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Article ; Online: Advances in understanding canine pregnancy: Endocrine and morpho-functional regulation.

Kowalewski, Mariusz P

Reproduction in domestic animals = Zuchthygiene

2023 Volume 58 Suppl 2, Page(s) 163–175

Abstract: Canine pregnancy relies on luteal steroidogenesis for progesterone (P4) production. The canine placenta responds to P4, depending on the nuclear P4 receptor (PGR). This has sparked interest in investigating the interaction between ovarian luteal steroids ...

Abstract	Canine pregnancy relies on luteal steroidogenesis for progesterone (P4) production. The canine placenta responds to P4, depending on the nuclear P4 receptor (PGR). This has sparked interest in investigating the interaction between ovarian luteal steroids and the placenta in dogs. Canine placentation is characterized by restricted (shallow) trophoblast invasion, making the dog an interesting model for studying decidua-derived modulation of trophoblast invasion, compared with the more invasive (hemochorial) placentation. The PGR is expressed in maternally derived decidual cells and plays a crucial role in feto-maternal communication during pregnancy maintenance. Understanding PGR-mediated signalling has clinical implications for improving reproductive performance control in dogs. Altering the PGR signalling induces the release of PGF2α from the foetal trophoblast, hindering placental homeostasis, which can also be achieved with antigestagens like aglepristone. Consequently, luteolysis, both natural and antigestagen-induced, involves apoptosis, vascular lesion, and immune cell infiltration in the placenta, resulting in placentolysis and foetal membranes expulsion. Our laboratory developed the immortalized dog uterine stromal (DUS) cell line to study canine-specific decidualization. We study canine reproduction by observing physiological processes and investigating evidence-based mechanisms of decidualization and feto-maternal interaction. Our focus on morphology, function and molecular aspects enhances understanding and enables targeted and translational studies.
MeSH term(s)	Female ; Pregnancy ; Dogs ; Animals ; Placenta ; Ovary ; Apoptosis ; Corpus Luteum ; Dinoprost
Chemical Substances	Dinoprost (B7IN85G1HY)
Language	English
Publishing date	2023-09-19
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14443
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Article ; Online: Advances in understanding canine pregnancy: Endocrine and morpho‐functional regulation

Kowalewski, Mariusz P.

Reproduction in Domestic Animals. 2023 Sept., v. 58 Suppl S2 p.163-175

2023

Abstract	Canine pregnancy relies on luteal steroidogenesis for progesterone (P4) production. The canine placenta responds to P4, depending on the nuclear P4 receptor (PGR). This has sparked interest in investigating the interaction between ovarian luteal steroids and the placenta in dogs. Canine placentation is characterized by restricted (shallow) trophoblast invasion, making the dog an interesting model for studying decidua‐derived modulation of trophoblast invasion, compared with the more invasive (hemochorial) placentation. The PGR is expressed in maternally derived decidual cells and plays a crucial role in feto‐maternal communication during pregnancy maintenance. Understanding PGR‐mediated signalling has clinical implications for improving reproductive performance control in dogs. Altering the PGR signalling induces the release of PGF2α from the foetal trophoblast, hindering placental homeostasis, which can also be achieved with antigestagens like aglepristone. Consequently, luteolysis, both natural and antigestagen‐induced, involves apoptosis, vascular lesion, and immune cell infiltration in the placenta, resulting in placentolysis and foetal membranes expulsion. Our laboratory developed the immortalized dog uterine stromal (DUS) cell line to study canine‐specific decidualization. We study canine reproduction by observing physiological processes and investigating evidence‐based mechanisms of decidualization and feto‐maternal interaction. Our focus on morphology, function and molecular aspects enhances understanding and enables targeted and translational studies.
Keywords	apoptosis ; cell lines ; dogs ; homeostasis ; luteolysis ; models ; pregnancy ; progesterone ; reproductive performance ; steroidogenesis ; trophoblast
Language	English
Dates of publication	2023-09
Size	p. 163-175.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14443
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evolut R and Evolut PRO vs. Sapien 3 for transcatheter aortic valve implantation - The 'generation gap' and beyond.

Gozdek, Mirosław / Kowalewski, Mariusz

International journal of cardiology

2023 Volume 398, Page(s) 131647

MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Prosthesis Design ; Treatment Outcome ; Postoperative Complications
Language	English
Publishing date	2023-12-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131647
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Article ; Online: Mechanical ventilation during extracorporeal membrane oxygenation support - New trends and continuing challenges.

Szuldrzynski, Konstanty / Kowalewski, Mariusz / Swol, Justyna

Perfusion

2024 Volume 39, Issue 1_suppl, Page(s) 107S–114S

Abstract: Background: The impact of mechanical ventilation on the survival of patients supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO) due to severe acute respiratory distress syndrome (ARDS) remains still a focus of research.: Methods! ...

Abstract	Background: The impact of mechanical ventilation on the survival of patients supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO) due to severe acute respiratory distress syndrome (ARDS) remains still a focus of research. Methods: Recent guidelines, randomized trials, and registry data underscore the importance of lung-protective ventilation during respiratory and cardiac support on ECMO. Results: This approach includes decreasing mechanical power delivery by reducing tidal volume and driving pressure as much as possible, using low or very low respiratory rate, and a personalized approach to positive-end expiratory pressure (PEEP) setting. Notably, the use of ECMO in awake and spontaneously breathing patients is increasing, especially as a bridging strategy to lung transplantation. During respiratory support in V-V ECMO, native lung function is of highest importance and adjustments of blood flow on ECMO, or ventilator settings significantly impact the gas exchange. These interactions are more complex in veno-arterial (V-A) ECMO configuration and cardiac support. The fraction on delivered oxygen in the sweep gas and sweep gas flow rate, blood flow per minute, and oxygenator efficiency have an impact on gas exchange on device side. On the patient side, native cardiac output, native lung function, carbon dioxide production (VCO2), and oxygen consumption (VO2) play a role. Avoiding pulmonary oedema includes left ventricle (LV) distension monitoring and prevention, pulse pressure >10 mm Hg and aortic valve opening assessment, higher PEEP adjustment, use of vasodilators, ECMO flow adjustment according to the ejection fraction, moderate use of inotropes, diuretics, or venting strategies as indicated and according to local expertise and resources. Conclusion: Understanding the physiological principles of gas exchange during cardiac support on femoro-femoral V-A ECMO configuration and the interactions with native gas exchange and haemodynamics are essential for the safe applications of these techniques in clinical practice. Proning during ECMO remains to be discussed until further data is available from prospective, randomized trials implementing individualized PEEP titration during proning.
MeSH term(s)	Extracorporeal Membrane Oxygenation/methods ; Extracorporeal Membrane Oxygenation/trends ; Humans ; Respiration, Artificial/methods ; Respiration, Artificial/trends ; Respiratory Distress Syndrome/therapy
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/02676591241232270
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Zs.A 2424: Show issues

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Article ; Online: Molecular Mechanisms of Lipopolysaccharide (LPS) Induced Inflammation in an Immortalized Ovine Luteal Endothelial Cell Line (OLENDO).

Gram, Aykut / Kowalewski, Mariusz P

Veterinary sciences

2022 Volume 9, Issue 3

Abstract: Escherichia coli (E. coli) is the most common Gram-negative bacterium causing infection of the uterus or mammary gland and is one of the major causes of infertility in livestock. In those animals affected by E. coli driven LPS-mediated infections, ... ...

Abstract	Escherichia coli (E. coli) is the most common Gram-negative bacterium causing infection of the uterus or mammary gland and is one of the major causes of infertility in livestock. In those animals affected by E. coli driven LPS-mediated infections, fertility problems occur in part due to disrupted follicular and luteal functionality. However, the molecular mechanisms by which LPS induces inflammation, and specifically, the role of LPS in the disruption of capillary morphogenesis and endothelial barrier function remain unclear. Here, we hypothesized that LPS may lead to alterations in luteal angiogenesis and vascular function by inducing inflammatory reactions in endothelial cells. Accordingly, OLENDO cells were treated with LPS followed by evaluation of the expression of selected representative proinflammatory cytokines: NF-kB, IL6, IL8, TNFα, and ICAM 1. While TNFα was not affected by treatment with LPS, transcripts of NF-kB, IL6, and IL8 were affected in a dosage-dependent manner. Additionally, the activity of TLR2 and TLR4 was blocked, resulting in suppression of the LPS-induced expression of ICAM 1, NF-kB, IL6, and IL8. Inhibition of the PKA or MAPK/ERK pathways suppressed the LPS-stimulated expression of NF-kB, IL6, and IL8, whereas blocking the PKC pathway had the opposite effect. Furthermore, LPS-induced phosphorylation of Erk1 and Erk2 was inhibited when the TLR4 or MAPK/ERK pathways were blocked. Finally, LPS seems to induce inflammatory processes in OLENDO cells via TLR2 and TLR4, utilizing different signaling pathways.
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci9030099
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Article ; Online: Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus).

Rüegg, Anna B / Kowalewski, Mariusz P / Ulbrich, Susanne E

Reproduction in domestic animals = Zuchthygiene

2023 Volume 58, Issue 5, Page(s) 594–604

Abstract: The modification of the endometrial extracellular matrix (ECM) is a crucial step for embryo implantation in many mammalian species. The embryo of the European roe deer (Capreolus capreolus) displays a 4-5 months long temporary reduction of developmental ... ...

Abstract	The modification of the endometrial extracellular matrix (ECM) is a crucial step for embryo implantation in many mammalian species. The embryo of the European roe deer (Capreolus capreolus) displays a 4-5 months long temporary reduction of developmental pace termed embryonic diapause. A reduction of epithelial cell height during diapause has previously been described. Co-occurring ECM modifications may contribute to the changes of the intra-uterine milieu during reactivation at which the embryo regains developmental velocity. We assessed the localization of five ECM proteins (collagen I and IV, fibronectin, laminin, and extracellular matrix protein 1) using immunohistochemistry in animals with early, late, and post-diapause (elongating) embryos. While our results confirmed the reduction of epithelial height during diapause, we only detected marginal differences in localization and staining intensities of the selected ECM proteins. Major ECM remodelling events in the roe deer endometrium are thus likely to occur only at implantation.
MeSH term(s)	Female ; Animals ; Deer/physiology ; Endometrium/metabolism ; Embryo Implantation/physiology ; Extracellular Matrix ; Diapause
Language	English
Publishing date	2023-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14320
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Article ; Online: Molecular Mechanisms of Lipopolysaccharide (LPS) Induced Inflammation in an Immortalized Ovine Luteal Endothelial Cell Line (OLENDO)

Aykut Gram / Mariusz P. Kowalewski

Veterinary Sciences, Vol 9, Iss 99, p

2022 Volume 99

Abstract: Escherichia coli ( E. coli ) is the most common Gram-negative bacterium causing infection of the uterus or mammary gland and is one of the major causes of infertility in livestock. In those animals affected by E. coli driven LPS-mediated infections, ... ...

Abstract	Escherichia coli ( E. coli ) is the most common Gram-negative bacterium causing infection of the uterus or mammary gland and is one of the major causes of infertility in livestock. In those animals affected by E. coli driven LPS-mediated infections, fertility problems occur in part due to disrupted follicular and luteal functionality. However, the molecular mechanisms by which LPS induces inflammation, and specifically, the role of LPS in the disruption of capillary morphogenesis and endothelial barrier function remain unclear. Here, we hypothesized that LPS may lead to alterations in luteal angiogenesis and vascular function by inducing inflammatory reactions in endothelial cells. Accordingly, OLENDO cells were treated with LPS followed by evaluation of the expression of selected representative proinflammatory cytokines: NF-kB , IL6 , IL8 , TNFα , and ICAM 1 . While TNFα was not affected by treatment with LPS, transcripts of NF-kB , IL6 , and IL8 were affected in a dosage-dependent manner. Additionally, the activity of TLR2 and TLR4 was blocked, resulting in suppression of the LPS-induced expression of ICAM 1 , NF-kB , IL6 , and IL8 . Inhibition of the PKA or MAPK/ERK pathways suppressed the LPS-stimulated expression of NF-kB , IL6 , and IL8 , whereas blocking the PKC pathway had the opposite effect. Furthermore, LPS-induced phosphorylation of Erk1 and Erk2 was inhibited when the TLR4 or MAPK/ERK pathways were blocked. Finally, LPS seems to induce inflammatory processes in OLENDO cells via TLR2 and TLR4, utilizing different signaling pathways.
Keywords	toll-like receptor ; ovary ; interleukins ; PKA ; PKC ; MAPKs ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Upper gastrointestinal bleeding in veno-arterial extracorporeal membrane oxygenation patients: a neglected (sometimes hidden) enemy deserving further investigation and action.

Lorusso, Roberto / Martucci, Gennaro / Di Mauro, Michele / Kowalewski, Mariusz

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2023 Volume 63, Issue 4

MeSH term(s)	Humans ; Adult ; Extracorporeal Membrane Oxygenation/adverse effects ; Cohort Studies ; Shock, Cardiogenic/therapy ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy
Language	English
Publishing date	2023-04-19
Publishing country	Germany
Document type	Journal Article ; Comment
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezad148
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Zs.A 2303: Show issues

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Article: The involvement of hypoxia-inducible factor 1α (HIF1α)-stabilising factors in steroidogenic acute regulatory (STAR) protein-dependent steroidogenesis in murine KK1 granulosa cells in vitro.

Gysin, Tina / Kowalewski, Mariusz P

Reproduction, fertility, and development

2021 Volume 33, Issue 18, Page(s) 865–880

Abstract: As a component of hypoxia-inducible factor1 (HIF1)-complexes, HIF1α regulates the expression of steroidogenic acute regulatory (STAR) protein in granulosa cells. However, severe hypoxia or exaggeratedly expressed HIF1α have detrimental effects. HIF1α is ... ...

Abstract	As a component of hypoxia-inducible factor1 (HIF1)-complexes, HIF1α regulates the expression of steroidogenic acute regulatory (STAR) protein in granulosa cells. However, severe hypoxia or exaggeratedly expressed HIF1α have detrimental effects. HIF1α is regulated by factor inhibiting HIF (FIH), prolyl hydroxylases (PHD1, 2, 3) and von Hippel-Lindau (VHL) suppressor protein. In this study, the expression of FIH, PHD1, 2, 3 and VHL was investigated in murine ovaries and immortalised KK1 granulosa cells. We found FIH, VHL and PHD2 transcripts predominantly in growing tertiary follicles. Functional aspects were assessed in KK1 cells exposed to decreasing O2 (20%, 10%, 1%), by determining HIF1α, FIH, VHL, PHD1-3 and STAR expression. The main findings indicated gradually increasing PHD2 under lowered O2. Functional blocking of PHDs revealed biphasic effects on STAR expression; concomitantly with increasing HIF1α, STAR expression, which was initially induced, decreased significantly when HIF1α was strongly stabilised. Finally, PHD2 in particular might act as a specific regulator of HIF1α and, thereby, of STAR availability in granulosa cells.
MeSH term(s)	Animals ; Cell Line ; Female ; Granulosa Cells/metabolism ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; Mixed Function Oxygenases/metabolism ; Ovary/metabolism ; Phosphoproteins/metabolism ; Signal Transduction/physiology ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
Chemical Substances	HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Phosphoproteins ; steroidogenic acute regulatory protein ; Mixed Function Oxygenases (EC 1.-) ; factor inhibiting hypoxia-inducible factor 1, mouse (EC 1.-) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; VHL protein, mouse (EC 6.3.2.-)
Language	English
Publishing date	2021-12-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RD21170
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Article ; Online: Limitations. Reprise.

Malvindi, Pietro Giorgio / Kowalewski, Mariusz / Paparella, Domenico

The Annals of thoracic surgery

2021 Volume 114, Issue 1, Page(s) 350–351

MeSH term(s)	Humans ; Mitral Valve
Language	English
Publishing date	2021-08-24
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2021.07.063
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