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  1. Article ; Online: Fever with atypical lymphocytosis: pearls and pitfalls in Epstein-Barr virus serology.

    Tan, Jia Wei / Hu, Jiun-Ruey

    BMJ case reports

    2023  Volume 16, Issue 5

    Abstract: The heterophile antibody (also known as the Monospot) test is a useful screening tool for infectious mononucleosis (IM) resulting from primary Epstein-Barr virus (EBV) infection. However, up to 10% of patients with IM are heterophile negative. ... ...

    Abstract The heterophile antibody (also known as the Monospot) test is a useful screening tool for infectious mononucleosis (IM) resulting from primary Epstein-Barr virus (EBV) infection. However, up to 10% of patients with IM are heterophile negative. Heterophile-negative patients who have lymphocytosis or atypical lymphocytes on peripheral blood smear should be further tested for EBV serologies, which include testing for specific IgM and IgG antibodies against viral capsid antigens, early antigens and EBV nuclear antigen proteins. A diagnostic dilemma arises when the patient has clinical and laboratory features of IM, but is both heterophile negative and seronegative for IM, as illustrated in this case presentation. To avoid missed diagnoses of IM, misdiagnosis of mononucleosis-like illnesses and unnecessary testing, knowledge of test characteristics and the evolving course of EBV serologies is important to assure and inform both the physician and the patient.
    MeSH term(s) Humans ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Lymphocytosis/diagnosis ; Infectious Mononucleosis/diagnosis ; Antigens, Viral ; Fever ; Antibodies, Viral
    Chemical Substances Antigens, Viral ; Antibodies, Viral
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial Comment.

    Hu, Jiun-Ruey / Hurley, Paula

    The Journal of urology

    2021  Volume 205, Issue 5, Page(s) 1377–1378

    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001531.01
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    Ui VI Zs.91: Show issues Location:
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  3. Article ; Online: Asian American Trainees During the COVID-19 Pandemic.

    Wang, Margaret Z / Hu, Jiun-Ruey

    Academic medicine : journal of the Association of American Medical Colleges

    2021  Volume 96, Issue 6, Page(s) 780

    MeSH term(s) Asian/psychology ; Asian/statistics & numerical data ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/psychology ; COVID-19/virology ; Humans ; Internship and Residency/statistics & numerical data ; SARS-CoV-2/genetics ; Training Support/statistics & numerical data ; Violence/ethnology ; Violence/psychology ; Violence/statistics & numerical data
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004038
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    Zs.A 112: Show issues Location:
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  4. Article ; Online: Optimizing the Virtual Interview Experience for Residency and Fellowship Applicants.

    Kosyakovsky, Leah / Shi, Hanyuan / Hu, Jiun-Ruey

    Academic medicine : journal of the Association of American Medical Colleges

    2022  Volume 97, Issue 7, Page(s) 941

    MeSH term(s) Fellowships and Scholarships ; Humans ; Internship and Residency ; Orthopedics/education
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004696
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  5. Article ; Online: Once-Weekly Semaglutide with Lifestyle Intervention Results in Clinically Significant Weight Loss.

    Chang, Rachel S / Hu, Jiun-Ruey / Yeh, Hsin-Chieh

    Journal of general internal medicine

    2022  Volume 37, Issue 7, Page(s) 1824–1826

    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptides ; Glycated Hemoglobin/analysis ; Humans ; Hypoglycemic Agents ; Life Style ; Weight Loss
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8)
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-021-07215-4
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    Zs.A 2205: Show issues Location:
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  6. Article ; Online: Acknowledge Racism in Academic Medicine: Addressing and Preventing Attacks on Asian Americans and Pacific Islanders.

    Chang, Rachel S / Hu, Jiun-Ruey / Kagetsu, Nolan J

    Academic medicine : journal of the Association of American Medical Colleges

    2022  Volume 97, Issue 6, Page(s) 766–767

    MeSH term(s) Humans ; Medicine/statistics & numerical data ; Racism/prevention & control ; United States ; White People ; Asian American Native Hawaiian and Pacific Islander/statistics & numerical data
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Letter
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004647
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    Zs.A 112: Show issues Location:
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  7. Article ; Online: The Brain-Heart Axis: Neuroinflammatory Interactions in Cardiovascular Disease.

    Hu, Jiun-Ruey / Abdullah, Ahmed / Nanna, Michael G / Soufer, Robert

    Current cardiology reports

    2023  Volume 25, Issue 12, Page(s) 1745–1758

    Abstract: Purpose of review: The role of neuroimmune modulation and inflammation in cardiovascular disease has been historically underappreciated. Physiological connections between the heart and brain, termed the heart-brain axis (HBA), are bidirectional, occur ... ...

    Abstract Purpose of review: The role of neuroimmune modulation and inflammation in cardiovascular disease has been historically underappreciated. Physiological connections between the heart and brain, termed the heart-brain axis (HBA), are bidirectional, occur through a complex network of autonomic nerves/hormones and cytokines, and play important roles in common disorders.
    Recent findings: At the molecular level, advances in the past two decades reveal complex crosstalk mediated by the sympathetic and parasympathetic nervous systems, the renin-angiotensin aldosterone and hypothalamus-pituitary axes, microRNA, and cytokines. Afferent pathways amplify proinflammatory signals via the hypothalamus and brainstem to the periphery, promoting neurogenic inflammation. At the organ level, while stress-mediated cardiomyopathy is the prototypical disorder of the HBA, cardiac dysfunction can result from a myriad of neurologic insults including stroke and spinal injury. Atrial fibrillation is not necessarily a causative factor for cardioembolic stroke, but a manifestation of an abnormal atrial substrate, which can lead to the development of stroke independent of AF. Central and peripheral neurogenic proinflammatory factors have major roles in the HBA, manifesting as complex bi-directional relationships in common conditions such as stroke, arrhythmia, and cardiomyopathy.
    MeSH term(s) Humans ; Cardiovascular Diseases/etiology ; Brain ; Cardiomyopathies ; Heart Atria ; Stroke/etiology ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-023-01990-8
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    Zs.A 5524: Show issues Location:
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  8. Article ; Online: Asian Americans and Native Hawaiian/Pacific Islanders Must Stand Up Against Anti-Blackness in Medicine.

    Kung, Sunny / Hu, Jiun-Ruey / Sivashanker, Karthik

    Academic medicine : journal of the Association of American Medical Colleges

    2021  Volume 96, Issue 6, Page(s) 773–774

    MeSH term(s) Black or African American ; Asian ; Humans ; Native Hawaiian or Other Pacific Islander ; Physicians/psychology ; Racism ; Social Support ; Stereotyping ; United States
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Letter
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004051
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    Zs.A 112: Show issues Location:
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  9. Article: Clinical Biochemistry of Serum Troponin.

    Gokhan, Ilhan / Dong, Weilai / Grubman, Daniel / Mezue, Kenechukwu / Yang, David / Wang, Yanting / Gandhi, Parul U / Kwan, Jennifer M / Hu, Jiun-Ruey

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Accurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS). Knowledge of the molecular characteristics of the ... ...

    Abstract Accurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS). Knowledge of the molecular characteristics of the troponin complex and test characteristics of troponin measurement assays allows for a deeper understanding of causes of false positive and false negative test results in myocardial injury. In this review, we discuss the molecular structure and functions of the constituent proteins of the troponin complex (TnT, TnC, and TnI); review the different isoforms of Tn and where they are from; survey the evolution of clinical Tn assays, ranging from first-generation to high-sensitivity (hs); provide a primer on statistical interpretation of assay results based on different clinical settings; and discuss potential causes of false results. We also summarize the advances in technologies that may lead to the development of future Tn assays, including the development of point of care assays and wearable Tn sensors for real-time continuous measurement.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040378
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  10. Article: Spontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review.

    Tan, Jia Wei / Shukla, Anant / Hu, Jiun-Ruey / Majumdar, Sachin K

    Case reports in endocrinology

    2022  Volume 2022, Page(s) 6538800

    Abstract: Background: Adrenal hemorrhage (AH) is a serious endocrine complication of antiphospholipid syndrome (APLS). : Conclusion: Depending on the degree of adrenal involvement in AH, patients can present with partial or complete primary adrenal ... ...

    Abstract Background: Adrenal hemorrhage (AH) is a serious endocrine complication of antiphospholipid syndrome (APLS).
    Conclusion: Depending on the degree of adrenal involvement in AH, patients can present with partial or complete primary adrenal insufficiency. More data are needed to characterize adrenal function after AH, and the safety of DOAC versus warfarin in patients with APLS warrants further studies.
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627633-1
    ISSN 2090-651X ; 2090-6501
    ISSN (online) 2090-651X
    ISSN 2090-6501
    DOI 10.1155/2022/6538800
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