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  1. Article ; Online: Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives.

    Nettelfield, Sam / Yu, Di / Cañete, Pablo F

    International immunology

    2023  Volume 35, Issue 12, Page(s) 571–582

    Abstract: Vaccination stands as the cornerstone in the battle against infectious diseases, and its efficacy hinges on several host-related factors like genetics, age, and metabolic status. Vulnerable populations, such as malnourished individuals, the obese, and ... ...

    Abstract Vaccination stands as the cornerstone in the battle against infectious diseases, and its efficacy hinges on several host-related factors like genetics, age, and metabolic status. Vulnerable populations, such as malnourished individuals, the obese, and the elderly, commonly exhibit diminished vaccine responses and efficacy. While the specific factors contributing to this impairment may vary, these individuals typically display a degree of metabolic dysregulation, thereby underscoring its potential significance as a fundamental determinant of suboptimal vaccine responses. The emerging field of immunometabolism aims to unravel the intricate interplay between immune regulation and metabolic pathways, and recent research has revealed diverse metabolic signatures linked to various vaccine responses and outcomes. In this review, we summarize the major metabolic pathways utilized by B and T cells during vaccine responses, their complex and varied metabolic requirements, and the impact of micronutrients and metabolic hormones on vaccine outcomes. Furthermore, we examine how systemic metabolism influences vaccine responses and the evidence suggesting that metabolic dysregulation in vulnerable populations can lead to impaired vaccine responses. Lastly, we reflect on the challenge of proving causality with respect to the contribution of metabolic dysregulation to poor vaccine outcomes, and highlight the need for a systems biology approach that combines multimodal profiling and mathematical modelling to reveal the underlying mechanisms of such complex interactions.
    MeSH term(s) Humans ; Aged ; Vaccines ; Vaccination ; Communicable Diseases
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxad021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2619: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: COVID-19 Makes B Cells Forget, but T Cells Remember.

    Cañete, Pablo F / Vinuesa, Carola G

    Cell

    2020  Volume 183, Issue 1, Page(s) 13–15

    Abstract: Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS- ... ...

    Abstract Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS-CoV-2 infection may blunt long-lived antibody responses, immune memory might still be achieved through virus-specific memory T cells.
    MeSH term(s) B-Lymphocytes ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; T-Lymphocytes
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.013
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    Zs.A 1167: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
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  3. Article ; Online: COVID-19 Makes B Cells Forget, but T Cells Remember

    Cañete, Pablo F. / Vinuesa, Carola G.

    Cell

    2020  Volume 183, Issue 1, Page(s) 13–15

    Keywords General Biochemistry, Genetics and Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  4. Article: COVID-19 Makes B Cells Forget, but T Cells Remember

    Cañete, Pablo F / Vinuesa, Carola G

    Cell

    Abstract: Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS- ... ...

    Abstract Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS-CoV-2 infection may blunt long-lived antibody responses, immune memory might still be achieved through virus-specific memory T cells.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #747289
    Database COVID19

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  5. Article: Evolution of γ chain cytokines: Mechanisms, methods and applications.

    Antczak, Magdalena / Cañete, Pablo F / Chen, Zhian / Belle, Clémence / Yu, Di

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 4746–4755

    Abstract: The common γ chain family of cytokines and their receptors play fundamental roles in the immune system. Evolutionary studies of γ chain cytokines have elegantly illustrated how the immune system adapts to ever-changing environmental conditions. Indeed, ... ...

    Abstract The common γ chain family of cytokines and their receptors play fundamental roles in the immune system. Evolutionary studies of γ chain cytokines have elegantly illustrated how the immune system adapts to ever-changing environmental conditions. Indeed, these studies have revealed the uniqueness of cytokine evolution, which exhibits strong positive selection pressure needed to adapt to rapidly evolving threats whilst still conserving their receptor binding capabilities. In this review, we summarise the evolutionary mechanisms that gave rise to the characteristically diverse family of γ chain cytokines. We also speculate on the benefits of studying cytokine evolution, which may provide alternative ways to design novel cytokine therapeutic strategies. Additionally, we discuss current evolutionary models that elucidate the emergence of distinct cytokines (IL-4 and IL-13) and cytokine receptors (IL-2Rα and IL-15Rα). Finally, we address and reflect on the difficulties associated with evolutionary studies of rapidly evolving genes and describe a variety of computational methods that have revealed numerous aspects of cytokine evolution.
    Language English
    Publishing date 2022-08-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.08.050
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  6. Article: COVID-19 Makes B Cells Forget, but T Cells Remember

    Cañete, Pablo F / Vinuesa, Carola G

    Cell. 2020 Oct. 01, v. 183, no. 1

    2020  

    Abstract: Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS- ... ...

    Abstract Understanding which arms of the immune response are responsible for protection against SARS-CoV-2 infection is key to predicting long-term immunity and to inform vaccine design. Two studies in this issue of Cell collectively suggest that, although SARS-CoV-2 infection may blunt long-lived antibody responses, immune memory might still be achieved through virus-specific memory T cells.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; immunologic memory ; vaccine development
    Language English
    Dates of publication 2020-1001
    Size p. 13-15.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.013
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  7. Article: Personalized Medicine in Infant Population with Cancer: Pharmacogenetic Pilot Study of Polymorphisms Related to Toxicity and Response to Chemotherapy.

    Urtasun, Andrea / Olivera, Gladys G / Sendra, Luis / Aliño, Salvador F / Berlanga, Pablo / Gargallo, Pablo / Hervás, David / Balaguer, Julia / Juan-Ribelles, Antonio / Andrés, María Del Mar / Cañete, Adela / Herrero, María José

    Cancers

    2023  Volume 15, Issue 5

    Abstract: Background: Pharmacogenetics is a personalized medicine tool that aims to optimize treatments by adapting them to each individual's genetics, maximizing their efficacy while minimizing their toxicity. Infants with cancer are especially vulnerable, and ... ...

    Abstract Background: Pharmacogenetics is a personalized medicine tool that aims to optimize treatments by adapting them to each individual's genetics, maximizing their efficacy while minimizing their toxicity. Infants with cancer are especially vulnerable, and their co-morbidities have vital repercussions. The study of their pharmacogenetics is new in this clinical field.
    Methods: A unicentric, ambispective study of a cohort of infants receiving chemotherapy (from January 2007 to August 2019). The genotypes of 64 patients under 18 months of age were correlated with severe drug toxicities and survival. A pharmacogenetics panel was configured based on PharmGKB, drug labels, and international experts' consortiums.
    Results: Associations between SNPs and hematological toxicity were found. Most meaningful were:
    Conclusions: This pharmacogenetic study is a pioneer in dealing with infants under 18 months of age. Further studies are needed to confirm the utility of the findings in this work to be used as predictive genetic biomarkers of toxicity and therapeutic efficacy in the infant population. If confirmed, their use in therapeutic decisions could improve the quality of life and prognosis of these patients.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051424
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  8. Article: Evolution of γ chain cytokines: mechanisms, methods and applications

    Antczak, Magdalena / Cañete, Pablo F. / Chen, Zhian / Belle, Clémence / Yu, Di

    Computational and Structural Biotechnology Journal. 2022 Aug. 22,

    2022  

    Abstract: The common γ chain family of cytokines and their receptors play fundamental roles in the immune system. Evolutionary studies of γ chain cytokines have elegantly illustrated how the immune system adapts to ever-changing environmental conditions. Indeed, ... ...

    Abstract The common γ chain family of cytokines and their receptors play fundamental roles in the immune system. Evolutionary studies of γ chain cytokines have elegantly illustrated how the immune system adapts to ever-changing environmental conditions. Indeed, these studies have revealed the uniqueness of cytokine evolution, which exhibits strong positive selection pressure needed to adapt to rapidly evolving threats whilst still conserving their receptor binding capabilities. In this review, we summarise the evolutionary mechanisms that gave rise to the characteristically diverse family of γ chain cytokines. We also speculate on the benefits of studying cytokine evolution, which may provide alternative ways to design novel cytokine therapeutic strategies. Additionally, we discuss current evolutionary models that elucidate the emergence of distinct cytokines (IL-4 and IL-13) and cytokine receptors (IL-2Rα and IL-15Rα). Finally, we address and reflect on the difficulties associated with evolutionary studies of rapidly evolving genes and describe a variety of computational methods that have revealed numerous aspects of cytokine evolution.
    Keywords biotechnology ; immune system ; interleukin-13 ; interleukin-4 ; selection pressure ; therapeutics
    Language English
    Dates of publication 2022-0822
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.08.050
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?

    Olivera, Gladys G / Urtasun, Andrea / Sendra, Luis / Aliño, Salvador F / Yáñez, Yania / Segura, Vanessa / Gargallo, Pablo / Berlanga, Pablo / Castel, Victoria / Cañete, Adela / Herrero, María José

    International journal of molecular sciences

    2021  Volume 22, Issue 18

    Abstract: Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients' clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy ... ...

    Abstract Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients' clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy and minimizing toxicity. This is of great importance, especially in pediatric cancer and even more in complex malignancies such as neuroblastoma, where the rates of therapeutic success are still below those of many other types of tumors. The studies are mainly focused on germline genetic variants and in the present review, state of the art is presented: which are the variants that have a level of evidence high enough to be implemented in the clinic, and how to distinguish them from the ones that still need validation to confirm their utility. Further aspects as relevant characteristics regarding ontogeny and future directions in the research will also be discussed.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Humans ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Pediatrics/trends ; Pharmacogenetics/trends ; Precision Medicine/trends
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22189815
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  10. Article ; Online: Pharmacogenetics in Neuroblastoma

    Gladys G. Olivera / Andrea Urtasun / Luis Sendra / Salvador F. Aliño / Yania Yáñez / Vanessa Segura / Pablo Gargallo / Pablo Berlanga / Victoria Castel / Adela Cañete / María José Herrero

    International Journal of Molecular Sciences, Vol 22, Iss 9815, p

    What Can Already Be Clinically Implemented and What Is Coming Next?

    2021  Volume 9815

    Abstract: Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients’ clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy ... ...

    Abstract Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients’ clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy and minimizing toxicity. This is of great importance, especially in pediatric cancer and even more in complex malignancies such as neuroblastoma, where the rates of therapeutic success are still below those of many other types of tumors. The studies are mainly focused on germline genetic variants and in the present review, state of the art is presented: which are the variants that have a level of evidence high enough to be implemented in the clinic, and how to distinguish them from the ones that still need validation to confirm their utility. Further aspects as relevant characteristics regarding ontogeny and future directions in the research will also be discussed.
    Keywords SNP (single nucleotide polymorphism) ; chemotherapy ; drug label ; clinical implementation guidelines ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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