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Article ; Online: PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging.

Salimi, Shabnam / Pettan-Brewer, Christina / Ladiges, Warren

Aging pathobiology and therapeutics

2022 Volume 3, Issue 4, Page(s) 107–126

Abstract: Background: Multimorbidity is a public health concern and an essential component of aging and healthspan but understudied because investigative tools are lacking that can be translatable to capture similarities and differences of the aging process ... ...

Abstract	Background: Multimorbidity is a public health concern and an essential component of aging and healthspan but understudied because investigative tools are lacking that can be translatable to capture similarities and differences of the aging process across species and variability between individuals and individual organs. Methods: To help address this need, body organ disease number (BODN) borrowed from human studies was applied to C57BL/6 (B6) and CB6F1 mouse strains at 8, 16, 24, and 32 months of age, as a measure of systems morbidity based on pathology lesions to develop a mouse PathoClock resembling clinically-based Body Clock in humans, using Bayesian inference. A mouse PhysioClock was also developed based on measures of physiological domains including cardiovascular, neuromuscular, and cognitive function in the same two mouse strains so that alignment with BODN was predictable. Results: Between- and within-age variabilities in PathoClock and PhysioClock, as well as between-strain variabilities. Both PathoClock and PhysioClock correlated with chronological age more strongly in CB6F1 than C57BL/6. Prediction models were then developed, designated as PathoAge and PhysioAge, using regression models of pathology and physiology measures on chronological age. PathoAge better predicted chronological age than PhysioAge as the predicted chronological and observed chronological age for PhysioAge were complex rather than linear. Conclusion: PathoClock and PhathoAge can be used to capture biological changes that predict BODN, a metric developed in humans, and compare multimorbidity across species. These mouse clocks are potential translational tools that could be used in aging intervention studies.
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article
ISSN	2690-1803
ISSN (online)	2690-1803
DOI	10.31491/apt.2021.12.074
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 and Crosstalk With the Hallmarks of Aging.

Salimi, Shabnam / Hamlyn, John M

The journals of gerontology. Series A, Biological sciences and medical sciences

2020 Volume 75, Issue 9, Page(s) e34–e41

Abstract: Within the past several decades, the emergence of new viral diseases with severe health complications and mortality is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute ... ...

Abstract	Within the past several decades, the emergence of new viral diseases with severe health complications and mortality is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, causes coronavirus disease 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases and those with a compromised immune system regardless of age and in older adults who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia, acute respiratory distress syndrome, lung fibrosis, cardiovascular events, acute kidney injury, stroke, hospitalization, and mortality have been reported that result from pathogen-host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence health span in older adults, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging, coupled with host-coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections, including immunosenescence, inflammation and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction, epigenetic alterations, telomere attrition, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of antiaging drug candidates that require paramount attention in COVID-19 research.
MeSH term(s)	Aged ; Aging/physiology ; Autophagy ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Epigenesis, Genetic ; Humans ; Immunosenescence ; Mitochondrial Diseases ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glaa149
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Article ; Online: Environmental Aspects of the Combined Cooling, Heating, and Power (CCHP) Systems

Mohsen Salimi / Morteza Hosseinpour / Shabnam Mansouri / Tohid N.Borhani

Processes, Vol 10, Iss 711, p

A Review

2022 Volume 711

Abstract: Expanding cities means increasing the need for energy in the residential sector. The supply of this energy must be in environmentally friendly ways; one method of meeting demand in the residential sector is the use of combined cooling, heating, and power ...

Abstract	Expanding cities means increasing the need for energy in the residential sector. The supply of this energy must be in environmentally friendly ways; one method of meeting demand in the residential sector is the use of combined cooling, heating, and power (CCHP) systems. The current review paper shows that due to the high cost of gas and electricity, CCHP can be used in various sectors, such as hospitals and airports, to reduce energy consumption with lower environmental impacts by using renewable energy systems as the main driver. While CCHP systems are not feasible in tropical regions with high cooling demand, a solar hybrid system is a superior candidate for regions with sufficient radiation. CCHP can also be used in sectors such as wastewater treatment units, desalination systems, and hydrogen production units to improve performance and increase productivity. The carbon and water footprints of CCHP systems are discussed in detail. The main drivers for reducing carbon and water footprints are improving system components such as the combustion engine and increasing productivity by expanding the system to multi-generation systems. Finally, the carbon tax index can help reduce carbon emissions if properly used in the right context. Based on our best knowledge, there is no extensive review of the environmental aspects of CCHP systems in the literature.
Keywords	CCHP ; LCA ; carbon footprint ; water footprint ; renewables ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 and Crosstalk With the Hallmarks of Aging

Salimi, Shabnam / Hamlyn, John M

The Journals of Gerontology: Series A

2020 Volume 75, Issue 9, Page(s) e34–e41

Abstract: Abstract Within the past several decades, the emergence of new viral diseases with severe health complications and mortality is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe ...

Abstract	Abstract Within the past several decades, the emergence of new viral diseases with severe health complications and mortality is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, causes coronavirus disease 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases and those with a compromised immune system regardless of age and in older adults who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia, acute respiratory distress syndrome, lung fibrosis, cardiovascular events, acute kidney injury, stroke, hospitalization, and mortality have been reported that result from pathogen–host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence health span in older adults, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging, coupled with host–coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections, including immunosenescence, inflammation and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction, epigenetic alterations, telomere attrition, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of antiaging drug candidates that require paramount attention in COVID-19 research.
Keywords	Ageing ; Geriatrics and Gerontology ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glaa149
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: COVID-19 and Crosstalk With the Hallmarks of Aging

Salimi, Shabnam / Hamlyn, John M

J Gerontol A Biol Sci Med Sci

Abstract	Within the past several decades, the emergence of new viral diseases with severe health complications and mortality is evidence of an age-dependent, compromised bodily response to abrupt stress with concomitantly reduced immunity. The new severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, causes coronavirus disease 2019 (COVID-19). It has increased morbidity and mortality in persons with underlying chronic diseases and those with a compromised immune system regardless of age and in older adults who are more likely to have these conditions. While SARS-CoV-2 is highly virulent, there is variability in the severity of the disease and its complications in humans. Severe pneumonia, acute respiratory distress syndrome, lung fibrosis, cardiovascular events, acute kidney injury, stroke, hospitalization, and mortality have been reported that result from pathogen-host interactions. Hallmarks of aging, interacting with one another, have been proposed to influence health span in older adults, possibly via mechanisms regulating the immune system. Here, we review the potential roles of the hallmarks of aging, coupled with host-coronavirus interactions. Of these hallmarks, we focused on those that directly or indirectly interact with viral infections, including immunosenescence, inflammation and inflammasomes, adaptive immunosenescence, genomic instability, mitochondrial dysfunction, epigenetic alterations, telomere attrition, and impaired autophagy. These hallmarks likely contribute to the increased pathophysiological responses to SARS-CoV-2 among older adults and may play roles as an additive risk of accelerated biological aging even after recovery. We also briefly discuss the role of antiaging drug candidates that require paramount attention in COVID-19 research.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #599215
Database	COVID19

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Article ; Online: Synthesis of Chiral Triazine Frameworks for Enantiodiscrimination.

Beyranvand, Fatemeh / Khosravi, Armaghan / Zabihi, Fatemeh / Nemati, Mohammad / Gholami, Mohammad Fardin / Tavakol, Mahdi / Beyranvand, Siamak / Satari, Shabnam / Rabe, Jürgen P / Salimi, Abdollah / Cheng, Chong / Adeli, Mohsen

ACS applied materials & interfaces

2023 Volume 15, Issue 48, Page(s) 56213–56222

Abstract: Manipulation of the structure of covalent organic frameworks at the molecular level is an efficient strategy to shift their biological, physicochemical, optical, and electrical properties in the desired windows. In this work, we report on a new method to ...

Abstract	Manipulation of the structure of covalent organic frameworks at the molecular level is an efficient strategy to shift their biological, physicochemical, optical, and electrical properties in the desired windows. In this work, we report on a new method to construct chiral triazine frameworks using metal-driven polymerization for enantiodiscrimination. The nucleophilic substitution reaction between melamine and cyanuric chloride was performed in the presence of PdCl
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16659
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Article: Evaluation of Cytotoxic Potentials of Novel Synthesized Chalconeferrocenyl Derivative against Melanoma and Normal Fibroblast and Its Anticancer Effect through Mitochondrial Pathway.

Salimi, Ahmad / Ghasempour, Mozhgan / Farzaneh, Shabnam / Khodaparast, Farzad / Naserzadeh, Parvaneh / Zarghi, Afshin / Pourahmad, Jalal

Iranian journal of pharmaceutical research : IJPR

2021 Volume 20, Issue 2, Page(s) 241–253

Abstract: The treatment of melanoma is still challenging and therefore identification of novel agents is needed for its better management. Our previous study suggested that cyclooxygenase-2 (COX-2) would be a novel target for treatment of several cancers. In the ... ...

Abstract	The treatment of melanoma is still challenging and therefore identification of novel agents is needed for its better management. Our previous study suggested that cyclooxygenase-2 (COX-2) would be a novel target for treatment of several cancers. In the present study, we searched selective cytotoxicity and mitochondria mediated apoptosis of novel synthesized chalconeferrocenyl derivative (1-Ferrocenyl-3-(dimethylamino)-3-(4-methylsulfonylphenyl) propan-1-one) (FDMPO) as a COX-2 inhibitor on normal and melanoma cells and their mitochondria. For this purpose, we evaluated the cellar parameters such as cytotoxicity, apoptosis%
Language	English
Publishing date	2021-07-24
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1726-6890 ; 1735-0328 ; 1735-0328
ISSN (online)	1726-6890 ; 1735-0328
ISSN	1735-0328
DOI	10.22037/ijpr.2020.113949.14578
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Article ; Online: A global systematic review and meta-analysis on illicit drug consumption rate through wastewater-based epidemiology.

Zarei, Shabnam / Salimi, Yahya / Repo, Eveliina / Daglioglu, Nebile / Safaei, Zahra / Güzel, Evsen / Asadi, Anvar

Environmental science and pollution research international

2020 Volume 27, Issue 29, Page(s) 36037–36051

Abstract: Wastewater-based epidemiology (WBE) is a complementary, well-established comprehensive, cost-effective, and rapid technique for monitoring of illicit drugs used in a general population. This systematic review and meta-analysis is the first to estimate ... ...

Abstract	Wastewater-based epidemiology (WBE) is a complementary, well-established comprehensive, cost-effective, and rapid technique for monitoring of illicit drugs used in a general population. This systematic review and meta-analysis is the first to estimate the rank and consumption rate of illicit drugs through WBE studies. In the current study, the related investigations regarding the illicit drug consumption rate based on WBE were searched among the international databases including Scopus, PubMed, Science direct, Google scholar, and local database, Magiran from 2012 up to May 2019. The illicit drug consumption rate with 95% confidence intervals was pooled between studies by using random effect model. The heterogeneity was determined using I
MeSH term(s)	Humans ; Illicit Drugs ; Methamphetamine ; Substance Abuse Detection ; Waste Water/analysis ; Wastewater-Based Epidemiological Monitoring ; Water Pollutants, Chemical/analysis
Chemical Substances	Illicit Drugs ; Waste Water ; Water Pollutants, Chemical ; Methamphetamine (44RAL3456C)
Language	English
Publishing date	2020-06-27
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-09818-6
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Article ; Online: In reply.

Cheng, Diana / Salimi, Shabnam / Terplan, Mishka / Chisolm, Margaret S

Obstetrics and gynecology

2015 Volume 125, Issue 6, Page(s) 1493–1494

MeSH term(s)	Female ; Humans ; Pregnancy/psychology ; Smoking/epidemiology ; Spouse Abuse
Language	English
Publishing date	2015-05-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000000877
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Article: Therapeutic Effects of Edaravone on Azoospermia: Free Radical Scavenging and Autophagy Modulation in Testicular Tissue of Mice.

Ghaffari Novin, Mahsa / Sabbagh Alvani, Mohammadamin / Mafi Balani, Mohammadreza / Aliaghaei, Abbas / Afshar, Azar / Aghajanpour, Fakhroddin / Soltani, Reza / Nazarian, Hamid / Salimi, Maryam / Seyed Hasani, Ahad Hasan / Abdi, Shabnam / Abdollahifar, Mohammad-Amin / Raee, Pourya

Journal of reproduction & infertility

2022 Volume 23, Issue 2, Page(s) 73–83

Abstract: Background: Chemotherapeutic agents such as cyclophosphamide and busulfan have been shown to have a negative impact on the spermatogenesis process. Based on this fact, the objective of this study was to investigate the effects of edaravone on ... ...

Abstract	Background: Chemotherapeutic agents such as cyclophosphamide and busulfan have been shown to have a negative impact on the spermatogenesis process. Based on this fact, the objective of this study was to investigate the effects of edaravone on spermatogenesis in busulfan-induced mice. Methods: Forty adult male mice were equally divided into the four groups: 1) control, 2) edaravone, 3) busulfan, and 4) busulfan + edaravone. Then, the sperm parameters, histopathological examinations, and serum levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were also assessed. Caspase-3, Beclin-1, and ATG-7 mRNA levels were also determined using real-time PCR. Results: Our results revealed that treatment of mice with edaravone in busulfan-induced azoospermia significantly improves sperm parameters, including total count, morphology, and viability (p<0.05). Furthermore, edaravone administration led to a significant increase in serum testosterone (p<0.0001) and FSH (p<0.001) levels, as well as testis weight (p<0.05) and volume (p<0.01). Edaravone also prevented a decrease in the number of testicular cells including spermatogonia (p<0.0001), primary spermatocytes (p<0.001), round spermatids (p<0.0001), Sertoli (p<0.01), and Leydig cells (p<0.0001) in busulfan-treated mice. Additionally, in busulfan-induced azoospermia, edaravone significantly reduced the percentage of sperm with immature chromatin (p<0.0001). Following treatment with edaravone, a decrease in reactive oxygen species (ROS) and an increase in glutathione (GSH) production were noted compared to busulfan-treated mice. Furthermore, caspase-3 (p<0.05), Beclin-1, and ATG-7 (p<0.001) genes expression decreased significantly in treatment groups compared to busulfan-induced azoospermia. Conclusion: According to our findings, edaravone can improve spermatogenesis in busulfan-induced azoospermia through free radical scavenging and autophagy modulation in testicular tissue.
Language	English
Publishing date	2022-08-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2548922-7
ISSN	2251-676X ; 1735-8507 ; 2228-5482 ; 1726-7536
ISSN (online)	2251-676X ; 1735-8507
ISSN	2228-5482 ; 1726-7536
DOI	10.18502/jri.v23i2.8990
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