LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 92

Search options

  1. Article ; Online: Adoption of linear no-threshold model violated basic scientific principles and was harmful: Letter from Mohan Doss regarding Edward Calabrese's paper "How the US National Academy of Sciences misled the world community on cancer risk assessment: new findings challenge historical foundations of the linear dose response" (Arch Toxicol (2013) 87:2063-2081) and the letter from Ralph J Cicerone (Arch Toxicol (2014) 88:171-172).

    Doss, Mohan

    Archives of toxicology

    2014  Volume 88, Issue 3, Page(s) 849–852

    MeSH term(s) Humans ; National Academy of Sciences (U.S.) ; Neoplasms/epidemiology ; Risk Assessment
    Language English
    Publishing date 2014-03
    Publishing country Germany
    Document type Comment ; Letter
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-014-1208-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Book ; Online ; E-Book: Wild edible underutilized plants

    Mohan, V. R. / Tresina, P. S. / Doss, A.

    nutritional, antinutritional, and nutraceutical aspects

    2020  

    Author's details by V.R. Mohan, P.S. Tresina, A. Doss
    Keywords Wild plants, Edible ; Wild plants, Edible/Nutrition
    Subject code 581.632
    Language English
    Size 1 Online-Ressource (xvi, 203 Seiten), Illustrationen, 23 cm
    Publisher Apple Academic Press
    Publishing place Oakville
    Publishing country Canada
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020155154
    ISBN 978-0-42966-580-6 ; 9781771887717 ; 0-42966-580-6 ; 1771887710
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Kategorien

  3. Book ; Online ; E-Book: Ethnomedicinal plants with therapeutic properties

    Mohan, V. R. / Doss, A. / Tresina, P. S.

    2019  

    Author's details edited by V.R. Mohan, A. Doss, P.S. Tresina
    Keywords Medicinal plants ; Ethnobotany ; Traditional medicine
    Subject code 615.321
    Language English
    Size 1 Online-Ressource (xvii, 447 Seiten), Ilustrationen
    Publisher Apple Academic Press
    Publishing place Oakville, ON
    Publishing country Canada
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020029313
    ISBN 978-0-429-94691-2 ; 9781771887090 ; 0-429-94691-0 ; 1771887095
    DOI 10.1201/9780429487767
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Kategorien

  4. Article: Interaction of eugenol-based anti-tuberculosis nanoemulsion with bovine serum albumin: A spectroscopic study including Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol.

    M, Keerthana / Mohan Menon, Parvathy / C, George Priya Doss / Natarajan, Chandrasekaran

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28306

    Abstract: Tuberculosis (TB), a deadly infectious disease, is primarily caused by the ... ...

    Abstract Tuberculosis (TB), a deadly infectious disease, is primarily caused by the bacterium
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28306
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Comment on 'Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection'.

    Doss, Mohan

    Journal of radiological protection : official journal of the Society for Radiological Protection

    2019  Volume 39, Issue 2, Page(s) 650–654

    MeSH term(s) Epidemiologic Studies ; Linear Models ; Radiation Protection
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639411-5
    ISSN 1361-6498 ; 0952-4746
    ISSN (online) 1361-6498
    ISSN 0952-4746
    DOI 10.1088/1361-6498/ab076a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Investigating the Impact of First-Line Anti-Tuberculosis Drugs Encapsulated in a Eugenol-Based Nanoemulsion on Human Serum Albumin.

    Menon, Parvathy Mohan / Chandrasekaran, Natarajan / Doss C, George Priya

    Discovery medicine

    2024  Volume 36, Issue 183, Page(s) 739–752

    Abstract: Background: Eugenol exhibits broad-spectrum antibacterial and anti-inflammatory properties. However, cytotoxicity at high concentrations limits the full utilization of eugenol-based drug complexes. Formulations of multidrug-loaded eugenol-based ... ...

    Abstract Background: Eugenol exhibits broad-spectrum antibacterial and anti-inflammatory properties. However, cytotoxicity at high concentrations limits the full utilization of eugenol-based drug complexes. Formulations of multidrug-loaded eugenol-based nanoemulsions have reduced cytotoxicity; however, it remains crucial to understand how these eugenol complexes interact with primary human carrier proteins to design and develop therapeutic alternatives. Consequently, this study primarily aims to investigate the impact on Human Serum Albumin (HSA) when it interacts with eugenol-based complexes loaded with first-line anti-tuberculosis drugs.
    Methods: This study used various spectroscopic such as UV-visible spectroscopy, Fluorescence spectroscopy, Fourier-transform infrared spectroscopy and computational methods such as molecular docking and 100 ns molecular simulation to understand the impact of eugenol-based first-line anti-tuberculosis drug-loaded nanoemulsions on HSA structure.
    Results: The binding of the HSA protein and eugenol-based complexes was studied using UV-visible spectroscopic analysis. Minor changes in the fluorophores of the protein further confirmed binding upon interaction with the complexes. The Fourier-transform infrared spectra showed no significant changes in protein structure upon interaction with eugenol-based multidrug-loaded nanoemulsions, suggesting that this complex is safe for internal administration. Unlike eugenol or first-line anti-tuberculosis alone, molecular docking revealed the strength of the binding interactions between the complexes and the protein through hydrogen bonds. The docked complexes were subjected to a 100 ns molecular dynamics simulation, which strongly supported the conclusion that the structure and stability of the protein were not compromised by the interaction.
    Conclusions: From the results we could comprehend that the eugenol (EUG)-drug complex showed greater stability in HSA protein structure when compared to HSA interacting with isoniazid (INH), rifampicin (RIF), pyrazinamide (PYR), or ethambutol (ETH) alone or with EUG alone. Thus, inferring the potential of EUG-based drug-loaded formulations for a safer and efficient therapeutic use.
    MeSH term(s) Eugenol/chemistry ; Eugenol/pharmacology ; Humans ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Antitubercular Agents/pharmacokinetics ; Molecular Docking Simulation ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/metabolism ; Emulsions/chemistry ; Spectroscopy, Fourier Transform Infrared ; Protein Binding
    Chemical Substances Eugenol (3T8H1794QW) ; Antitubercular Agents ; Serum Albumin, Human (ZIF514RVZR) ; Emulsions
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415544-5
    ISSN 1944-7930 ; 1944-7930
    ISSN (online) 1944-7930
    ISSN 1944-7930
    DOI 10.24976/Discov.Med.202436183.70
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Letter by Doss Regarding Article, "Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair".

    Doss, Mohan

    Circulation

    2018  Volume 137, Issue 24, Page(s) 2678–2679

    MeSH term(s) Aortic Aneurysm, Abdominal ; DNA Damage ; Endovascular Procedures ; Humans ; Radiation Injuries
    Language English
    Publishing date 2018-06-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.033691
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Pediatric Computed Tomography Scans and Cancer Risk.

    Doss, Mohan

    JAMA pediatrics

    2018  Volume 172, Issue 11, Page(s) 1099–1100

    MeSH term(s) Child ; Humans ; Neoplasms ; Radiation Dosage ; Tomography, X-Ray Computed ; Wounds, Nonpenetrating
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2018.2657
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: The Conclusion of the BEIR VII Report Endorsing the Linear No-Threshold Model Is No Longer Valid Due to Advancement of Knowledge.

    Doss, Mohan

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2018  Volume 59, Issue 11, Page(s) 1777

    MeSH term(s) DNA Damage ; Humans ; Neoplasms, Radiation-Induced ; Radiation Dosage
    Language English
    Publishing date 2018-08-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.118.217489
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Radiation dose from cardiac catheterization procedures in young patients may not contribute to increased cancer risk.

    Doss, Mohan

    European journal of epidemiology

    2018  Volume 33, Issue 4, Page(s) 425–426

    MeSH term(s) Cardiac Catheterization/adverse effects ; Female ; Humans ; Male ; Neoplasms, Radiation-Induced ; Radiation Dosage ; Radiation Exposure/adverse effects ; Radiography, Interventional
    Language English
    Publishing date 2018-04-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-018-0379-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top