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  1. Article ; Online: Persistent Luminescence Zn

    Calderón-Olvera, Roxana M / Arroyo, Encarnación / Jankelow, Aaron M / Bashir, Rashid / Valera, Enrique / Ocaña, Manuel / Becerro, Ana Isabel

    ACS applied materials & interfaces

    2023  Volume 15, Issue 17, Page(s) 20613–20624

    Abstract: Zinc germanate doped with ... ...

    Abstract Zinc germanate doped with Mn
    MeSH term(s) Humans ; Luminescence ; Nanoparticles/chemistry ; Acrylic Resins ; Zinc/chemistry
    Chemical Substances carbopol 940 (4Q93RCW27E) ; Acrylic Resins ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c21735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Reconfiguration of a parallel kinematic manipulator with 2T2R motions for avoiding singularities through minimizing actuator forces

    Valero, Francisco / Diaz-Rodriguez, Miguel / Valles, Marina / Besa, Antonio / Bernabeu, Enrique / Valera, Angel

    2024  

    Abstract: This paper aims to develop an approach for the reconfiguration of a parallel kinematic manipulator (PKM) with four degrees of freedom (DoF) designed to tackle tasks of diagnosis and rehabilitation in an injured knee. The original layout of the 4-DoF ... ...

    Abstract This paper aims to develop an approach for the reconfiguration of a parallel kinematic manipulator (PKM) with four degrees of freedom (DoF) designed to tackle tasks of diagnosis and rehabilitation in an injured knee. The original layout of the 4-DoF manipulator presents Type-II singular configurations within its workspace. Thus, we proposed to reconfigure the manipulator to avoid such singularities (owing to the Forward Jacobian of the PKM) during typical rehabilitation trajectories. We achieve the reconfiguration of the PKM through a minimization problem where the design variables correspond to the anchoring points of the robot limbs on fixed and mobile platforms. The objective function relies on the minimization of the forces exerted by the actuators for a specific trajectory. The minimization problem considers constraint equations to avoid Type-II singularities, which guarantee the feasibility of the active generalized coordinates for a particular path. To evaluate the proposed conceptual strategy, we build a prototype where reconfiguration occurs by moving the position of the anchoring points to holes bored in the fixed and mobile platforms. Simulations and experiments of several study cases enable testing the strategy performance. The results show that the reconfiguration strategy allows obtaining trajectories having minimum actuation forces without Type-II singularities.
    Keywords Computer Science - Robotics ; Electrical Engineering and Systems Science - Systems and Control
    Subject code 629
    Publishing date 2024-01-16
    Publishing country us
    Document type Book ; Online
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  3. Article ; Online: Multiplexed electrical detection of whole viruses from plasma in a microfluidic platform.

    Jankelow, Aaron / Chen, Chih-Lin / Cowell, Thomas W / Espinosa de Los Monteros, Javier / Bian, Zheng / Kindratenko, Victoria / Koprowski, Katherine / Darsi, Sriya / Han, Hee-Sun / Valera, Enrique / Bashir, Rashid

    The Analyst

    2024  Volume 149, Issue 4, Page(s) 1190–1201

    Abstract: The advancement of point-of-care diagnostics is crucial to improving patient outcomes, especially in areas with low access to hospitals or specialized laboratories. In particular, rapid, sensitive, and multiplexed detection of disease biomarkers has ... ...

    Abstract The advancement of point-of-care diagnostics is crucial to improving patient outcomes, especially in areas with low access to hospitals or specialized laboratories. In particular, rapid, sensitive, and multiplexed detection of disease biomarkers has great potential to achieve accurate diagnosis and inform high quality care for patients. Our Coulter counting and immunocapture based detection system has previously shown its broad applicability in the detection of cells, proteins, and nucleic acids. This paper expands the capability of the platform by demonstrating multiplexed detection of whole-virus particles using electrically distinguishable hydrogel beads by demonstrating the capability of our platform to achieve simultaneous detection at clinically relevant concentrations of hepatitis A virus (>2 × 10
    MeSH term(s) Humans ; Microfluidics ; Parvovirus B19, Human ; Nucleic Acids ; Proteins
    Chemical Substances Nucleic Acids ; Proteins
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an01510f
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2423: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Plasma glycocalyx pattern: a mirror of endothelial damage in chronic kidney disease.

    Valera, Gemma / Figuer, Andrea / Caro, Jara / Yuste, Claudia / Morales, Enrique / Ceprián, Noemí / Bodega, Guillermo / Ramírez, Rafael / Alique, Matilde / Carracedo, Julia

    Clinical kidney journal

    2023  Volume 16, Issue 8, Page(s) 1278–1287

    Abstract: Background: Endothelial damage and cardiovascular disease complicate chronic kidney disease (CKD). The increased atherogenicity observed in patients with CKD can be linked to microinflammation and endothelial damage. Circulating endothelial glycocalyx ... ...

    Abstract Background: Endothelial damage and cardiovascular disease complicate chronic kidney disease (CKD). The increased atherogenicity observed in patients with CKD can be linked to microinflammation and endothelial damage. Circulating endothelial glycocalyx degradation products, such as perlecan and decorin, tend to be elevated in CKD. We aimed to explore the association between the plasma perlecan and decorin levels and this pro-inflammatory and atherogenic state by studying monocyte subpopulations and intracellular adhesion molecule (ICAM)-1 expression in patients with CKD.
    Methods: We studied 17 healthy controls, 23 patients with advanced CKD, 25 patients on haemodialysis, 23 patients on peritoneal dialysis and 20 patients who underwent kidney transplantation. Perlecan and decorin levels were evaluated using enzyme-linked immunosorbent assays, and the monocyte phenotype was analysed using direct immunofluorescence and flow cytometry.
    Results: The plasma perlecan levels were higher in patients with CKD than in the healthy controls. These levels were associated with a higher prevalence of ICAM-1+ monocytes. Conversely, patients with advanced CKD (pre-dialysis) had higher plasma decorin levels, which were associated with a reduced ICAM-1 expression per monocyte.
    Conclusions: Elevated perlecan levels in CKD may be associated with a higher prevalence of ICAM-1+ monocytes and a pro-inflammatory phenotype. Elevated decorin levels may act as a negative regulator of ICAM-1 expression in monocytes. Therefore, perlecan and decorin may be related to inflammation and monocyte activation in CKD and may act as potential markers of endothelial damage.
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad051
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    Zs.A 6587: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Blood Drying Process for DNA Amplification.

    Lim, Jongwon / Zhou, Shuaizhen / Baek, Janice / Kim, Alicia Yeaeun / Valera, Enrique / Sweedler, Jonathan / Bashir, Rashid

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 11, Page(s) e2307959

    Abstract: The presence of numerous inhibitors in blood makes their use in nucleic acid amplification techniques difficult. Current methods for extracting and purifying pathogenic DNA from blood involve removal of inhibitors, resulting in low and inconsistent DNA ... ...

    Abstract The presence of numerous inhibitors in blood makes their use in nucleic acid amplification techniques difficult. Current methods for extracting and purifying pathogenic DNA from blood involve removal of inhibitors, resulting in low and inconsistent DNA recovery rates. To address this issue, a biphasic method is developed that simultaneously achieves inhibitor inactivation and DNA amplification without the need for a purification step. Inhibitors are physically trapped in the solid-phase dried blood matrix by blood drying, while amplification reagents can move into the solid nano-porous dried blood and initiate the amplification. It is demonstrated that the biphasic method has significant improvement in detection limits for bacteria such as Escherichia coli, Methicillin-resistant Staphylococcus aureus, Methicillin-Sensitive Staphylococcus aureus using loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA). Several factors, such as drying time, sample volume, and material properties are characterized to increase sensitivity and expand the application of the biphasic assay to blood diagnostics. With further automation, this biphasic technique has the potential to be used as a diagnostic platform for the detection of pathogens eliminating lengthy culture steps.
    MeSH term(s) Methicillin-Resistant Staphylococcus aureus/genetics ; Polymerase Chain Reaction ; Nucleic Acid Amplification Techniques/methods ; Staphylococcus aureus/genetics ; Escherichia coli/genetics ; Sensitivity and Specificity
    Language English
    Publishing date 2023-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202307959
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  6. Article ; Online: Detecting sepsis by observing neutrophil motility.

    Hassan, Umer / Valera, Enrique / Bashir, Rashid

    Nature biomedical engineering

    2018  Volume 2, Issue 4, Page(s) 197–198

    MeSH term(s) Cytological Techniques/instrumentation ; Cytological Techniques/methods ; Humans ; Lab-On-A-Chip Devices ; Microfluidic Analytical Techniques/instrumentation ; Neutrophils/cytology ; Sepsis/diagnosis
    Language English
    Publishing date 2018-04-02
    Publishing country England
    Document type Journal Article
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-018-0223-0
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  7. Article ; Online: Estratificación de riesgo de trasmisión de arbovirosis en manzanas del municipio Abreus

    Jorge Enrique Rodríguez León / Sonia Monteagudo Díaz / Niuvys Valera Rodríguez / Esther Yarinely Hernández Diéguez

    Correo Científico Médico, Vol 26, Iss

    2015-2019

    2022  Volume 1

    Abstract: Introducción: La estratificación de riesgos es una herramienta que permite identificar y/o agrupar pacientes con mayor riesgo de empeorar o de padecer un problema de salud, requieren una atención más intensa, mayores recursos y para definir ... ...

    Abstract Introducción: La estratificación de riesgos es una herramienta que permite identificar y/o agrupar pacientes con mayor riesgo de empeorar o de padecer un problema de salud, requieren una atención más intensa, mayores recursos y para definir intervenciones que se adapten a sus necesidades de cuidados sanitarios futuros. Objetivos: Estratificar el riesgo de trasmisión de arbovirosis por manzanas y caracterizar los estratos de muy alto y alto riesgo teniendo en cuenta variables seleccionadas. Método: Se realizó un estudio observacional, ecológico analítico y retrospectivo. El universo estuvo conformado por 214 manzanas del municipio Abreus, Cienfuegos, Cuba en el quinquenio 2015-2019. Resultados: Se definieron como muy alto riesgo: 49 (22,1%) y alto riesgo: 44 (20,5%); con la mayor cantidad de casos reportados, tasa de incidencia acumulada, aportaron más de 5 casos, fueron iniciadoras de las epidemias, índice de infestación y Breteau elevado, con mayor cantidad de depósitos por habitantes y de sitios de alta concentración, estando la mayor cantidad de ellas en el consejo popular Abreus. Al superponer espacialmente el dengue con el Zika según Morán I coinciden con manzanas de riesgo del consejo popular Juraguá. Conclusiones: En el municipio quedaron estratificadas el 22,1% (49) y el 20,5% (44) como manzanas de muy alto y alto riesgo respectivamente, la mayoría ubicadas en el consejo popular Abreus (19), se realizó una asociación entre los estratos epidemiológicos de riesgo obtenidos y la distribución espacial de los focos de Aedes aegypti y los casos de dengue notificados. Palabras clave: Estratos, riesgo, toma de decisiones, dengue, Zika, Aedes aegypti
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Universidad de Ciencias Médicas de Holguín
    Document type Article ; Online
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  8. Article ; Online: Aedes Aegypti mosquito’s breeding grounds characterization in Abreus municipality. 2016-2022

    Lisbeth Fundora Filgueiras / Jorge Enrique Rodríguez León / Esther Yarinely Hernández Dieguez / Niuvys Valera Rodríguez / Julian Sobral Rey / Idalmis Valero Valero

    Medisur, Vol 21, Iss 2, Pp 367-

    2023  Volume 375

    Abstract: Background : knowledge about the mosquito’s breeding grounds motivates residents and decision makers to work on the issues that affect the mosquito proliferation; as well as effective community participation, and success in the prevention and control of ... ...

    Abstract Background : knowledge about the mosquito’s breeding grounds motivates residents and decision makers to work on the issues that affect the mosquito proliferation; as well as effective community participation, and success in the prevention and control of arboviral diseases. Objective : to characterize the Aedes aegypti mosquito’s breeding grounds. Methods : an observational, retrospective, and cross-sectional study was carried out on Aedes aegypti’s breeding grounds detected in the Abreus municipality, Cienfuegos province, from 2016 to 2022. 390 breeding grounds were the universe, for which the described variables were: statistical week, month and year of diagnosis, neighborhood, type of deposit, place of residence where it was found, and phase of the mosquito at diagnosis. Data from entomological surveys and records from the Municipal Hygiene and Epidemiology Unit’s Medical Entomology laboratory were used. Results : the median number of Aedes aegypti breeding grounds corresponded to statistical week 32 of each year. The largest number of outbreaks was detected in the Abreus’ neighborhood (165) and Juraguá (102); found mainly in yards (85.5 %) and low tanks (55.5 %). The larval phase in IV stage predominated (82.3 %). Conclusions : in the municipality of Abreus, the focality of Aedes aegypti mosquitoes was characterized by its highest incidence in the months of June to September, with predominance in the popular council of Abreus, especially in low tanks and yards. The largest number was diagnosed in the IV phase.
    Keywords aedes ; mosquitos vectores ; control de vectores de las enfermedades ; servicios de vigilancia epidemiológica ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
    Subject code 590
    Language Spanish
    Publishing date 2023-03-01T00:00:00Z
    Publisher Centro Provincial de Información de Ciencias Médicas. Cienfuegos
    Document type Article ; Online
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  9. Article ; Online: Bioanalytical chemistry: Eavesdropping on interactions.

    Valera, Enrique / Bailey, Ryan C

    Nature chemistry

    2015  Volume 7, Issue 10, Page(s) 767–769

    MeSH term(s) Binding Sites ; Electrophoresis, Capillary ; Molecular Probes ; Surface Plasmon Resonance
    Chemical Substances Molecular Probes
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/nchem.2355
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  10. Article: Electrochemical point-of-care devices for the diagnosis of sepsis.

    Valera, Enrique / Kindratenko, Victoria / Jankelow, Aaron M / Heredia, John / Kim, Alicia Y / Cowell, Thomas W / Chen, Chih-Lin / White, Karen / Han, Hee-Sun / Bashir, Rashid

    Current opinion in electrochemistry

    2023  Volume 39

    Abstract: Sepsis is a life-threatening dysfunction of organ systems caused by a dysregulated immune system because of an infectious process. It remains one of the leading causes of hospital mortality and of hospital readmissions in the United States. Mortality ... ...

    Abstract Sepsis is a life-threatening dysfunction of organ systems caused by a dysregulated immune system because of an infectious process. It remains one of the leading causes of hospital mortality and of hospital readmissions in the United States. Mortality from sepsis increases with each hour of delayed treatment, therefore, diagnostic devices that can reduce the time from the onset of a patient's infection to the delivery of appropriate therapy are urgently needed. Likewise, tools that are capable of high-frequency testing of clinically relevant biomarkers are required to study disease progression. Electrochemical biosensors offer important advantages such as high sensitivity, fast response, miniaturization, and low cost that can be adapted to clinical needs. In this review paper, we discuss the current state, limitations, and future directions of electrochemical-based point-of-care detection platforms that contribute to the diagnosis and monitoring of sepsis.
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-9103
    ISSN 2451-9103
    DOI 10.1016/j.coelec.2023.101300
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