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  1. Article ; Online: Tetramine in Patients with Myasthenia Gravis.

    Inoue, Ken-Ichiro

    Internal medicine (Tokyo, Japan)

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3627-24
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
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  2. Article: Airborne Suspended Particulate Matter and the Prevalence of Allergic Conjunctivitis in Japan.

    Mimura, Tatsuya / Ichinose, Takamichi / Inoue, Ken-Ichiro / Yoshida, Yasuhiro / Fujishima, Hiroshi

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53292

    Abstract: Background This study aimed to examine the association of suspended particulate matter (SPM) with outpatient attendance for allergic conjunctivitis. Methodology The information on air pollution, encompassing total hydrocarbons, non-methane hydrocarbons, ... ...

    Abstract Background This study aimed to examine the association of suspended particulate matter (SPM) with outpatient attendance for allergic conjunctivitis. Methodology The information on air pollution, encompassing total hydrocarbons, non-methane hydrocarbons, methane, carbon monoxide, nitrogen oxide, nitric oxide, oxidants, and SPM alongside data concerning daily weather conditions such as temperature, wind speed, and humidity, was gathered. Subsequently, the weekly mean values for outpatient visits, air pollution, and weather parameters were computed. Results The number of outpatient visits for allergic conjunctivitis was significantly associated with SPM levels (r = 0.70, p = 0.0037), oxidant levels (r = 0.70, p = 0.0038), wind speed (r = 0.48, p = 0.0472), and humidity (r = 0.77, p = 0.0009) from January to March, as well as SPM levels (r = 0.53, p = 0.0309) and carbon monoxide (r = 0.56, p = 0.0230) from April to June. Multivariate analysis showed that SPM (odds ratio = 1.37, p = 0.0161) and wind velocity (odds ratio = 1.52, p = 0.0038) were significant predictors of the number of outpatient visits from January to December. Conclusions SPM levels were the only independent predictor of outpatient visits for allergic conjunctivitis, suggesting that SPM contributes to the pathophysiology of this condition.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53292
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  3. Article ; Online: COVID-19 and Coagulopathy.

    Inoue, Ken-Ichiro / Sagawa, Tomoya / Takano, Hirohisa

    American journal of respiratory cell and molecular biology

    2021  Volume 64, Issue 6, Page(s) 764

    MeSH term(s) Blood Coagulation Disorders ; COVID-19 ; Humans ; Lung ; SARS-CoV-2 ; Thrombosis
    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0588LE
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    Zs.A 2851: Show issues Location:
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  4. Article ; Online: Hemodynamic Variability During Drainage of Large Volumes of Malignant Ascites in Patients With Cancer.

    Kawamura, Tomoko / Tanaka, Noriyoshi / Hori, Megumi / Inoue, Ken-Ichiro / Kawamura, Masahiko / Matsusaki, Keisuke

    Clinical nursing research

    2023  Volume 32, Issue 4, Page(s) 815–820

    Abstract: This study compared the variability in mean arterial pressure (MAP) during drainage of ascites in patients with cancer who underwent drainage of a large (5-10 L) or small (<5 L) volume of ascites. We prospectively enrolled 50 patients scheduled for cell- ... ...

    Abstract This study compared the variability in mean arterial pressure (MAP) during drainage of ascites in patients with cancer who underwent drainage of a large (5-10 L) or small (<5 L) volume of ascites. We prospectively enrolled 50 patients scheduled for cell-free and concentrated ascites reinfusion therapy. Equivalence was considered to be established if the 95% confidence interval (95% CI) for the highest variability rate of MAP was within ±20%. The median volume of ascites removed was 3.30 L (95% CI [2.84, 4.40]) in the small-drainage-volume group (
    MeSH term(s) Humans ; Ascites/therapy ; Ascites/pathology ; Paracentesis ; Drainage ; Neoplasms/complications ; Hemodynamics
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146553-0
    ISSN 1552-3799 ; 1054-7738
    ISSN (online) 1552-3799
    ISSN 1054-7738
    DOI 10.1177/10547738231157157
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    Zs.A 3652: Show issues Location:
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  5. Article ; Online: Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust

    Akiko Honda / Ken-ichiro Inoue / Makoto Higashihara / Takamichi Ichinose / Kayo Ueda / Hirohisa Takano

    International Journal of Molecular Sciences, Vol 24, Iss 10544, p

    2023  Volume 10544

    Abstract: The combined toxicological effects of airborne particulate matter (PM), such as PM2.5, and Asian sand dust (ASD), with surrounding chemicals, particularly quinones, on human airway epithelial cells remain underexplored. In this study, we established an ... ...

    Abstract The combined toxicological effects of airborne particulate matter (PM), such as PM2.5, and Asian sand dust (ASD), with surrounding chemicals, particularly quinones, on human airway epithelial cells remain underexplored. In this study, we established an in vitro combination exposure model using 1,2-naphthoquinones (NQ) and 9,10-phenanthroquinones (PQ) along with heated PM (h-PM2.5 and h-ASD) to investigate their potential synergistic effects. The impacts of quinones and heated PM on tetrazolium dye (WST-1) reduction, cell death, and cytokine and reactive oxygen species (ROS) production were examined. Results revealed that exposure to 9,10-PQ with h-PM2.5 and/or h-ASD dose-dependently increased WST-1 reduction at 1 μM compared to the corresponding control while markedly decreasing it at 10 μM. Higher early apoptotic, late apoptotic, or necrotic cell numbers were detected in 9,10-PQ + h-PM2.5 exposure than in 9,10-PQ + h-ASD or 9,10-PQ + h-PM2.5 + h-ASD. Additionally, 1,2-NQ + h-PM2.5 exposure also resulted in an increase in cell death compared to 1,2-NQ + h-ASD and 1,2-NQ + h-PM2.5 + h-ASD. Quinones with or without h-PM2.5, h-ASD, or h-PM2.5 + h-ASD significantly increased ROS production, especially with h-PM2.5. Our findings suggest that quinones, at relatively low concentrations, induce cell death synergistically in the presence of h-PM2.5 rather than h-ASD and h-PM2.5 + h-ASD, partially through the induction of apoptosis with increased ROS generation.
    Keywords quinones ; h-PM2.5 ; h-ASD ; inflammation ; apoptosis ; reactive oxidative stress ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Biological Response-Enhancing Activity with Antigens in A549 Cells Exposed to Representative Polycyclic Aromatic Hydrocarbons

    Kentaro Misaki / Hirohisa Takano / Hiroaki Kanazawa / Ken-ichiro Inoue

    ACS Omega, Vol 6, Iss 34, Pp 22224-

    2021  Volume 22232

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
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  7. Article ; Online: Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust.

    Honda, Akiko / Inoue, Ken-Ichiro / Higashihara, Makoto / Ichinose, Takamichi / Ueda, Kayo / Takano, Hirohisa

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: The combined toxicological effects of airborne particulate matter (PM), such as PM2.5, and Asian sand dust (ASD), with surrounding chemicals, particularly quinones, on human airway epithelial cells remain underexplored. In this study, we established an ... ...

    Abstract The combined toxicological effects of airborne particulate matter (PM), such as PM2.5, and Asian sand dust (ASD), with surrounding chemicals, particularly quinones, on human airway epithelial cells remain underexplored. In this study, we established an in vitro combination exposure model using 1,2-naphthoquinones (NQ) and 9,10-phenanthroquinones (PQ) along with heated PM (h-PM2.5 and h-ASD) to investigate their potential synergistic effects. The impacts of quinones and heated PM on tetrazolium dye (WST-1) reduction, cell death, and cytokine and reactive oxygen species (ROS) production were examined. Results revealed that exposure to 9,10-PQ with h-PM2.5 and/or h-ASD dose-dependently increased WST-1 reduction at 1 μM compared to the corresponding control while markedly decreasing it at 10 μM. Higher early apoptotic, late apoptotic, or necrotic cell numbers were detected in 9,10-PQ + h-PM2.5 exposure than in 9,10-PQ + h-ASD or 9,10-PQ + h-PM2.5 + h-ASD. Additionally, 1,2-NQ + h-PM2.5 exposure also resulted in an increase in cell death compared to 1,2-NQ + h-ASD and 1,2-NQ + h-PM2.5 + h-ASD. Quinones with or without h-PM2.5, h-ASD, or h-PM2.5 + h-ASD significantly increased ROS production, especially with h-PM2.5. Our findings suggest that quinones, at relatively low concentrations, induce cell death synergistically in the presence of h-PM2.5 rather than h-ASD and h-PM2.5 + h-ASD, partially through the induction of apoptosis with increased ROS generation.
    MeSH term(s) Humans ; Dust/analysis ; Quinones/metabolism ; Reactive Oxygen Species/metabolism ; Sand ; Particulate Matter/toxicity ; Epithelial Cells/metabolism ; Naphthoquinones/pharmacology ; Cell Death
    Chemical Substances Dust ; Quinones ; Reactive Oxygen Species ; Sand ; Particulate Matter ; Naphthoquinones
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310544
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  8. Article ; Online: Role of IL-6 in Severe Inflammation.

    Inoue, Ken-Ichiro / Sagawa, Tomoya / Takano, Hirohisa

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 1, Page(s) 140–141

    MeSH term(s) Asthma ; COVID-19 ; Humans ; Inflammation ; Interleukin-6 ; SARS-CoV-2
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202007-3001LE
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    Uh II Zs.80: Show issues Location:
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  9. Article ; Online: Effects of styrene monomer on a mouse model of atopic dermatitis.

    Tanaka, Michitaka / Inoue, Ken-Ichiro / Honda, Akiko / Miyasaka, Natsuko / Koike, Eiko / Yanagisawa, Rie / Takano, Hirohisa

    Immunopharmacology and immunotoxicology

    2023  Volume 45, Issue 4, Page(s) 455–460

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Mice ; Male ; Animals ; Dermatitis, Atopic/pathology ; Histamine ; Cytokines ; Polystyrenes/adverse effects ; Allergens ; Disease Models, Animal
    Chemical Substances Histamine (820484N8I3) ; Cytokines ; Polystyrenes ; Allergens
    Language English
    Publishing date 2023-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 807033-7
    ISSN 1532-2513 ; 0892-3973
    ISSN (online) 1532-2513
    ISSN 0892-3973
    DOI 10.1080/08923973.2023.2165944
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    Zs.A 1481: Show issues Location:
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  10. Article ; Online: Biological Response-Enhancing Activity with Antigens in A549 Cells Exposed to Representative Polycyclic Aromatic Hydrocarbons.

    Misaki, Kentaro / Takano, Hirohisa / Kanazawa, Hiroaki / Inoue, Ken-Ichiro

    ACS omega

    2021  Volume 6, Issue 34, Page(s) 22224–22232

    Abstract: The question of what kinds of airborne particles, including diesel exhaust particles and their adherent chemical constituents, exacerbate the activity of allergic and inflammatory respiratory diseases has not been elucidated in detail. Therefore, ... ...

    Abstract The question of what kinds of airborne particles, including diesel exhaust particles and their adherent chemical constituents, exacerbate the activity of allergic and inflammatory respiratory diseases has not been elucidated in detail. Therefore, chemicals that have amplifying actions on
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c02929
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