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  1. Article: Current smoking reduces small airway eosinophil counts in COPD.

    Beech, Augusta / Booth, Sophie / Higham, Andrew / Singh, Dave

    ERJ open research

    2024  Volume 10, Issue 1

    Abstract: Current smoking reduces small airway intraepithelial eosinophil counts in COPD patients and controls. This provides evidence of an attenuation of type-2 related inflammation in the small airways imposed by current smoking, which may affect ICS response. ...

    Abstract Current smoking reduces small airway intraepithelial eosinophil counts in COPD patients and controls. This provides evidence of an attenuation of type-2 related inflammation in the small airways imposed by current smoking, which may affect ICS response.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00870-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exhaled nitric oxide levels in COPD patients who use electronic cigarettes.

    Higham, Andrew / Beech, Augusta / Singh, Dave

    Nitric oxide : biology and chemistry

    2024  Volume 145, Page(s) 57–59

    Abstract: Emerging data from clinical studies have shown pro-inflammatory effects associated with e-cigarette use. Fractional exhaled nitric oxide (FeNO) is a biomarker of pulmonary type 2 (T2) inflammation. The effect of chronic e-cigarette use on FeNO is unclear. ...

    Abstract Emerging data from clinical studies have shown pro-inflammatory effects associated with e-cigarette use. Fractional exhaled nitric oxide (FeNO) is a biomarker of pulmonary type 2 (T2) inflammation. The effect of chronic e-cigarette use on FeNO is unclear. The aim of this study was to compare FeNO levels in COPD ex-smokers who use e-cigarettes (COPDE + e-cig) to COPDE ex-smokers (COPDE) and COPD current smokers (COPDS). FeNO levels were significantly higher in COPDE + e-cig (median 16.2 ppb) and COPDE (median 18.0 ppb) compared to COPDS (median 7.6 ppb) (p = 0.0003 and p < 0.0001 respectively). There was no difference in FeNO levels between COPDE + e-cig compared to COPDE (p > 0.9). The importance of our results is that electronic cigarette use does not alter the interpretation of FeNO results, and so does not interfere with the use of FeNO as a practical biomarker of T2 inflammation, unlike current cigarette smoking in COPD. Whilst the effect of electronic cigarette use on FeNO levels is not the same as cigarette smoke, this cannot be taken as evidence that electronic cigarettes are harmless. These differential pulmonary effects can be attributed to differences in the chemical composition of the two products.
    MeSH term(s) Humans ; Electronic Nicotine Delivery Systems ; Pulmonary Disease, Chronic Obstructive ; Nitric Oxide ; Breath Tests ; Inflammation ; Exhalation ; Biomarkers
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Biomarkers
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2024.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4677: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Inhaled corticosteroid responses in COPD: do mast cells hold the answer?

    Higham, Andrew / Singh, Dave

    Thorax

    2022  Volume 78, Issue 4, Page(s) 323–324

    MeSH term(s) Humans ; Mast Cells ; Adrenal Cortex Hormones/therapeutic use ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Administration, Inhalation ; Eosinophils
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219534
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  4. Article: Exhaled nitric oxide, eosinophils and current smoking in COPD patients.

    Higham, Andrew / Beech, Augusta / Dean, James / Singh, Dave

    ERJ open research

    2023  Volume 9, Issue 6

    Abstract: ... ...

    Abstract High
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00686-2023
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  5. Article ; Online: How inhaled corticosteroids target inflammation in COPD.

    Lea, Simon / Higham, Andrew / Beech, Augusta / Singh, Dave

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 170

    Abstract: Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the treatment of COPD. COPD has been previously described as a "corticosteroid-resistant" condition, but current clinical trial evidence shows that selected COPD ... ...

    Abstract Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the treatment of COPD. COPD has been previously described as a "corticosteroid-resistant" condition, but current clinical trial evidence shows that selected COPD patients, namely those with increased exacerbation risk plus higher blood eosinophil count (BEC), can benefit from ICS treatment. This review describes the components of inflammation modulated by ICS in COPD and the reasons for the variation in response to ICS between individuals. There are corticosteroid-insensitive inflammatory pathways in COPD, such as bacteria-induced macrophage interleukin-8 production and resultant neutrophil recruitment, but also corticosteroid-sensitive pathways including the reduction of type 2 markers and mast cell numbers. The review also describes the mechanisms whereby ICS can skew the lung microbiome, with reduced diversity and increased relative abundance, towards an excess of proteobacteria. BEC is a biomarker used to enable the selective use of ICS in COPD, but the clinical outcome in an individual is decided by a complex interacting network involving the microbiome and airway inflammation.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Lung ; Adrenal Cortex Hormones/adverse effects ; Inflammation/drug therapy ; Anti-Inflammatory Agents/adverse effects ; Administration, Inhalation
    Chemical Substances Adrenal Cortex Hormones ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0084-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3265: Show issues Location:
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  6. Article ; Online: Exhaled nitric oxide, eosinophils and current smoking in COPD patients

    Andrew Higham / Augusta Beech / James Dean / Dave Singh

    ERJ Open Research, Vol 9, Iss

    2023  Volume 6

    Keywords Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Relationships between Airway Remodeling and Clinical Characteristics in COPD Patients.

    Higham, Andrew / Dungwa, Josiah / Jackson, Natalie / Singh, Dave

    Biomedicines

    2022  Volume 10, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10081992
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  8. Article ; Online: Using video docuseries to explore male professional football head coaches' well-being experiences throughout a season.

    Higham, Andrew J / Rumbold, James L / Newman, James A / Stone, Joseph A

    Psychology of sport and exercise

    2023  Volume 69, Page(s) 102488

    Abstract: Football coaches have disclosed how their work environment is unpredictable and demanding, comprising a multitude of stressors which can impede well-being. Additionally, the masculine culture within football often promotes suppression of voice, causing ... ...

    Abstract Football coaches have disclosed how their work environment is unpredictable and demanding, comprising a multitude of stressors which can impede well-being. Additionally, the masculine culture within football often promotes suppression of voice, causing internalisation of thoughts and isolation. Due to professional football head coaches being a seldom-heard group, little is known about how they experience well-being within their given context (i.e., ecological niche). The present study utilised football docuseries and a bioecological framework to explore how four male professional head coaches experienced well-being whilst working in one of the top European football leagues (Premier League, La Liga). Four docuseries were sampled and resulted in the analysis of 31 episodes (M
    MeSH term(s) Humans ; Male ; Soccer ; Seasons ; Motor Vehicles ; Communications Media
    Language English
    Publishing date 2023-07-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1878-5476
    ISSN (online) 1878-5476
    DOI 10.1016/j.psychsport.2023.102488
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  9. Article ; Online: Stability of eosinophilic inflammation in COPD bronchial biopsies.

    Higham, Andrew / Singh, Dave

    The European respiratory journal

    2020  Volume 56, Issue 6

    MeSH term(s) Biopsy ; Humans ; Inflammation ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Sputum
    Language English
    Publishing date 2020-12-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.04167-2020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  10. Article ; Online: Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight.

    Higham, Andrew / Singh, Dave

    Obesity (Silver Spring, Md.)

    2020  Volume 28, Issue 9, Page(s) 1586–1589

    Abstract: Objective: Mortality from coronavirus disease 2019 (COVID-19) is increased in patients with chronic obstructive pulmonary disease (COPD). Furthermore, higher BMI is related to severe disease. Severe acute respiratory syndrome coronavirus 2 utilizes ... ...

    Abstract Objective: Mortality from coronavirus disease 2019 (COVID-19) is increased in patients with chronic obstructive pulmonary disease (COPD). Furthermore, higher BMI is related to severe disease. Severe acute respiratory syndrome coronavirus 2 utilizes angiotensin converting enzyme 2 (ACE2) to gain cellular entry.
    Methods: Whether ACE2 bronchial epithelial expression is increased in COPD patients who have overweight compared with those who do not was investigated by RNA sequencing.
    Results: Increased ACE2 expression was observed in patients with COPD with overweight (mean BMI, 29 kg/m
    Conclusions: Increased ACE2 expression may cause increased severe acute respiratory syndrome coronavirus 2 infection of the respiratory tract. Overweight COPD patients may be at greater risk for developing severe COVID-19.
    MeSH term(s) Aged ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; Bronchi ; COVID-19 ; Coronavirus Infections ; Epithelium/metabolism ; Female ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Overweight/complications ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/genetics ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22907
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    Zs.A 4061: Show issues Location:
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    Zs.MG 87: Show issues

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