes, Marília Mazzi / Grotto, Rejane Maria Tommasini / Souza-Neto, Jayme A / Nogueira, Maurício Lacerda / Fukumasu, Heidge / Coutinho, Luiz Lehmann / Calado, Rodrigo Tocantins / Neto, Raul Machado / de Filippis, Ana Maria Bispo / da Cunha, Rivaldo Venancio / Freitas, Carla / Peterka, Cassio Roberto Leonel / de Fátima Rangel Fernandes, Cássia / de Araújo, Wildo Navegantes / do Carmo Said, Rodrigo Fabiano / Almiron, Maria / de Albuquerque E Melo, Carlos Frederico Campelo / Lourenço, José / de Oliveira, Tulio / Holmes, Edward C / Haddad, Ricardo / Sampaio, Sandra Coccuzzo / Elias, Maria Carolina / Kashima, Simone / de Alcantara, Luiz Carlos Junior / Covas, Dimas Tadeu

medRxiv : the preprint server for health sciences

2022

Abstract: Brazil has experienced some of the highest numbers of COVID-19 cases and deaths globally and from May 2021 made Latin America a pandemic epicenter. Although SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, important gaps ... ...

Abstract	Brazil has experienced some of the highest numbers of COVID-19 cases and deaths globally and from May 2021 made Latin America a pandemic epicenter. Although SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, important gaps remain in our understanding of virus transmission dynamics at the national scale. Here, we describe the genomic epidemiology of SARS-CoV-2 using near-full genomes sampled from 27 Brazilian states and a bordering country - Paraguay. We show that the early stage of the pandemic in Brazil was characterised by the co-circulation of multiple viral lineages, linked to multiple importations predominantly from Europe, and subsequently characterized by large local transmission clusters. As the epidemic progressed under an absence of effective restriction measures, there was a local emergence and onward international spread of Variants of Concern (VOC) and Variants Under Monitoring (VUM), including Gamma (P.1) and Zeta (P.2). In addition, we provide a preliminary genomic overview of the epidemic in Paraguay, showing evidence of importation from Brazil. These data reinforce the usefulness and need for the implementation of widespread genomic surveillance in South America as a toolkit for pandemic monitoring that provides a means to follow the real-time spread of emerging SARS-CoV-2 variants with possible implications for public health and immunization strategies.
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.10.07.21264644
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Genomic epidemiology reveals how restriction measures shaped the SARS-CoV-2 epidemic in Brazil

Giovanetti, Marta / Nanev Slavov, Svetoslav / Fonseca, Vagner / Wilkinson, Eduan / Tegally, Houriiyah / Patane, Jose / Viala, Vincent Louis / San, Emmanuel James / Strazza Rodrigues, Evandra / Vieira Santos, Elaine / Aburjaile, Flavia / Xavier, Joilson / Fritsch, Hegger / Ribeiro Adelino, Talita Emile / Pereira, Felicidade / Leal, Arabela / Campos de Melo Iani, Felipe / de Carvalho Pereira, Glauco / Vazquez, Cynthia /

Mercedes Estigarribia Sanabria, Gladys / Cristina de Oliveira, Elaine / Demarchi, Luiz / Croda, Julio / Bezerra, Rafael Dos Santos / Oliveira de Lima, Loyze Paola / Martins, Antonio Jorge / dos Santos Barros, Claudia Renata / Marqueze, Elaine Cristina / de Souza Todao Bernardino, Jardelina / Botequio Moretti, Debora / Brassaloti, Ricardo Augusto / de Lello Rocha Campos Cassano, Raquel / Drummond Sampaio Correa Mariani, Pilar / Paulo Kitajima, Joao / Santos, Bibiana / Proto Siqueira, Rodrigo / Cantarelli, Vlademir Vicente / Tosta, Stephane / Brandao Nardy, Vanessa / Reboredo de Oliveira da Silva, Luciana / Astete Gomez, Marcela Kelly / Gomes Lima, Jaqueline / Ribeiro, Adriana Aparecida / Rocha Guimaraes, Natalia / Takao Watanabe, Luiz / Barbosa Da Silva, Luana / da Silva Ferreira, Raquel / F. da Penha, Mara Patricia / Ortega, Maria Jose / Gomez de la Fuente, Andrea / Villalba, Shirley / Torales, Juan / Gamarra, Maria Liz / Aquino, Carolina / Martinez Figueredo, Gloria Patricia / Santos Fava, Wellington / Motta Castro, Ana Rita C. / Venturini, James / do Vale Leone de Oliveira, Sandra Maria / Cavalheiro Maymone Goncalves, Crhistinne / do Carmo Debur Rossa, Maria / Nardi Becker, Guilherme / Marinho Presibella, Mayra / Quallio Marques, Nelson / Nastassja Riediger, Irina / Raboni, Sonia / Mattoso, Gabriela / Cataneo, Allan D. / Zanluca, Camila / Duarte dos Santos, Claudia N / Akemi Assato, Patricia / da Silva da Costa, Felipe Allan / Poleti, Mirele Daiana / Chagas Lesbon, Jessika Cristina / Chicaroni Mattos, Elisangela / Artico Banho, Cecilia / Sacchetto, Livia S / Mazzi Moraes, Marilia / Tommasini Grotto, Rejane Maria / Souza-Neto, Jayme A. / Nogueira, Mauricio L / Fukumasu, Heidge / Lehmann Coutinho, Luiz / Tocantins Calado, Rodrigo / Machado Neto, Raul / Bispo de Filippis, Ana Maria / Venancio da Cunha, Rivaldo / Freitas, Carla / Leonel Peterka, Cassio Roberto / Rangel Fernandes, Cassia de Fatima / Navegantes, Wildo / do Carmo Said, Rodrigo Fabiano / Almiron, Maria / Campelo de A e Melo, Carlos F / Lourenco, Jose / de Oliveira, Tulio / Holmes, Edward C / Haddad, Ricardo / Sampaio, Sandra Coccuzzo / Elias, Maria Carolina / Kashima, Simone / Alcantara, Luiz Carlos Junior / Covas, Dimas Tadeu

medRxiv

Abstract: Brazil has experienced some of the highest numbers of COVID-19 infections and deaths globally and made Latin America a pandemic epicenter from May 2021. Although SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, important ... ...

Abstract	Brazil has experienced some of the highest numbers of COVID-19 infections and deaths globally and made Latin America a pandemic epicenter from May 2021. Although SARS-CoV-2 established sustained transmission in Brazil early in the pandemic, important gaps remain in our understanding of local virus transmission dynamics. Here, we describe the genomic epidemiology of SARS-CoV-2 using near-full genomes sampled from 27 Brazilian states and an adjacent country - Paraguay. We show that the early stage of the pandemic in Brazil was characterised by the co-circulation of multiple viral lineages, linked to multiple importations predominantly from Europe, and subsequently characterized by large local transmission clusters. As the epidemic progressed, the absence of effective restriction measures led to the local emergence and international spread of Variants of Concern (VOC) and under monitoring (VUM), including the Gamma (P.1) and Zeta (P.2) variants. In addition, we provide a preliminary genomic overview of the epidemic in Paraguay, showing evidence of importation from Brazil. These data reinforce the need for the implementation of widespread genomic surveillance in South America as a toolkit for pandemic monitoring and providing a means to follow the real-time spread of emerging SARS-CoV-2 variants with possible implications for public health and immunization strategies.
Keywords	covid19
Language	English
Publishing date	2021-10-14
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.10.07.21264644
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A Combination of

Nascimento, Chirlene Pinheiro / Ferreira, Luan Oliveira / da Silva, Alex Luiz Menezes / da Silva, Ana Beatriz Nardelli / Rodrigues, Joao Cleiton Martins / Teixeira, Leonan Lima / Azevedo, Julianne Elba Cunha / de Araujo, Daniella Bastos / Hamoy, Akira Otake / Gonçalves, Beatriz Holanda / Coelho, Brenda Hosana De Oliveira / Lopes, Dielly Catrina Favacho / Hamoy, Moisés

Frontiers in cellular neuroscience

2022 Volume 16, Page(s) 884813

Abstract: Epilepsy is one of the most common neurological disorders, which occurs due to the instability in the inhibitory and excitatory synaptic transmissions in the brain. However, many patients develop resistance to the available drugs, which results in cell ... ...

Abstract	Epilepsy is one of the most common neurological disorders, which occurs due to the instability in the inhibitory and excitatory synaptic transmissions in the brain. However, many patients develop resistance to the available drugs, which results in cell degeneration caused due to inadequate control of the seizures. Curcumin,
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2022.884813
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

Full text online

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito