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  1. Article ; Online: Patent foramen ovale: diagnostic evaluation and the role of device closure.

    Gonnah, Ahmed R / Bharadwaj, Mahima S / Nassar, Hassan / Abdelaziz, Hesham K / Roberts, David Hesketh

    Clinical medicine (London, England)

    2022  Volume 22, Issue 5, Page(s) 441–448

    Abstract: Although seemingly benign, the presence of a patent foramen ovale (PFO) may play an important role in the pathophysiology of disease, specifically a paradoxical embolism leading to cryptogenic stroke. The European Society of Cardiology recently published ...

    Abstract Although seemingly benign, the presence of a patent foramen ovale (PFO) may play an important role in the pathophysiology of disease, specifically a paradoxical embolism leading to cryptogenic stroke. The European Society of Cardiology recently published guidelines detailing how PFOs are associated with paradoxical embolism and how they are diagnosed and managed. This review guides physicians in the diagnostic and referral process to a multidisciplinary team involved in PFO closure. It reviews the clinical trials comparing device closure with medical therapy and highlights the current NHS England commissioning process on PFO management. Finally, we give an overview of other conditions where PFO device closure may need to be considered.
    MeSH term(s) Humans ; Stroke/complications ; Secondary Prevention ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnosis ; Foramen Ovale, Patent/therapy ; Embolism, Paradoxical/complications ; Embolism, Paradoxical/diagnosis ; England ; Treatment Outcome
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2022-0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5439: Show issues Location:
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  2. Article ; Online: Aspirin for primary prevention in the elderly.

    Saad, Marwan / Abdelaziz, Hesham K / Mehta, Jawahar L

    Aging

    2019  Volume 11, Issue 17, Page(s) 6618–6619

    MeSH term(s) Aged ; Aged, 80 and over ; Aspirin/therapeutic use ; Cardiovascular Diseases/prevention & control ; Female ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Primary Prevention/methods
    Chemical Substances Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-09-06
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.102255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel safe method for treatment of giant coronary artery aneurysm: Wire Looping Technique.

    Abdelaziz, Hesham K / Chalil, Shajil / Patel, Billal

    Coronary artery disease

    2019  Volume 30, Issue 5, Page(s) 352–353

    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/instrumentation ; Cardiac Catheterization/instrumentation ; Cardiac Catheters ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/therapy ; Drug-Eluting Stents ; Humans ; Male ; Treatment Outcome
    Language English
    Publishing date 2019-01-15
    Publishing country England
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000000691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3039: Show issues Location:
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  4. Article ; Online: COVID-19 Pandemic and Acute Myocardial Infarction: Management Protocol From a British Cardiac Centre.

    Abdelaziz, Hesham K / Patel, Billal / Chalil, Shajil / Choudhury, Tawfiq

    Critical pathways in cardiology

    2020  Volume 19, Issue 2, Page(s) 55–57

    MeSH term(s) COVID-19 ; Cardiac Care Facilities/standards ; Clinical Protocols/standards ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Humans ; Myocardial Infarction/therapy ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079676-6
    ISSN 1535-2811 ; 1535-282X
    ISSN (online) 1535-2811
    ISSN 1535-282X
    DOI 10.1097/HPC.0000000000000222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Meta-Analysis Comparing Direct Oral Anticoagulants to Vitamin K Antagonists for The Management of Left Ventricular Thrombus.

    Abdelaziz, Hesham K / Megaly, Michael / Debski, Maciej / Abdelrahman, Amr / Abdelaziz, Shehab / Kamal, Diaa / Patel, Billal / More, Ranjit / Choudhury, Tawfiq

    Expert review of cardiovascular therapy

    2021  Volume 19, Issue 5, Page(s) 427–432

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Administration, Oral ; Anticoagulants/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/chemically induced ; Humans ; Thrombosis/drug therapy ; Vitamin K/antagonists & inhibitors
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2021.1915134
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    Zs.A 6107: Show issues Location:
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  6. Article: COVID-19 Pandemic and Acute Myocardial Infarction: Management Protocol From a British Cardiac Centre

    Abdelaziz, Hesham K / Patel, Billal / Chalil, Shajil / Choudhury, Tawfiq

    Crit Pathw Cardiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #19795
    Database COVID19

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  7. Article ; Online: Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF

    Hassan, Alaa A / Mohamed, Nasr K / Aly, Ashraf A / Ramadan, Mohamed / Gomaa, Hesham A M / Abdel-Aziz, Ahmed T / Youssif, Bahaa G M / Bräse, Stefan / Fuhr, Olaf

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 24

    Abstract: Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore, ...

    Abstract Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore, searching for new lead compounds that show the highest anticancer potency with the fewest adverse effects is a major drug-discovery challenge. Because the thiazole ring is present in dasatinib, which is currently used in anticancer therapy, it is important to highlight the ring. In this study, cycloalkylidenehydrazinecarbothioamides (cyclopentyl, cyclohexyl, cyclooctyl, dihydronapthalenylidene, flurine-9-ylidene, and indolinonyl) reacted with 2-bromoacetophenone and diethylacetylenedicarboxylate to yield thiazole and 4-thiazolidinone derivatives. The structure of the products was confirmed by using infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and single-crystal X-ray analyses. The antiproliferative activity of the newly synthesized compounds was evaluated. The most effective inhibitory compounds were further tested in vitro against both epidermal growth factor receptor (EGFR) and B-Raf proto-oncogene, serine/threonine kinase (BRAF
    MeSH term(s) Humans ; Thiazoles/chemistry ; Proto-Oncogene Proteins B-raf ; Molecular Docking Simulation ; Neoplasm Recurrence, Local ; ErbB Receptors ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor
    Chemical Substances 4-thiazolidinone ; Thiazoles ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Antineoplastic Agents ; BRAF protein, human (EC 2.7.11.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28247951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  8. Article ; Online: COVID-19 Pandemic and Acute Myocardial Infarction ; Management Protocol From a British Cardiac Centre

    Abdelaziz, Hesham K. / Patel, Billal / Chalil, Shajil / Choudhury, Tawfiq

    Critical Pathways in Cardiology

    2020  Volume 19, Issue 2, Page(s) 55–57

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2079676-6
    ISSN 1535-2811 ; 1535-282X
    ISSN (online) 1535-2811
    ISSN 1535-282X
    DOI 10.1097/hpc.0000000000000222
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 5660: Show issues Location:
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  9. Article ; Online: Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF V600E

    Alaa A. Hassan / Nasr K. Mohamed / Ashraf A. Aly / Mohamed Ramadan / Hesham A. M. Gomaa / Ahmed T. Abdel-Aziz / Bahaa G. M. Youssif / Stefan Bräse / Olaf Fuhr

    Molecules, Vol 28, Iss 24, p

    2023  Volume 7951

    Abstract: Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore, ...

    Abstract Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore, searching for new lead compounds that show the highest anticancer potency with the fewest adverse effects is a major drug-discovery challenge. Because the thiazole ring is present in dasatinib, which is currently used in anticancer therapy, it is important to highlight the ring. In this study, cycloalkylidenehydrazinecarbothioamides (cyclopentyl, cyclohexyl, cyclooctyl, dihydronapthalenylidene, flurine-9-ylidene, and indolinonyl) reacted with 2-bromoacetophenone and diethylacetylenedicarboxylate to yield thiazole and 4-thiazolidinone derivatives. The structure of the products was confirmed by using infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and single-crystal X-ray analyses. The antiproliferative activity of the newly synthesized compounds was evaluated. The most effective inhibitory compounds were further tested in vitro against both epidermal growth factor receptor (EGFR) and B-Raf proto-oncogene, serine/threonine kinase (BRAF V600E ) targets. Additionally, molecular docking analysis examined how these molecules bind to the active sites of EGFR and BRAF V600E .
    Keywords thiazole ; 4-thiazolidinone ; EGFR ; BRAF ; dual inhibitors ; anticancer ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A Novel, Simple, and Safe Technique for Retrieving a Crushed Stent From the Coronary Artery: Balloon-Assisted Stent Retraction.

    Abdelaziz, Hesham K / Eichhofer, Jonas / Patel, Billal

    The Journal of invasive cardiology

    2017  Volume 29, Issue 12, Page(s) E203–E204

    Abstract: Various percutaneous methods have been described for the retrieval of damaged stents; however, these methods can be complex and carry a risk of stent embolization or vascular damage. We present a simple and safe technique using a compliant balloon for ... ...

    Abstract Various percutaneous methods have been described for the retrieval of damaged stents; however, these methods can be complex and carry a risk of stent embolization or vascular damage. We present a simple and safe technique using a compliant balloon for stent retrieval.
    MeSH term(s) Aged ; Coronary Angiography/methods ; Coronary Artery Disease/surgery ; Device Removal/instrumentation ; Device Removal/methods ; Humans ; Intraoperative Complications/diagnosis ; Intraoperative Complications/etiology ; Intraoperative Complications/surgery ; Male ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/methods ; Prosthesis Failure ; Stents/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
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    Zs.MO 272: Show issues
    Zs.MG 31: Show issues

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