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  1. Book: Stress challenges and immunity in space

    Choukèr, Alexander

    from mechanisms to monitoring and preventive strategies

    2012  

    Author's details Alexander Choukèr ed
    Keywords Bemannte Raumfahrt ; Stressreaktion ; Immunsystem
    Subject Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte ; Vegetative Stressreaktion ; Stressverarbeitung ; Stress ; Physiologische Stressreaktion ; Stressantwort
    Language English
    Size XIII, 469 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017100556
    ISBN 978-3-642-22271-9 ; 3-642-22271-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 368 order for loan Magazin

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  2. Article: Editorial: Microbiota, nutrition and stress: modulators of immunity.

    Ponomarev, Sergey / Mack, Isabelle / Choukér, Alexander

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1328346

    Language English
    Publishing date 2023-11-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1328346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Wirkung von Adenosinrezeptor-Agonisten und Pentoxifyllin auf die Endotoxin-induzierte Bildung von Tumornekrosefaktor-alpha-humaner polymorphkerniger Leukozyten in vitro

    Choukèr, Alexander

    1997  

    Author's details vorgelegt von Alexander Choukèr
    Language German
    Size 57 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1997
    HBZ-ID HT008591625
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    98 D 1562 order for loan Magazin

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  4. Article ; Online: Questionnaire-based study of COVID-19 vaccination induced headache: evidence of clusters of adverse events.

    Zhou, Qiao / Eggert, Thomas / Zhelyazkova, Ana / Choukér, Alexander / Adorjan, Kristina / Straube, Andreas

    BMC neurology

    2024  Volume 24, Issue 1, Page(s) 84

    Abstract: Background: The adverse events (AEs) after a Coronavirus disease 2019 (Covid-19) Pfizer-Biotech mRNA vaccination present a medical and epidemiological issue of increasing interest. Headache is the most frequent neurological adverse effect and generally ... ...

    Abstract Background: The adverse events (AEs) after a Coronavirus disease 2019 (Covid-19) Pfizer-Biotech mRNA vaccination present a medical and epidemiological issue of increasing interest. Headache is the most frequent neurological adverse effect and generally the third most common adverse event after a Covid-19 vaccination, but only a few studies focus on the link between headache and other AEs after vaccination. This study aims to investigate the correlation between headaches and Covid-19 vaccination, as well as the possible links between headaches and other AEs after Covid-19 vaccination, thereby helping the management of AEs and avoiding further occurrences.
    Methods: This study is based on a published questionnaire survey of 1,402 healthcare workers. Our study focused on the 5 questions including 12 AEs and headaches extracted from the questionnaire post the first and second Covid-19 vaccination. The severity of the 12 AEs and headaches could be classified by the participants on a five-step scale: "Not at all", "Little", "Average", "Quite", and "Very" (abbreviated as "N", "L", "A", "Q", "V"). We used the Bowker test to study the comparison of headache severity, indicated on a 5-point Likert scale between the first and second vaccinations. We applied an ordinal logistic regression to the 5 categories with headache severity serving as the dependent variable and the ratings of the other 12 AEs serving as the independent variable to further explore to what extent the severity of the 12 AEs is associated with the severity of headaches. Receiver Operating Characteristic (ROC) analysis was conducted to evaluate the predictive value of the ratings of the 12 AEs to headache severity.
    Results: We found that participants rated their headaches as more severe after the second vaccination, and participants who reported experiencing fatigue, flu-like symptoms, pain at the injection site, known tension-type headache, fever, dizziness/balance problems and known migraine are associated with headache symptoms.
    Conclusions: There are clusters of headache-associated AEs post Covid-19 vaccination. The association of various AEs with headaches may be due to similar causative mechanisms.
    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/complications ; Headache/epidemiology ; Headache/etiology ; Surveys and Questionnaires ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-024-03583-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: COVID-19-The largest isolation study in history: the value of shared learnings from spaceflight analogs.

    Choukér, Alexander / Stahn, Alexander C

    NPJ microgravity

    2020  Volume 6, Page(s) 32

    Abstract: The world is currently experiencing the largest isolation experiment in history. In an attempt to slow down the spread of the COVID-19 pandemic numerous countries across the world have been shutting down economies, education, and public life. Governments ...

    Abstract The world is currently experiencing the largest isolation experiment in history. In an attempt to slow down the spread of the COVID-19 pandemic numerous countries across the world have been shutting down economies, education, and public life. Governments have mandated strict regulations of quarantine and social distancing in an unprecedented manner. The effects of these measures on brain, behavior, neuro-humoral and immunological responses in humans are largely unknown. Life science research for space exploration has a long history in using high-fidelity spaceflight analogs to better understand the effect of prolonged isolation and confinement on genes, molecules, cells, neural circuits, and physiological systems to behavior. We here propose to leverage the extensive experience and data from these studies and build a bridge between spaceflight research and clinical settings to foster transdisciplinary approaches to characterize the neurobehavioral effects on the immune system and vice versa. These approaches are expected to develop innovative and efficient health screening tools, diagnostic systems, and treatments to mitigate health risks associated with isolation and confinement on Earth and during future exploratory spaceflight missions.
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2823626-9
    ISSN 2373-8065
    ISSN 2373-8065
    DOI 10.1038/s41526-020-00122-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Differential effects of acute and chronic hydrocortisone treatment on pyroptosis in vitro

    Han, Bing [Verfasser] / Choukèr, Alexander [Akademischer Betreuer]

    2023  

    Author's details Bing Han ; Betreuer: Alexander Choukèr
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  7. Article ; Online: Back to Earth.

    Cerri, Matteo / Bereiter-Hahn, Jürgen / Heldmaier, Gerhard / Choukér, Alexander / Summerer, Leopold

    Innovation (Cambridge (Mass.))

    2023  Volume 4, Issue 3, Page(s) 100429

    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2023.100429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19—The largest isolation study in history

    Alexander Choukér / Alexander C. Stahn

    npj Microgravity, Vol 6, Iss 1, Pp 1-

    the value of shared learnings from spaceflight analogs

    2020  Volume 7

    Abstract: Abstract The world is currently experiencing the largest isolation experiment in history. In an attempt to slow down the spread of the COVID-19 pandemic numerous countries across the world have been shutting down economies, education, and public life. ... ...

    Abstract Abstract The world is currently experiencing the largest isolation experiment in history. In an attempt to slow down the spread of the COVID-19 pandemic numerous countries across the world have been shutting down economies, education, and public life. Governments have mandated strict regulations of quarantine and social distancing in an unprecedented manner. The effects of these measures on brain, behavior, neuro-humoral and immunological responses in humans are largely unknown. Life science research for space exploration has a long history in using high-fidelity spaceflight analogs to better understand the effect of prolonged isolation and confinement on genes, molecules, cells, neural circuits, and physiological systems to behavior. We here propose to leverage the extensive experience and data from these studies and build a bridge between spaceflight research and clinical settings to foster transdisciplinary approaches to characterize the neurobehavioral effects on the immune system and vice versa. These approaches are expected to develop innovative and efficient health screening tools, diagnostic systems, and treatments to mitigate health risks associated with isolation and confinement on Earth and during future exploratory spaceflight missions.
    Keywords Biotechnology ; TP248.13-248.65 ; Physiology ; QP1-981 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Assessing Stress Induced by Fluid Shifts and Reduced Cerebral Clearance during Robotic-Assisted Laparoscopic Radical Prostatectomy under Trendelenburg Positioning (UroTreND Study).

    Peschke, Tobias / Feuerecker, Matthias / Siegl, Daniel / Schicktanz, Nathalie / Stief, Christian / Zu Eulenburg, Peter / Choukér, Alexander / Buchheim, Judith-Irina

    Methods and protocols

    2024  Volume 7, Issue 2

    Abstract: In addition to general anesthesia and mechanical ventilation, robotic-assisted laparoscopic radical prostatectomy (RALP) necessitates maintaining a capnoperitoneum and placing the patient in a pronounced downward tilt (Trendelenburg position). While the ... ...

    Abstract In addition to general anesthesia and mechanical ventilation, robotic-assisted laparoscopic radical prostatectomy (RALP) necessitates maintaining a capnoperitoneum and placing the patient in a pronounced downward tilt (Trendelenburg position). While the effects of the resulting fluid shift on the cardiovascular system seem to be modest and well tolerated, the effects on the brain and the blood-brain barrier have not been thoroughly investigated. Previous studies indicated that select patients showed an increase in the optic nerve sheath diameter (ONSD), detected by ultrasound during RALP, which suggests an elevation in intracranial pressure. We hypothesize that the intraoperative fluid shift results in endothelial dysfunction and reduced cerebral clearance, potentially leading to transient neuronal damage. This prospective, monocentric, non-randomized, controlled clinical trial will compare RALP to conventional open radical prostatectomy (control group) in a total of 50 subjects. The primary endpoint will be the perioperative concentration of neurofilament light chain (NfL) in blood using single-molecule array (SiMoA) as a measure for neuronal damage. As secondary endpoints, various other markers for endothelial function, inflammation, and neuronal damage as well as the ONSD will be assessed. Perioperative stress will be evaluated by questionnaires and stress hormone levels in saliva samples. Furthermore, the subjects will participate in functional tests to evaluate neurocognitive function. Each subject will be followed up until discharge. Conclusion: This trial aims to expand current knowledge as well as to develop strategies for improved monitoring and higher safety of patients undergoing RALP. The trial was registered with the German Clinical Trials Register DRKS00031041 on 11 January 2023.
    Language English
    Publishing date 2024-04-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-9279
    ISSN (online) 2409-9279
    DOI 10.3390/mps7020031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Differential effects of hypergravity on immune dysfunctions induced by simulated microgravity.

    Moser, Dominique / Biere, Katharina / Liemersdorf, Christian / Tuschen, Marina / Hemmersbach, Ruth / Choukér, Alexander

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Volume 37, Issue 5, Page(s) e22910

    Abstract: Microgravity (μg) is among the major stressors in space causing immune cell dysregulations. These are frequently expressed as increased pro-inflammatory states of monocytes and reduced activation capacities in T cells. Hypergravity (as artificial gravity) ...

    Abstract Microgravity (μg) is among the major stressors in space causing immune cell dysregulations. These are frequently expressed as increased pro-inflammatory states of monocytes and reduced activation capacities in T cells. Hypergravity (as artificial gravity) has shown to have beneficial effects on the musculoskeletal and cardiovascular system both as a countermeasure option for μg-related deconditioning and as "gravitational therapy" on Earth. Since the impact of hypergravity on immune cells is sparsely explored, we investigated if an application of "mild" mechanical loading of 2.8 g is able to avoid or treat μg-mediated immune dysregulations. For this, T cell and monocyte activation states and cytokine pattern were first analyzed after whole blood antigen incubation in simulated μg (s-μg) by using the principle of fast clinorotation or in hypergravity. Subsequent hypergravity countermeasure approaches were run at three different sequences: one preconditioning setting, where 2.8 g was applied before s-μg exposure and two therapeutic approaches in which 2.8 g was set either intermediately or at the end of s-μg. In single g-grade exposure experiments, monocyte pro-inflammatory state was enhanced in s-μg and reduced in hypergravity, whereas T cells displayed reduced activation when antigen incubation was performed in s-μg. Hypergravity application in all three sequences did not alleviate the increased pro-inflammatory potential of monocytes. However, in T cells the preconditioning approach restored antigen-induced CD69 expression and IFNγ secretion to 1 g control values and beyond. This in vitro study demonstrates a proof of concept that mild hypergravity is a gravitational preconditioning option to avoid adaptive immune cell dysfunctions induced by (s-)μg and that it may act as a booster of immune cell functions.
    MeSH term(s) Hypergravity ; Weightlessness ; T-Lymphocytes ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202201781R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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