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  1. Article: Editorial: Vascular function and mechanisms of aging: hypertension, obesity and metabolic disorders.

    Nava, Eduardo / Trache, Andreea / Diaz, Alejandro / Colantuoni, Antonio

    Frontiers in physiology

    2024  Volume 14, Page(s) 1339619

    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1339619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Methods and applications in vascular physiology: 2022.

    Colantuoni, Antonio / Brugniaux, Julien V / Goltsov, Alexey / Rodriguez-Rodriguez, Rosalia

    Frontiers in physiology

    2023  Volume 14, Page(s) 1264518

    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1264518
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  3. Article: Effects of physical exercise associated with a diet enriched with natural antioxidants on cerebral hypoperfusion and reperfusion injury in spontaneously hypertensive rats.

    Lapi, Dominga / Federighi, Giuseppe / Lonardo, Maria Serena / Chiurazzi, Martina / Muscariello, Espedita / Tenore, Giancarlo / Colantuoni, Antonio / Novellino, Ettore / Scuri, Rossana

    Frontiers in physiology

    2023  Volume 14, Page(s) 1091889

    Abstract: Oxidative stress is implicated in the pathogenesis of arterial hypertension. The reduction in the bioavailability of nitric oxide (NO) causes endothelial dysfunction, altering the functions of cerebral blood vessels. Physical exercise and intake of ... ...

    Abstract Oxidative stress is implicated in the pathogenesis of arterial hypertension. The reduction in the bioavailability of nitric oxide (NO) causes endothelial dysfunction, altering the functions of cerebral blood vessels. Physical exercise and intake of antioxidants improve the redox state, increasing the vascular NO production and/or the decrease in NO scavenging by reactive oxygen species (ROS). The present study was aimed at assessing the effects of physical exercise associated with a diet enriched with antioxidants from the Annurca apple in preventing the microvascular damage due to cerebral hypoperfusion and reperfusion injury in spontaneously hypertensive rats (SHRs). The rat pial microcirculation was investigated by intravital fluorescence microscopy through a parietal closed cranial window. As expected, SHRs subjected to physical exercise or an antioxidants-enriched diet showed a reduction of microvascular permeability, ROS formation, and leukocyte adhesion to venular walls, with a major effect of the antioxidants-enriched diet, when compared to untreated SHRs. Moreover, capillary perfusion was preserved by both treatments in comparison with untreated SHRs. Unexpectedly, the combined treatments did not induce higher effects than the single treatment. In conclusion, our results support the efficacy of physical activity or antioxidant supplement in reducing the microvascular alterations due to hypertension and ascribe to an antioxidants-enriched diet effective microvascular protection in SHRs.
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1091889
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  4. Article: Editorial: Methods and applications in vascular physiology: 2021.

    Brugniaux, Julien V / Rodriguez-Rodriguez, Rosalia / Dabiri, Ali / Kılıç, Kıvılcım / Wilson, Calum / Goltsov, Alexey / Colantuoni, Antonio

    Frontiers in physiology

    2022  Volume 13, Page(s) 1078988

    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1078988
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  5. Article ; Online: Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation.

    Chiurazzi, Martina / Di Maro, Martina / Cozzolino, Mauro / Colantuoni, Antonio

    International journal of molecular sciences

    2020  Volume 21, Issue 10

    Abstract: Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have a key role in ensuring a ... ...

    Abstract Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have a key role in ensuring a constant energy supply to neurons. Mitochondria are cellular organelles that are involved in dynamic processes; their dysfunction has been associated with many diseases, such as obesity and type 2 diabetes, indicating their importance in cellular metabolism and bioenergetics. Food intake excess can induce mitochondrial dysfunction with consequent production of reactive oxygen species (ROS) and oxidative stress. Several studies have shown the involvement of mitochondrial dynamics in the modulation of releasing agouti-related protein (AgRP) and proopiomelanocortin (POMC) neuronal activity, although the mechanisms are still unclear. However, recent studies have shown that changes in mitochondrial metabolism, such as in inflammation, can contribute also to the activation of the microglial system in several diseases, especially degenerative diseases. This review is aimed to summarize the link between mitochondrial dynamics and hypothalamic neurons in the regulation of glucose and energy homeostasis. Furthermore, we focus on the importance of microglia activation in the pathogenesis of many diseases, such as obesity, and on the relationship with mitochondrial dynamics, although this process is still largely unknown.
    MeSH term(s) Agouti-Related Protein/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Energy Metabolism/genetics ; Humans ; Hypothalamus/metabolism ; Microglia/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Dynamics/genetics ; Neurons/metabolism ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Oxidative Stress/genetics ; Proprotein Convertases/genetics
    Chemical Substances AGRP protein, human ; Agouti-Related Protein ; Proprotein Convertases (EC 3.4.21.-)
    Language English
    Publishing date 2020-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21103450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study.

    Chiurazzi, Martina / De Conno, Barbara / Di Lauro, Mariastella / Guida, Bruna / Nasti, Gilda / Schiano, Elisabetta / Stornaiuolo, Mariano / Tenore, Gian Carlo / Colantuoni, Antonio / Novellino, Ettore

    Nutrients

    2023  Volume 15, Issue 24

    Abstract: Obesity is a risk factor for several diseases present worldwide. Currently, dietary changes and physical activity are considered the most effective treatment to reduce obesity and its associated comorbidities. To promote weight loss, hypocaloric diets ... ...

    Abstract Obesity is a risk factor for several diseases present worldwide. Currently, dietary changes and physical activity are considered the most effective treatment to reduce obesity and its associated comorbidities. To promote weight loss, hypocaloric diets can be supported by nutraceuticals. The aim of this study was to evaluate the effects of a hypocaloric diet associated with
    MeSH term(s) Adult ; Humans ; Obesity/metabolism ; Overweight ; Cinchona ; Diet, Reducing ; Weight Loss ; Body Composition ; Dietary Supplements
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15245033
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  7. Article ; Online: Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial.

    Alharbi, Mushari / Chiurazzi, Martina / Nasti, Gilda / Muscariello, Espedita / Mastantuono, Teresa / Koechl, Christina / Stephan, Blossom Cm / Shannon, Oliver M / Colantuoni, Antonio / Siervo, Mario

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: Caloric restriction (CR) and dietary nitrate supplementation are nutritional interventions with pleiotropic physiological functions. This pilot study investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on metabolic, vascular, ... ...

    Abstract Caloric restriction (CR) and dietary nitrate supplementation are nutritional interventions with pleiotropic physiological functions. This pilot study investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. This was a two-arm, parallel randomized clinical trial including 29 participants allocated to CR + BRJ (
    MeSH term(s) Middle Aged ; Humans ; Aged ; Nitrates/pharmacology ; Pilot Projects ; Overweight ; Caloric Restriction ; Dietary Supplements ; Blood Pressure ; Antioxidants/pharmacology ; Cognition ; Beta vulgaris ; Double-Blind Method ; Fruit and Vegetable Juices
    Chemical Substances Nitrates ; Antioxidants
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15040890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Remodeling of Cerebral Microcirculation after Ischemia-Reperfusion.

    Lapi, Dominga / Colantuoni, Antonio

    Journal of vascular research

    2015  Volume 52, Issue 1, Page(s) 22–31

    Abstract: Clinical and experimental studies have been focused on the pathophysiological mechanisms induced by brain ischemia-reperfusion injury. Recovery events, such as neurogenesis, angiogenesis and the growth of new blood vessels from the preexisting vascular ... ...

    Abstract Clinical and experimental studies have been focused on the pathophysiological mechanisms induced by brain ischemia-reperfusion injury. Recovery events, such as neurogenesis, angiogenesis and the growth of new blood vessels from the preexisting vascular tree, have been intensively studied in the last decades to clarify the vascular remodeling crucial for stroke outcome. This review aims to discuss the cerebral microcirculation remodeling induced by ischemia-reperfusion and the mechanisms involved in angiogenesis and vasculogenesis. The first in vivo observations were focused on anastomotic shunting of cerebral blood flow (CBF) in experimental and clinical models. Thereafter, vascular remodeling induced by cerebral ischemia-reperfusion was reported in mice and rats. Successively, other studies have assessed that within 30 days of middle cerebral artery (MCA) occlusion in rats, there is an increase in CBF and recovery from stroke. Recently, rats submitted to transient MCA occlusion showed pial microcirculation remodeling with the formation of new arterioles sprouting from penumbra vessels and overlapping the ischemic core. This review focuses on the production and/or activation of vasculotrophic factors able to trigger and facilitate microvascular remodeling. Vascular endothelial growth factor and endothelium-released nitric oxide appear to be the main factors involved in the formation of new vessels during microvascular remodeling. These studies are fundamental for consequent interventions on molecular targets, useful for fostering vascular remodeling and the recovery of functions.
    MeSH term(s) Angiopoietins/physiology ; Animals ; Arterioles/physiology ; Brain/blood supply ; Brain Ischemia/physiopathology ; Cerebral Arteries/physiopathology ; Cerebrovascular Circulation/physiology ; Collateral Circulation ; Endothelium, Vascular/physiopathology ; Humans ; Infarction, Middle Cerebral Artery/physiopathology ; Mice ; Microcirculation/physiology ; Neovascularization, Physiologic/physiology ; Nitric Oxide/physiology ; Pia Mater/blood supply ; Rats ; Reperfusion Injury/physiopathology ; Vascular Endothelial Growth Factor A/physiology ; Vascular Remodeling/physiology
    Chemical Substances Angiopoietins ; Vascular Endothelial Growth Factor A ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1105259-4
    ISSN 1423-0135 ; 1018-1172
    ISSN (online) 1423-0135
    ISSN 1018-1172
    DOI 10.1159/000381096
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    In stock of ZB MED Cologne/Königswinter

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  9. Article: The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19.

    Di Maro, Martina / Cataldi, Mauro / Santillo, Mariarosaria / Chiurazzi, Martina / Damiano, Simona / De Conno, Barbara / Colantuoni, Antonio / Guida, Bruna

    Frontiers in physiology

    2021  Volume 12, Page(s) 653985

    Abstract: The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these ... ...

    Abstract The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally interact with each other, a mechanism that could have a more general physiological relevance than only COVID-19 infection.
    Language English
    Publishing date 2021-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.653985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation

    Martina Chiurazzi / Martina Di Maro / Mauro Cozzolino / Antonio Colantuoni

    International Journal of Molecular Sciences, Vol 21, Iss 3450, p

    2020  Volume 3450

    Abstract: Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have a key role in ensuring a ... ...

    Abstract Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have a key role in ensuring a constant energy supply to neurons. Mitochondria are cellular organelles that are involved in dynamic processes; their dysfunction has been associated with many diseases, such as obesity and type 2 diabetes, indicating their importance in cellular metabolism and bioenergetics. Food intake excess can induce mitochondrial dysfunction with consequent production of reactive oxygen species (ROS) and oxidative stress. Several studies have shown the involvement of mitochondrial dynamics in the modulation of releasing agouti-related protein (AgRP) and proopiomelanocortin (POMC) neuronal activity, although the mechanisms are still unclear. However, recent studies have shown that changes in mitochondrial metabolism, such as in inflammation, can contribute also to the activation of the microglial system in several diseases, especially degenerative diseases. This review is aimed to summarize the link between mitochondrial dynamics and hypothalamic neurons in the regulation of glucose and energy homeostasis. Furthermore, we focus on the importance of microglia activation in the pathogenesis of many diseases, such as obesity, and on the relationship with mitochondrial dynamics, although this process is still largely unknown.
    Keywords energy homeostasis ; hypothalamus ; mitochondrial dynamics ; microglia ; obesity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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