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  1. AU=Sheikh Fatima
  2. AU="Machado, Clarissa Maria Goncalves" AU="Machado, Clarissa Maria Goncalves"
  3. AU="Goldfaden, Rebecca F"
  4. AU="Jacques, Simon"
  5. AU="Calatayud, David G"
  6. AU="Yan, Dingfei"
  7. AU="Rippin, Ido"
  8. AU="Krista M. Pullen"
  9. AU="Higo, Tomoya"
  10. AU="Bremadesam Raman, Lakshmi"
  11. AU="Duffner, P K"
  12. AU="Walsh, Jacinta"

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  1. Artikel: Salicylic acid protects gentamicin-induced hepatotoxicity: Study in rabbits.

    Syeda Nuzhat Fatima Zaidi, - / Gulnaz, - / Sheikh Muhammad Usman, -

    Pakistan journal of pharmaceutical sciences

    2023  Band 36, Heft 3, Seite(n) 873–878

    Abstract: Gentamicin (GM) is a broadly used antibiotic against severe and life-threatening infections, but its efficacy is restricted by the development of liver toxicity. The present study was designed to evaluate the protective effect of salicylic acid (SA) in ... ...

    Abstract Gentamicin (GM) is a broadly used antibiotic against severe and life-threatening infections, but its efficacy is restricted by the development of liver toxicity. The present study was designed to evaluate the protective effect of salicylic acid (SA) in gentamicin-induced hepatotoxicity in rabbits. Gentamicin and salicylic acid were given at a dose of 80 mg/kg i.p for twenty days. For this purpose, 24 male albino rabbits were randomly divided into four groups. Group I remained untreated and served as control. Group II was given gentamicin, group III was given gentamicin along with Salicylic acid (SA) and group IV was given only salicylic acid. The degree of hepatoprotection was measured by assessment of body weight, liver weight, absolute liver weight and estimations of plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin, tissue malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities. Significant reduction in the elevated liver weight, plasma levels of AST, ALT, bilirubin and tissue MDA and significant elevation in reduced body weight, SOD and CAT activities were found that confirms the protective role of salicylic acid in gentamicin induced hepatotoxicity.
    Mesh-Begriff(e) Animals ; Rabbits ; Male ; Gentamicins/toxicity ; Salicylic Acid/pharmacology ; Antioxidants/pharmacology ; Liver ; Superoxide Dismutase/metabolism ; Bilirubin/metabolism ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemical and Drug Induced Liver Injury/drug therapy ; Body Weight ; Oxidative Stress ; Alanine Transaminase ; Aspartate Aminotransferases/metabolism
    Chemische Substanzen Gentamicins ; Salicylic Acid (O414PZ4LPZ) ; Antioxidants ; Superoxide Dismutase (EC 1.15.1.1) ; Bilirubin (RFM9X3LJ49) ; Alanine Transaminase (EC 2.6.1.2) ; Aspartate Aminotransferases (EC 2.6.1.1)
    Sprache Englisch
    Erscheinungsdatum 2023-08-15
    Erscheinungsland Pakistan
    Dokumenttyp Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6588: Hefte anzeigen Standort:
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  2. Artikel: Inhibition of anti-inflammatory pathway through suppressors of cytokine signalling (Socs2/Socs3) in the initiation of hepatocellular carcinoma.

    Ashfaq, Isbah / Sheikh, Nadeem / Fatima, Naz / Tayyeb, Asima

    Saudi journal of biological sciences

    2022  Band 29, Heft 8, Seite(n) 103348

    Abstract: Hepatocellular carcinoma (HCC), a leading cause of cancer related deaths is predominantly driven by chronic inflammatory responses. Due to asymptomatic nature and lack of early patient biopsies, precise involvement of inflammation in hepatic injury ... ...

    Abstract Hepatocellular carcinoma (HCC), a leading cause of cancer related deaths is predominantly driven by chronic inflammatory responses. Due to asymptomatic nature and lack of early patient biopsies, precise involvement of inflammation in hepatic injury initiation remains unidentified. Aim of the study was to elucidate the regulation patterns of inflammatory signalling from initiation of hepatic injury to development of HCC. HCC mice model was established using DEN followed by repeated doses of CCl
    Sprache Englisch
    Erscheinungsdatum 2022-06-20
    Erscheinungsland Saudi Arabia
    Dokumenttyp Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2022.103348
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  3. Artikel ; Online: Tears of Sorrow: Forgotten or Abandoned.

    Sheikh, Fatima

    Journal of the American Medical Directors Association

    2017  Band 18, Heft 9, Seite(n) 803–804

    Mesh-Begriff(e) Aged ; Attitude to Death ; Family/psychology ; Female ; Hospice Care ; Humans ; Quality of Life ; Terminal Care
    Sprache Englisch
    Erscheinungsdatum 2017-07-18
    Erscheinungsland United States
    Dokumenttyp Letter ; Personal Narrative
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2017.06.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5971: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Artikel ; Online: Plan for blood banks to protect blood donors and healthcare workers during COVID-19 pandemic.

    Ali, Sheikh Muhammad Ebad / Fatima, Sarosh

    Hematology, transfusion and cell therapy

    2020  Band 42, Heft 4, Seite(n) 316–317

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-25
    Erscheinungsland Brazil
    Dokumenttyp Letter
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2020.07.001
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  5. Artikel ; Online: Electrochemical analysis of glyphosate using porous biochar surface corrosive nZVI nanoparticles.

    Qureashi, Aaliya / Pandith, Altaf Hussain / Bashir, Arshid / Malik, Lateef Ahmad / Manzoor, Taniya / Sheikh, Faheem A / Fatima, Kaniz / Haq, Zia-Ul

    Nanoscale advances

    2023  Band 5, Heft 3, Seite(n) 742–755

    Abstract: Glyphosate [ ...

    Abstract Glyphosate [
    Sprache Englisch
    Erscheinungsdatum 2023-01-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d2na00610c
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  6. Artikel: Advancements in Polymeric Nanocarriers to Mediate Targeted Therapy against Triple-Negative Breast Cancer.

    Fatima, Mahak / Sheikh, Afsana / Abourehab, Mohammed A S / Kesharwani, Prashant

    Pharmaceutics

    2022  Band 14, Heft 11

    Abstract: Triple-negative breast cancer (TNBC) is a destructive disease with a poor prognosis, low survival rate and high rate of metastasis. It comprises 15% of total breast cancers and is marked by deficiency of three important receptor expressions, i.e., ... ...

    Abstract Triple-negative breast cancer (TNBC) is a destructive disease with a poor prognosis, low survival rate and high rate of metastasis. It comprises 15% of total breast cancers and is marked by deficiency of three important receptor expressions, i.e., progesterone, estrogen, and human epidermal growth factor receptors. This absence of receptors is the foremost cause of current TNBC therapy failure, resulting in poor therapeutic response in patients. Polymeric nanoparticles are gaining much popularity for transporting chemotherapeutics, genes, and small-interfering RNAs. Due to their exclusive properties such as great stability, easy surface modification, stimuli-responsive and controlled drug release, ability to condense more than one therapeutic moiety inside, tumor-specific delivery of payload, enhanced permeation and retention effect, present them as ideal nanocarriers for increasing efficacy, bioavailability and reducing the toxicity of therapeutic agents. They can even be used as theragnostic agents for the diagnosis of TNBC along with its treatment. In this review, we discuss the limitations of already existing TNBC therapies and highlight the novel approach to designing and the functionalization of polymeric nanocarriers for the effective treatment of TNBC.
    Sprache Englisch
    Erscheinungsdatum 2022-11-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14112432
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Sepsis and obesity: a scoping review of diet-induced obesity murine models.

    Eng, Mikaela / Suthaaharan, Keshikaa / Newton, Logan / Sheikh, Fatima / Fox-Robichaud, Alison

    Intensive care medicine experimental

    2024  Band 12, Heft 1, Seite(n) 15

    Abstract: Background: Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the "obesity paradox". This scoping review ... ...

    Abstract Background: Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the "obesity paradox". This scoping review systematically maps the literature on outcomes associated with diet-induced obesity and sepsis-induced organ injury, focusing on non-transgenic murine models.
    Methods: A literature search of primary articles was conducted from database inception to June 2023. Eligible articles compared diet-induced obesity to non-obese mice in sepsis models involving live pathogens. Two reviewers screened articles and extracted data on obesogenic and sepsis models utilized, and organ injury outcomes, including physiological dysfunction, histological alterations, and biochemical changes.
    Results: Seventeen studies met eligibility criteria; 82% used male C57BL/6 mice, and 88% used cecal ligation and puncture to induce sepsis. Most studies used 60% high-fat diets compared to 10-16% fat in controls. Seven (64%) studies reported increased mortality in obese septic mice, one (9%) observed a decrease, and three (37%) found no significant difference. The liver, lungs, and kidneys were the most studied organs. Alanine transaminase results were inconclusive. Myeloperoxidase levels were increased in the livers of two studies and inconclusive in the lungs of obese septic mice. Creatinine and neutrophil gelatinase-associated lipocalin were elevated in obese septic mice.
    Conclusions: There is variability in the methodology and measured outcomes in murine models of diet-induced obesity and sepsis and a lack of studies in female mice. The absence of standardized models has produced conflicting findings on the impact of obesity on sepsis outcomes.
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00603-0
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  8. Artikel ; Online: Borjeson-Forssman-Lehmann Syndrome: Clinical Features and Diagnostic Challenges.

    Hameed, Marya / Siddiqui, Fatima / Sheikh, Fahad Hassan / Khan, Muhammad Khuzzaim / Admani, Bushra / Gangishetti, Prasanna Kumar

    Brain & NeuroRehabilitation

    2023  Band 16, Heft 3, Seite(n) e32

    Abstract: Borjeson-Forssman-Lehmann syndrome (BFLS) is an X-linked recessive disorder resulting from mutations in ... ...

    Abstract Borjeson-Forssman-Lehmann syndrome (BFLS) is an X-linked recessive disorder resulting from mutations in the
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland Korea (South)
    Dokumenttyp Case Reports
    ISSN 2383-9910
    ISSN (online) 2383-9910
    DOI 10.12786/bn.2023.16.e32
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Advanced methods of algal pigments extraction: A review.

    Fatima, Ishrat / Munir, Mubashrah / Qureshi, Rahmatullah / Hanif, Uzma / Gulzar, Nabila / Sheikh, Ali Ahmad

    Critical reviews in food science and nutrition

    2023  , Seite(n) 1–18

    Abstract: Algae are exclusively aquatic photosynthetic organisms that are microscopic or macroscopic, unicellular or multicellular and distributed across the globe. They are a potential source of food, feed, medicine and natural pigments. A variety of natural ... ...

    Abstract Algae are exclusively aquatic photosynthetic organisms that are microscopic or macroscopic, unicellular or multicellular and distributed across the globe. They are a potential source of food, feed, medicine and natural pigments. A variety of natural pigments are available from algae including chlorophyll a, b, c d, phycobiliproteins, carotenes and xanthophylls. The xanthophylls include acyloxyfucoxanthin, alloxanthin, astaxanthin, crocoxanthin, diadinoxanthin, diatoxanthin, fucoxanthin, loroxanthin, monadoxanthin, neoxanthin, nostoxanthin, perdinin, Prasinoxanthin, siphonaxanthin, vaucheriaxanthin, violaxanthin, lutein, zeaxanthin, β-cryptoxanthin, while carotenes include echinenone, α-carotene, β-carotene, γ-carotene, lycopene, phytoene, phytofluene. These pigments have applications as pharmaceuticals and nutraceuticals and in the food industry for beverages and animal feed production. The conventional methods for the extraction of pigments are solid-liquid extraction, liquid-liquid extraction and soxhlet extraction. All these methods are less efficient, time-consuming and have higher solvent consumption. For a standardized extraction of natural pigments from algal biomass advanced procedures are in practice which includes Supercritical fluid extraction, Pressurized liquid extraction, Microwave-assisted extraction, Pulsed electric field, Moderate electric field, Ultrahigh pressure extraction, Ultrasound-assisted extraction, Subcritical dimethyl ether extraction, Enzyme assisted extraction and Natural deep eutectic solvents. In the present review, these methods for pigment extraction from algae are discussed in detail.
    Sprache Englisch
    Erscheinungsdatum 2023-05-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2023.2216782
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    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1459: Hefte anzeigen Standort:
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  10. Artikel ; Online: Revolutionizing Glucose Monitoring: Enzyme-Free 2D-MoS

    Bano, Mustri / Naikoo, Gowhar A / BaOmar, Fatima / Rather, Jahangir Ahmad / Hassan, Israr U / Sheikh, Rayees Ahmad / Kannan, Palanisamy / Tambuwala, Murtaza M

    ACS omega

    2024  Band 9, Heft 18, Seite(n) 20021–20029

    Abstract: The growing requirement for real-time monitoring of health factors such as heart rate, temperature, and blood glucose levels has resulted in an increase in demand for electrochemical sensors. This study focuses on enzyme-free glucose sensors based on 2D- ... ...

    Abstract The growing requirement for real-time monitoring of health factors such as heart rate, temperature, and blood glucose levels has resulted in an increase in demand for electrochemical sensors. This study focuses on enzyme-free glucose sensors based on 2D-MoS
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c10117
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