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  1. Article: Beyond Human Limits: Harnessing Artificial Intelligence to Optimize Immunosuppression in Kidney Transplantation.

    Basuli, Debargha / Roy, Sasmit

    Journal of clinical medicine research

    2023  Volume 15, Issue 8-9, Page(s) 391–398

    Abstract: The field of kidney transplantation is being revolutionized by the integration of artificial intelligence (AI) and machine learning (ML) techniques. AI equips machines with human-like cognitive abilities, while ML enables computers to learn from data. ... ...

    Abstract The field of kidney transplantation is being revolutionized by the integration of artificial intelligence (AI) and machine learning (ML) techniques. AI equips machines with human-like cognitive abilities, while ML enables computers to learn from data. Challenges in transplantation, such as organ allocation and prediction of allograft function or rejection, can be addressed through AI-powered algorithms. These algorithms can optimize immunosuppression protocols and improve patient care. This comprehensive literature review provides an overview of all the recent studies on the utilization of AI and ML techniques in the optimization of immunosuppression in kidney transplantation. By developing personalized and data-driven immunosuppression protocols, clinicians can make informed decisions and enhance patient care. However, there are limitations, such as data quality, small sample sizes, validation, computational complexity, and interpretability of ML models. Future research should validate and refine AI models for different populations and treatment durations. AI and ML have the potential to revolutionize kidney transplantation by optimizing immunosuppression and improving outcomes. AI-powered algorithms enable personalized and data-driven immunosuppression protocols, enhancing patient care and decision-making. Limitations include data quality, small sample sizes, validation, computational complexity, and interpretability of ML models. Further research is needed to validate and enhance AI models for different populations and longer-term dosing decisions.
    Language English
    Publishing date 2023-09-30
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2548987-2
    ISSN 1918-3011 ; 1918-3003
    ISSN (online) 1918-3011
    ISSN 1918-3003
    DOI 10.14740/jocmr5012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Elevated Anion Gap Metabolic Acidosis With High Osmolar Gap and Increased Serum Acetone Level: A Case Report.

    Basuli, Debargha / Roy, Sasmit

    Cureus

    2022  Volume 14, Issue 7, Page(s) e27085

    Abstract: Acetone poisoning, although not very common, can present with varied signs and symptoms. High acetone levels in serum can be due to exogenous exposure or endogenous production of acetone. Unlike certain alcohol toxicities, acetone does not cause high ... ...

    Abstract Acetone poisoning, although not very common, can present with varied signs and symptoms. High acetone levels in serum can be due to exogenous exposure or endogenous production of acetone. Unlike certain alcohol toxicities, acetone does not cause high anion gap metabolic acidosis. A 69-year-old male presented to our service with shock and acute encephalopathy and required intensive care support. Initial laboratory investigation showed high anion gap metabolic acidosis with high osmolar gap. Serum acetone level was elevated. Clinicians need to be aware of how to elucidate such metabolic disturbances and associated toxicities.
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.27085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Daptomycin-induced hyperkalemia: A case report and brief description of mechanism.

    Errabelli, Praveen / Lathiya, Maulik / Roy, Sasmit

    Clinical case reports

    2023  Volume 11, Issue 11, Page(s) e8188

    Abstract: Key clinical message: Daptomycin causes serious side effects like rhabdomyolysis at high doses. At lower doses it can cause isolated hyperkalemia without frank rhabdomyolysis. Checking BMP along with CK helps taking timely measures to prevent adverse ... ...

    Abstract Key clinical message: Daptomycin causes serious side effects like rhabdomyolysis at high doses. At lower doses it can cause isolated hyperkalemia without frank rhabdomyolysis. Checking BMP along with CK helps taking timely measures to prevent adverse consequences.
    Abstract: Hyperkalemia is a common yet challenging clinical condition faced daily by physicians worldwide. Accurate etiology and timely management are paramount in correcting this preventable yet life-threatening electrolyte imbalance. Very seldom has Daptomycin been implicated as a culprit for hyperkalemia. We present one such unique case where a low dose of Daptomycin led to hyperkalemia, and timely identification improved patient outcomes. We present a 69-year-old woman with multiple comorbidities admitted to the intensive care unit to manage diabetic ketoacidosis and sepsis. She developed acute kidney injury due to intravenous contrast, volume depletion, and obstructive uropathy. Interestingly although initially normokalemic, as her renal function started improving with sound urine output, she developed recurrent hyperkalemia, which required medical management. The etiology of hyperkalemia was initially unclear, but on closer review, it was discovered that Daptomycin was the potential culprit. Although case studies with high-dose Daptomycin causing rhabdomyolysis and hyperkalemia have been reported, low-dose Daptomycin causing hyperkalemia without rhabdomyolysis has never been reported, bringing forth the uniqueness of our article.
    Language English
    Publishing date 2023-11-12
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rhizobium radiobacter

    Roy, Sasmit / Basuli, Debargha / Rahman, Ebad U / Adapa, Sreedhar / Reddy, Sohil N

    Journal of medical cases

    2022  Volume 13, Issue 9, Page(s) 471–474

    Abstract: Rhizobium ... ...

    Abstract Rhizobium radiobacter
    Language English
    Publishing date 2022-09-28
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4163
    ISSN (online) 1923-4163
    ISSN 1923-4163
    DOI 10.14740/jmc3999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Brevibacterium casei

    Roy, Sasmit / Garcha, Amarinder S / Patel, Sumit S / Rahman, Ebad / Adapa, Sreedhar

    Journal of community hospital internal medicine perspectives

    2022  Volume 12, Issue 1, Page(s) 64–67

    Abstract: Brevibacterium ... ...

    Abstract Brevibacterium casei
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Emerging Uncommon Non-Albicans Candida: Candida Parapsilosis Peritonitis in a Peritoneal Dialysis Patient.

    Roy, Sasmit / Vantipalli, Praveena / Garcha, Amarinder / Pokal, Mytri / Adapa, Sreedhar

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17083

    Abstract: ... Candida ... ...

    Abstract Candida parapsilosis
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Incidental detection of operational tolerance in a deceased donor kidney transplant recipient lost to follow-up for more than 10 years: A case report and literature review.

    Roy, Sasmit / Chowdhury, Monzurul Hasan / Basuli, Debargha / Adapa, Sreedhar / Bodziak, Kenneth

    Clinical nephrology. Case studies

    2023  Volume 11, Page(s) 12–16

    Abstract: Graft tolerance is a clinical state of absence of an immune response in the recipient toward a donor allograft without any exogenous immunosuppression. Although more prevalent in liver transplantation recipients, it has rarely been reported in renal ... ...

    Abstract Graft tolerance is a clinical state of absence of an immune response in the recipient toward a donor allograft without any exogenous immunosuppression. Although more prevalent in liver transplantation recipients, it has rarely been reported in renal transplant recipients. We present a 62-year-old deceased donor kidney transplant recipient who exhibited operational tolerance as they stopped immunosuppressant medications for more than 10 years and yet demonstrated stable graft function. Although various hypotheses, such as deletion, anergy, immunoregulation, and clonal exhaustion, have been experimentally validated, clinical "operational tolerance" of a renal allograft on a prolonged basis has been infrequently reported in the medical literature. This review intends to highlight possible etiologies and make clinicians aware of this possible rare condition to which more research is needed.
    Language English
    Publishing date 2023-02-16
    Publishing country Germany
    Document type Case Reports
    ISSN 2196-5293
    ISSN (online) 2196-5293
    DOI 10.5414/CNCS111030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Case of Ischemic Monomelic Neuropathy After Arteriovenous Fistula Placement.

    Sangani, Vikram / Pokal, Mytri / Noel, Edva / Keetha, Narsimha R / Roy, Sasmit / Mahata, Indrajeet

    Journal of community hospital internal medicine perspectives

    2023  Volume 13, Issue 3, Page(s) 113–117

    Abstract: Ischemic monomelic neuropathy (IMN) is a relatively uncommon and under-recognized complication of vascular access creation for arteriovenous (AV) fistula in hemodialysis patients. They usually develop distal muscle weakness, sensation loss, and severe ... ...

    Abstract Ischemic monomelic neuropathy (IMN) is a relatively uncommon and under-recognized complication of vascular access creation for arteriovenous (AV) fistula in hemodialysis patients. They usually develop distal muscle weakness, sensation loss, and severe acute pain without muscle necrosis soon after AV fistula creation. Physicians should be aware of this condition as prompt diagnosis and timely vascular interventions are necessary to save the limbs and prevent permanent functional disability. Once the diagnosis of IMN is made, the patients will need emergent ligation of the fistula to restore the distal perfusion. We report a case of a 59-year-old male patient with End-stage Renal Disease on hemodialysis who developed severe pain, weakness, and loss of sensation in the left arm a few hours after left brachiocephalic vascular access creation. He was subsequently diagnosed with ischemic monomelic neuropathy and underwent emergent AV fistula ligation. Symptoms were relieved immediately after the ligation.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Roseomonas mucosa

    Roy, Sasmit / Patel, Sumit / Kummamuru, Hardhik / Garcha, Amarinder Singh / Gupta, Rohan / Adapa, Sreedhar

    Case reports in nephrology

    2021  Volume 2021, Page(s) 1979332

    Abstract: ... ...

    Abstract Roseomonas
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2021/1979332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Megadose Vitamin C Prescription Through Alternative Medicine Leading to End-Stage Renal Disease: Case Study and Literature Review.

    Roy, Sasmit / Chourasia, Prabal / Sangani, Vikram / Errabelli, Praveen Kumar / Patel, Sumit S / Adapa, Sreedhar

    Journal of investigative medicine high impact case reports

    2023  Volume 11, Page(s) 23247096231158954

    Abstract: Modern medicine has made tremendous advancements and succeeded in increasing longevity through adequate screening and diagnosis and various new therapeutic approaches. However, alternative medicine is a branch of health care practicing different ... ...

    Abstract Modern medicine has made tremendous advancements and succeeded in increasing longevity through adequate screening and diagnosis and various new therapeutic approaches. However, alternative medicine is a branch of health care practicing different traditional and unconventional, potentially hazardous therapies to treat commonly known ailments. Standard low-dose vitamin C, ie, 500-1000 mg, is approved in medical conditions like methemoglobinemia, scurvy, burns and also helps iron absorption in anemia. However, toxic doses carry high nephrotoxicity potential like in our case. We present a 74-year-old Caucasian female falling victim to one such alternative therapy leading to acute kidney injury requiring lifelong hemodialysis. She had endometrial cancer and received 100 gm of intravenous vitamin C weekly through a provider for the last 6 weeks as part of this alternate approach to cure her cancer. Upon admission, the serum creatinine level was elevated at 8.2 mg/dl, which subsequently did not improve with conservative management. Renal biopsy revealed diffuse acute tubular injury with polarized microscopy demonstrating calcium oxalate crystals. While her blood vitamin C levels were high, the serum oxalate level was normal. She ended up requiring renal replacement therapy permanently. Alternative medicine continues to be a significant health care hazard with the potential to cause unwanted irreversible nephrotoxicity. Public attention is necessary at various social levels to counter the detrimental outcomes of alternative medicine.
    MeSH term(s) Female ; Humans ; Aged ; Ascorbic Acid/adverse effects ; Hyperoxaluria ; Vitamins/adverse effects ; Kidney Failure, Chronic/therapy ; Complementary Therapies
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Review ; Journal Article ; Case Reports
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096231158954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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