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  1. Book ; Online ; E-Book: Obesity and its impact on health

    Elengoe, Asita / Kutty, Methil Kannan

    2021  

    Author's details Methil Kannan Kutty, Asita Elengoe, editors
    Keywords Obesity ; Obesitat
    Subject code 616.398
    Language English
    Size 1 online resource (195 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-336-408-4 ; 981-336-407-6 ; 978-981-336-408-0 ; 978-981-336-407-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: COVID-19 Outbreak in Malaysia.

    Elengoe, Asita

    Osong public health and research perspectives

    2018  Volume 11, Issue 3, Page(s) 93–100

    Abstract: In 2020 a significant threat to public health emerged. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic outbreak emerged in December 2019 from Wuhan City, Hubei Province, China and spread to the rest of the world. This ... ...

    Abstract In 2020 a significant threat to public health emerged. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic outbreak emerged in December 2019 from Wuhan City, Hubei Province, China and spread to the rest of the world. This disease was named COVID-19 by World Health Organization. To date (17
    Keywords covid19
    Language English
    Publishing date 2018-10-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2656431-2
    ISSN 2233-6052 ; 2210-9099
    ISSN (online) 2233-6052
    ISSN 2210-9099
    DOI 10.24171/j.phrp.2020.11.3.08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: COVID-19 Outbreak in Malaysia

    Elengoe, Asita

    Osong Public Health Res Perspect

    Abstract: In 2020 a significant threat to public health emerged The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic outbreak emerged in December 2019 from Wuhan City, Hubei Province, China and spread to the rest of the world This ... ...

    Abstract In 2020 a significant threat to public health emerged The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic outbreak emerged in December 2019 from Wuhan City, Hubei Province, China and spread to the rest of the world This disease was named COVID-19 by World Health Organization To date (17th April 2020) a total of 2,230,439 cases of COVID-19;150,810 cases of deaths and 564,210 recovered cases have been reported worldwide In this review the SARS-CoV-2 morphology, pathogenic mechanism, similarities and differences between SARS-CoV and Middle East Respiratory Syndrome and severe acute respiratory syndrome, transmission mode, diagnosis, treatment, and preventive measures were investigated The outbreak of COVID-19 from a Malaysian perspective was explored and mental health care during the COVID-19 outbreak was explored To date, there is no vaccine or no specific treatment for COVID-19 Therefore, preventive measures are very important to prevent and control the rapid spread of the SARS-CoV-2 virus Preparedness should be a priority for future pandemic outbreaks
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #456731
    Database COVID19

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  4. Article ; Online: Overview on Origin, Transmission, Treatment and Clinical Researches of Sars-Cov-2

    Asita Elengoe / Shalini Selvam

    Journal of Health Sciences and Surveillance System, Vol 10, Iss 1, Pp 2-

    2022  Volume 12

    Abstract: Background: The year 2020 began with a new public health hazard. A novel coronavirus, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was discovered in Wuhan, China on 12th December 2019. In 2020, the World Health Organization (WHO) introduced the ... ...

    Abstract Background: The year 2020 began with a new public health hazard. A novel coronavirus, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was discovered in Wuhan, China on 12th December 2019. In 2020, the World Health Organization (WHO) introduced the name of the disease as ‘COVID-19’. Objective: The morphology, pathogenic mechanisms, causes, transmission, symptoms, diagnosis, therapeutic potential, clinical studies on COVID-19 infection, preventive measures, and mental health care were described in this study. Methods: A literature search was conducted using electronic databases such as PubMed, Scopus, Elsevier, Frontiers, Medline, EMBASE, Web of Science, Science Direct, and Google Scholar. The search was broadly scoped, using key terms such as SARS-CoV-2, COVID-19, etc. Results: The genomic characterization of SARS-CoV-2, drugs, and their potential mechanisms used in humans to inhibit the SARS-CoV-2 were tabulated. Moreover, twenty-five clinical researches carried out against COVID-19 infection were also tabulated in this study. Preventive measures such as chemical disinfectants and increasing test capacity were also discussed. Conclusion: The current study provides a snapshot of the overview of the SARS-CoV-2 and COVID-19. The findings suggested the effective preventive measures to halt the spread of SARS-CoV-2 and develop a better vaccine. The information from this review study also aids in early preparations for future pandemic outbreaks.
    Keywords sars-cov-2 ; covid-19 ; pandemic ; Public aspects of medicine ; RA1-1270
    Subject code 001
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Shiraz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: In silico

    Parvizpour, Sepideh / Elengoe, Asita / Alizadeh, Effat / Razmara, Jafar / Shamsir, Mohd Shahir

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 19, Page(s) 10037–10050

    Abstract: Worldwide, breast cancer is the leading type of cancer among women. Overexpression of various prognostic indicators, including nuclear receptors, is linked to breast cancer features. To date, no effective drug has been discovered to block the ... ...

    Abstract Worldwide, breast cancer is the leading type of cancer among women. Overexpression of various prognostic indicators, including nuclear receptors, is linked to breast cancer features. To date, no effective drug has been discovered to block the proliferation of breast cancer cells. This study has been designed to discover target-based small molecular-like natural drug candidates that have anti-cancer potential without causing any serious side effects. A comprehensive substrate-based drug design was carried out to discover the potential plant compounds against the target breast cancer biomarkers including phytochemicals screening, active site identification, molecular docking, pharmacokinetic (PK) properties prediction, toxicity prediction, and molecular dynamics (MD) simulation approaches. Twenty plant compounds extracted from the rambutan (
    MeSH term(s) Female ; Humans ; Biomarkers, Tumor ; Breast Neoplasms/drug therapy ; Molecular Docking Simulation ; Drug Design ; Drug-Related Side Effects and Adverse Reactions ; Molecular Dynamics Simulation
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2152868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2093: Show issues Location:
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  6. Article ; Online: In Silico Molecular Modeling and Docking Studies on Novel Mutants (E229V, H225P and D230C) of the Nucleotide-Binding Domain of Homo sapiens Hsp70.

    Elengoe, Asita / Hamdan, Salehhuddin

    Interdisciplinary sciences, computational life sciences

    2017  Volume 9, Issue 4, Page(s) 478–498

    Abstract: In this study, we explored the possibility of determining the synergistic interactions between nucleotide-binding domain (NBD) of Homo sapiens heat-shock 70 kDa protein (Hsp70) and E1A 32 kDa of adenovirus serotype 5 motif (PNLVP) in the efficiency of ... ...

    Abstract In this study, we explored the possibility of determining the synergistic interactions between nucleotide-binding domain (NBD) of Homo sapiens heat-shock 70 kDa protein (Hsp70) and E1A 32 kDa of adenovirus serotype 5 motif (PNLVP) in the efficiency of killing of tumor cells in cancer treatment. At present, the protein interaction between NBD and PNLVP motif is still unknown, but believed to enhance the rate of virus replication in tumor cells. Three mutant models (E229V, H225P and D230C) were built and simulated, and their interactions with PNLVP motif were studied. The PNLVP motif showed the binding energy and intermolecular energy values with the novel E229V mutant at -7.32 and -11.2 kcal/mol. The E229V mutant had the highest number of hydrogen bonds (7). Based on the root mean square deviation, root mean square fluctuation, hydrogen bonds, salt bridge, secondary structure, surface-accessible solvent area, potential energy and distance matrices analyses, it was proved that the E229V had the strongest and most stable interaction with the PNLVP motif among all the four protein-ligand complex structures. The knowledge of this protein-ligand complex model would help in designing Hsp70 structure-based drug for cancer therapy.
    MeSH term(s) Adenoviridae/genetics ; Binding Sites/genetics ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Hydrogen Bonding ; Models, Molecular
    Chemical Substances HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2017-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2493085-4
    ISSN 1867-1462 ; 1913-2751
    ISSN (online) 1867-1462
    ISSN 1913-2751
    DOI 10.1007/s12539-016-0181-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Recent perspectives and awareness on transmission, clinical manifestation, quarantine measures, prevention and treatment of COVID-19 among people living in Malaysia in 2020.

    Alabed, Alabed Ali A / Elengoe, Asita / Anandan, Elan Selvi / Almahdi, Abdullah Y

    Zeitschrift fur Gesundheitswissenschaften = Journal of public health

    2020  Volume 30, Issue 5, Page(s) 1133–1142

    Abstract: Background: There is a major public health challenge threatening the world with the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in December 2019 from Wuhan, China.: Objective: The aim of this study was ... ...

    Abstract Background: There is a major public health challenge threatening the world with the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in December 2019 from Wuhan, China.
    Objective: The aim of this study was to assess the knowledge, attitude and practice regarding COVID-19 and its transmission, causes and prevention among people living in Malaysia.
    Methods: A cross-sectional study was conducted among people living in Malaysia by using an online survey in March and April 2020.
    Results: Out of 520 respondents, the mean age was 36.9 ± 14.9, between 19 and 67 years with the majority being female. Most respondents had good knowledge, attitude and practice towards COVID-19 with mean ± sd 18.2 ± 1.7, 5.2 ± 1.1 and 4.1 ± 1.4, respectively. In addition, the majority had good knowledge regarding cause, mode of transmission, signs and symptoms, prevention and treatment and quarantine measures after answering 21 questions.
    Conclusion: To date, there is no specific treatment or vaccine for COVID-19, thus staying at home is the best preventive measure to curb the further growth of positive cases in the country. These findings could provide an insight in designing effective preparedness for future pandemic outbreaks.
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1149070-6
    ISSN 2198-1833 ; 0943-1853
    ISSN 2198-1833 ; 0943-1853
    DOI 10.1007/s10389-020-01395-9
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    Zs.A 3710: Show issues Location:
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  8. Article: Recent perspectives and awareness on transmission, clinical manifestation, quarantine measures, prevention and treatment of COVID-19 among people living in Malaysia in 2020

    Alabed, Alabed Ali A / Elengoe, Asita / Anandan, Elan Selvi / Almahdi, Abdullah Y

    Z Gesundh Wiss

    Abstract: Background: There is a major public health challenge threatening the world with the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in December 2019 from Wuhan, China. Objective: The aim of this study was to ... ...

    Abstract Background: There is a major public health challenge threatening the world with the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in December 2019 from Wuhan, China. Objective: The aim of this study was to assess the knowledge, attitude and practice regarding COVID-19 and its transmission, causes and prevention among people living in Malaysia. Methods: A cross-sectional study was conducted among people living in Malaysia by using an online survey in March and April 2020. Results: Out of 520 respondents, the mean age was 36.9 ± 14.9, between 19 and 67 years with the majority being female. Most respondents had good knowledge, attitude and practice towards COVID-19 with mean ± sd 18.2 ± 1.7, 5.2 ± 1.1 and 4.1 ± 1.4, respectively. In addition, the majority had good knowledge regarding cause, mode of transmission, signs and symptoms, prevention and treatment and quarantine measures after answering 21 questions. Conclusion: To date, there is no specific treatment or vaccine for COVID-19, thus staying at home is the best preventive measure to curb the further growth of positive cases in the country. These findings could provide an insight in designing effective preparedness for future pandemic outbreaks.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #880325
    Database COVID19

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  9. Article: Molecular dynamics simulation and docking studies on novel mutants (T11V, T12P and D364S) of the nucleotide-binding domain of human heat shock 70 kDa protein

    Elengoe, Asita / Mohammed Abu Naser / Salehhuddin Hamdan

    Biologia. 2016 Jan. 23, v. 70, no. 12

    2016  

    Abstract: The aim of investigating protein interaction between Homo sapiens adenovirus and heat shock 70 kDa protein (Hsp70) is to study a potentially synergistic interaction that would enhance the anti-apoptotic mechanisms, hence increasing the virus replication ... ...

    Abstract The aim of investigating protein interaction between Homo sapiens adenovirus and heat shock 70 kDa protein (Hsp70) is to study a potentially synergistic interaction that would enhance the anti-apoptotic mechanisms, hence increasing the virus replication rate and improve the killing efficiency of tumour cells in cancer therapy. Currently, the protein interaction between Hsp70 and E1A 32 kDa of human adenovirus C serotype 5 (Ad5) is still unknown. Mutant models (T11V, T12P and D364S) were built, simulated and their interactions with Ad5 were studied. The E1A 32 kDa of human Ad5 motif (PNLVP) showed the lowest binding energy and intermolecular energy values with the novel T11V mutant at -8.26 kcal/mol and -11.21 kcal/mol. The protein-ligand complex models revealed that the T11V mutant had the strongest and most stable interaction with the PNLVP motif among all the four protein-ligand complex structures. This knowledge would assist future in vivo investigations of this protein-ligand complex structure in cancer treatment research.
    Keywords Homo sapiens ; Human adenovirus C ; energy ; humans ; models ; molecular dynamics ; mutants ; neoplasm cells ; neoplasms ; protein-protein interactions ; serotypes ; therapeutics ; virus replication ; NBD of Hsp70 ; adenovirus serotype 5 ; PNLVP motif ; molecular dynamics simulation ; docking
    Language English
    Dates of publication 2016-0123
    Size p. 1655-1671.
    Publishing place De Gruyter Open
    Document type Article
    ZDB-ID 419136-5
    ISSN 1336-9563 ; 0006-3088 ; 1335-6372 ; 1335-6380
    ISSN (online) 1336-9563
    ISSN 0006-3088 ; 1335-6372 ; 1335-6380
    DOI 10.1515/biolog-2015-0194
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: A Novel Protein Interaction between Nucleotide Binding Domain of Hsp70 and p53 Motif

    Asita Elengoe / Mohammed Abu Naser / Salehhuddin Hamdan

    International Journal of Genomics, Vol

    2015  Volume 2015

    Keywords Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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