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  1. Article ; Online: COVID-19 Outbreak: an Update on Therapeutic Options.

    Panati, Kalpana / Narala, Venkata Ramireddy

    SN comprehensive clinical medicine

    2020  Volume 2, Issue 4, Page(s) 379–380

    Keywords covid19
    Language English
    Publishing date 2020-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00264-6
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  2. Article ; Online: Code inside the codon: The role of synonymous mutations in regulating splicing machinery and its impact on disease.

    Sarkar, Avik / Panati, Kalpana / Narala, Venkata Ramireddy

    Mutation research. Reviews in mutation research

    2022  Volume 790, Page(s) 108444

    Abstract: In eukaryotes, precise pre-mRNA processing, including alternative splicing, is essential to carry out the intricate protein translation process. Both point mutations (that alter the translated protein sequence) and synonymous mutations (that do not alter ...

    Abstract In eukaryotes, precise pre-mRNA processing, including alternative splicing, is essential to carry out the intricate protein translation process. Both point mutations (that alter the translated protein sequence) and synonymous mutations (that do not alter the translated protein sequence) are capable of affecting the splicing process. Synonymous mutations are known to affect gene expression via altering mRNA stability, mRNA secondary structure, splicing processes, and translational kinetics. In higher eukaryotes, precise splicing is regulated by three weakly conserved cis-elements, 5' and 3' splice sites and the branch site. Many other cis-acting elements (exonic/intronic splicing enhancers and silencers) and trans-acting splicing factors (serine and arginine-rich proteins and heterogeneous nuclear ribonucleoproteins) have also been found to enhance or suppress the splicing process. The appearance of synonymous mutations in cis-acting elements can alter the splicing process by changing the binding pattern of splicing factors to exonic splicing enhancers or silencer motifs. This results in exon skipping, intron retention, and various other forms of alternative splicing, eventually leading to the emergence of a wide range of diseases. The focus of this review is to elucidate the role of synonymous mutations and their impact on abnormal splicing mechanisms. Further, this study highlights the function of synonymous mutation in mediating abnormal splicing in cancer and development of X-linked, and autosomal inherited diseases.
    Language English
    Publishing date 2022-10-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2727833-5
    ISSN 1388-2139 ; 1383-5742
    ISSN (online) 1388-2139
    ISSN 1383-5742
    DOI 10.1016/j.mrrev.2022.108444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1316 -Rev-: Show issues Location:
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  3. Article ; Online: Nitrated fatty acid, 10-nitrooleate protects against hyperoxia-induced acute lung injury in mice.

    Narala, Venkata Ramireddy / Thimmana, Lokesh V / Panati, Kalpana / Kolliputi, Narasaiah

    International immunopharmacology

    2022  Volume 109, Page(s) 108838

    Abstract: The antioxidant and anti-inflammatory effects of electrophilic nitrated fatty acid (NFA); 10-nitrooleate, have been reported. The present study investigated whether 10-nitrooleate has a protective role against hyperoxic-induced acute lung injury (HALI). ... ...

    Abstract The antioxidant and anti-inflammatory effects of electrophilic nitrated fatty acid (NFA); 10-nitrooleate, have been reported. The present study investigated whether 10-nitrooleate has a protective role against hyperoxic-induced acute lung injury (HALI). Using a C57BL/6 mice model of HALI, we investigated the protective effect of 10-nitrooleate. C57BL/6 mice were administered with NFA intratracheally, exposed to hyperoxia for 48 h to induce HALI, and kept at room air for 24 h. Bronchoalveolar lavage (BAL) fluid and lung samples were collected after 24 h of post hyperoxia to analyze markers associated with HALI. Intratracheal (IT) and intraperitoneal (IP) administration of NFA notably attenuated hyperoxia-induced infiltration of inflammatory cells, alveolar-capillary leakage, upregulation of proinflammatory cytokine levels (IL-6 and TNFα) into the BAL fluid, and resolution of inflammation in the lung. Western blot analyses showed that 10-nitrooleate reduced the expression of the inflammatory transcription factor NFκB p65 subunit and increased antioxidant proteins HO-1 and NQO1 expression in the lung tissues compared to vehicle-treated animals. Moreover, 10-nitrooleate reversed the hyperoxia-induced expression of mitophagy-associated markers (PINK1 and p62/SQSTM1), thereby protecting the HALI/ acute respiratory distress syndrome (ARDS). IT and IP delivery of 10-nitrooleate reduces hyperoxia-induced ALI/ARDS by regulating the antioxidant pathways and restoring the mitochondrial homeostasis by regulating mitophagy. It is suggested that NFAs can be further evaluated as supplementary therapy for critically ill patients like COVID-19/ARDS.
    MeSH term(s) Acute Lung Injury/chemically induced ; Animals ; Antioxidants/metabolism ; Antioxidants/therapeutic use ; COVID-19 ; Fatty Acids/metabolism ; Humans ; Hyperoxia/complications ; Hyperoxia/metabolism ; Lung/metabolism ; Lung Injury/metabolism ; Mice ; Mice, Inbred C57BL ; Nitrates/adverse effects ; Nitrates/metabolism ; Respiratory Distress Syndrome
    Chemical Substances Antioxidants ; Fatty Acids ; Nitrates
    Language English
    Publishing date 2022-05-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2022.108838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: COVID-19 Outbreak

    Panati, Kalpana / Narala, Venkata Ramireddy

    SN Comprehensive Clinical Medicine

    an Update on Therapeutic Options

    2020  Volume 2, Issue 4, Page(s) 379–380

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2947211-8
    ISSN 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00264-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: An Overview on COVID-19 Pandemic: from Discovery to Treatment.

    Panati, Kalpana / Tatireddygari, Venkatramana Reddy Arva / Narala, Venkata Ramireddy

    Infectious disorders drug targets

    2020  Volume 21, Issue 7, Page(s) e160921187709

    Abstract: Recently, novel coronavirus infection (COVID-19) emerged in Wuhan, China has been declared as pandemic by WHO. Until now, no evidence is documented regarding its wild animal reservoir or intermediary host, but, human-to-human transmission, asymptomatic ... ...

    Abstract Recently, novel coronavirus infection (COVID-19) emerged in Wuhan, China has been declared as pandemic by WHO. Until now, no evidence is documented regarding its wild animal reservoir or intermediary host, but, human-to-human transmission, asymptomatic carriers were very much observed. The number of confirmed cases and death toll have been increased almost all over the world indicating its potential threat to public health. Though the phylogenetic analysis shows some similarity of SARS-CoV2 to bat betacoronaviruses, it exhibited significant variation in S1 domain of spike protein from bat-derived viruses. S1 domain plays an important role in receptor binding and it can be a target for the development of therapeutics and vaccines. In this review, we have discussed the updates on transmission, diagnosis, genome analysis and comparison, treatment options and clinical trials of COVID-19.
    MeSH term(s) Animals ; COVID-19 ; Humans ; Pandemics/prevention & control ; Phylogeny ; RNA, Viral ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances RNA, Viral ; Spike Glycoprotein, Coronavirus
    Keywords covid19
    Language English
    Publishing date 2020-11-09
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/1871526520666201109115820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5598: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Biochanin A Ameliorates Ovalbumin-induced Airway Inflammation through Peroxisome Proliferator-Activated Receptor-Gamma in a Mouse Model.

    Derangula, Madhavi / Panati, Kalpana / Narala, Venkata R

    Endocrine, metabolic & immune disorders drug targets

    2020  Volume 21, Issue 1, Page(s) 145–155

    Abstract: Objective: Asthma is an inflammatory airway disease affecting most of the population in the world. The current medication for asthma relieves airway inflammation but it has serious adverse effects. Biochanin A (BCA), a phytoestrogen, is an active ... ...

    Abstract Objective: Asthma is an inflammatory airway disease affecting most of the population in the world. The current medication for asthma relieves airway inflammation but it has serious adverse effects. Biochanin A (BCA), a phytoestrogen, is an active component present in red clover, alfalfa, soy having anti-oxidant and anti-inflammatory properties. BCA was identified as a natural activator of peroxisome proliferator-activated receptor-gamma (PPARγ).
    Methods: The study aims to evaluate the effects of BCA in ovalbumin (OVA)-induced murine model of asthma and to study the role of PPARγ.
    Results: We found that BCA administration reduced the severity of murine allergic asthma as evidenced histologically, and measurement of allergen-specific IgE levels in serum as well as in BAL fluid. BCA also reversed the elevated levels of inflammatory cytokines, cell infiltration, protein leakage into the airways and expression of hemoxygenase-1 in OVA-induced lungs. Further, we confirmed that BCA mediated inhibitory effects are mediated through PPARγ as assessed by treatment with PPARγ antagonist GW9662.
    Conclusion: Our results suggest that BCA is efficacious in a preclinical model of asthma and may have the potential for the treatment of asthma in humans.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Asthma/chemically induced ; Asthma/drug therapy ; Asthma/genetics ; Asthma/pathology ; Disease Models, Animal ; Female ; Genistein/therapeutic use ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/pathology ; Mice ; Ovalbumin ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Respiratory Tract Diseases/chemically induced ; Respiratory Tract Diseases/drug therapy ; Respiratory Tract Diseases/genetics ; Respiratory Tract Diseases/pathology ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; PPAR gamma ; Ovalbumin (9006-59-1) ; Genistein (DH2M523P0H) ; biochanin A (U13J6U390T)
    Language English
    Publishing date 2020-05-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530320666200503051609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5824: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Electrophilic nitrated fatty acids are potential therapeutic candidates for inflammatory and fibrotic lung diseases.

    Panati, Kalpana / Thimmana, Lokesh V / Narala, Venkata Ramireddy

    Nitric oxide : biology and chemistry

    2020  Volume 102, Page(s) 28–38

    Abstract: Several types of exposures can cause acute or chronic inflammatory reactions in the lungs often leading to asthma, pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), acute lung injury, lung cancer, and other deleterious health outcomes. ... ...

    Abstract Several types of exposures can cause acute or chronic inflammatory reactions in the lungs often leading to asthma, pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), acute lung injury, lung cancer, and other deleterious health outcomes. Current therapy, with inhaled or oral glucocorticoids, successfully targets inflammation but also produces adverse effects that limit their enthusiastic use. Accordingly, the need remains for interventions that are safer and more effective. Nitrated fatty acids (NFAs) are highly electrophilic and are produced endogenously by non-enzymatic reactions of nitric oxide with conjugated unsaturated fatty acids. The literature indicates that NFAs are detected in humans at the nanomolar range and are produced more robustly under inflammatory conditions. Recent studies on novel NFAs report antiinflammatory, antioxidant, and antifibrotic effects, while also acting as partial agonists of peroxisome proliferator-activated receptor-gamma (PPAR-γ). Furthermore, these functions of NFAs occur via reversible electrophilic alkylation of cysteine residues and regulation of antiinflammatory, antioxidant signaling through modulation of transcription factors, including nuclear factor E2-related factor 2 (Nrf2), PPAR-γ, and NF-κB. Here, we review and update the role of NFA signaling mechanisms and their therapeutic potential in various lung diseases. As NFAs display strong electrophilic interaction with multimechanistic pathways, they can be considered promising drug candidates for challenging lung diseases.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antioxidants/therapeutic use ; Fatty Acids/therapeutic use ; Humans ; Inflammation/drug therapy ; Lung Diseases/drug therapy ; Nitrates/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants ; Fatty Acids ; Nitrates
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2020.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4677: Show issues Location:
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  9. Article ; Online: Virology and Molecular Pathogenesis of Coronavirus Disease 2019

    Kalpana Panati / Lokesh V Timmana / Venkatramana Reddy AT / Rajeswara Reddy Saddala / Venkata Ramireddy Narala

    Eurasian Journal of Medicine, Vol 54, Iss 3, Pp 299-

    An Update

    2022  Volume 304

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Angiotensin-converting enzyme gene polymorphism may be a risk factor for covid-19 clinical outcome

    Panati, Kalpana / Surendranatha Reddy, E. C. / Narala, Venkata Ramireddy

    Curr. Trends Biotechnol. Pharm.

    Abstract: Angiotensin-converting enzyme 1(ACE1) and ACE2 play a major role in regulation of blood pressure and electrolytic balance. They are known to express in epithelial cells of various tissues. SARS-CoV2 uses ACE2 as one of the receptors to enter into the ... ...

    Abstract Angiotensin-converting enzyme 1(ACE1) and ACE2 play a major role in regulation of blood pressure and electrolytic balance. They are known to express in epithelial cells of various tissues. SARS-CoV2 uses ACE2 as one of the receptors to enter into the host cells. Coronavirus infection-associated decrease in the expression of ACE2 is known to associate with vasoconstriction, hypertension and other cardiovascular problems. Patients who are on ACE1 inhibitors show increased ACE2 expression, which is known to protect the lung from acute lung injury. ACE1 and ACE2 polymorphisms might be associated with the infectivity, severity and recovery from the COVID-19. Association studies of ACE gene polymorphisms in affected population may suggest the clinical outcome of the COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #714722
    Database COVID19

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