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Article ; Online: Proton Beam Therapy in the Reirradiation Setting of Brain and Base of Skull Tumour Recurrences.

Gaito, S / Burnet, N G / Aznar, M C / Marvaso, G / Jereczek-Fossa, B A / Crellin, A / Indelicato, D / Pan, S / Colaco, R / Rieu, R / Smith, E / Whitfield, G

Clinical oncology (Royal College of Radiologists (Great Britain))

2023 Volume 35, Issue 10, Page(s) 673–681

Abstract: The therapeutic management of local tumour recurrence after a first course of radical radiotherapy is always complex. Surgery and reirradiation carry increased morbidity due to radiation-induced tissue changes. Proton beam therapy (PBT) might be ... ...

Abstract	The therapeutic management of local tumour recurrence after a first course of radical radiotherapy is always complex. Surgery and reirradiation carry increased morbidity due to radiation-induced tissue changes. Proton beam therapy (PBT) might be advantageous in the reirradiation setting, thanks to its distinct physical characteristics. Here we systematically reviewed the use of PBT in the management of recurrent central nervous system (CNS) and base of skull (BoS) tumours, as published in the literature. The research question was framed following the Population, Intervention, Comparison and Outcomes (PICO) criteria: the population of the study was cancer patients with local disease recurrence in the CNS or BoS; the intervention was radiation treatment with PBT; the outcomes of the study focused on the clinical outcomes of PBT in the reirradiation setting of local tumour recurrences of the CNS or BoS. The identification stage resulted in 222 records in Embase and 79 in Medline as of March 2023. Sixty-eight duplicates were excluded at this stage and 56 were excluded after screening as not relevant, not in English or not full-text articles. Twelve full-text articles were included in the review and are presented according to the site of disease, namely BoS, brain or both brain and BoS. This review showed that reirradiation of brain/BoS tumour recurrences with PBT can provide good local control with acceptable toxicity rates. However, reirradiation of tumour recurrences in the CNS or BoS setting needs to consider several factors that can increase the risk of toxicities. Therefore, patient selection is crucial. Randomised evidence is needed to select the best radiation modality in this group of patients.
MeSH term(s)	Humans ; Re-Irradiation/methods ; Proton Therapy/adverse effects ; Proton Therapy/methods ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/pathology ; Brain Neoplasms/radiotherapy ; Brain/pathology
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2023.07.010
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Article ; Online: Introducing the ESTRO Guidelines Committee, the driving force for the new generation of ESTRO guidelines.

McDonald, Fiona / Belka, Claus / Hurkmans, Coen / Jereczek-Fossa, Barbara Alicja / Poortmans, Philip / van de Kamer, Jeroen B / Azizaj, Eralda / Franco, Pierfrancesco

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 185, Page(s) 109724

Language	English
Publishing date	2023-05-25
Publishing country	Ireland
Document type	Editorial
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.109724
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Article ; Online: Interim

Garibaldi, C / Ferrari, M / Grana, C M / Jereczek-Fossa, B A / Cremonesi, M

Clinical oncology (Royal College of Radiologists (Great Britain))

2019 Volume 31, Issue 4, Page(s) 267–268

Language	English
Publishing date	2019-02-02
Publishing country	England
Document type	Letter
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2019.01.008
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Article: The Anatomical Conditions of the Alveolar Process of the Anterior Maxilla in Terms of Immediate Implantation-Radiological Retrospective Case Series Study.

Wychowański, Piotr / Starzyńska, Anna / Osiak, Martyna / Kowalski, Jan / Jereczek-Fossa, Barbara Alicja / Seklecka, Blanka / Morawiec, Tadeusz / Adamska, Paulina / Woliński, Jarosław

Journal of clinical medicine

2021 Volume 10, Issue 8

Abstract: The feasibility and the level of difficulty of immediate flapless implantation depend largely on the residual alveolar bone. The purpose of the study was to determine how often immediate flapless implantation in the anterior maxilla is feasible and ... ...

Abstract	The feasibility and the level of difficulty of immediate flapless implantation depend largely on the residual alveolar bone. The purpose of the study was to determine how often immediate flapless implantation in the anterior maxilla is feasible and assess the difficulty level using cone-beam computed tomography (CBCT) scans. A radiological retrospective case series study was conducted. In total, 1200 CBCT scans from 300 consecutive patients were analyzed with dedicated planning software. Immediate flapless implants were possible in 78.33% of cases. Drilling direction was either through the apex or the palatal slope.
Language	English
Publishing date	2021-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10081688
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Article ; Online: Towards a European prospective data registry for particle therapy.

Grau, Cai / Dasu, Alexandru / Troost, Esther G C / Haustermans, Karin / Weber, Damien C / Langendijk, Johannes A / Gregoire, Vincent / Orlandi, Ester / Thariat, Juliette / Journy, Neige / Chaikh, Abdulhamid / Isambert, Aurelie / Alicja Jereczek-Fossa, Barbara / Vaniqui, Ana / Vitek, Pavel / Kopec, Renata / Fijten, Rianne / Luetgendorf-Caucig, Carola / Olko, Pawel

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 196, Page(s) 110293

Abstract: The evidence for the value of particle therapy (PT) is still sparse. While randomized trials remain a cornerstone for robust comparisons with photon-based radiotherapy, data registries collecting real-world data can play a crucial role in building ... ...

Abstract	The evidence for the value of particle therapy (PT) is still sparse. While randomized trials remain a cornerstone for robust comparisons with photon-based radiotherapy, data registries collecting real-world data can play a crucial role in building evidence for new developments. This Perspective describes how the European Particle Therapy Network (EPTN) is actively working on establishing a prospective data registry encompassing all patients undergoing PT in European centers. Several obstacles and hurdles are discussed, for instance harmonization of nomenclature and structure of technical and dosimetric data and data protection issues. A preferred approach is the adoption of a federated data registry model with transparent and agile governance to meet European requirements for data protection, transfer, and processing. Funding of the registry, especially for operation after the initial setup process, remains a major challenge.
Language	English
Publishing date	2024-04-21
Publishing country	Ireland
Document type	Editorial
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110293
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Article ; Online: Photon vs proton hypofractionation in prostate cancer: A systematic review and meta-analysis.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 195, Page(s) 110264

Abstract: ... relapse-free survival (b-RFS), clinical relapse-free, distant metastasis-free, and prostate cancer ...

Abstract	Background: High-level evidence on hypofractionated proton therapy (PT) for localized and locally advanced prostate cancer (PCa) patients is currently missing. The aim of this study is to provide a systematic literature review to compare the toxicity and effectiveness of curative radiotherapy with photon therapy (XRT) or PT in PCa. Methods: PubMed, Embase, and the Cochrane Library databases were systematically searched up to April 2022. Men with a diagnosis of PCa who underwent curative hypofractionated RT treatment (PT or XRT) were included. Risk of grade (G) ≥ 2 acute and late genitourinary (GU) OR gastrointestinal (GI) toxicity were the primary outcomes of interest. Secondary outcomes were five-year biochemical relapse-free survival (b-RFS), clinical relapse-free, distant metastasis-free, and prostate cancer-specific survival. Heterogeneity between study-specific estimates was assessed using Chi-square statistics and measured with the I2 index (heterogeneity measure across studies). Results: A total of 230 studies matched inclusion criteria and, due to overlapped populations, 160 were included in the present analysis. Significant lower rates of G ≥ 2 acute GI incidence (2 % vs 7 %) and improved 5-year biochemical relapse-free survival (95 % vs 91 %) were observed in the PT arm compared to XRT. PT benefits in 5-year biochemical relapse-free survival were maintained for the moderate hypofractionated arm (p-value 0.0122) and among patients in intermediate and low-risk classes (p-values < 0.0001 and 0.0368, respectively). No statistically relevant differences were found for the other considered outcomes. Conclusion: The present study supports that PT is safe and effective for localized PCa treatment, however, more data from RCTs are needed to draw solid evidence in this setting and further effort must be made to identify the patient subgroups that could benefit the most from PT.
Language	English
Publishing date	2024-03-30
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110264
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Article ; Online: Association between Alcohol Intake and Prostate Cancer Mortality and Survival.

D'Ecclesiis, Oriana / Pastore, Elisa / Gandini, Sara / Caini, Saverio / Marvaso, Giulia / Jereczek-Fossa, Barbara A / Corrao, Giulia / Raimondi, Sara / Bellerba, Federica / Ciceri, Silvia / Latella, Marialetizia / Cavalcabò, Nora de Bonfioli / Bendinelli, Benedetta / Saieva, Calogero / Fontana, Miriam / Gnagnarella, Patrizia

Nutrients

2023 Volume 15, Issue 4

Abstract: We conducted a systematic review and meta-analysis to investigate the role of alcohol consumption with the prognosis of prostate cancer (PCa). Published reports were gathered on 15 October 2022, from PUBMED/MEDLINE and EMBASE. We found 19 independent ... ...

Abstract	We conducted a systematic review and meta-analysis to investigate the role of alcohol consumption with the prognosis of prostate cancer (PCa). Published reports were gathered on 15 October 2022, from PUBMED/MEDLINE and EMBASE. We found 19 independent eligible studies on the association between consumption of alcoholic beverages and the risk of fatal PCa (n = 5), PCa mortality (n = 5) in healthy subjects, and PCa patients' survival (n = 7) or surrogates thereof (n = 2). We used random effects meta-analysis to obtain a summary risk estimate (SRE) and 95% confidence intervals (95%CI) for incidence of fatal PCa and PCa mortality. The meta-analysis revealed no association between alcohol consumption and fatal prostate cancer incidence risk in healthy subjects with an indication for publication bias, but omitting the study that mainly increased the between-study heterogeneity, the SRE becomes significant (SRE 1.33, 95%CI 1.12-1.58), and the heterogeneity disappeared (
MeSH term(s)	Male ; Humans ; Alcohol Drinking/adverse effects ; Prostatic Neoplasms/epidemiology ; Prostate ; Prognosis ; Incidence
Language	English
Publishing date	2023-02-12
Publishing country	Switzerland
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15040925
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Article: Proton Beam Therapy in the Oligometastatic/Oligorecurrent Setting: Is There a Role? A Literature Review.

Gaito, Simona / Marvaso, Giulia / Ortiz, Ramon / Crellin, Adrian / Aznar, Marianne C / Indelicato, Daniel J / Pan, Shermaine / Whitfield, Gillian / Alongi, Filippo / Jereczek-Fossa, Barbara Alicja / Burnet, Neil / Li, Michelle P / Rothwell, Bethany / Smith, Ed / Colaco, Rovel J

Cancers

2023 Volume 15, Issue 9

Abstract: Background: Stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS) with conventional photon radiotherapy (XRT) are well-established treatment options for selected patients with oligometastatic/oligorecurrent disease. The use of ... ...

Abstract	Background: Stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS) with conventional photon radiotherapy (XRT) are well-established treatment options for selected patients with oligometastatic/oligorecurrent disease. The use of PBT for SABR-SRS is attractive given the property of a lack of exit dose. The aim of this review is to evaluate the role and current utilisation of PBT in the oligometastatic/oligorecurrent setting. Methods: Using Medline and Embase, a comprehensive literature review was conducted following the PICO (Patients, Intervention, Comparison, and Outcomes) criteria, which returned 83 records. After screening, 16 records were deemed to be relevant and included in the review. Results: Six of the sixteen records analysed originated in Japan, six in the USA, and four in Europe. The focus was oligometastatic disease in 12, oligorecurrence in 3, and both in 1. Most of the studies analysed (12/16) were retrospective cohorts or case reports, two were phase II clinical trials, one was a literature review, and one study discussed the pros and cons of PBT in these settings. The studies presented in this review included a total of 925 patients. The metastatic sites analysed in these articles were the liver (4/16), lungs (3/16), thoracic lymph nodes (2/16), bone (2/16), brain (1/16), pelvis (1/16), and various sites in 2/16. Conclusions: PBT could represent an option for the treatment of oligometastatic/oligorecurrent disease in patients with a low metastatic burden. Nevertheless, due to its limited availability, PBT has traditionally been funded for selected tumour indications that are defined as curable. The availability of new systemic therapies has widened this definition. This, together with the exponential growth of PBT capacity worldwide, will potentially redefine its commissioning to include selected patients with oligometastatic/oligorecurrent disease. To date, PBT has been used with encouraging results for the treatment of liver metastases. However, PBT could be an option in those cases in which the reduced radiation exposure to normal tissues leads to a clinically significant reduction in treatment-related toxicities.
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15092489
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Article ; Online: Gene expression profiling and FDG-PET radiomics uncover radiometabolic signatures associated with outcome in DLBCL.

Mazzara, Saveria / Travaini, Laura / Botta, Francesca / Granata, Chiara / Motta, Giovanna / Melle, Federica / Fiori, Stefano / Tabanelli, Valentina / Vanazzi, Anna / Ramadan, Safaa / Radice, Tommaso / Raimondi, Sara / Lo Presti, Giuliana / Ferrari, Mahila E / Jereczek-Fossa, Barbara Alicja / Tarella, Corrado / Ceci, Francesco / Pileri, Stefano / Derenzini, Enrico

Blood advances

2023 Volume 7, Issue 4, Page(s) 630–643

Abstract: ... profiles in diffuse large B-cell lymphoma (DLBCL). We retrospectively analyzed a discovery cohort of 48 ...

Abstract	Emerging evidence indicates that chemoresistance is closely related to altered metabolism in cancer. Here, we hypothesized that distinct metabolic gene expression profiling (GEP) signatures might be correlated with outcome and with specific fluorodeoxyglucose positron emission tomography (FDG-PET) radiomic profiles in diffuse large B-cell lymphoma (DLBCL). We retrospectively analyzed a discovery cohort of 48 consecutive patients with DLBCL treated at our center with standard first-line chemoimmunotherapy by performing targeted GEP (T-GEP)- and FDG-PET radiomic analyses on the same target lesions at baseline. T-GEP-based metabolic profiling identified a 6-gene signature independently associated with outcomes in univariate and multivariate analyses. This signature included genes regulating mitochondrial oxidative metabolism (SCL25A1, PDK4, PDPR) that were upregulated and was inversely associated with genes involved in hypoxia and glycolysis (MAP2K1, HIF1A, GBE1) that were downregulated. These data were validated in 2 large publicly available cohorts. By integrating FDG-PET radiomics and T-GEP, we identified a radiometabolic signature (RadSig) including 4 radiomic features (histo kurtosis, histo energy, shape sphericity, and neighboring gray level dependence matrix contrast), significantly associated with the metabolic GEP-based signature (r = 0.43, P = .0027) and with progression-free survival (P = .028). These results were confirmed using different target lesions, an alternative segmentation method, and were validated in an independent cohort of 64 patients. RadSig retained independent prognostic value in relation to the International Prognostic Index score and metabolic tumor volume (MTV). Integration of RadSig and MTV further refined prognostic stratification. This study provides the proof of principle for the use of FDG-PET radiomics as a tool for noninvasive assessment of cancer metabolism and prognostic stratification in DLBCL.
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Retrospective Studies ; Positron-Emission Tomography/methods ; Lymphoma, Large B-Cell, Diffuse/pathology ; Gene Expression Profiling
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022007825
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Article ; Online: Investigating Nutritional and Inflammatory Status as Predictive Biomarkers in Oligoreccurent Prostate Cancer-A RADIOSA Trial Preliminary Analysis.

Zaffaroni, Mattia / Vincini, Maria Giulia / Corrao, Giulia / Lorubbio, Chiara / Repetti, Ilaria / Mastroleo, Federico / Putzu, Costantino / Villa, Riccardo / Netti, Sofia / D'Ecclesiis, Oriana / Luzzago, Stefano / Mistretta, Francesco Alessandro / Musi, Gennaro / Cattani, Federica / Gandini, Sara / Marvaso, Giulia / Jereczek-Fossa, Barbara Alicja

Nutrients

2023 Volume 15, Issue 21

Abstract: ... localizations were randomized 1:1 to receive SBRT alone (arm A) or SBRT + 6 months of ADT (arm B). Common serum ... 3) Results: The current analysis comprised 88 patients (45 arm A, SBRT only, and 43 arm B, SBRT ...

Abstract	(1) Background: In the RADIOSA phase II randomized clinical trial (NCT03940235), the biology task entails the identification of predictive and prognostic biomarkers in the context of oligorecurrent, castration-sensitive prostate cancer in order to distinguish polymetastatic from oligometastatic disease. This may lay the groundwork for personalized treatments for those patients who could really benefit from metastasis-directed therapies. (2) Methods: Oligorecurrent PCa pts with three or fewer bone or lymph nodal localizations were randomized 1:1 to receive SBRT alone (arm A) or SBRT + 6 months of ADT (arm B). Common serum-derived biomarkers were collected at baseline, and at 3 months after RT. The prognostic nutritional index, an immune and nutrition-based prognostic score, and the controlling nutritional status (CONUT) score, a scoring system for evaluating patient's nutritional status, were calculated in accordance with the body of available literature. As inflammatory indicators, neutrophil-lymphocyte ratio (NLR) and the NLR-albumin ratio (NLRAR) were assessed. Changes in these parameters between baseline and the 3-month timepoint were evaluated both in absolute and relative values. Changes in these parameters between baseline and the 3-month timepoint were evaluated. Significant differences in the trend of these parameters were assessed using the non-parametric Wilcoxon rank-sum test. A network analysis to analyze the relationships between different features stratifying patients according to the arm of study and site of metastases was performed. (3) Results: The current analysis comprised 88 patients (45 arm A, SBRT only, and 43 arm B, SBRT + ADT). When patients were stratified by ADT administration, cholesterol values showed an increasing trend in the group receiving ADT (
MeSH term(s)	Humans ; Male ; Biomarkers ; Bone and Bones/pathology ; Lymph Nodes ; Nutritional Status ; Prostatic Neoplasms/drug therapy
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-10-28
Publishing country	Switzerland
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15214583
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