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Article ; Online: Unilateral Proptosis (Exophthalmos) Caused by Axillary-Subclavian Venous Thrombosis in a Patient with Upper Extremity Arteriovenous Dialysis Fistula.

Gómez-Arbeláez, Diego / García-Gutiérrez, Ania / González-Fajardo, José Antonio

Methodist DeBakey cardiovascular journal

2021 Volume 17, Issue 3, Page(s) 24–27

Abstract: Arterialization of orbital veins is most often due to dural arteriovenous malformations of the cavernous sinus area. We report an unusual case of unilateral proptosis (exophthalmos) caused by arterialized retrograde venous flow in the external jugular ... ...

Abstract	Arterialization of orbital veins is most often due to dural arteriovenous malformations of the cavernous sinus area. We report an unusual case of unilateral proptosis (exophthalmos) caused by arterialized retrograde venous flow in the external jugular vein and cavernous sinus in a patient with an upper extremity hemodialysis fistula and ipsilateral acute central venous thrombosis. The patient's symptoms improved after surgical closure of the hemodialysis fistula.
MeSH term(s)	Exophthalmos/diagnostic imaging ; Exophthalmos/etiology ; Humans ; Renal Dialysis ; Upper Extremity ; Upper Extremity Deep Vein Thrombosis ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology ; Venous Thrombosis/therapy
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2544079-2
ISSN	1947-6108 ; 1947-6094
ISSN (online)	1947-6108
ISSN	1947-6094
DOI	10.14797/mdcvj.699
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Article ; Online: Relationship among the leptin-to-adiponectin ratio, systemic inflammation, and anisocytosis: a plausible pathophysiological mechanism of a novel cardiovascular risk marker.

López-Jaramillo, Patricio / Gómez-Arbeláez, Diego / López-López, Jose

Kardiologia polska

2020 Volume 78, Issue 5, Page(s) 381–382

MeSH term(s)	Adiponectin ; Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Humans ; Inflammation ; Leptin ; Risk Factors
Chemical Substances	Adiponectin ; Leptin
Language	English
Publishing date	2020-05-25
Publishing country	Poland
Document type	Editorial ; Comment
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.15381
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Article ; Online: Mortality of COVID-19 patients with vascular thrombotic complications.

Gonzalez-Fajardo, José A / Ansuategui, Marina / Romero, Carmen / Comanges, Alejandra / Gómez-Arbeláez, Diego / Ibarra, Gabriela / Garcia-Gutierrez, Ania

Medicina clinica (English ed.)

2020 Volume 156, Issue 3, Page(s) 112–117

Abstract: Purpose: To analyze the survival of patients hospitalized with COVID-19 and who presented some vascular thrombotic complication.: Material and methods: All consecutive patients with COVID-19 who were treated during the months of March and April 2020 ... ...

Abstract	Purpose: To analyze the survival of patients hospitalized with COVID-19 and who presented some vascular thrombotic complication. Material and methods: All consecutive patients with COVID-19 who were treated during the months of March and April 2020 at our institution were included. All patients were symptomatic and the thrombotic event objectively confirmed. Patients with deep vein thrombosis (DVT), pulmonary embolism (PE), ischemic stroke, and peripheral arterial thrombosis (PAT) were included. Survival curves for all groups were analyzed using Kaplan-Meier with Log Rank test, and Cox regression. Results: During the pandemic period from March-1 to April-30, 2943 patients were treated with confirmed COVID-19 in our center. 106 patients showed some symptomatic vascular thrombosis: 13 patients had PAT, 15 ischemic stroke, 20 DVT and 58 PE. 11 patients presented multiple vascular thrombosis. Although the mean age was 65 years, there were differences between groups being older those patients with arterial thrombosis. A 67.92% were men. In total, 25 patients died during their hospital admission (23.58%), with differences between groups, being more common in patients with PAT (9 patients out of 13) and ischemic stroke (8 patients out of 15), than in those with DVT (1 patient out of 20) or PE (7 patients out of 58). Conclusions: The venous thromboembolic risk in these patients is greater than the arterial, but arterial thrombosis when it occurs was associated with high mortality rates. Survival was better in patients with DVT and PE than in patients with ischemic stroke or PAT.
Language	English
Publishing date	2020-12-30
Publishing country	Spain
Document type	Journal Article
ISSN	2387-0206
ISSN (online)	2387-0206
DOI	10.1016/j.medcle.2020.10.008
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Article ; Online: Mortalidad de los pacientes covid-19 con complicaciones trombóticas.

Gonzalez-Fajardo, José A / Ansuategui, Marina / Romero, Carmen / Comanges, Alejandra / Gómez-Arbeláez, Diego / Ibarra, Gabriela / Garcia-Gutierrez, Ania

Medicina clinica

2020 Volume 156, Issue 3, Page(s) 112–117

Abstract: Objective: To analyze the survival of patients hospitalized with covid-19 and who presented some vascular thrombotic complication.: Material and methods: All consecutive patients with covid-19 who were treated during the months of March and April ... ...

Title translation	Mortality of covid-19 patients with vascular thrombotic complications.
Abstract	Objective: To analyze the survival of patients hospitalized with covid-19 and who presented some vascular thrombotic complication. Material and methods: All consecutive patients with covid-19 who were treated during the months of March and April 2020 at our institution were included. All patients were symptomatic and the thrombotic event objectively confirmed. Patients with deep vein thrombosis (DVT), pulmonary embolism (PE), ischemic stroke, and peripheral arterial thrombosis (PAT) were included. Survival curves for all groups were analyzed using Kaplan-Meier with log rank test, and Cox regression. Results: During the pandemic period from March-1 to April-30, 2943 patients were treated with confirmed covid-19 in our center. Of them, 106 patients showed some symptomatic vascular thrombosis: 13 patients had PAT, 15 ischemic stroke, 20 DVT and 58 PE. Another 11 patients presented multiple vascular thrombosis. Although the mean age was 65 years, there were differences between groups being older those patients with arterial thrombosis. A 67.92% were men. In total, 25 patients died during their hospital admission (23.58%), with differences between groups, being more common in patients with PAT (9 patients out of 13) and ischemic stroke (8 patients out of 15), than in those with DVT (1 patient out of 20) or PE (7 patients out of 58). Conclusions: The venous thromboembolic risk in these patients is greater than the arterial, but arterial thrombosis when it occurs was associated with high mortality rates. Survival was better in patients with DVT and PE than in patients with ischemic stroke or PAT.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/mortality ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Male ; Middle Aged ; Pulmonary Embolism/mortality ; Pulmonary Embolism/virology ; Risk Factors ; Spain/epidemiology ; Stroke/mortality ; Stroke/virology ; Survival Analysis ; Thrombosis/mortality ; Thrombosis/virology
Language	Spanish
Publishing date	2020-11-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2020.10.004
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Article ; Online: Atrial Fibrillation and Surgical Patients with Peripheral Arterial Disease.

González-Fajardo, José A / Ansuategui, Marina / Romero, Carmen / Comanges, Alejandra / Cases, Cristina / Gómez-Arbeláez, Diego

Annals of vascular surgery

2020 Volume 67, Page(s) 411–416

Abstract: Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and its prevalence rate significantly increases with age. The prognostic implication of AF in surgical patients with peripheral arterial disease (PAD) has ... ...

Abstract	Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice and its prevalence rate significantly increases with age. The prognostic implication of AF in surgical patients with peripheral arterial disease (PAD) has not been analyzed. The aims of this study were to analyze the prevalence of AF among patients operated on with symptomatic PAD, and to determine whether these patients are at a higher risk of death or amputation. Methods: We designed a retrospective cohort study, from January 2013 to December 2017, in which we analyzed the medical records of all consecutive patients with symptomatic PAD admitted to our hospital and underwent a vascular procedure. We compared the outcomes of patients with and without AF. All statistically significant demographic variables that underwent a univariate analysis were inserted in the stepwise multivariate model along with AF. A survival analysis was performed to evaluate the factors associated with mortality through a Cox regression model. P-value of 0.05 was considered statistically significant. Results: Four hundred three patients were admitted in-hospital with symptomatic PAD and they underwent a vascular intervention. The mean follow-up was 2 years. Seventy-six patients (18.8%) had AF. These patients were older (78 ± 9.1 years) than the 327 patients without AF (68 ± 12.37 years) (P < 0.0001), and more likely to undergo emergency surgery (18.42% vs. 7.34%, P = 0.0029). Age and emergency admission were dependent associates of AF. The patients with AF were frequently men (69.7%) with previous hypertension (96% %). The presence of AF was associated with higher rate of all-cause mortality (55.26%, P < 0.0001, hazard ratio 2.24, confidence interval 1.55-3.25), but the multivariate analysis adjusted for risk factors showed that the mortality was only associated with age because these patients were older and with many comorbidities. The majority of this population with AF showed some tissue lesion when they were admitted in-hospital (Rutherford V-VI, AF 80.2%, P = 0.0004), and this fact justified that a 22.36% underwent a major amputation affecting the ischemic lower limb in admission (P = 0.018). During the follow-up the free amputation rate was similar between groups (60.5% AF vs. 78.3% non-AF). Conclusions: This study showed the high prevalence of AF in patients with symptomatic PAD that required surgical admission in-hospital. The presence of AF was related with a greater and serious risk of mortality, but this was independently associated to age, because patients with AF were older and frailer. Clearly, this group of patients had a high risk of amputation when they arrived to the hospital and they needed emergency surgery.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Amputation ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/mortality ; Emergencies ; Female ; Frail Elderly ; Humans ; Limb Salvage ; Male ; Middle Aged ; Patient Admission ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/mortality ; Peripheral Arterial Disease/surgery ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Spain/epidemiology ; Time Factors ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/mortality
Language	English
Publishing date	2020-03-21
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2020.02.035
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Article ; Online: Mechanisms of acute coronary syndromes.

Gómez-Arbeláez, Diego / López-Jaramillo, Patricio

The New England journal of medicine

2013 Volume 369, Issue 9, Page(s) 882

MeSH term(s)	Acute Coronary Syndrome/etiology ; Humans ; Plaque, Atherosclerotic/complications
Language	English
Publishing date	2013-08-29
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1307806#SA1
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Article: Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia.

Lopez-Lopez, Jose P / Gonzalez, Ana María / Lanza, Paola / Martinez-Bello, Daniel / Gomez-Arbelaez, Diego / Otero, Johanna / Cohen, Daniel D / Perez-Mayorga, Maritza / Garcia-Peña, Angel A / Rangarajan, Sumathy / Yusuf, Salim / Lopez-Jaramillo, Patricio

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1204885

Abstract: Background: Abdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the ...

Abstract	Background: Abdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the WC cut-off points to predict major cardiovascular events (MACE) and incident diabetes. Methods: We analyzed data from the cohort PURE study in Colombia. WC cut-off points were defined according to the maximum Youden index. Multivariate logistic regression was used to obtain associations between WC and MACE, diabetes, and cumulative incidence of outcomes visualized using Kaplan-Meier curves. Results: After a mean follow-up of 12 years, 6,580 individuals with a mean age of 50.7 ± 9.7 years were included; 64.2% were women, and 53.5% were from rural areas. The mean WC was 85.2 ± 11.6 cm and 88.3 ± 11.1 cm in women and men, respectively. There were 635 cases of the MACE composite plus incident diabetes (5.25 events per 1,000 person-years). Using a cut-off value of 88.85 cm in men (sensitivity = 0.565) and 85.65 cm in women (sensitivity = 0.558) resulted in the highest value for the prediction of the main outcome. These values were associated with a 1.76 and 1.41-fold increased risk of presenting the composite outcome in men and women, respectively. Conclusions: We defined WC cut-off points of 89 cm in men and 86 cm in women to identify the elevated risk of MACE and incident diabetes. Therefore, we suggest using these values in cardiovascular risk assessment in Latin America.
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1204885
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Article ; Online: MORTALIDAD DE LOS PACIENTES COVID-19 CON COMPLICACIONES TROMBÓTICAS VASCULARES

Gonzalez-fajardo, José A. / Ansuategui, Marina / Romero, Carmen / Comanges, Alejandra / Gómez-Arbeláez, Diego / Ibarra, Gabriela / Garcia-Gutierrez, Ania

Medicina Clínica ; ISSN 0025-7753

2020

Keywords	General Medicine ; covid19
Language	Spanish
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.medcli.2020.10.004
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Article ; Online: Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population.

Pérez-Mayorga, Maritza / Lopez-Lopez, Jose P / Chacon-Manosalva, Maria A / Castillo, Maria G / Otero, Johanna / Martinez-Bello, Daniel / Gomez-Arbelaez, Diego / Cohen, Daniel D / Lopez-Jaramillo, Patricio

Canadian journal of gastroenterology & hepatology

2022 Volume 2022, Page(s) 1782221

Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease and is closely associated with cardiometabolic disorders, being insulin resistance (IR) the common pathogenic mechanism. The triglycerides/glucose ...

Abstract	Background: Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease and is closely associated with cardiometabolic disorders, being insulin resistance (IR) the common pathogenic mechanism. The triglycerides/glucose (TyG) index and triglycerides/HDL-c (TG/HDL) ratio are markers correlated with IR. We compared the capacity of these two indexes, alongside IR, to detect NAFLD. Methods: In a cross-sectional cohort study, we examined 263 active military personnel from the Colombian Air Force, aged between 29 and 54 years. Anthropometric measurements and biochemical determinations (glycemia, lipid profile, and insulin) were obtained, and ultrasound studies were performed to evaluate the presence of NAFLD. HOMA-IR index was calculated as (fasting insulin ( Results: NAFLD ultrasound criteria were met in 70 individuals (26.6%). Subjects with NAFLD had significantly higher values of HOMA-IR (2.55 ± 1.36 vs. 1.51 ± 0.91), TyG (9.17 ± 0.53 vs. 8.7 ± 0.51), and TG/HDL (6.6 ± 4.54 vs. 3.52 ± 2.32) compared to those without NAFLD ( Conclusion: Our study shows that novel and lower-cost markers of IR are useful for detecting NALFD, with a performance comparable to the HOMA-IR index. These markers should be used as the first step when screening patients for NAFLD.
MeSH term(s)	Adult ; Biomarkers ; Cross-Sectional Studies ; Glucose ; Hispanic or Latino ; Humans ; Insulin ; Insulin Resistance ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/diagnosis ; Triglycerides
Chemical Substances	Biomarkers ; Insulin ; Triglycerides ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-08-03
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2762182-0
ISSN	2291-2797 ; 1916-7237 ; 0835-7900
ISSN (online)	2291-2797 ; 1916-7237
ISSN	0835-7900
DOI	10.1155/2022/1782221
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Article ; Online: Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight.

Lorenzo, Paula M / Sajoux, Ignacio / Izquierdo, Andrea G / Gomez-Arbelaez, Diego / Zulet, M Angeles / Abete, Itziar / Castro, Ana I / Baltar, Javier / Portillo, María P / Tinahones, Francisco J / Martinez, J Alfredo / Casanueva, Felipe F / Crujeiras, Ana B

Clinical nutrition (Edinburgh, Scotland)

2022 Volume 41, Issue 7, Page(s) 1566–1577

Abstract: Background & aim: Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a ... ...

Abstract	Background & aim: Inflammation and oxidative stress are the most probable mechanistic link between obesity and its co-diseases with cancer among them. The aim of this study was to evaluate whether the nutritional ketosis and weight loss induced by a very-low-calorie ketogenic diet (VLCKD) modulates the inflammatory and oxidative stress profile, compared with a standard, balanced hypocaloric diet (LCD) or bariatric surgery (BS) in patients with obesity. Methods: The study was performed in 79 patients with overweight or obesity and 32 normal-weight volunteers as the control group. Patients with obesity underwent a weight reduction therapy based on VLCKD, LCD or BS. The quantification of the circulating levels of a multiplexing test of cytokines and carcinogenesis/aging biomarkers, as well as of lipid peroxides and total antioxidant power, was carried out. Results: First, we observed that pro-inflammatory cytokines increase, while anti-inflammatory cytokines decrease under excessive body weight. Relevantly, when patients underwent weight loss strategies, it was shown that energy-restricted and surgical strategies of weight loss induced changes in circulating cytokine and lipid peroxides. This effect was more notable in patients following the VLCKD than the LCD or BS and it was observed mainly in the ketosis phase of the intervention. Particularly, IL-11, IL-12, IL-2, INF-γ, INF-β, Pentraxin-3 or MMP1 changed after VLCKD. Whereas, APRIL, TWEAK, osteocalcin and IL-28A increased after BS. Conclusion: As far as we know, this is the first study that evaluate the time-course of cytokines and oxidative stress markers after a VLCKD as compared with a standard LCD and BS. The observed results support the immunomodulatory effect of nutritional ketosis induced by a VLCKD synergistically with weight loss as a strategy to improve innate-immunity and to prevent infections and carcinogenesis in patients with obesity.
MeSH term(s)	Bariatric Surgery ; Biomarkers ; Caloric Restriction ; Carcinogenesis ; Cytokines ; Diet, Ketogenic/adverse effects ; Diet, Reducing ; Humans ; Ketosis ; Lipid Peroxides ; Obesity/surgery ; Weight Gain ; Weight Loss
Chemical Substances	Biomarkers ; Cytokines ; Lipid Peroxides
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2022.05.007
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