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  1. Article ; Online: Importance of Tricuspid Regurgitation-Time to Move on.

    Wang, Nelson / Lal, Sean

    Circulation. Cardiovascular imaging

    2023  Volume 16, Issue 7, Page(s) 577–579

    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Heart Valve Prosthesis Implantation
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.123.015733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6743: Show issues Location:
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  2. Article ; Online: Primary Sjögren’s Syndrome.

    Lal, Sean

    The New England journal of medicine

    2018  Volume 379, Issue 1, Page(s) 96–97

    MeSH term(s) Humans ; Sjogren's Syndrome
    Language English
    Publishing date 2018--05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1804598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  3. Article: Editorial: Molecular and cellular mechanisms of heart failure: pathophysiology, pathogenesis and therapeutics.

    Lal, Sean / Campbell, Kenneth / Li, Amy

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1260483

    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1260483
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  4. Article ; Online: Regenerating Hearts by Arresting Development With Hypothyroidism.

    Lal, Sean / Kühn, Bernhard

    Circulation research

    2019  Volume 124, Issue 12, Page(s) 1725–1726

    MeSH term(s) Heart ; Humans ; Hypothyroidism
    Language English
    Publishing date 2019-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.119.315106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
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  5. Article ; Online: Giant mitochondria in cardiomyocytes: cellular architecture in health and disease.

    Li, Amy / Shami, Gerald J / Griffiths, Lisa / Lal, Sean / Irving, Helen / Braet, Filip

    Basic research in cardiology

    2023  Volume 118, Issue 1, Page(s) 39

    Abstract: Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and ... ...

    Abstract Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and exercise, and clinically in alcohol-induced heart disease and various cardiomyopathies. This mitochondrial aberration is widely considered an early structural hallmark of disease leading to adverse organ function. In this thematic paper, we discuss the current state-of-knowledge on the presence, structure and functional implications of giant mitochondria in heart muscle. Despite its demonstrated reoccurrence in different heart diseases, the literature on this pathophysiological phenomenon remains relatively sparse since its initial observations in the early 60s. We review historical and contemporary investigations from cultured cardiomyocytes to human tissue samples to address the role of giant mitochondria in cardiac health and disease. Finally, we discuss their significance for the future development of novel mitochondria-targeted therapies to improve cardiac metabolism and functionality.
    MeSH term(s) Humans ; Myocytes, Cardiac/metabolism ; Mitochondrial Swelling ; Mitochondria/metabolism ; Cardiomyopathies ; Myocardium/metabolism ; Mitochondria, Heart/metabolism
    Language English
    Publishing date 2023-09-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-023-01011-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.30: Show issues Location:
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  6. Article ; Online: Recurrent immunosuppressive-responsive myocarditis in a patient with desmoplakin cardiomyopathy: a case report.

    McColl, Hayden / Cordina, Rachael / Lal, Sean / Parker, Matthew / Hunyor, Imre / Medi, Caroline / Gray, Belinda

    European heart journal. Case reports

    2024  Volume 8, Issue 3, Page(s) ytae129

    Abstract: Background: Desmoplakin (DSP) cardiomyopathy is a rare genetic condition characterized by repeated inflammatory myocardial injury and is associated with ventricular arrhythmia and sudden cardiac death. Diagnosis is challenging and requires a combination ...

    Abstract Background: Desmoplakin (DSP) cardiomyopathy is a rare genetic condition characterized by repeated inflammatory myocardial injury and is associated with ventricular arrhythmia and sudden cardiac death. Diagnosis is challenging and requires a combination of genetic testing and advanced imaging techniques.
    Case summary: We present the case of a 38-year-old woman with recurrent episodes of subclinical myocarditis. Investigation using cardiac magnetic resonance imaging (cMRI) and genetic testing revealed a diagnosis of DSP cardiomyopathy. Her disease was initially responsive to corticosteroid therapy but quickly relapsed when treatment was tapered. Management of her condition required significant immunosuppression and the subsequent insertion of an implantable cardiac defibrillator due to her risk of sudden cardiac death.
    Discussion: Cardiac MRI and genetic testing are key diagnostic techniques in the assessment of patients with recurrent myocarditis and cardiomyopathy. The management of cardiomyopathies with an inflammatory component is not completely understood; however, there is likely a key role for immune suppression therapies. Furthermore, there are several cardiomyopathy genetic variants including DSP which require careful risk stratification due to an increased risk of sudden cardiac death.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae129
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  7. Article ; Online: Cholesterol lowering: to live longer, start younger?

    Wang, Nelson / Wilcox, Ian / Lal, Sean

    Aging

    2020  Volume 12, Issue 4, Page(s) 3119–3120

    MeSH term(s) Cholesterol, LDL/blood ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Longevity/drug effects ; Risk Factors
    Chemical Substances Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.102867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19: getting to the heart of the matter.

    Wang, Nelson / Cao, Jacob / Lal, Sean

    European journal of heart failure

    2020  Volume 22, Issue 12, Page(s) 2216–2218

    MeSH term(s) COVID-19 ; Heart Failure ; Humans ; Incidence ; Prevalence ; Prognosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2007
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    Zs.A 5299: Show issues Location:
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  9. Article ; Online: Sex-specific differences in the efficacy of heart failure therapies: a meta-analysis of 84,818 patients.

    Wang, Nelson / Evans, Jack / Sawant, Sonia / Sindone, James / Lal, Sean

    Heart failure reviews

    2022  Volume 28, Issue 4, Page(s) 949–959

    Abstract: Women have been historically underrepresented in clinical trials of heart failure (HF). We aimed to assess for sex differences in patient characteristics and the efficacy of guideline-directed medical therapy (GDMT) in HF. Systematic literature search ... ...

    Abstract Women have been historically underrepresented in clinical trials of heart failure (HF). We aimed to assess for sex differences in patient characteristics and the efficacy of guideline-directed medical therapy (GDMT) in HF. Systematic literature search for randomized controlled trials (RCTs) of GDMT reporting cardiovascular outcomes by sex in patients with HF. The primary outcome was the composite of cardiovascular death and hospitalization for HF. Risk ratios (RR) with 95% confidence intervals (CI) were pooled using inverse variance weighting and random effects meta-analysis. Twenty-six RCTs totaling 84,818 participants (27% women) were included. Women with HF were older, had higher New York Heart Association (NYHA) class, more hypertension and obesity, and higher mean left ventricular ejection fraction compared to men. There was evidence for most GDMT in reducing the primary outcome in women with HF with reduced ejection fraction (HFrEF) (angiotensin-converting enzyme inhibitors/angiotensin-receptor blocker [RR 0.86, 95% CI 0.75-0.97], angiotensin-receptor blocker/neprilysin inhibitor (ARNI) [RR 0.77, 95% CI 0.62-0.94], beta-blocker [RR 0.67, 95% CI 0.51-0.89], ivabradine [RR 0.74, 95% CI 0.60-0.91], and sodium-glucose cotransporter-2 (SGLT2) inhibitors [RR 0.66, 95% CI 0.54-0.81]) and a non-significant trend for benefit with mineralocorticoid-receptor-antagonist (MRA) [RR 0.77, 95% CI 0.52-1.16]). Compared to men with HFrEF, GDMT reduced the primary outcome in women to a similar degree across all drug classes (ratio of RR 1.05, 95% CI 0.96-1.14). Despite differences in baseline characteristics and an underrepresentation of women in HF clinical trials, GDMT are as efficacious in women as compared to men in reducing cardiovascular events in HF.
    MeSH term(s) Male ; Female ; Humans ; Sex Characteristics ; Heart Failure/drug therapy ; Ivabradine ; Angiotensin Receptor Antagonists ; Stroke Volume ; Angiotensins
    Chemical Substances Ivabradine (3H48L0LPZQ) ; Angiotensin Receptor Antagonists ; Angiotensins
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-022-10275-1
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    Zs.A 5212: Show issues Location:
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  10. Article: A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection.

    Li, Amy / Lal, Sean / Dos Remedios, Cristobal G

    Biophysical reviews

    2019  Volume 11, Issue 2, Page(s) 241–244

    Language English
    Publishing date 2019-03-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-019-00514-5
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