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Article ; Online: Conformation of Pyroglutamated Amyloid β (3-40) and (11-40) Fibrils - Extended or Hairpin?

Scheidt, Holger A / Korn, Alexander / Schwarze, Benedikt / Krueger, Martin / Huster, Daniel

The journal of physical chemistry. B

2024 Volume 128, Issue 7, Page(s) 1647–1655

Abstract: Amyloid β (Aβ) is a hallmark protein of Alzheimer's disease. One physiologically important Aβ variant is formed by initial N-terminal truncation at a glutamic acid position (either ... ...

Abstract	Amyloid β (Aβ) is a hallmark protein of Alzheimer's disease. One physiologically important Aβ variant is formed by initial N-terminal truncation at a glutamic acid position (either E
MeSH term(s)	Humans ; Amyloid beta-Peptides/chemistry ; Alzheimer Disease/metabolism ; Molecular Conformation ; Molecular Structure ; Magnetic Resonance Spectroscopy ; Amyloid ; Peptide Fragments/chemistry
Chemical Substances	Amyloid beta-Peptides ; Amyloid ; Peptide Fragments
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c07285
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Article ; Online: Reconstruction of Full-Thickness Eyelid Defects Following Tumor Resection: The Bucket Handle Modification.

Gur, Zvi / Men, Clara / Ozzello, Daniel J / Liu, Catherine Y / Kikkawa, Don O / Korn, Bobby S

The Journal of craniofacial surgery

2024

Abstract: Purpose: To describe a modified approach for full-thickness lower eyelid defect reconstruction.: Methods: This is a retrospective review of 5 patients with large full-thickness lower eyelid defects after tumor resection requiring reconstruction. For ... ...

Abstract	Purpose: To describe a modified approach for full-thickness lower eyelid defect reconstruction. Methods: This is a retrospective review of 5 patients with large full-thickness lower eyelid defects after tumor resection requiring reconstruction. For these lower eyelid defects, a lateral-based or superior-based tarsoconjunctival pedicle flap from the upper eyelid was used to rebuild the posterior lamella. In all cases, the anterior lamella was supplied from an adjacent myocutaneous flap in a bucket handle configuration. Data collection included tumor type and location, size of eyelid defect, presence of canalicular involvement, postoperative eyelid position, patient satisfaction, and complication rates. Results: Five eyelids of 5 patients underwent Mohs micrographic excision of basal cell carcinoma followed by reconstruction with a bucket handle flap. Age range was 68 to 96 years old (mean of 81 y). Five patients presented with lower eyelid involvement. The defect size ranged from 80% to 100% of the eyelid. Three patients had canalicular involvement and required bicanalicular nasolacrimal stent placement. After reconstruction, all patients showed good eyelid apposition to the globe with excellent esthetic outcome. No revision procedures were done. Average follow-up time was 13 months (range of 8 to 21 mo). Conclusion: The bucket handle flap for full-thickness eyelid reconstruction is a simple technique that allows for preservation of all anatomical layers of the anterior lamella. This technique shows promising functional and esthetic outcomes.
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000010006
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: First-in-Human Phase I Study of Minnelide in Patients With Advanced Gastrointestinal Cancers: Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity.

Borazanci, Erkut / Saluja, Ashok / Gockerman, Jon / Velagapudi, Mohana / Korn, Ronald / Von Hoff, Daniel / Greeno, Ed

The oncologist

2024 Volume 29, Issue 2, Page(s) 132–141

Abstract: Background: Minnelide is a water-soluble prodrug of triptolide. Triptolide is an anticancer agent that targets cancer resistance through several mechanisms. Minnelide was evaluated in a phase I study in patients with advanced GI carcinomas to establish ... ...

Abstract	Background: Minnelide is a water-soluble prodrug of triptolide. Triptolide is an anticancer agent that targets cancer resistance through several mechanisms. Minnelide was evaluated in a phase I study in patients with advanced GI carcinomas to establish the safety, pharmacodynamic, antitumor activity, and recommended phase II dose (RP2D). Patients and methods: Patients with refractory GI carcinoma and with measurable disease on CT scan were eligible. The study used a 3 + 3 dose-escalation scheme. Due to neutropenia toxicity, 2 dosing schedules were evaluated to determine the RP2D for future studies. Response was assessed using RECIST 1.1 and Choi criteria. Minnelide and triptolide PK were evaluated. Patients who completed the first 28-day treatment cycle without DLTs continued treatment until disease progression or unacceptable toxicity. Results: Forty-five patients were enrolled (23 pancreatic cancer, 10 colorectal, and the remaining 9 had other GI tumors); 42 patients received at least one dose of Minnelide. Grade ≥ 3 toxicities occurred in 69% of patients, most common neutropenia (38%). 2 patients with severe cerebellar toxicity who had a 2-fold higher triptolide concentration than other participants. ORR was 4%; the disease control rate (DCR) was 54% (15/28). Choi criteria demonstrated a decrease in average tumor density in 57% (16/28) patients. Conclusions: This first-in-human, phase I clinical study identified a dose and schedule of Minnelide in patients with refractory GI cancers. The primary toxicity experienced was hematologic. Evidence of efficacy of Minnelide treatment in this group of patients was observed. The DCR ranged from ~2 to 6 months in 14/28 (50%) of evaluable patients. Studies in monotherapy and combination treatments are underway.
MeSH term(s)	Humans ; Antineoplastic Agents/therapeutic use ; Gastrointestinal Neoplasms/drug therapy ; Neutropenia/chemically induced ; Neutropenia/drug therapy ; Diterpenes ; Epoxy Compounds ; Phenanthrenes ; Organophosphates
Chemical Substances	triptolide (19ALD1S53J) ; 14-O-phosphonooxymethyltriptolide disodium salt (1CIV2UMO40) ; Antineoplastic Agents ; Diterpenes ; Epoxy Compounds ; Phenanthrenes ; Organophosphates
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyad278
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 494: Show issues

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Article ; Online: A detailed solution framework for the out‐of‐plane displacement of circular dielectric elastomer actuators

Daniel Korn / Carson Farmer / Hector Medina

Engineering Reports, Vol 4, Iss 1, Pp n/a-n/a (2022)

2022

Abstract: Abstract The out‐of‐plane displacement (OPD) of a circular dielectric elastomer actuator (DEA) membrane has been explored in recent years for a variety of important applications. Circular DEAs consist of an elastomer membrane that is prestretched to a ... ...

Abstract	Abstract The out‐of‐plane displacement (OPD) of a circular dielectric elastomer actuator (DEA) membrane has been explored in recent years for a variety of important applications. Circular DEAs consist of an elastomer membrane that is prestretched to a rigid frame and coated with compliant electrodes. Such a simple configuration has found many interesting applications such as in pumps, pulse tracking, hopping search and rescue robots, dielectric elastomer generators for renewable energy harvesting, linear actuators, and many others. Here, we present an easy‐to‐implement solution framework of the OPD for circular DEAs via a detailed numerical solution using the shooting method (SM) on a system of differential algebraic equations (DAE). The material model incorporated follows the robust Gent hyperelastic representation, and a comparison (of the OPD of a single‐cone DEA) against a neo‐Hookean based solution is included. The SM‐based numerical solution to the resulting boundary value DAE problem is applied to a practical range of values based on the reported literature. Analysis of the results and comparison against other studies are provided. The current work provides a go‐to framework for implementation in further research and development that can be useful to a broader audience including nonexperts in the field of soft robotics.
Keywords	dielectric elastomer ; numerical solution ; soft actuators ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	518
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.

Korn, Marina A / Steffensen, Marie / Brandl, Carolin / Royzman, Dmytro / Daniel, Christoph / Winkler, Thomas H / Nitschke, Lars

Frontiers in immunology

2023 Volume 14, Page(s) 1095830

Abstract: Systemic lupus erythematosus (SLE) is a severe autoimmune disease that displays considerable heterogeneity not only in its symptoms, but also in its environmental and genetic causes. Studies in SLE patients have revealed that many genetic variants ... ...

Abstract	Systemic lupus erythematosus (SLE) is a severe autoimmune disease that displays considerable heterogeneity not only in its symptoms, but also in its environmental and genetic causes. Studies in SLE patients have revealed that many genetic variants contribute to disease development. However, often its etiology remains unknown. Existing efforts to determine this etiology have focused on SLE in mouse models revealing not only that mutations in specific genes lead to SLE development, but also that epistatic effects of several gene mutations significantly amplify disease manifestation. Genome-wide association studies for SLE have identified loci involved in the two biological processes of immune complex clearance and lymphocyte signaling. Deficiency in an inhibitory receptor expressed on B lymphocytes, Siglec-G, has been shown to trigger SLE development in aging mice, as have mutations in DNA degrading DNase1 and DNase1l3, that are involved in clearance of DNA-containing immune complexes. Here, we analyze the development of SLE-like symptoms in mice deficient in either
MeSH term(s)	Animals ; Mice ; Disease Models, Animal ; DNA ; Endodeoxyribonucleases/genetics ; Genome-Wide Association Study ; Lupus Erythematosus, Systemic/genetics ; Deoxyribonuclease I/genetics ; Sialic Acid Binding Immunoglobulin-like Lectins/genetics
Chemical Substances	DNA (9007-49-2) ; Dnase1l3 protein, mouse (EC 3.1.-) ; Endodeoxyribonucleases (EC 3.1.-) ; Siglecg protein, mouse ; Deoxyribonuclease I (EC 3.1.21.1) ; Sialic Acid Binding Immunoglobulin-like Lectins
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1095830
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Article ; Online: Indoor radon survey in Whitehorse, Canada, and dose assessment.

Hansen, Violeta / Sabo, Angela / Korn, Juergen / MacLean, Douglas / Rigét, Frank Farsø / Clausen, Daniel Spelling / Cubley, Joel

Journal of radiological protection : official journal of the Society for Radiological Protection

2023 Volume 43, Issue 1

Abstract: Radon-222 ( ...

Abstract	Radon-222 (
MeSH term(s)	Animals ; Air Pollution, Indoor/analysis ; Wolves ; Radon/analysis ; Air Pollutants, Radioactive/analysis ; Canada ; Housing ; Radiation Monitoring/methods
Chemical Substances	Radon (Q74S4N8N1G) ; Air Pollutants, Radioactive
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639411-5
ISSN	1361-6498 ; 0952-4746
ISSN (online)	1361-6498
ISSN	0952-4746
DOI	10.1088/1361-6498/acb82a
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Zs.A 1886: Show issues

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Article ; Online: Biomarkers Associated with Lung Function Decline and Dupilumab Response in Patients with Asthma.

Pavord, Ian D / De Prado Gómez, Lucia / Brusselle, Guy / Jackson, Daniel J / Brightling, Christopher E / Papi, Alberto / Maspero, Jorge F / Rabe, Klaus F / Korn, Stephanie / Zhang, Mei / Soler, Xavier / Jacob-Nara, Juby A / Hardin, Megan

American journal of respiratory and critical care medicine

2024 Volume 209, Issue 8, Page(s) 1031–1033

MeSH term(s)	Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Biomarkers ; Lung/diagnostic imaging ; Anti-Asthmatic Agents/therapeutic use ; Double-Blind Method
Chemical Substances	dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized ; Biomarkers ; Anti-Asthmatic Agents
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Letter
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202310-1751LE
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Uh II Zs.80: Show issues

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Article ; Online: Early experience with teprotumumab for chronic thyroid eye disease.

Ozzello, Daniel J / Kikkawa, Don O / Korn, Bobby S

American journal of ophthalmology case reports

2020 Volume 19, Page(s) 100744

Abstract: Purpose: To report the first case of a patient with chronic thyroid eye disease (TED) treated with teprotumumab.: Observations: A 50-year-old female with a 3-year history of Graves' disease presented with bilateral exophthalmos greatest on the left ... ...

Abstract	Purpose: To report the first case of a patient with chronic thyroid eye disease (TED) treated with teprotumumab. Observations: A 50-year-old female with a 3-year history of Graves' disease presented with bilateral exophthalmos greatest on the left side. She was followed for 2 years with stable proptosis measurements (23mm OD, 28mm OS). Her clinical activity score (CAS) was 1 and there were no examination findings reflective of active inflammation. The patient underwent systemic treatment with teprotumumab and despite chronic TED and low CAS, she had notable improvement in proptosis (18mm OD, 22mm OS) and decrease in extraocular muscle volume as noted on orbital imaging. Conclusion and importance: This case report suggests that teprotumumab may be used in patients with chronic TED and low CAS. Improvement in the proptosis and reduction in extraocular muscle volume suggest that teprotumumab may alter disease course even in patients with inactive or quiescent TED.
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2020.100744
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Article: Tumor Response to Stroma-Modifying Therapy: Magnetic Resonance Imaging Findings in Early-Phase Clinical Trials of Pegvorhyaluronidase alpha (PEGPH20).

Arias-Lorza, Andrés M / Costello, James R / Hingorani, Sunil R / Von Hoff, Daniel D / Korn, Ronald L / Raghunand, Natarajan

Research square

2023

Abstract: Pre-clinical and clinical studies have shown that PEGPH20 depletes intratumoral hyaluronic acid (HA), which is linked to high interstitial fluid pressures and poor distribution of chemotherapies. 29 patients with metastatic advanced solid tumors received ...

Abstract	Pre-clinical and clinical studies have shown that PEGPH20 depletes intratumoral hyaluronic acid (HA), which is linked to high interstitial fluid pressures and poor distribution of chemotherapies. 29 patients with metastatic advanced solid tumors received quantitative magnetic resonance imaging (qMRI) in 3 prospective clinical trials of PEGPH20, HALO-109-101 (NCT00834704), HALO-109-102 (NCT01170897), and HALO-109-201 (NCT01453153). Apparent Diffusion Coefficient of water (ADC), T1,
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3314770/v1
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Article ; Online: ZINC Express: A Virtual Assistant for Purchasing Compounds Annotated in the ZINC Database.

Bobrowski, Tesia M / Korn, Daniel R / Muratov, Eugene N / Tropsha, Alexander

Journal of chemical information and modeling

2021 Volume 61, Issue 3, Page(s) 1033–1036

Abstract: Many laboratories working in the field of drug discovery use the ZINC database to identify and then acquire commercially available chemicals. However, finding the best deal for a given compound is often time-intensive and laborious, as the process ... ...

Abstract	Many laboratories working in the field of drug discovery use the ZINC database to identify and then acquire commercially available chemicals. However, finding the best deal for a given compound is often time-intensive and laborious, as the process involves searching for all vendors selling the desired compound, comparing prices, and interacting with the preferred vendor. To streamline this process, we have developed ZINC Express, a web application that simplifies the online purchase of chemicals annotated in the ZINC database. For any compound with a known ZINC ID, ZINC Express finds a list of vendors offering that compound and for each such vendor returns the available package quantities, the price of each package, and the price per milligram along with a link to that vendor. We expect that ZINC Express will be of use to both computational and experimental researchers. ZINC Express is freely accessible online at https://zincexpress.mml.unc.edu/.
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.0c01419
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