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Article ; Online: Circadian biology to advance therapeutics for mood disorders.

Bhatnagar, Apoorva / Murray, Greg / Ray, Sandipan

2023 Volume 44, Issue 10, Page(s) 689–704

Abstract: Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian and sleep dysfunction in the pathogenesis of mood disorders, ... ...

Abstract	Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian and sleep dysfunction in the pathogenesis of mood disorders, and there is growing interest in these chronobiological pathways as a focus for treatment innovation. We review contemporary evidence in three promising areas in circadian-clock-based therapeutics in mood disorders: targeting the circadian system informed by mechanistic molecular advances; time-tailoring of medications; and personalizing treatment using circadian parameters. We also consider the limitations and challenges in accelerating the development of new circadian-informed pharmacotherapies for mood disorders.
MeSH term(s)	Humans ; Mood Disorders/drug therapy ; Circadian Clocks ; Biology
Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	282846-7
ISSN	1873-3735 ; 0165-6147
ISSN (online)	1873-3735
ISSN	0165-6147
DOI	10.1016/j.tips.2023.07.008
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Article ; Online: Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges.

Banerjee, Srishti / Ray, Sandipan

Progress in neurobiology

2022 Volume 220, Page(s) 102387

Abstract: Aging causes progressive deterioration of daily rhythms in behavioral and metabolic processes and disruption in the regular sleep-wake cycle. Circadian disruption is directly related to diverse age-induced health abnormalities. Rising evidence from ... ...

Abstract	Aging causes progressive deterioration of daily rhythms in behavioral and metabolic processes and disruption in the regular sleep-wake cycle. Circadian disruption is directly related to diverse age-induced health abnormalities. Rising evidence from various organisms shows that core clock gene mutations cause premature aging, reduced lifespan, and sleeping irregularities. Improving the clock functions and correcting its disruption by pharmacological interventions or time-regulated feeding patterns could be a novel avenue for effective clinical management of aging and sleep disorders. To this end, many drugs for sleep disorders and anti-aging compounds interact with the core clock machinery and alter the circadian output. Evaluation of dosing time-dependency and circadian regulation of drug metabolism for therapeutic improvement of the existing drugs is another fundamental facet of chronomedicine. Multiple studies have demonstrated dose-dependent manipulation of the circadian period and phase-shifting by pharmacologically active compounds. The chronobiology research field is gradually moving towards the development of novel therapeutic strategies based on targeting the molecular clock or dosing time-oriented medications. However, such translational research ventures would require more experimental evidence from studies on humans. This review discusses the impact of circadian rhythms on aging and sleep, emphasizing the potentiality of circadian medicine in aging attenuation and sleep disorders.
MeSH term(s)	Humans ; Circadian Rhythm ; Sleep ; Aging/physiology ; Sleep Wake Disorders/drug therapy
Language	English
Publishing date	2022-12-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	185535-9
ISSN	1873-5118 ; 0301-0082
ISSN (online)	1873-5118
ISSN	0301-0082
DOI	10.1016/j.pneurobio.2022.102387
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Article ; Online: The Promises of Proteomics and Metabolomics for Unravelling the Mechanism and Side Effect Landscape of Beta-Adrenoceptor Antagonists in Cardiovascular Therapeutics.

Chakraborty, Shreyayukta / Kannihalli, Arpita / Mohanty, Abhishek / Ray, Sandipan

Omics : a journal of integrative biology

2023 Volume 27, Issue 3, Page(s) 87–92

Abstract: Cardiovascular medicine witnessed notable advances for the past decade. Multiomics research offers a new lens for precision/personalized medicine for existing and emerging drugs used in the cardiovascular clinic. Beta-blockers are vital in treating ... ...

Abstract	Cardiovascular medicine witnessed notable advances for the past decade. Multiomics research offers a new lens for precision/personalized medicine for existing and emerging drugs used in the cardiovascular clinic. Beta-blockers are vital in treating hypertension and chronic heart failure. However, clinical use of beta-blockers is also associated with side effects and person-to-person variations in their pharmacokinetics and pharmacodynamics. A comprehensive understanding of the mechanisms that underpin the side effect landscape of beta-blockers is imperative to optimize their therapeutic value. In addition, current research emphasizes the circadian clock's vital roles in regulating pharmacological parameters. Administration of the beta-blockers at specific dosing times could potentially improve their effectiveness and reduce their toxic effects. The rapid development of mass spectrometry technologies with chemical proteomics and thermal proteome profiling methods has also substantially advanced our understanding of underlying side effects mechanisms by unbiased deconvolution of drug targets and off-targets. Metabolomics is steadily demonstrating its utility for conducting mechanistic and toxicological analyses of pharmacological compounds. This article discusses the promises of cutting-edge proteomics and metabolomics approaches to investigate the molecular targets, mechanism of action, adverse effects, and dosing time dependency of beta-blockers.
MeSH term(s)	Humans ; Proteomics/methods ; Hypertension ; Adrenergic beta-Antagonists/adverse effects ; Metabolomics ; Drug Delivery Systems
Chemical Substances	Adrenergic beta-Antagonists
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2023.0003
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Article ; Online: Telomerase: a nexus between cancer nanotherapy and circadian rhythm.

Ghosh, Pramit Kumar / Rao, Maddila Jagapathi / Putta, Chandra Lekha / Ray, Sandipan / Rengan, Aravind Kumar

Biomaterials science

2024

Abstract: Cancer represents a complex disease category defined by the unregulated proliferation and dissemination of anomalous cells within the human body. According to the GLOBOCAN 2020 report, the year 2020 witnessed the diagnosis of approximately 19.3 million ... ...

Abstract	Cancer represents a complex disease category defined by the unregulated proliferation and dissemination of anomalous cells within the human body. According to the GLOBOCAN 2020 report, the year 2020 witnessed the diagnosis of approximately 19.3 million new cases of cancer and 10.0 million individuals succumbed to the disease. A typical cell eventually becomes cancerous because of a long-term buildup of genetic instability and replicative immortality. Telomerase is a crucial regulator of cancer progression as it induces replicative immortality. In cancer cells, telomerase inhibits apoptosis by elongating the length of the telomeric region, which usually protects the genome from shortening. Many nanoparticles are documented as being available for detecting the presence of telomerase, and many were used as delivery systems to transport drugs. Furthermore, telomere homeostasis is regulated by the circadian time-keeping machinery, leading to 24-hour rhythms in telomerase activity and TERT mRNA expression in mammals. This review provides a comprehensive discussion of various kinds of nanoparticles used in telomerase detection, inhibition, and multiple drug-related pathways, as well as enlightens an imperative association between circadian rhythm and telomerase activity from the perspective of nanoparticle-based anticancer therapeutics.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d4bm00024b
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Article ; Online: Recent global climate change effects: A study of Eleutheronema rhadinum in Chang-Yuen Ridge, Taiwan.

Sihombing, Riah Irawati / Mondal, Sandipan / Ray, Aratrika / Lee, Ming-An / Lu, Quang-Huy

Marine environmental research

2024 Volume 195, Page(s) 106352

Abstract: This study investigated the potential effects of climatic oscillations on CPUE of Eleutheronema rhadinum (East Asian fourfinger threadfin), a commercially valuable fish species in East Asia. Fishery data from Chang-Yuen Ridge between 2015 and 2022 was ... ...

Abstract	This study investigated the potential effects of climatic oscillations on CPUE of Eleutheronema rhadinum (East Asian fourfinger threadfin), a commercially valuable fish species in East Asia. Fishery data from Chang-Yuen Ridge between 2015 and 2022 was analyzed in conjunction with four climatic oscillation indices that were lagged by up to 5 years. The results revealed a fluctuating CPUE associated with the 1-year-lagged Ocean Niño Index (ONI lag 1) and 1-year-lagged Southern Oscillation Index (SOI lag 1) suggesting a potential effect between climatic oscillation indices and East Asian fourfinger threadfin CPUE. These findings can provide insights into the association between East Asian fourfinger threadfin abundance and climatic oscillations in Chang-Yuen Ridge, Taiwan; the insights are valuable for fishery management amidst changing climate conditions.
MeSH term(s)	Animals ; Taiwan ; Climate Change ; Fishes ; Seasons ; Temperature
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2024.106352
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Article ; Online: COVID-19 management in light of the circadian clock.

Ray, Sandipan / Reddy, Akhilesh B

Nature reviews. Molecular cell biology

2020 Volume 21, Issue 9, Page(s) 494–495

MeSH term(s)	Animals ; Betacoronavirus/physiology ; COVID-19 ; Circadian Clocks ; Circadian Rhythm ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2031313-5
ISSN	1471-0080 ; 1471-0072
ISSN (online)	1471-0080
ISSN	1471-0072
DOI	10.1038/s41580-020-0275-3
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Article ; Online: Virtualization of science education: a lesson from the COVID-19 pandemic.

Ray, Sandipan / Srivastava, Sanjeeva

Journal of proteins and proteomics

2020 Volume 11, Issue 2, Page(s) 77–80

Abstract: Nowadays, e-learning and virtual labs have gained substantial popularity in science education. Amid the COVID-19 shutdowns, regular in-person classroom teaching and lab courses are suspended in several countries worldwide. In this scenario, virtual ... ...

Abstract	Nowadays, e-learning and virtual labs have gained substantial popularity in science education. Amid the COVID-19 shutdowns, regular in-person classroom teaching and lab courses are suspended in several countries worldwide. In this scenario, virtual classes and online resources could serve more effectively as a possible alternative way of learning science from home.
Keywords	covid19
Language	English
Publishing date	2020-05-31
Publishing country	India
Document type	Journal Article
ZDB-ID	2890453-9
ISSN	2524-4663 ; 0975-8151
ISSN (online)	2524-4663
ISSN	0975-8151
DOI	10.1007/s42485-020-00038-7
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Article ; Online: A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in malaria.

Rankawat, Sourbh / Kundal, Kavita / Chakraborty, Shreyayukta / Kumar, Rahul / Ray, Sandipan

Frontiers in immunology

2023 Volume 14, Page(s) 1210299

Abstract: Background: Circadian rhythms broadly impact human health by regulating our daily physiological and metabolic processes. The circadian clocks substantially regulate our immune responses and susceptibility to infections. Malaria parasites have intrinsic ... ...

Abstract	Background: Circadian rhythms broadly impact human health by regulating our daily physiological and metabolic processes. The circadian clocks substantially regulate our immune responses and susceptibility to infections. Malaria parasites have intrinsic molecular oscillations and coordinate their infection cycle with host rhythms. Considering the cyclical nature of malaria, a clear understanding of the circadian regulations in malaria pathogenesis and host responses is of immense importance. Methods: We have thoroughly investigated the transcript level rhythmic patterns in blood proteins altered in falciparum and vivax malaria and malaria-related immune factors in mice, baboons, and humans by analyzing datasets from published literature and comprehensive databases. Using the Metascape and DAVID platforms, we analyzed Gene Ontology terms and physiological pathways associated with the rhythmic malaria-associated host immune factors. Results: We observed that almost 50% of the malaria-associated host immune factors are rhythmic in mice and humans. Overlapping rhythmic genes identified in mice, baboons, and humans, exhibited enrichment (Q < 0.05, fold-enrichment > 5) of multiple physiological pathways essential for host immune and defense response, including cytokine production, leukocyte activation, cellular defense, and response, regulation of kinase activity, B-cell receptor signaling pathway, and cellular response to cytokine stimulus. Conclusions: Our analysis indicates a robust circadian regulation on multiple interconnected host response pathways and immunological networks in malaria, evident from numerous rhythmic genes involved in those pathways. Host immune rhythms play a vital role in the temporal regulation of host-parasite interactions and defense machinery in malaria.
MeSH term(s)	Humans ; Animals ; Mice ; Circadian Clocks/genetics ; Malaria ; Immunologic Factors ; Cytokines ; Papio
Chemical Substances	Immunologic Factors ; Cytokines
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1210299
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Article ; Online: Systems Biology of COVID-19 and Human Diseases: Beyond a Bird's Eye View, and Toward One Health.

Banerjee, Srishti / Chakraborty, Shreyayukta / Ray, Sandipan

Omics : a journal of integrative biology

2022 Volume 27, Issue 1, Page(s) 2–5

Abstract: As we gaze into the future beyond the current coronavirus disease 2019 (COVID-19) pandemic, there is a need to rethink our priorities in planetary health, research funding, and, importantly, the concepts and unchecked assumptions by which we attempt to ... ...

Abstract	As we gaze into the future beyond the current coronavirus disease 2019 (COVID-19) pandemic, there is a need to rethink our priorities in planetary health, research funding, and, importantly, the concepts and unchecked assumptions by which we attempt to understand health and prevent illness. Next-generation quantitative omics technologies promise a more profound and panoptic understanding of the dynamic pathophysiological processes and their aberrations in diverse diseased conditions. Systems biology research is highly relevant for COVID-19, a systemic disease affecting multiple organs and biological pathways. In addition, expanding the concept of health beyond humans so as to capture the importance of ecosystem health and recognizing the interdependence of human, animal, and plant health are enormously relevant and timely in the current historical moment of the pandemic. Notably, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19, can affect our body clock, and the circadian aspects of this viral infection and host immunity need to be considered for its effective clinical management. Finally, we need to rethink and expand beyond the false binaries such as humans versus nature, and deploy multiomics systems biology research if we intend to design effective, innovative, and socioecological planetary health interventions to prevent future pandemics and ecological crises. We argue here that juxtaposing ecology and human health sciences scholarship is one of the key emerging tenets of 21st-century integrative biology.
MeSH term(s)	Animals ; Humans ; COVID-19 ; SARS-CoV-2 ; Ecosystem ; One Health ; Systems Biology
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2022.0107
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Article ; Online: COVID-19 Pandemic: Hopes from Proteomics and Multiomics Research.

Ray, Sandipan / Srivastava, Sanjeeva

Omics : a journal of integrative biology

2020 Volume 24, Issue 8, Page(s) 457–459

Abstract: The successful sequencing of the novel coronavirus SARS-CoV-2 nucleic acid paved the way for exploration of omics systems science and integrative biology research approaches for combating this unprecedented planetary health challenge. Omics-scale studies ...

Abstract	The successful sequencing of the novel coronavirus SARS-CoV-2 nucleic acid paved the way for exploration of omics systems science and integrative biology research approaches for combating this unprecedented planetary health challenge. Omics-scale studies on this viral infection are emerging rapidly and offer a tremendous potential to unravel the puzzles of the SARS-CoV-2 pathobiology, and ways forward for diagnostic and therapeutic innovation.
MeSH term(s)	Betacoronavirus/physiology ; Betacoronavirus/ultrastructure ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/etiology ; Coronavirus Infections/metabolism ; Cryoelectron Microscopy ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Host-Pathogen Interactions/genetics ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/etiology ; Pneumonia, Viral/metabolism ; Proteomics/methods ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2020.0073
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