LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 629

Search options

  1. Article ; Online: PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition.

    Guo, Xia / Qian, Guoqing

    Journal of cellular immunology

    2022  Volume 4, Issue 4, Page(s) 141–144

    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 2689-2812
    ISSN (online) 2689-2812
    DOI 10.33696/immunology.4.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Comment on "Predicting metastasis at initial diagnosis and radiotherapy effectiveness in patients with metastatic osteosarcoma".

    Liu, Guoqing / Huang, Shu / Hu, Qian / Chen, Chunyan

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 15, Page(s) 14471–14472

    Language English
    Publishing date 2023-08-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05212-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Extracting Skeleton Lines from Building Footprints by Integration of Vector and Raster Data

    Chen, Guoqing / Qian, Haizhong

    ISPRS international journal of geo-information. 2022 Sept. 10, v. 11, no. 9

    2022  

    Abstract: The extraction of skeleton lines of buildings is a key step in building spatial analysis, which is widely performed for building matching and updating. Several methods for vector data skeleton line extraction have been established, including the improved ...

    Abstract The extraction of skeleton lines of buildings is a key step in building spatial analysis, which is widely performed for building matching and updating. Several methods for vector data skeleton line extraction have been established, including the improved constrained Delaunay triangulation (CDT) and raster data skeleton line extraction methods, which are based on image processing technologies. However, none of the existing studies have attempted to combine these methods to extract the skeleton lines of buildings. This study aimed to develop a building skeleton line extraction method based on vector–raster data integration. The research object was buildings extracted from remote sensing images. First, vector–raster data mapping relationships were identified. Second, the buildings were triangulated using CDT. The extraction results of the Rosenfeld thin algorithm for raster data were then used to remove redundant triangles. Finally, the Shi–Tomasi corner detection algorithm was used to detect corners. The building skeleton lines were extracted by adjusting the connection method of the type three triangles in CDT. The experimental results demonstrate that the proposed method can effectively extract the skeleton lines of complex vector buildings. Moreover, the skeleton line extraction results included a few burrs and were robust against noise.
    Keywords algorithms ; raster data ; skeleton ; vector data
    Language English
    Dates of publication 2022-0910
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2655790-3
    ISSN 2220-9964
    ISSN 2220-9964
    DOI 10.3390/ijgi11090480
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Case Report: Metagenomic Next-Generation Sequencing in Diagnosis of Talaromycosis of an Immunocompetent Patient.

    Shi, Jiejun / Yang, Naibin / Qian, Guoqing

    Frontiers in medicine

    2021  Volume 8, Page(s) 656194

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.656194
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Fc-MBL-modified Fe

    Yu, Menghuan / Zhang, Li / Qian, Guoqing / Shi, Haimei / Yu, Shaoning

    Mikrochimica acta

    2022  Volume 189, Issue 4, Page(s) 169

    Abstract: Functional bacterial enrichment magnetic beads ( ... ...

    Abstract Functional bacterial enrichment magnetic beads (Fe
    MeSH term(s) Bacteria ; Escherichia coli ; Magnetic Fields ; Magnetic Phenomena ; Silicon Dioxide ; Staining and Labeling
    Chemical Substances Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2022-04-01
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-022-05277-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
    Z 8.1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A microfluidic device for enhanced capture and high activity release of heterogeneous CTCs from whole blood

    Li, Qiaoyu / Wang, Yanlin / Gao, Wenjing / Qian, Guoqing / Chen, Xueqin / Liu, Yushan / Yu, Shaoning

    Talanta. 2024 Jan., v. 266 p.125007-

    2024  

    Abstract: Circulating tumor cells (CTCs) are tumor cells that spontaneously detach from the primary focus, and early detection and characterization of CTCs is vital for cancer diagnosis and appropriate treatment. Current methods commonly use EpCAM to capture CTCs, ...

    Abstract Circulating tumor cells (CTCs) are tumor cells that spontaneously detach from the primary focus, and early detection and characterization of CTCs is vital for cancer diagnosis and appropriate treatment. Current methods commonly use EpCAM to capture CTCs, but this results in a loss of information on other CTC subsets (EpCAM-negative cells) due to the heterogeneity of CTCs. Here, we report a novel microfluidic device that integrates the capture and release of heterogeneous CTCs directly from whole blood. A spiral chip was designed for the separation of differently sized cells, and larger CTCs were effectively separated from smaller blood cells with a 98% recovery rate. CD146-containing magnetic beads were used to complement the EpCAM-based CTC capture methods, and the capture efficiency of Fe₃O₄@Gelatin@CD146/EpCAM increased by 20% over Fe₃O₄@Gelatin@EpCAM. Finally, MMP-9 was employed to release CTCs with high efficiency and less damage by degrading gelatins on the surface of Fe₃O₄. The established method was successfully applied to CTC capture and release in a simulated patient's whole blood. The developed method achieved enhanced capture and high activity release of heterogeneous CTCs with less interference by blood cells, which contributes to the early detection and clinical downstream analysis of CTCs.
    Keywords blood ; magnetism ; neoplasms ; patients ; Circulating tumor cells ; Microfluidic ; Spiral chip ; CD146 ; Heterogeneous CTCs ; MMP-9
    Language English
    Dates of publication 2024-01
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.125007
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Obesity and the Development of Lung Fibrosis.

    Guo, Xia / Sunil, Christudas / Qian, Guoqing

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 812166

    Abstract: Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory complications including fibrotic changes in the lung. The influence of obesity on the lung is multi-factorial, which is related to both mechanical injury and various ...

    Abstract Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory complications including fibrotic changes in the lung. The influence of obesity on the lung is multi-factorial, which is related to both mechanical injury and various inflammatory mediators produced by excessive adipose tissues, and infiltrated immune cells. Adiposity causes increased production of inflammatory mediators, for example, cytokines, chemokines, and adipokines, both locally and in the systemic circulation, thereby rendering susceptibility to respiratory diseases, and altered responses. Lung fibrosis is closely related to chronic inflammation in the lung. Current data suggest a link between lung fibrosis and diet-induced obesity, although the mechanism remains incomplete understood. This review summarizes findings on the association of lung fibrosis with obesity, highlights the role of several critical inflammatory mediators (e.g., TNF-α, TGF-β, and MCP-1) in obesity related lung fibrosis and the implication of obesity in the outcomes of idiopathic pulmonary fibrosis patients.
    Language English
    Publishing date 2022-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.812166
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells

    Guoqing Qian / Oluwaseun Adeyanju / Ayobami Olajuyin / Xia Guo

    Life, Vol 12, Iss 191, p

    2022  Volume 191

    Abstract: Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. ... ...

    Abstract Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smooth muscle cell (SMC) phenotypic switching and dysfunction, and extracellular matrix degradation. With open surgery being the only therapeutic option up to date, the lack of pharmaceutical treatment approach calls for identifying novel and effective targets and further understanding the pathological process of AAA. Both lifestyle and genetic predisposition have an important role in increasing the risk of AAA. Several cell types are closely related to the pathogenesis of AAA. Among them, vascular SMCs (VSMCs) are gaining much attention as a critical contributor for AAA initiation and/or progression. In this review, we summarize what is known about AAA, including the risk factors, the pathophysiology, and the established animal models of AAA. In particular, we focus on the VSMC phenotypic switching and dysfunction in AAA formation. Further understanding the regulation of VSMC phenotypic changes may provide novel therapeutic targets for the treatment or prevention of AAA.
    Keywords abdominal aortic aneurysm ; inflammation ; vascular smooth muscle cell ; oxidative stress ; apoptosis ; extracellular matrix ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells.

    Qian, Guoqing / Adeyanju, Oluwaseun / Olajuyin, Ayobami / Guo, Xia

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. ... ...

    Abstract Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smooth muscle cell (SMC) phenotypic switching and dysfunction, and extracellular matrix degradation. With open surgery being the only therapeutic option up to date, the lack of pharmaceutical treatment approach calls for identifying novel and effective targets and further understanding the pathological process of AAA. Both lifestyle and genetic predisposition have an important role in increasing the risk of AAA. Several cell types are closely related to the pathogenesis of AAA. Among them, vascular SMCs (VSMCs) are gaining much attention as a critical contributor for AAA initiation and/or progression. In this review, we summarize what is known about AAA, including the risk factors, the pathophysiology, and the established animal models of AAA. In particular, we focus on the VSMC phenotypic switching and dysfunction in AAA formation. Further understanding the regulation of VSMC phenotypic changes may provide novel therapeutic targets for the treatment or prevention of AAA.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12020191
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: miR-378 associated with proliferation, migration and apoptosis properties in A549 cells and targeted NPNT in COPD

    Guoqing Qian / Qi Liao / Guoxiang Li / Fengying Yin

    PeerJ, Vol 10, p e

    2022  Volume 14062

    Abstract: Background microRNAs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). However, the underlying molecular mechanisms are largely unclear. The goal of this study was to investigate the roles of miR-378 in ... ...

    Abstract Background microRNAs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). However, the underlying molecular mechanisms are largely unclear. The goal of this study was to investigate the roles of miR-378 in alveolar epithelial type II cells and identify molecular mechanisms which contribute to the pathogenesis of COPD. Materials and methods Human alveolar epithelial (A549) cells were cultured in Dulbecco’s Modified Eagle Medium. Cell proliferation was studied by using a cell counting kit-8 (CCK-8) and colony formation assays. Cell apoptosis and cell cycle were analyzed by flow cytometry and wound healing and Transwell were used to analyze the cell migration and. We performed bioinformatics analysis including target gene prediction, gene ontology (GO), Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment and construction of protein-protein interaction (PPI) network. The expression of miR-378 and NPNT from publically available expression microarray of COPD lung tissues was analyzed. Results Overexpression of miR-378 significantly increases cell proliferation, migration, and suppress apoptosis. GO analysis demonstrated that the miR-378 involved in transcription, vascular endothelial growth factor receptor signaling pathway, phosphatidylinositol 3-kinase signaling, cell migration, blood coagulation, cell shape, protein stabilization and phosphorylation. Pathway enrichment showed that the 1,629 target genes of miR-378 were associated with mTOR, ErbB, TGF-β, MAPK, and FoxO signaling pathways. Notably, miR-378 directly targets Nephronectin in A549 cells, and miR-378 was upregulated while NPNT was downregulated in COPD lung tissue samples. Conclusions These findings suggest that miR-378 can regulate the proliferation, migration, and apoptosis of A549 cells and target NPNT. miR-378 increased in COPD lung tissues while NPNT decreased, and might prove a potential target for novel drug therapy.
    Keywords NPNT ; Nephronectin ; Emphysema ; COPD ; Chronic obstructive pulmonary disease ; microRNA ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top