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Article ; Online: The Dysferlinopathies Conundrum: Clinical Spectra, Disease Mechanism and Genetic Approaches for Treatments.

Anwar, Saeed / Yokota, Toshifumi

2024 Volume 14, Issue 3

Abstract: Dysferlinopathies refer to a spectrum of muscular dystrophies that cause progressive muscle weakness and degeneration. They are caused by mutations in ... ...

Abstract	Dysferlinopathies refer to a spectrum of muscular dystrophies that cause progressive muscle weakness and degeneration. They are caused by mutations in the
MeSH term(s)	Animals ; Muscle Proteins/genetics ; Membrane Proteins/genetics ; Muscular Dystrophies, Limb-Girdle/genetics ; Muscular Dystrophies, Limb-Girdle/therapy ; Muscular Dystrophies, Limb-Girdle/metabolism ; Muscular Dystrophies/genetics ; Mutation
Chemical Substances	Muscle Proteins ; Membrane Proteins
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14030256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Navigating the Complex Landscape of Fibrodysplasia Ossificans Progressiva: From Current Paradigms to Therapeutic Frontiers.

Anwar, Saeed / Yokota, Toshifumi

Genes

2023 Volume 14, Issue 12

Abstract: Fibrodysplasia ossificans progressiva (FOP) is an enigmatic, ultra-rare genetic disorder characterized by progressive heterotopic ossification, wherein soft connective tissues undergo pathological transformation into bone structures. This incapacitating ... ...

Abstract	Fibrodysplasia ossificans progressiva (FOP) is an enigmatic, ultra-rare genetic disorder characterized by progressive heterotopic ossification, wherein soft connective tissues undergo pathological transformation into bone structures. This incapacitating process severely limits patient mobility and poses formidable challenges for therapeutic intervention. Predominantly caused by missense mutations in the
MeSH term(s)	Humans ; Myositis Ossificans/genetics ; Myositis Ossificans/therapy ; Proteomics ; Rare Diseases ; Ossification, Heterotopic/genetics ; Ossification, Heterotopic/pathology ; Bone and Bones/pathology
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14122162
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Article: Perceptions of students regarding innovative approaches introduced in nutrition and metabolism module at Shifa college of medicine.

Anwar, Iqra / Mansoor, Sumreena / Saeed, Saima / Rashid, Sajid

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 1, Page(s) 28–32

Abstract: Objective: To assess the perceptions of 2nd year medical students regarding certain approaches introduced in the course of Nutrition and Metabolism module.: Methods: The descriptive study was conducted at the Shifa College of Medicine, Islamabad, ... ...

Abstract	Objective: To assess the perceptions of 2nd year medical students regarding certain approaches introduced in the course of Nutrition and Metabolism module. Methods: The descriptive study was conducted at the Shifa College of Medicine, Islamabad, Pakistan, in December 2020, and comprised all 2nd year medical students who completed the Nutrition and Metabolism module in which new components had been added, including introduction to community nutrition, school visits, Islamic perspective of nutrition, journal club and e-posters. Data was collected using a questionnaire based on the modified Dundee Ready Education Environment Measure, and had 5 categories with a total of 25 questions that were scored on a 5-point Likert scale. Data was analysed using SPSS 22. Results: Of the 100 students, 65(65%) were females and 35(35%) were males. The overall mean age was 20.5 ± 0.5 years. The total mean score was 74.68±2.53. Mean score for student's perception of learning was 38.17±0.17, student's perception of teachers 9.27±0.18, student's academic self-perceptions 12.1±0.11, student's perceptions of atmosphere 9.03±0.03 and student's social self-perceptions 6.11± 0.01. Conclusion: The perceptions medical students about innovations were positive, showing an encouraging attitude in terms of learning approach and outcome.
MeSH term(s)	Male ; Female ; Humans ; Young Adult ; Adult ; Education, Medical, Undergraduate ; Cross-Sectional Studies ; Learning ; Students, Medical ; Social Perception ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-25
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.5081
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Article ; Online: Statistical computation for heat and mass transfers of water-based nanofluids containing Cu, Al

Lone, Showkat Ahmad / Raizah, Zehba / Saeed, Anwar / Bognár, Gabriella

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6908

Abstract: Nanofluid is a specially crafted fluid comprising a pure fluid with dispersed nanometer-sized particles. Incorporation these nanoparticles into pure fluid results in a fluid with improved thermal properties in comparison of pure fluid. The enhanced ... ...

Abstract	Nanofluid is a specially crafted fluid comprising a pure fluid with dispersed nanometer-sized particles. Incorporation these nanoparticles into pure fluid results in a fluid with improved thermal properties in comparison of pure fluid. The enhanced properties of nanofluids make them highly sought after, in diverse applications, consisting of coolant of devices, heat exchangers, and thermal solar systems. In this study hybrid nanofluid consisting of copper, alumina and titanium nanoparticles on a curved sheet has investigated with impact of chemical reactivity, magnetic field and Joule heating. The leading equations have converted to normal equations by using appropriate set of variables and has then evaluated by homotopy analysis method. The outcomes are shown through Figures and Tables and are discussed physically. It has revealed in this study that Cu-nanofluid flow has augmented velocity, temperature, and volume fraction distributions than those of Al
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57532-x
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Article ; Online: A numerical exploration of the comparative analysis on water and kerosene oil-based Cu-CuO/hybrid nanofluid flows over a convectively heated surface.

Algehyne, Ebrahem A / Alamrani, Fahad Maqbul / Saeed, Anwar / Bognár, Gabriella

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2540

Abstract: The fluid flow over an extending sheet has many applications in different fields which include, manufacturing processes, coating, thin film decomposition, heat and mass transfer, biomedical applications, aerospace engineering, environmental science, ... ...

Abstract	The fluid flow over an extending sheet has many applications in different fields which include, manufacturing processes, coating, thin film decomposition, heat and mass transfer, biomedical applications, aerospace engineering, environmental science, energy production. Keeping in mind these applications, the non-Newtonian hybrid nanofluid flow comprising of Cu and CuO nanoparticles over an extending sheet is analyzed in this work. Two different base fluids called kerosene oil and water have been incorporated. The sheet is considered to be thermally convective along with zero mass flux condition. The main equations of modeled problem have been transformed to dimensionless form by using similarity variables. The designed problem is evaluated computationally by using bvp4c Matlab function. Validation of the present results is also performed. The impacts of magnetic, Brownian motion, chemical reaction, suction and thermophoresis factors are analyzed and discussed in details. The outcomes of the present investigation declare that the kerosene oil-based hybrid nanofluid flow has greater velocity and concentration profiles than that of the water-based hybrid nanofluid flow. The water-based hybrid nanofluid has greater temperature distribution than that of kerosene oil-based hybrid nanofluid flow. The streamlines of the kerosene oil-based Newtonian and non-Newtonian hybrid nanofluid flows are more stretched than water-based Newtonian and non-Newtonian hybrid nanofluid flows.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53024-0
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Article: Pneumonia classification: A limited data approach for global understanding.

Haque, Anwar Ul / Ghani, Sayeed / Saeed, Muhammad / Schloer, Hardy

Heliyon

2024 Volume 10, Issue 4, Page(s) e26177

Abstract: As the human race has advanced, so too have the ailments that afflict it. Diseases such as pneumonia, once considered to be basic flu or allergies, have evolved into more severe forms, including SARs and COVID-19, presenting significant risks to people ... ...

Abstract	As the human race has advanced, so too have the ailments that afflict it. Diseases such as pneumonia, once considered to be basic flu or allergies, have evolved into more severe forms, including SARs and COVID-19, presenting significant risks to people worldwide. In our study, we focused on categorizing pneumonia-related inflammation in chest X-rays (CXR) using a relatively small dataset. Our approach was to encompass a comprehensive view, addressing every potential area of inflammation in the CXR. We employed enhanced class activation maps (mCAM) to meet the clinical criteria for classification rationale. Our model incorporates capsule network clusters (CNsC), which aids in learning different aspects such as geometry, orientation, and position of the inflammation seen in the CXR. Our Capsule Network Clusters (CNsC) rapidly interpret various perspectives in a single CXR without needing image augmentation, a common necessity in existing detection models. This approach significantly cuts down on training and evaluation durations. We conducted thorough testing using the RSNA pneumonia dataset of CXR images, achieving accuracy and recall rates as high as 98.3% and 99.5% in our conclusive tests. Additionally, we observed encouraging outcomes when applying our trained model to standard X-ray images obtained from medical clinics.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26177
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Article ; Online: A stratified flow of a non-Newtonian Casson fluid comprising microorganisms on a stretching sheet with activation energy.

Lone, Showkat Ahmad / Anwar, Sadia / Saeed, Anwar / Bognár, Gabriella

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11240

Abstract: A stratified flow may be seen regularly in a number of significant industrial operations. For instance, the stratified flow regime is typically used by gas-condensate pipelines. Clearly, only a limited set of working situations for which this flow ... ...

Abstract	A stratified flow may be seen regularly in a number of significant industrial operations. For instance, the stratified flow regime is typically used by gas-condensate pipelines. Clearly, only a limited set of working situations for which this flow arrangement is stable allow for the achievement of the stratified two-phase flow zone. In this paper, the authors are considered the laminar, steady and incompressible magnetohydrodynamic flow of a non-Newtonian Casson fluid flow past a stratified extending sheet. The features of bio-convection, Brownian motion, thermal radiation thermophoresis, heat source, and chemically reactive activation energy have been employed. The set of equations administered flow of fluid is converted into ordinary differential equation by suitable variables. A semi-analytical investigation of the present analysis is performed with homotopy analysis method. Endorsement of the current results with previous results is also investigated. The outcomes showed that the velocity distribution of the fluid flow lessens with higher Casson and magnetic factors. The temperature profiles of fluid flow shrinkage as the Prandtl number and Casson factor increase and enlarges with higher values of thermal radiation, magnetic, and Brownian motion factors. It is found that the growing thermophoretic and Brownian motion factors reduce the rate of thermal flow of the Casson fluid flow. In contrast, the increasing thermal stratification parameter increases the thermal flow rate of fluid.
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38260-0
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Article ; Online: Lupus Vasculitis.

Butt, Nauman Ismat / Ashfaq, Fahmina / Mahmood, Khalid / Aftab, Sabeen / Anwar, Ali / Saeed, Minhal

Journal of Ayub Medical College, Abbottabad : JAMC

2024 Volume 35, Issue 3, Page(s) 475–478

Abstract: We present the case of a 30-year-old woman who presented with 8-month history of intermittent fever, joint pains with morning stiffness, recurrent oral ulcers, photosensitivity, weight loss and hair fall. For the last 2 months, she had developed a dry ... ...

Abstract	We present the case of a 30-year-old woman who presented with 8-month history of intermittent fever, joint pains with morning stiffness, recurrent oral ulcers, photosensitivity, weight loss and hair fall. For the last 2 months, she had developed a dry cough with progressive shortening of breath. On examination, a cachexic lady with malar hyperpigmentation, alopecia, pallor, nail dystrophy and erythema over her hands and feet were noted. There were multiple punched-out skin ulcers of variable size over legs, arms and abdomen usually round in shape with well-defined even wound margins and scant serous discharge. Musculoskeletal examination revealed synovitis of both elbows and a few metacarpophalangeal and proximal interphalangeal joints. Chest X-ray and HRCT showed bilateral ground-glass opacification. Anti-Nuclear Antibody (ANA) was positive, 1:320, homogenous nuclear pattern. Anti-Ro antibody was highly positive and serum complement (C3, C4) levels were reduced. She was diagnosed with Lupus Vasculitis and started on steroids, mycophenolate mofetil and hydroxychloroquine.
MeSH term(s)	Humans ; Female ; Adult ; Mycophenolic Acid ; Fever ; Arthralgia ; Vasculitis
Chemical Substances	Mycophenolic Acid (HU9DX48N0T)
Language	English
Publishing date	2024-02-26
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
DOI	10.55519/JAMC-03-10849
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Article ; Online: Densely Residual Laplacian Super-Resolution.

Anwar, Saeed / Barnes, Nick

IEEE transactions on pattern analysis and machine intelligence

2022 Volume 44, Issue 3, Page(s) 1192–1204

Abstract: Super-Resolution convolutional neural networks have recently demonstrated high-quality restoration for single images. However, existing algorithms often require very deep architectures and long training times. Furthermore, current convolutional neural ... ...

Abstract	Super-Resolution convolutional neural networks have recently demonstrated high-quality restoration for single images. However, existing algorithms often require very deep architectures and long training times. Furthermore, current convolutional neural networks for super-resolution are unable to exploit features at multiple scales and weigh them equally or at only static scale only, limiting their learning capability. In this exposition, we present a compact and accurate super-resolution algorithm, namely, densely residual laplacian network (DRLN). The proposed network employs cascading residual on the residual structure to allow the flow of low-frequency information to focus on learning high and mid-level features. In addition, deep supervision is achieved via the densely concatenated residual blocks settings, which also helps in learning from high-level complex features. Moreover, we propose Laplacian attention to model the crucial features to learn the inter and intra-level dependencies between the feature maps. Furthermore, comprehensive quantitative and qualitative evaluations on low-resolution, noisy low-resolution, and real historical image benchmark datasets illustrate that our DRLN algorithm performs favorably against the state-of-the-art methods visually and accurately.
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2020.3021088
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Article ; Online: Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay.

Anwar, Saeed / Yokota, Toshifumi

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2587, Page(s) 183–196

Abstract: Dysferlinopathies are a group of disabling muscular dystrophies that includes limb girdle muscular dystrophy type 2B (LGMD2B), Miyoshi myopathy, and distal myopathy with anterior tibial onset (DMAT) as the main phenotypes. They are associated with ... ...

Abstract	Dysferlinopathies are a group of disabling muscular dystrophies that includes limb girdle muscular dystrophy type 2B (LGMD2B), Miyoshi myopathy, and distal myopathy with anterior tibial onset (DMAT) as the main phenotypes. They are associated with molecular defects in DYSF, which encodes dysferlin, a key player in sarcolemmal homeostasis. Previous investigations have suggested that exon skipping may be a promising therapy for many patients with dysferlinopathies. It was reported that exons 28-29 of DYSF are dispensable for dysferlin functions. Here, we present a method for multiexon skipping of DYSF exons 28-29 using a cocktail of two phosphorodiamidate morpholino oligomers (PMOs) on cells derived from a dystrophinopathy patient. Also, we describe assays to characterize the multiexon skipped dysferlin at several levels by using one-step RT-PCR, immunoblotting, and a membrane wounding assay.
MeSH term(s)	Humans ; Dysferlin/genetics ; Morpholinos/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Muscle Proteins/genetics ; Membrane Proteins/genetics ; Mutation ; Exons/genetics ; Distal Myopathies/genetics ; Immunoblotting
Chemical Substances	Dysferlin ; Morpholinos ; Muscle Proteins ; Membrane Proteins
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2772-3_11
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