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Article ; Online: Reply to Carmen Gravina, Riccardo Lombardo, and Cosimo De Nunzio's Letter to the Editor re: Georges Mjaess, Alexandre Peltier, Jean-Baptiste Roche, et al. A Novel Nomogram to Identify Candidates for Focal Therapy Among Patients with Localized Prostate Cancer Diagnosed via Magnetic Resonance Imaging-Targeted and Systematic Biopsies: A European Multicenter Study. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2023.04.008.

Mjaess, Georges / Roumeguère, Thierry / Diamand, Romain

European urology focus

2023 Volume 10, Issue 1, Page(s) 75–76

MeSH term(s)	Male ; Humans ; Nomograms ; Prostatic Neoplasms ; Magnetic Resonance Imaging ; Patients
Language	English
Publishing date	2023-08-04
Publishing country	Netherlands
Document type	Multicenter Study ; Letter
ISSN	2405-4569
ISSN (online)	2405-4569
DOI	10.1016/j.euf.2023.07.005
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Article ; Online: New robotic platforms for prostate surgery: the future is now.

Mjaess, Georges / Orecchia, Luca / Albisinni, Simone

Prostate cancer and prostatic diseases

2023 Volume 26, Issue 3, Page(s) 519–520

MeSH term(s)	Male ; Humans ; Robotic Surgical Procedures ; Prostate/surgery ; Prostatic Neoplasms/surgery ; Robotics ; Laparoscopy
Language	English
Publishing date	2023-07-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-023-00697-9
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Zs.A 5277: Show issues

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Article ; Online: Increase in urolithiasis prevalence due to vitamins C and D supplementation during the COVID-19 pandemic.

Karam, Aya / Mjaess, Georges / Younes, Hadi / Aoun, Fouad

Journal of public health (Oxford, England)

2021 Volume 44, Issue 4, Page(s) e625–e626

MeSH term(s)	Humans ; Ascorbic Acid/therapeutic use ; COVID-19 ; Dietary Supplements ; Pandemics ; Prevalence ; Urolithiasis ; Vitamins/therapeutic use ; Vitamin D/therapeutic use
Chemical Substances	Ascorbic Acid (PQ6CK8PD0R) ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2021-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdab328
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Zs.B 2186: Show issues

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Article ; Online: Renorrhaphy techniques in minimally invasive partial nephrectomy: a systematic review of the literature.

Daou, Samah / Albeaini, Sylvana / Mjaess, Georges / Diamand, Romain / Albisinni, Simone / Roumeguère, Thierry / Aoun, Fouad

Minerva urology and nephrology

2023 Volume 75, Issue 6, Page(s) 683–695

Abstract: Introduction: In the absence of consensus on the optimal approach to renorrhaphy in partial nephrectomy, this systematic review aims to assess the various renorrhaphy techniques and their impact on surgical outcomes.: Evidence acquisition: A ... ...

Abstract	Introduction: In the absence of consensus on the optimal approach to renorrhaphy in partial nephrectomy, this systematic review aims to assess the various renorrhaphy techniques and their impact on surgical outcomes. Evidence acquisition: A systematic review of the literature was performed in March 2022, using PubMed and Scopus, without time restrictions and research filters for studies investigating renorrhaphy techniques in partial nephrectomy. Studies providing sufficient details on renorrhaphy techniques and their outcomes during minimally invasive partial nephrectomy (PN) were included in this analysis. Evidence synthesis: Thirty-one studies with 5720 patients were included in the analysis. In most studies, tumor diameter was <4 cm. RENAL and PADUA scores as well as tumor locations were heterogeneous between the studies. The results of the use of hemostatic agents were conflicting among different studies with limited evidence regarding the benefits of its routine use in partial nephrectomy. The use of barbed and running sutures was associated with a reduced warm ischemia time. While some studies showed a decreased warm ischemia time when omitting cortical renorrhaphy, others found that it may lead to higher incidence of minor complications without any significant improvement in other outcomes. Conclusions: There is ongoing research to determine the optimal approach to renorrhaphy. The current evidence on the routine use of hemostatic agents is limited. The use of certain techniques such as barbed sutures, sliding clips and running sutures reduced the warm ischemia time. The omission of cortical renorrhaphy is still controversial.
MeSH term(s)	Humans ; Kidney Neoplasms/surgery ; Suture Techniques ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Kidney/surgery ; Hemostatics
Chemical Substances	Hemostatics
Language	English
Publishing date	2023-12-21
Publishing country	Italy
Document type	Systematic Review ; Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.23.05345-4
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Zs.A 16: Show issues

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Article ; Online: Displaced Orbital Fractures with Concurrent Orbital Compartment Syndrome: A Case-Based Systematic Review.

Zogheib, Serge / Sukkarieh, Georges / Mjaess, Georges / Zeid, Samer Abou

Facial plastic surgery : FPS

2021 Volume 38, Issue 3, Page(s) 274–278

Abstract: Orbital compartment syndrome (OCS) is an emergency that complicates intra-orbital, retrobulbar hemorrhage in most cases. Bony orbital decompression is an effective treatment for OCS, and displaced orbital fractures are protective. Nevertheless, in rare ... ...

Abstract	Orbital compartment syndrome (OCS) is an emergency that complicates intra-orbital, retrobulbar hemorrhage in most cases. Bony orbital decompression is an effective treatment for OCS, and displaced orbital fractures are protective. Nevertheless, in rare cases, OCS occurs despite a displaced orbital fracture. The aim of the current review is to present its pathophysiology and management based on what is published in the medical literature, and our center's experience. A systematic review of literature was conducted through PubMed, Medline, Embase, and Cochrane from inception through February 2021. The following search query was used: "orbital fracture" and "trauma" and "orbital compartment syndrome." Studies tackling the pathophysiology and management of concurrent displaced orbital fracture with OCS were included and a cohort of patients was constituted. A cohort of 18 cases reported in the literature were included (49.3 ± 30.6 years, 50% M). Given that OCS occurs with or without orbital fracture, pathophysiology of OCS is mostly explained by the division of the orbital fat into many compartments, due to the presence of Koorneef's fibrous septa. Management of OCS in such circumstances consisted of inferior-lateral canthotomy and cantholysis in 50% of cases, subperiosteal drainage with myringotomy in 22.2% of cases, subperiosteal drainage in 16.7% of cases, and complete lateral cantholysis in 16.7% of cases. Two cases who presented to our tertiary care center were also added to this review. Physicians should be aware that OCS can occur even with displaced fractures of the orbital cavity. When clinical suspicion is present, an emergent management is needed.
MeSH term(s)	Compartment Syndromes/etiology ; Compartment Syndromes/surgery ; Drainage ; Eyelids ; Humans ; Orbit/surgery ; Orbital Fractures/complications ; Orbital Fractures/surgery
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	630090-x
ISSN	1098-8793 ; 0736-6825
ISSN (online)	1098-8793
ISSN	0736-6825
DOI	10.1055/s-0041-1740290
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Article ; Online: A Systematic Review of Pressure Injuries Associated with Urethrocutaneous Fistula.

Zogheib, Serge / Khalil, Nour / Mjaess, Georges / Feghaly, Charbel / Daou, Bechara / Hanna, Cyril / Nasr, Marwan

Advances in skin & wound care

2023 Volume 36, Issue 9, Page(s) 1–8

Abstract: Objective: To review the literature about combined urologic and reconstructive management of pressure injuries (PIs) with urethral fistulas.: Data sources: Authors searched the PubMed, MEDLINE, EMBASE, and Cochrane databases using the following ... ...

Abstract	Objective: To review the literature about combined urologic and reconstructive management of pressure injuries (PIs) with urethral fistulas. Data sources: Authors searched the PubMed, MEDLINE, EMBASE, and Cochrane databases using the following keywords: "Perineum" or "Perineal" and "Pressure Ulcers" or '' Pressure Injury'' and "Urethral Fistula." Study selection: The search yielded a total of 95 articles. Study selection followed the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement, and the study was designed according to the PICOS (Population, Intervention, Comparison, Outcomes, Study) guidelines. Congress abstracts, letters to the editor, and editorial comments were excluded. After screening, a total of 9 studies (30 patients) were included in the review. Data extraction: Included patients received treatment for a perineal or ischial PI associated with a urinary fistula. The outcomes were recovery, complications, treatment failure, recurrence, and illness-related death. Data synthesis: Pressure injuries were mainly ischiatic (50%) and perineal (43%). Forty-six percent of patients had spinal cord injuries, and at least 40% reported voiding dysfunction. Sixteen percent had previous ischiectomy. Flaps such as posterior thigh flap, biceps femoris flap, and inferiorly based transverse rectus abdominal muscle flap had 88% to 100% success rates when used with urinary diversion techniques. Suprapubic cystostomy, the simplest method of urinary diversion, was successful in 47% of cases when performed alone and in 100% when combined with a pedicled omental flap or a transverse rectus abdominal muscle flap. Conclusions: Prevention and wound care are essential for PI management, but when combined with a urinary fistula, surgical management is unavoidable. Urinary diversion is essential before undergoing any type of ulcer reconstruction. Urethral reconstruction showed favorable results, further strengthened when combined with a musculocutaneous flap.
MeSH term(s)	Humans ; Pressure Ulcer/etiology ; Urinary Fistula/etiology ; Urinary Fistula/surgery ; Crush Injuries ; Plastic Surgery Procedures ; Surgical Flaps
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2012792-3
ISSN	1538-8654 ; 1527-7941
ISSN (online)	1538-8654
ISSN	1527-7941
DOI	10.1097/ASW.0000000000000023
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Zs.A 3164: Show issues

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Article ; Online: Successful outcomes with flaps for recurrent cerebrospinal fluid leaks: A systematic review of the literature.

Zogheib, Serge / Hanna, Cyril / Daou, Bechara / Mjaess, Georges / Sleilati, Fadi

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2022 Volume 75, Issue 4, Page(s) 1380–1388

Abstract: Complex back wounds with cerebrospinal fluid (CSF) leak constitute a challenge for surgeons in clinical practice. While repair of complex back wounds with various flaps is well described in the literature, there is a paucity of reviews and articles ... ...

Abstract	Complex back wounds with cerebrospinal fluid (CSF) leak constitute a challenge for surgeons in clinical practice. While repair of complex back wounds with various flaps is well described in the literature, there is a paucity of reviews and articles regarding optimal treatment for refractory CSF leaks. The aim of this systematic review was to present the different flap techniques proposed in the literature for CSF leaks fistulas and pseudo-meningoceles. A systematic review of the literature was conducted using the PubMed, Medline, Embase, and Cochrane databases. Studies tackling different flap techniques used for spinal or skull base CSF leak were included in the studies. The main outcomes were complications and recurrences after previous failed treatments. Fifteen studies were included in the study, constituting a cohort of 42 patients (mean age 45 years; F/M ratio 1.15:1). A previous unsuccessful non-flap procedure was proposed in 88.1% of patients for their CSF leak. Only 16.7% had a recurrence of their CSF leak after the flap procedure. Free radial forearm flap and regional muscle flaps were more frequently used in the skull base region. Pedicled omental flaps and reverse turnover latissimus dorsi were the most commonly used flaps in the thoracolumbar region. No statistically significant differences were found between these flaps regarding rates of complications and recurrence. Flaps should be considered as a safe and effective treatment option for complex back wounds with CSF leaks. All proposed flaps in the literature seem to provide an equivalent cure rate for recurrent and refractory leaks.
MeSH term(s)	Cerebrospinal Fluid Leak/etiology ; Cerebrospinal Fluid Leak/surgery ; Humans ; Middle Aged ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Skull Base/surgery ; Skull Base Neoplasms/surgery ; Surgical Flaps/surgery
Language	English
Publishing date	2022-01-22
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2022.01.022
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Article ; Online: Antibodies targeting Prostate-Specific Membrane Antigen positive prostate cancer: from diagnostic imaging to theranostics.

Roumeguère, Thierry / Aoun, Fouad / Albisinni, Simone / Mjaess, Georges

Current opinion in oncology

2021 Volume 33, Issue 5, Page(s) 500–506

Abstract: Purpose of review: Targeting Prostate-Specific Membrane Antigen (PSMA) has paved the way for personalized medicine in prostate cancer (PCa) patients. This review aims to highlight the role of PSMA targeting antibodies in PCa, for diagnostic and ... ...

Abstract	Purpose of review: Targeting Prostate-Specific Membrane Antigen (PSMA) has paved the way for personalized medicine in prostate cancer (PCa) patients. This review aims to highlight the role of PSMA targeting antibodies in PCa, for diagnostic and therapeutic purposes. Recent findings: PSMA Positron Emission Tomography/Computed Tomography has been a game changer in the diagnosis of PCa in the recent decade. Two anti-PSMA monoclonal antibodies have been studied in PCa: 7E11-C35 (limited use) and J591. J591 antibody was used for diagnostic purposes coupled with different radionuclides. Most importantly, it was combined to numerous therapeutic radionuclides such as Lutetium-177 (177Lu), Yttrium-90 (90Y), Indium-111 (111In), and Actinium-225 (225Ac). It was also conjugated to drugs forming antibody-drug conjugates (e.g. MLN2704 and PSMA-ADC). These compounds were tested in recent phase I/II clinical trials. Summary: PSMA targeting antibodies are very promising for further clinical investigation and continue to be a momentous research area, for both imaging and therapeutic settings. Although some clinical trials resulted in unfavorably safety profiles for some antibodies, they validated PSMA as a crucial immunoconjugate target.
MeSH term(s)	Actinium ; Humans ; Male ; Positron Emission Tomography Computed Tomography ; Precision Medicine ; Prostate ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Yttrium Radioisotopes
Chemical Substances	Actinium-225 ; Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1) ; Prostate-Specific Antigen (EC 3.4.21.77) ; Actinium (NIK1K0956U)
Language	English
Publishing date	2021-07-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000000767
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Zs.A 3046: Show issues

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Article: Cancer de Prostate, déprivation androgénique, et risques d’infection par la COVID-19 : revue systématique et méta-analyse.

Manolache, Narcis-Georges / Mjaess, Georges / Diamand, Romain / Albisinni, Simone / Roumeguère, Thierry

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2022 Volume 32, Issue 16, Page(s) 1421–1430

Abstract: Introduction: Male gender has been shown to be a risk factor for COVID-19 infection, and men are more likely to develop severe disease. The aim of this study was to evaluate the effect of androgen deprivation therapy (ADT) on the incidence of infection ... ...

Title translation	Prostate cancer, androgen deprivation, and risk of COVID-19 infection : A systematic review and meta-analysis.
Abstract	Introduction: Male gender has been shown to be a risk factor for COVID-19 infection, and men are more likely to develop severe disease. The aim of this study was to evaluate the effect of androgen deprivation therapy (ADT) on the incidence of infection and severity of SARS-CoV-2 in prostate cancer patients. Methods: A systematic review and meta-analysis were performed after searching PubMed, Scopus, and ClinicalTrial.org databases, between January 2020 and March 2022. Analyses were interpreted through forest plots for the following parameters: risk of infection, hospitalization, intensive care admission, and SARS-CoV-2-related death, with random or fixed-effects models. Results: Fifteen articles were included in the systematic review and ten in the meta-analysis. Seven studies evaluated risk of infection in patients on ADT: OR=1.11 (95 % IC : [0.48-2.58] ; P=0.81). Six studies evaluated the risk of hospitalization in patients on ADT: TDA : OR=1.58 (95 % IC : [0.94-2.64] ; P=0.08). Seven studies evaluated risk of ICU admission in patients on ADT: OR=0.90 (95 % IC : [0.71-1.13] ; P=0.37). Nine studies evaluated mortality risk in patients on ADT: OR=1.07 (95 % IC : [0.61-1.87] ; P=0.82). Conclusion: ADT does not protect against SARS-CoV-2 in prostate cancer patients, nor does it protect against hospitalization, ICU admission, or mortality. These results remain questionable given the retrospective nature of the majority of studies included in our meta-analysis.
MeSH term(s)	Humans ; Male ; Androgen Antagonists/adverse effects ; Prostatic Neoplasms/epidemiology ; Androgens ; COVID-19 ; Retrospective Studies ; SARS-CoV-2 ; Risk Factors
Chemical Substances	Androgen Antagonists ; Androgens
Language	French
Publishing date	2022-09-13
Publishing country	France
Document type	Meta-Analysis ; Systematic Review ; English Abstract ; Journal Article
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
DOI	10.1016/j.purol.2022.09.005
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Zs.A 3959: Show issues

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Article ; Online: Fecal microbiota transplantation for immunotherapy-resistant urological tumors: Is it time? An update of the recent literature.

Mjaess, Georges / Karam, Aya / Aoun, Fouad / Albisinni, Simone / Roumeguère, Thierry

Cancer

2021 Volume 128, Issue 1, Page(s) 14–19

MeSH term(s)	Carcinoma, Renal Cell ; Fecal Microbiota Transplantation ; Humans ; Immunotherapy ; Kidney Neoplasms ; Urologic Neoplasms/therapy
Language	English
Publishing date	2021-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.33893
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