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  1. Article ; Online: DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations.

    Kgatle, Mankgopo Magdeline / Spearman, Catherine Wendy / Kalla, Asgar Ali / Hairwadzi, Henry Norman

    Oxidative medicine and cellular longevity

    2017  Volume 2017, Page(s) 3179421

    Abstract: Approximately 20% of human cancers is attributable to DNA oncogenic viruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV). Unrepaired DNA damage is the most common and overlapping feature of these DNA oncogenic ...

    Abstract Approximately 20% of human cancers is attributable to DNA oncogenic viruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV). Unrepaired DNA damage is the most common and overlapping feature of these DNA oncogenic viruses and a source of genomic instability and tumour development. Sustained DNA damage results from unceasing production of reactive oxygen species and activation of inflammasome cascades that trigger genomic changes and increased propensity of epigenetic alterations. Accumulation of epigenetic alterations may interfere with genome-wide cellular signalling machineries and promote malignant transformation leading to cancer development. Untangling and understanding the underlying mechanisms that promote these detrimental effects remain the major objectives for ongoing research and hope for effective virus-induced cancer therapy. Here, we review current literature with an emphasis on how DNA damage influences HPV, HVB, and EBV replication and epigenetic alterations that are associated with carcinogenesis.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2017/3179421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks.

    Kgatle, Mankgopo Magdeline / Lawal, Ismaheel Opeyemi / Mashabela, Gabriel / Boshomane, Tebatso Moshoeu Gillian / Koatale, Palesa Caroline / Mahasha, Phetole Walter / Ndlovu, Honest / Vorster, Mariza / Rodrigues, Hosana Gomes / Zeevaart, Jan Rijn / Gordon, Siamon / Moura-Alves, Pedro / Sathekge, Mike Machaba

    Frontiers in immunology

    2021  Volume 12, Page(s) 752380

    Abstract: The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery ...

    Abstract The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.
    MeSH term(s) COVID-19/genetics ; COVID-19/immunology ; DNA Methylation/immunology ; Epigenesis, Genetic/immunology ; Humans ; Organ Specificity ; Pandemics ; SARS-CoV-2/immunology
    Language English
    Publishing date 2021-10-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.752380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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