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Article ; Online: Pinch Anatomy of Forehead: An Injection Guide for Forehead Filler Treatment.

Kapoor, Krishan M / Chatrath, Vandana / Li, Chris Q / Bertossi, Dario

2022 Volume 38, Issue 2, Page(s) 156–162

Abstract: Filler injections have become very popular in recent years, and injectors globally use them for facial shaping and reversing age-related changes. Detailed knowledge about important vessels' and tissue planes' anatomy is essential for injectors. While ... ...

Abstract	Filler injections have become very popular in recent years, and injectors globally use them for facial shaping and reversing age-related changes. Detailed knowledge about important vessels' and tissue planes' anatomy is essential for injectors. While giving the filler injections, injectors tend to gently pinch or pull the tissue fold with the nondominant hand during the procedure. The deformational forces cause some changes in the anatomy of tissue layers held in a pinch. During the pinch and "pinch and pull" maneuver, the crucial vessels in the area can get pulled up in the tissue layers in a pinch or stay in their position unaffected depending on the force applied. The "pinch and pull" maneuver also increases the tissue space for injections by moving the mobile tissue layers away from the fixed ones. The injector can use knowledge of the "'pinch anatomy" in the forehead to avoid important arteries and place filler in the correct plane. With the understanding of the anatomical changes occurring during the pinched state of tissue layers, filler injection can be performed in the right and safer tissue plane in the forehead. This study reflects level of evidence V.
MeSH term(s)	Cosmetic Techniques ; Dermal Fillers ; Face ; Forehead/anatomy & histology ; Humans ; Injections
Chemical Substances	Dermal Fillers
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	630090-x
ISSN	1098-8793 ; 0736-6825
ISSN (online)	1098-8793
ISSN	0736-6825
DOI	10.1055/a-1730-8436
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Article: Pinch Anatomy of Forehead: An Injection Guide for Forehead Filler Treatment

Kapoor, Krishan M. / Chatrath, Vandana / Li, Chris Q. / Bertossi, Dario

Facial Plastic Surgery

(Nonsurgical Facial Treatments)

2022 Volume 38, Issue 02, Page(s) 156–162

Series title	Nonsurgical Facial Treatments
Abstract	Filler injections have become very popular in recent years, and injectors globally use them for facial shaping and reversing age-related changes. Detailed knowledge about important vessels' and tissue planes' anatomy is essential for injectors. While giving the filler injections, injectors tend to gently pinch or pull the tissue fold with the nondominant hand during the procedure. The deformational forces cause some changes in the anatomy of tissue layers held in a pinch. During the pinch and “pinch and pull” maneuver, the crucial vessels in the area can get pulled up in the tissue layers in a pinch or stay in their position unaffected depending on the force applied. The “pinch and pull” maneuver also increases the tissue space for injections by moving the mobile tissue layers away from the fixed ones. The injector can use knowledge of the “‘pinch anatomy” in the forehead to avoid important arteries and place filler in the correct plane. With the understanding of the anatomical changes occurring during the pinched state of tissue layers, filler injection can be performed in the right and safer tissue plane in the forehead. This study reflects level of evidence V.
Keywords	pinch anatomy ; fillers ; dermal filler ; filler injection ; facial anatomy ; injection anatomy ; hyaluronic acid ; filler complications ; filler technique ; forehead fillers
Language	English
Publishing date	2022-01-04
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	630090-x
ISSN	1098-8793 ; 0736-6825
ISSN (online)	1098-8793
ISSN	0736-6825
DOI	10.1055/a-1730-8436
Database	Thieme publisher's database

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Article ; Online: Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils.

Kaur, Gundeep / Kaundal, Soni / Kapoor, Srajan / Grimes, Jonathan M / Huiskonen, Juha T / Thakur, Krishan Gopal

Scientific reports

2018 Volume 8, Issue 1, Page(s) 10124

Abstract: CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two distinct, ... ...

Abstract	CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two distinct, monomeric and domain-swapped homodimeric, oligomeric states of CarD. However, the actual oligomeric state of CarD in solution and its biological relevance has remained unclear. Here, we confirm the presence of the homodimeric state of CarD in solution by using synchrotron-based small-angle X-ray scattering. Furthermore, by using biochemical and biophysical experiments, in addition to mass-spectrometry, transmission electron microscopy, and confocal imaging, we show that CarD is the first soluble cytosolic protein in Mtb which displays the tendency to form amyloid-like fibrils both in vitro as well as in vivo. We demonstrate that the deletion of the fourteen N-terminal residues involved in domain-swapping hampers amyloid formation, thus, suggesting that domain-swapping is crucial in amyloidogenesis. The discovery of the amyloidogenic property of an essential cytosolic global transcription regulator, CarD, in a pathogenic bacteria will further open up new frontiers in research.
MeSH term(s)	Amyloid/chemistry ; Amyloid/genetics ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Mutation ; Mycobacterium tuberculosis/metabolism ; Polymerization ; Transcription Factors/chemistry ; Transcription Factors/genetics
Chemical Substances	Amyloid ; Bacterial Proteins ; Transcription Factors
Language	English
Publishing date	2018-07-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-28290-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID ‐19 Pandemic

Kapoor, Krishan M. / Chatrath, Vandana / Boxley, Sarah G. / Nurlin, Iman / Snozzi, Philippe / Demosthenous, Nestor / Belo, Victoria / Chan, Wai M. / Kanaris, Nicole / Kapoor, Puneet

Dermatologic Therapy

Consensus guidelines for preferred practices in an aesthetic clinic

2020 Volume 33, Issue 4

Keywords	Dermatology ; General Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.13597
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 Pandemic: Consensus guidelines for preferred practices in an aesthetic clinic.

Kapoor, Krishan M / Chatrath, Vandana / Boxley, Sarah G / Nurlin, Iman / Snozzi, Philippe / Demosthenous, Nestor / Belo, Victoria / Chan, Wai M / Kanaris, Nicole / Kapoor, Puneet

Dermatologic therapy

2020 Volume 33, Issue 4, Page(s) e13597

Abstract: Strict infection control measures in response to the current COVID-19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, ... ...

Abstract	Strict infection control measures in response to the current COVID-19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, guidelines detailing the infection control measures for aesthetic clinics are of particular importance. An online meeting of an international group of experts in the field of aesthetic medicine, with experience in administration of an aesthetic clinic, was convened. The meeting aimed to provide a set of consensus guidelines to protect clinic staff and patients from SARS-CoV-2 infection. Consensus guidelines for "preferred practices" were provided for scheduling of patients, patient evaluation and triaging, and for safety precautions about the different procedures. Procedures were categorized into low-risk, moderate risk, and high-risk based on the likelihood of transmission of SARS-CoV-2 virus from the patient to the treating physician or therapist. While not intended to be complete or exhaustive, these guidelines provide sound infection control measures for aesthetic practices. Since guidelines regarding safety measures and use of PPEs may vary from country to country, the local guidelines should also be followed to prevent COVID-19 infection in aesthetic clinics.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Consensus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Esthetics ; Humans ; Infection Control/standards ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.13597
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management.

Heydenrych, Izolda / Kapoor, Krishan M / De Boulle, Koenraad / Goodman, Greg / Swift, Arthur / Kumar, Narendra / Rahman, Eqram

Clinical, cosmetic and investigational dermatology

2018 Volume 11, Page(s) 603–611

Abstract: The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful ... ...

Abstract	The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Other exclusion criteria include autoimmune diseases and multiple allergies. The temporal proximity of dental or routine medical procedures is discouraged. Insightful patient assessment, with the consideration of ethnicity, gender, and generational needs, is of paramount importance. Specified informed consent is vital due to the concerning increase in vascular complications, which carry the risk for skin compromise and loss of vision. Informed consent should be signed for both adverse events and their treatment. Product-related factors include reversibility, which is a powerful advantage when using hyaluronic acid (HA) products. Complications from nonreversible or minimally degradable products, especially when layered over vital structures, are more difficult to control. Product characteristics such as HA concentration and proprietary cross-linking should be understood in the context of ideal depth, placement, and expected duration. Product layering over late or minimally degradable fillers is discouraged, while layering of HA of over the same brand, or even across brands, seems to be feasible. Procedural factors such as photographic documentation, procedural planning, aseptic technique, and anatomical and technical knowledge are of pivotal importance. A final section is dedicated to algorithms and protocols for the management and treatment of complications such as hypersensitivity, vascular events, infection, and late-onset nodules. The 10-point plan is a systematic, effective strategy aimed at reducing the risk of dermal filler complications.
Language	English
Publishing date	2018-11-23
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S180904
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Gundeep Kaur / Soni Kaundal / Srajan Kapoor / Jonathan M. Grimes / Juha T. Huiskonen / Krishan Gopal Thakur

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 13

Abstract: Abstract CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two ... ...

Abstract	Abstract CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two distinct, monomeric and domain-swapped homodimeric, oligomeric states of CarD. However, the actual oligomeric state of CarD in solution and its biological relevance has remained unclear. Here, we confirm the presence of the homodimeric state of CarD in solution by using synchrotron-based small-angle X-ray scattering. Furthermore, by using biochemical and biophysical experiments, in addition to mass-spectrometry, transmission electron microscopy, and confocal imaging, we show that CarD is the first soluble cytosolic protein in Mtb which displays the tendency to form amyloid-like fibrils both in vitro as well as in vivo. We demonstrate that the deletion of the fourteen N-terminal residues involved in domain-swapping hampers amyloid formation, thus, suggesting that domain-swapping is crucial in amyloidogenesis. The discovery of the amyloidogenic property of an essential cytosolic global transcription regulator, CarD, in a pathogenic bacteria will further open up new frontiers in research.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A cross-sectional survey to assess the knowledge regarding coronavirus disease (COVID-19) among health care professionals.

Mehrotra, Sameer / Jambunathan, Prashant / Jindal, Manisha / Gupta, Aditya / Kapoor, Krishan

Medical journal, Armed Forces India

2020 Volume 77, Page(s) S437–S442

Abstract: Background: In late 2019, the world saw a viral outbreak of unprecedented scale that sent a significant fraction of humankind into either quarantine or lockdown. Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the Severe ... ...

Abstract	Background: In late 2019, the world saw a viral outbreak of unprecedented scale that sent a significant fraction of humankind into either quarantine or lockdown. Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which was first recognized in Wuhan, China, in December 2019. Methods: We created and administered a 17-item questionnaire for health care professionals (HCPs) to assess their level of knowledge towards this ongoing and evolving pandemic. It was disseminated through Web- and mobile-based social networks. The questions were sourced and created from various standard national and international guidelines available at the time of writing. Results: A total of 827 medical personnel participated in the study. Among them, 65.5% scored between 60% and 79%, indicating a moderate level of knowledge. There was no statistically significant difference in the scores of doctors, nursing officers and dental surgeons ( Conclusion: With this understanding, regular training, drills and knowledge dissemination along with skill development through learning correct practices focusing on HCP at all levels are the current needs.
Keywords	covid19
Language	English
Publishing date	2020-08-15
Publishing country	India
Document type	Journal Article
ZDB-ID	196342-9
ISSN	0377-1237
ISSN	0377-1237
DOI	10.1016/j.mjafi.2020.07.001
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Article: COVID-19 Pandemic: Consensus guidelines for preferred practices in an aesthetic clinic

Kapoor, Krishan M / Chatrath, Vandana / Boxley, Sarah G / Nurlin, Iman / Snozzi, Philippe / Demosthenous, Nestor / Belo, Victoria / Chan, Wai M / Kanaris, Nicole / Kapoor, Puneet

Dermatol Ther

Abstract	Strict infection control measures in response to the current COVID-19 pandemic are expected to remain for an extended period. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. In such a scenario, guidelines detailing the infection control measures for aesthetic clinics are of particular importance. An online meeting of an international group of experts in the field of aesthetic medicine, with experience in administration of an aesthetic clinic, was convened. The meeting aimed to provide a set of consensus guidelines to protect clinic staff and patients from SARS-CoV-2 infection. Consensus guidelines for "preferred practices" were provided for scheduling of patients, patient evaluation and triaging, and for safety precautions about the different procedures. Procedures were categorized into low-risk, moderate risk, and high-risk based on the likelihood of transmission of SARS-CoV-2 virus from the patient to the treating physician or therapist. While not intended to be complete or exhaustive, these guidelines provide sound infection control measures for aesthetic practices. Since guidelines regarding safety measures and use of PPEs may vary from country to country, the local guidelines should also be followed to prevent COVID-19 infection in aesthetic clinics.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32415753
Database	COVID19

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Article: Managing Complications of Submental Artery Involvement after Hyaluronic Acid Filler Injection in Chin Region.

Fang, Martha / Rahman, Eqram / Kapoor, Krishan Mohan

Plastic and reconstructive surgery. Global open

2018 Volume 6, Issue 5, Page(s) e1789

Abstract: Hyaluronic acid dermal fillers are becoming popular all over the world, but due to the presence of many blood vessels in the face, there is always a small possibility of vascular complications. We present a case with the ischemic involvement of chin and ... ...

Abstract	Hyaluronic acid dermal fillers are becoming popular all over the world, but due to the presence of many blood vessels in the face, there is always a small possibility of vascular complications. We present a case with the ischemic involvement of chin and neck skin after accidental submental artery involvement after hyaluronic acid filler injection for chin region. Impending skin necrosis on the chin and upper neck on the right side was diagnosed quickly by observing the skin changes in the immediate postfiller phase. Pain in the mandible and in the muscles during swallowing due to possible ischemia of muscles supplied by submental artery was another crucial diagnostic feature. All parts of the affected zone were treated with high-dose pulsed hyaluronidase protocol using 4 pulses of hyaluronidase injection in first 24 hours after filler injection. Complete resolution of cutaneous ischemic changes and painful swallowing was achieved within days after treatment. Knowledge of presenting features of postfiller vascular complications and the extent of vascular territory of the involved artery is quite helpful in quickly instituting treatment leading to the near-complete recovery with minimal sequelae.
Language	English
Publishing date	2018-05-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000001789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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