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  1. Article: Prototype Salivary Assay for Quantification of Two Biomarkers for In Vitro Diagnosis of Endometriosis.

    Signorile, Pietro Giulio / Dominici, Sabrina / Viceconte, Rosa / Baldi, Alfonso

    Critical reviews in eukaryotic gene expression

    2024  Volume 34, Issue 4, Page(s) 25–31

    Abstract: Endometriosis, a very common disease in women, is characterized by endometrial structures outside the uterine cavity. The lack of a reliable noninvasive diagnostic test and the often nonspecific symptoms of this pathology are responsible for the delay in ...

    Abstract Endometriosis, a very common disease in women, is characterized by endometrial structures outside the uterine cavity. The lack of a reliable noninvasive diagnostic test and the often nonspecific symptoms of this pathology are responsible for the delay in definitive diagnosis of this disease. Recently, through a proteomics approach, our research group has identified two potential diagnostic markers for endometriosis in serum (Zn-alpha2-glycoprotein and complement C3 precursor). In this article, we describe the experimental conditions of a simple ELISA for rapid quantification of these two biomarkers in the saliva of patients with endometriosis. Finally, preliminary experiments on a small cohort of patients and controls have confirmed the potential diagnostic value of this assay.
    MeSH term(s) Humans ; Female ; Endometriosis/diagnosis ; Glycoproteins ; Enzyme-Linked Immunosorbent Assay ; Biomarkers
    Chemical Substances Glycoproteins ; Biomarkers
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2023051116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3226: Show issues Location:
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  2. Article: COVID-19 R0: Magic number or conundrum?

    Viceconte, Giulio / Petrosillo, Nicola

    Infectious disease reports

    2020  Volume 12, Issue 1, Page(s) 8516

    Keywords covid19
    Language English
    Publishing date 2020-02-24
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.4081/idr.2020.8516
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  3. Article ; Online: Pneumocystis jirovecii pneumonia in COVID-19: an overlooked clinical entity-Response to "Pneumocystis pneumonia risk among viral acute respiratory distress syndrome related or not to COVID 19".

    Buonomo, Antonio Riccardo / Viceconte, Giulio / Gentile, Ivan

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 418

    MeSH term(s) COVID-19 ; Humans ; Pneumocystis carinii ; Pneumonia, Pneumocystis/complications ; Respiratory Distress Syndrome ; SARS-CoV-2
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03836-7
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  4. Article ; Online: COVID-19 R0

    Giulio Viceconte / Nicola Petrosillo

    Infectious Disease Reports, Vol 12, Iss

    Magic number or conundrum?

    2020  Volume 1

    Abstract: There is an increasing concern about COVID-19 worldwide. This is a new emerging infectious disease caused by a novel coronavirus (SARS-CoV-2), which recently broke out from the Chinese city of Wuhan and has quickly spread in China, with sporadic cases in ...

    Abstract There is an increasing concern about COVID-19 worldwide. This is a new emerging infectious disease caused by a novel coronavirus (SARS-CoV-2), which recently broke out from the Chinese city of Wuhan and has quickly spread in China, with sporadic cases in each continent [.].
    Keywords COVID-19 ; SARS-CoV-2 ; reproductive number ; transmission ; Other systems of medicine ; RZ201-999 ; covid19
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Optimizing COVID-19 treatment in immunocompromised patients: early combination therapy with remdesivir, nirmatrelvir/ritonavir and sotrovimab.

    Gentile, Ivan / Foggia, Maria / Silvitelli, Maria / Sardanelli, Alessia / Cattaneo, Letizia / Viceconte, Giulio

    Virology journal

    2023  Volume 20, Issue 1, Page(s) 301

    Abstract: Background: Morbidity and mortality are higher in immunocompromised patients affected by COVID-19 than in the general population. Some authors have successfully used antiviral combination, but never in the early phase of the infection.: Methods: We ... ...

    Abstract Background: Morbidity and mortality are higher in immunocompromised patients affected by COVID-19 than in the general population. Some authors have successfully used antiviral combination, but never in the early phase of the infection.
    Methods: We conducted a retrospective cohort study to determine the efficacy and safety of the combination of two antivirals, with and without a monoclonal antibody (mAb), in both the early (within 10 days of symptoms) and in a later phase (after 10 days) of SARS-CoV-2 infection in immunocompromised patients admitted to our Facility.
    Results: We treated 11 patients (seven in an early phase and four in a late phase of COVID-19) with 10 days of intravenous remdesivir plus five days of oral nirmatelvir/ritonavir, also combined with sotrovimab in 10/11 cases. Notably, all the "early" patients reached virological clearance at day 30 from the end of the therapy and were alive and well at follow-up, whereas the corresponding numbers in the "late" patients were 50% and 75%. Patients in the "late" group more frequently needed oxygen supplementation (p = 0.015) and steroid therapy (p = 0.045) during admission and reached higher COVID-19 severity (p = 0.017).
    Discussion: The combination of antiviral and sotrovimab in the early phase of COVID-19 is well tolerated by immunocompromised patients and is associated with 100% of virological clearance. Patients treated later have lower response rates and higher disease severity, but whether therapy plays a causative role in such findings has yet to be determined.
    MeSH term(s) Humans ; Ritonavir/therapeutic use ; COVID-19 Drug Treatment ; Retrospective Studies ; COVID-19 ; SARS-CoV-2 ; Immunocompromised Host ; Antiviral Agents/therapeutic use
    Chemical Substances nirmatrelvir (7R9A5P7H32) ; sotrovimab (1MTK0BPN8V) ; Ritonavir (O3J8G9O825) ; remdesivir (3QKI37EEHE) ; Antiviral Agents
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-023-02269-8
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  7. Article: Prevalence of

    Buonomo, Antonio Riccardo / Viceconte, Giulio / Fusco, Ludovica / Sarno, Marina / di Filippo, Isabella / Fanasca, Luca / Salvatore, Paola / Gentile, Ivan

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: Background: Pneumocystis jirovecii: Methods: All patients over 18 years of age admitted to the Infectious Diseases Unit for SARS-CoV-2 pneumonia between July 2021 and December 2022 were included. Patients undergoing invasive mechanical ventilation or ...

    Abstract Background: Pneumocystis jirovecii
    Methods: All patients over 18 years of age admitted to the Infectious Diseases Unit for SARS-CoV-2 pneumonia between July 2021 and December 2022 were included. Patients undergoing invasive mechanical ventilation or ECMO, those with risk factors for developing PJP, and those receiving prophylaxis for
    Results: Of 290 screened patients, 59 (20%) met the inclusion criteria and were enrolled. Only 1 of 59 patients (1.7%) tested positive for
    Conclusions: Our results are in line with the previous findings of other studies that confirmed a very low prevalence of
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122839
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  8. Article ; Online: Microbiota and hepatitis C virus in the era of direct-acting antiviral agents.

    Pinchera, Biagio / Moriello, Nicola Schiano / Buonomo, Antonio Riccardo / Zappulo, Emanuela / Viceconte, Giulio / Villari, Riccardo / Gentile, Ivan

    Microbial pathogenesis

    2023  Volume 175, Page(s) 105968

    Abstract: The gut microbiota plays a fundamental role in Hepatitis C Virus (HCV)-related liver disease. Indeed, HCV infection alters the gut microbiota, whereas intestinal dysbiosis induces an underlying inflammatory state. This status may lead to liver disease ... ...

    Abstract The gut microbiota plays a fundamental role in Hepatitis C Virus (HCV)-related liver disease. Indeed, HCV infection alters the gut microbiota, whereas intestinal dysbiosis induces an underlying inflammatory state. This status may lead to liver disease progression. The advent of direct acting antivirals (DAAs) was a turning point in the history of HCV infection, which enhances the chances of recovery. Beyond the elimination of the virus, DAA therapy can affect the gut microbiota of the HCV patient. The study of the gut microbiota in the patient with HCV-related liver disease could be the first step in understanding the etiopathogenesis of hepatopathy thereby opening the way to new therapeutic opportunities. Herein we evaluate current knowledge regarding the gut microbiota in patients with HCV infection and the impact of DAA therapy.
    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Antiviral Agents/pharmacology ; Hepacivirus ; Hepatitis C, Chronic/drug therapy ; Hepatitis C/drug therapy ; Gastrointestinal Microbiome
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-01-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.105968
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    Zs.A 2136: Show issues Location:
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  9. Article ; Online: Should SARS CoV-2 infection be considered an independent risk factor for Pneumocystis jirovecii pneumonia? Emerging data after two years of pandemic from a single center experience.

    Buonomo, Antonio Riccardo / Viceconte, Giulio / Pinchera, Biagio / Scotto, Riccardo / Zappulo, Emanuela / Foggia, Maria / Gentile, Ivan

    Reviews on recent clinical trials

    2022  

    Language English
    Publishing date 2022-05-11
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2251879-4
    ISSN 1876-1038 ; 1574-8871
    ISSN (online) 1876-1038
    ISSN 1574-8871
    DOI 10.2174/1574887117666220511123826
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    Zs.A 6436: Show issues Location:
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  10. Article ; Online: Prevalence of Pneumocystis jirovecii Colonization in Non-Critical Immunocompetent COVID-19 Patients

    Antonio Riccardo Buonomo / Giulio Viceconte / Ludovica Fusco / Marina Sarno / Isabella di Filippo / Luca Fanasca / Paola Salvatore / Ivan Gentile

    Microorganisms, Vol 11, Iss 12, p

    A Single-Center Prospective Study (JiroCOVID Study)

    2023  Volume 2839

    Abstract: Background: Pneumocystis jirovecii pneumonia (PJP) is an invasive fungal infection (IFI) that occurs mainly in immunocompromised hosts. After observing a high prevalence of PJP as a complication of COVID-19 in immunocompetent patients, we conducted a ... ...

    Abstract Background: Pneumocystis jirovecii pneumonia (PJP) is an invasive fungal infection (IFI) that occurs mainly in immunocompromised hosts. After observing a high prevalence of PJP as a complication of COVID-19 in immunocompetent patients, we conducted a study to evaluate the prevalence of P. jirovecii colonization with PCR on oral washing samples (OWS) among non-immunocompromised and non-critical patients admitted with COVID-19 pneumonia at our university hospital. Methods: All patients over 18 years of age admitted to the Infectious Diseases Unit for SARS-CoV-2 pneumonia between July 2021 and December 2022 were included. Patients undergoing invasive mechanical ventilation or ECMO, those with risk factors for developing PJP, and those receiving prophylaxis for P. jirovecii were excluded. Samples were collected by gargling with 10 mL of 0.9% NaCl on day 14 of the hospital stay or at discharge. Results: Of 290 screened patients, 59 (20%) met the inclusion criteria and were enrolled. Only 1 of 59 patients (1.7%) tested positive for P. jirovecii detection with PCR, and the same patient was the only one to develop PJP in the follow-up period. Conclusions: Our results are in line with the previous findings of other studies that confirmed a very low prevalence of P. jirovecii colonization on OWS in the immunocompetent population. Despite the limitations of the study, the fact that the only patient who tested positive for P. jirovecii was the only one in our cohort to develop PJP leads us to reflect on the role of this non-invasive sample in predicting the risk of PJP in patients with COVID-19.
    Keywords COVID-19 ; Pneumocystis jirovecii ; SARS-CoV-2 ; immunocompromised ; pneumonia ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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