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  1. Article ; Online: When Studying Affective Responses to Exercise, the Definition of "Intensity" Must Reference Homeostatic Perturbations: A Retort to Vollaard et al.

    Ekkekakis, Panteleimon / Hartman, Mark E / Ladwig, Matthew A

    Journal of sport & exercise psychology

    2024  Volume 46, Issue 2, Page(s) 66–72

    Abstract: In articles on the methodology of studies investigating affective and enjoyment responses to high-intensity interval training, we noted that, occasionally, exercise conditions described as involving "high" intensity exhibited heart rates that were only ... ...

    Abstract In articles on the methodology of studies investigating affective and enjoyment responses to high-intensity interval training, we noted that, occasionally, exercise conditions described as involving "high" intensity exhibited heart rates that were only as high as, or even lower than, heart rates recorded during comparator conditions described as being of "moderate" intensity. Drs. Vollaard, Metcalfe, Kinghorn, Jung, and Little suggest instead that exercise intensity in high-intensity interval-training studies can be defined in terms of percentages of peak workload. Although we maintain that defining exercise intensity in terms of percentages of maximal heart rate is a suboptimal way to quantify the degree of homeostatic perturbations in response to exercise, we are unconvinced that definitions of intensity relying solely on workload are appropriate for studies investigating affective and enjoyment responses to exercise. The reason is that affect is theorized to have evolved to relay information about homeostatic perturbations to consciousness.
    MeSH term(s) Humans ; Exercise/psychology ; Pleasure/physiology ; Happiness ; High-Intensity Interval Training/methods ; High-Intensity Interval Training/psychology ; Heart Rate/physiology ; Oxygen Consumption/physiology
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 1543-2904
    ISSN (online) 1543-2904
    DOI 10.1123/jsep.2024-0064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Methodological Checklist for Studies of Pleasure and Enjoyment Responses to High-Intensity Interval Training: Part I. Participants and Measures.

    Ekkekakis, Panteleimon / Hartman, Mark E / Ladwig, Matthew A

    Journal of sport & exercise psychology

    2023  Volume 45, Issue 2, Page(s) 77–91

    Abstract: For decades, the exercise psychology research literature echoed the conclusion that exercise makes most people feel better, with no clear evidence that this "feel-better effect" is moderated by intensity. An overhaul of the methodological approach ... ...

    Abstract For decades, the exercise psychology research literature echoed the conclusion that exercise makes most people feel better, with no clear evidence that this "feel-better effect" is moderated by intensity. An overhaul of the methodological approach subsequently showed that high-intensity exercise is experienced as unpleasant, and the "feel-better effect," although possible, is conditional and therefore not as robust or prevalent as initially thought. Recently, several studies investigating high-intensity interval training (HIIT) have concluded that HIIT is pleasant and enjoyable, despite the high intensity. Considering that HIIT is emerging as an option in physical activity recommendations and exercise prescription guidelines, in part due to these claims, a methodological checklist is presented to aid researchers, peer reviewers, editors, and other readers in critically appraising studies examining the effects of HIIT on affect and enjoyment. This first part addresses the characteristics and number of participants, as well as the selection of measures of affect and enjoyment.
    MeSH term(s) Humans ; Pleasure ; High-Intensity Interval Training/psychology ; Checklist ; Happiness ; Exercise/psychology
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 1543-2904
    ISSN (online) 1543-2904
    DOI 10.1123/jsep.2022-0027
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  3. Article ; Online: A Methodological Checklist for Studies of Pleasure and Enjoyment Responses to High-Intensity Interval Training: Part II. Intensity, Timing of Assessments, Data Modeling, and Interpretation.

    Ekkekakis, Panteleimon / Hartman, Mark E / Ladwig, Matthew A

    Journal of sport & exercise psychology

    2023  Volume 45, Issue 2, Page(s) 92–109

    Abstract: Recent studies have concluded that high-intensity interval training should be seen as a "viable alternative" to, and may be more enjoyable than, moderate-intensity continuous exercise. If true, these claims have the potential to revolutionize the science ...

    Abstract Recent studies have concluded that high-intensity interval training should be seen as a "viable alternative" to, and may be more enjoyable than, moderate-intensity continuous exercise. If true, these claims have the potential to revolutionize the science and practice of exercise, establishing high-intensity interval training as not only a physiologically effective exercise modality but also a potentially sustainable one. However, these claims stand in contrast to voluminous evidence according to which high levels of exercise intensity are typically experienced as less pleasant than moderate levels. To help researchers, peer reviewers, editors, and critical readers appreciate possible reasons for the apparently conflicting results, we present a checklist that identifies crucial methodological elements in studies investigating the effects of high-intensity interval training on affect and enjoyment. This second installment covers how "high-intensity" and "moderate-intensity" experimental conditions are defined, the timing of assessments of affect, the modeling of affective responses, and data interpretation.
    MeSH term(s) Humans ; Pleasure ; High-Intensity Interval Training/psychology ; Checklist ; Oxygen Consumption/physiology ; Happiness
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 1543-2904
    ISSN (online) 1543-2904
    DOI 10.1123/jsep.2022-0029
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  4. Article ; Online: Epidemiology of Intensive Care Admissions for Children in the US From 2001 to 2019.

    Killien, Elizabeth Y / Keller, Matthew R / Watson, R Scott / Hartman, Mary E

    JAMA pediatrics

    2023  Volume 177, Issue 5, Page(s) 506–515

    Abstract: Importance: Estimates of the number of US children receiving intensive care unit (ICU) care and ICU admission patterns over time are lacking.: Objective: To determine how ICU admission patterns, use of critical care services, and the characteristics ... ...

    Abstract Importance: Estimates of the number of US children receiving intensive care unit (ICU) care and ICU admission patterns over time are lacking.
    Objective: To determine how ICU admission patterns, use of critical care services, and the characteristics and outcomes of critically ill children have changed from 2001 to 2019.
    Design, setting, and participants: This population-based retrospective cohort study used data from the Healthcare Cost and Utilization Project's state inpatient databases from a total of 21 US states in 2001, 2004, 2010, 2016, and 2019. Hospitalized children aged 0 to 17 years, excluding newborns (during birth hospitalization), were included. Patients admitted to rehabilitation institutions or psychiatric hospitals were also excluded. Data were analyzed from July 2021 to December 2022.
    Exposures: Care in a nonneonatal ICU.
    Main outcomes and measures: From extracted patient data, International Classification of Diseases, Ninth Revision, Clinical Modification, and Tenth Revision, Clinical Modification, codes were used to identify diagnoses, comorbid conditions, organ failures, and mechanical ventilation. Generalized linear Poisson regression and the Cuzick test were used to evaluate trends. US Census data were used to generate age- and sex-adjusted national estimates of ICU admissions and costs.
    Results: Of 2 157 991 pediatric admissions, 275 656 (12.8%) included ICU care. The mean (SD) age was 6.43 (6.10) years; 121 894 individuals were female (44.2%), and 153 731 were male (55.8%). From 2001 to 2019, the prevalence of ICU care among hospitalized children increased from 10.6% to 15.5%. The percentage of ICU admissions in children's hospitals rose from 51.2% to 85.1% (relative risk [RR], 1.66; 95% CI, 1.64-1.68). The percentage of children admitted to an ICU with an underlying comorbidity increased from 46.2% to 57.0% (RR, 1.23; 95% CI, 1.22-1.25), and the percentage with preadmission technology dependence increased from 16.4% to 23.5% (RR, 1.44; 95% CI, 1.40-1.48). The prevalence of multiple organ dysfunction syndrome increased from 6.8% to 21.0% (RR, 3.12; 95% CI, 2.98-3.26), while mortality decreased from 2.5% to 1.8% (RR, 0.72; 95% CI, 0.66-0.79). Hospital length of stay increased by 0.96 days (95% CI, 0.73-1.18) for ICU admissions from 2001 to 2019. After inflation adjustment, total costs for a pediatric admission involving ICU care nearly doubled between 2001 and 2019. Nationally, an estimated 239 000 children were admitted to a US ICU in 2019, corresponding to $11.6 billion in hospital costs.
    Conclusions and relevance: In this study, the prevalence of children receiving ICU care in the US increased, as did length of stay, technology use, and associated costs. The US health care system must be equipped to care for these children in the future.
    MeSH term(s) Child ; Humans ; Male ; Infant, Newborn ; Female ; Length of Stay ; Retrospective Studies ; Hospitalization ; Intensive Care Units ; Critical Care ; Health Care Costs
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.0184
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  5. Article ; Online: Corrigendum: Non-canonical Amino Acid Substrates of E. coli Aminoacyl-tRNA Synthetases.

    Hartman, Matthew C T

    Chembiochem : a European journal of chemical biology

    2022  Volume 23, Issue 20, Page(s) e202200453

    Language English
    Publishing date 2022-09-20
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202200453
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  6. Article ; Online: Contactless differentiation of pleasant and unpleasant valence: Assessment of the acoustic startle eyeblink response with infrared reflectance oculography.

    Hartman, Mark E / Ladwig, Matthew A / Ekkekakis, Panteleimon

    Behavior research methods

    2021  Volume 53, Issue 5, Page(s) 2092–2104

    Abstract: The ability to distinguish between discrete emotions by monitoring autonomic or facial features has been an elusive "holy grail" for fields such as psychophysiology, affective computing, and human-computer interface design. However, cross-validated ... ...

    Abstract The ability to distinguish between discrete emotions by monitoring autonomic or facial features has been an elusive "holy grail" for fields such as psychophysiology, affective computing, and human-computer interface design. However, cross-validated models are lacking, and contemporary theory suggests that emotions may lack distinct physiological or facial "signatures." Therefore, in this study, we propose a reorientation toward distinguishing between pleasant and unpleasant affective valence. We focus on the acoustic eyeblink response, which exhibits affective modulation but remains underutilized. The movement of the eyelid was monitored in a contactless manner via infrared reflectance oculography at 1 kHz while 36 participants viewed normatively pleasant, neutral, and unpleasant images, and 50-ms bursts of white noise were presented binaurally via headphones. Startle responses while viewing pleasant images exhibited significantly smaller amplitudes than those while viewing unpleasant images, with a large effect size (d = 1.56). The affective modulation of the eyeblink startle response is a robust phenomenon that can be assessed in a contactless manner. As research continues on whether systems based on psychophysiological or facial features can distinguish between discrete emotions, the eyeblink startle response offers a relatively simple way to distinguish between pleasant and unpleasant affective valence.
    MeSH term(s) Acoustics ; Blinking ; Electromyography ; Emotions ; Humans ; Photic Stimulation ; Reflex, Startle
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 231560-9
    ISSN 1554-3528 ; 0743-3808 ; 1554-351X
    ISSN (online) 1554-3528
    ISSN 0743-3808 ; 1554-351X
    DOI 10.3758/s13428-021-01555-z
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  7. Article ; Online: Rad Path in a Flash: Creation of the First AMSER Sponsored Digital Flashcard Deck and a Review of Digital Flashcard Use among? Medical Students.

    Hartman, Matthew / Debiec, Nicholas / Kim, Esther / Syed, Hamid / Adhya, Julie / Giardino, Angela / Hill, Jeanne

    Academic radiology

    2024  Volume 31, Issue 2, Page(s) 426–430

    Abstract: Rationale and objectives: Digital flashcards are an increasingly popular study method for medical students today. The purpose of this study is to assess students' opinions on digital flashcards and to evaluate the need for radiology-focused digital ... ...

    Abstract Rationale and objectives: Digital flashcards are an increasingly popular study method for medical students today. The purpose of this study is to assess students' opinions on digital flashcards and to evaluate the need for radiology-focused digital flashcards. We created the first official Radiology-Pathology (Rad-Path) Correlation course digital flashcard deck sponsored by the Alliance of Medical Student Educators in Radiology (AMSER), and evaluated its effectiveness in increasing medical students' confidence levels of understanding Rad-Path concepts.
    Materials and methods: A 16-question survey was developed and publicly shared with medical students to assess the need for a high-quality radiology deck. In addition, students who trialed the AMSER Rad-Path Anki deck were assessed on their confidence of radiology pathology concepts prior to and after using these digital flashcards.
    Results: 185 survey responses were received for the first survey about digital flashcard use. Overall, 87.6% of medical student respondents had used digital flashcards during medical school, and 33.5% had used digital flashcards to study radiology topics specifically. 67.6% of respondents stated they would use a digital flashcard deck if sponsored by an academic radiology society. Regarding the survey of the students who used the AMSER Rad-Path flashcards, 31 responses were received in the pre- and follow-up survey. Mean confidence in understanding the radiology pathology learning objectives increased when the Rad-Path Anki deck was utilized, and students rated the flashcards favorably.
    Conclusion: Students reported a high use of digital flashcards for studying topics in medical school. We identified a perceived need in students for a series of high-quality digital flashcards covering radiology topics. We created the first deck of AMSER Rad-Path flashcards which was well received by the medical students.
    MeSH term(s) Humans ; Computer-Assisted Instruction/methods ; Curriculum ; Education, Medical, Undergraduate/methods ; Educational Measurement/methods ; Learning ; Students, Medical
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2023.12.039
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4594: Show issues Location:
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  8. Article ; Online: Non-canonical Amino Acid Substrates of E. coli Aminoacyl-tRNA Synthetases.

    Hartman, Matthew C T

    Chembiochem : a European journal of chemical biology

    2021  Volume 23, Issue 1, Page(s) e202100299

    Abstract: In this comprehensive review, I focus on the twenty E. coli aminoacyl-tRNA synthetases and ... The review catalogues the structures of all known ncAA substrates for each of the 20 E. coli aminoacyl-tRNA ...

    Abstract In this comprehensive review, I focus on the twenty E. coli aminoacyl-tRNA synthetases and their ability to charge non-canonical amino acids (ncAAs) onto tRNAs. The promiscuity of these enzymes has been harnessed for diverse applications including understanding and engineering of protein function, creation of organisms with an expanded genetic code, and the synthesis of diverse peptide libraries for drug discovery. The review catalogues the structures of all known ncAA substrates for each of the 20 E. coli aminoacyl-tRNA synthetases, including ncAA substrates for engineered versions of these enzymes. Drawing from the structures in the list, I highlight trends and novel opportunities for further exploitation of these ncAAs in the engineering of protein function, synthetic biology, and in drug discovery.
    MeSH term(s) Amino Acids/chemistry ; Amino Acids/metabolism ; Amino Acyl-tRNA Synthetases/chemistry ; Amino Acyl-tRNA Synthetases/metabolism ; Escherichia coli/enzymology ; Protein Engineering ; Synthetic Biology
    Chemical Substances Amino Acids ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-)
    Language English
    Publishing date 2021-09-22
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202100299
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  9. Article ; Online: Reply to J.R. Rider et al.

    Soni, Payal D / Hartman, Holly E / Schipper, Matthew J / Spratt, Daniel E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2019  Volume 37, Issue 29, Page(s) 2696–2697

    MeSH term(s) Humans ; Medical Oncology ; Randomized Controlled Trials as Topic ; Research Design
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.19.01653
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near-IR Light.

    Mitra, Koushambi / Lyons, Charles E / Hartman, Matthew C T

    Angewandte Chemie (International ed. in English)

    2018  Volume 57, Issue 32, Page(s) 10263–10267

    Abstract: Controlled generation of cytotoxic agents with near-IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. A heptamethine cyanine scaffolded ... ...

    Abstract Controlled generation of cytotoxic agents with near-IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. A heptamethine cyanine scaffolded Pt
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carbocyanines/chemistry ; Carbocyanines/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Density Functional Theory ; Drug Screening Assays, Antitumor ; Humans ; Infrared Rays ; MCF-7 Cells ; Molecular Structure ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/pharmacology ; Photochemical Processes ; Photochemotherapy ; Platinum/chemistry ; Platinum/pharmacology
    Chemical Substances Antineoplastic Agents ; Carbocyanines ; Organoplatinum Compounds ; Platinum (49DFR088MY)
    Language English
    Publishing date 2018-07-16
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201806911
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