LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Search options

Article ; Online: COVID-19 and Fake News in the Dominican Republic.

Tapia, Leandro

The American journal of tropical medicine and hygiene

2020 Volume 102, Issue 6, Page(s) 1172–1174

Abstract: The first case of novel coronavirus disease (COVID-19) in the Dominican Republic coincided with a period of political crisis. Distrust in governmental institutions shaped the critical phase of early response. Having a weak public health infrastructure ... ...

Abstract	The first case of novel coronavirus disease (COVID-19) in the Dominican Republic coincided with a period of political crisis. Distrust in governmental institutions shaped the critical phase of early response. Having a weak public health infrastructure and a lack of public trust, the Ministry of Health (MoH) began the fight against COVID-19 with a losing streak. Within 45 days of the first reported case, the political crisis and turmoil caused by "fake news" are limiting the capacity and success of the MoH response to the pandemic.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/supply & distribution ; Antiviral Agents/therapeutic use ; Azithromycin/supply & distribution ; Azithromycin/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; COVID-19 ; Civil Disorders ; Coronavirus Infections/drug therapy ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Dissent and Disputes ; Dominican Republic/epidemiology ; Drug Repositioning ; Humans ; Hydroxychloroquine/supply & distribution ; Hydroxychloroquine/therapeutic use ; Ivermectin/supply & distribution ; Ivermectin/therapeutic use ; Pandemics/economics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Politics ; Public Health/economics ; Public Health/trends ; SARS-CoV-2 ; Social Media/ethics ; Trust/psychology
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Ivermectin (70288-86-7) ; Azithromycin (83905-01-5) ; tocilizumab (I031V2H011)
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0234
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.61: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: COVID-19 and Fake News in the Dominican Republic

Tapia, Leandro

Am J Trop Med Hyg

Abstract	The first case of novel coronavirus disease (COVID-19) in the Dominican Republic coincided with a period of political crisis. Distrust in governmental institutions shaped the critical phase of early response. Having a weak public health infrastructure and a lack of public trust, the Ministry of Health (MoH) began the fight against COVID-19 with a losing streak. Within 45 days of the first reported case, the political crisis and turmoil caused by "fake news" are limiting the capacity and success of the MoH response to the pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #601671
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality.

Rojas, Macarena / Prado, Yolanda / Tapia, Pablo / Carreño, Leandro J / Cabello-Verrugio, Claudio / Simon, Felipe

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 12

Abstract: During systemic inflammation, reactive oxygen species (ROS) are generated in the bloodstream, producing large amounts of oxidized HDL (oxHDL). OxHDL loses the vascular protective features of native HDL, acquiring detrimental actions. Systemic ... ...

Abstract	During systemic inflammation, reactive oxygen species (ROS) are generated in the bloodstream, producing large amounts of oxidized HDL (oxHDL). OxHDL loses the vascular protective features of native HDL, acquiring detrimental actions. Systemic inflammation promotes endothelial fibrosis, characterized by adhesion protein downregulation and fibrotic-specific gene upregulation, disrupting endothelial monolayer integrity. Severe systemic inflammatory conditions, as found in critically ill patients in the intensive care unit (ICU), exhibit endothelial hyperpermeability, hypotension, and organ hypoperfusion, promoting organ dysfunction and increased mortality. Because endothelial fibrosis disturbs the endothelium, it is proposed that it is the cellular and molecular origin of endothelial hyperpermeability and the subsequent deleterious consequences. However, whether oxHDL is involved in this process is unknown. The aim of this study was to investigate the fibrotic effect of oxHDL on the endothelium, to elucidate the underlying molecular and cellular mechanism, and to determine its effects on vascular permeability, blood pressure, and mortality. The results showed that oxHDL induces endothelial fibrosis through the LOX-1/NOX-2/ROS/NF-κB pathway, TGF-β secretion, and ALK-5/Smad activation. OxHDL-treated rats showed endothelial hyperpermeability, hypotension, and an enhanced risk of death and mortality, which was prevented using an ALK-5 inhibitor and antioxidant diet consumption. Additionally, the ICU patients showed fibrotic endothelial cells, and the resuscitation fluid volume administered correlated with the plasma oxHDL levels associated with an elevated risk of death and mortality. We conclude that oxHDL generates endothelial fibrosis, impacting blood pressure regulation and survival.
Language	English
Publishing date	2022-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11122469
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Serological Confirmed Syphilis Among Transgender Women in Dominican Republic.

Paulino-Ramírez, Robert / Hearld, Kristine R / Butane, Seyram A / Tapia, Leandro / Budhwani, Henna / Naar, Sylvie / Rodriguez-Lauzurique, Mayra

Transgender health

2022 Volume 7, Issue 3, Page(s) 237–241

Abstract: Purpose: Transgender women (TW) in the Dominican Republic (DR) are at high risk for syphillis infection. Although treatable, infection rates remain at epidemic proportions.: Methods: In 2016, we conducted a national survey, with serological sampling ... ...

Abstract	Purpose: Transgender women (TW) in the Dominican Republic (DR) are at high risk for syphillis infection. Although treatable, infection rates remain at epidemic proportions. Methods: In 2016, we conducted a national survey, with serological sampling of TW in the DR ( Results: In our sample, syphillis seropositivity was 47.45%. There was a statistically significant association between age ( Conclusions: There is a need for education and public health campaigns focused on TW specifically.
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ISSN	2688-4887
ISSN	2688-4887
DOI	10.1089/trgh.2020.0173
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transgender Women in Dominican Republic: HIV, Stigma, Substances, and Sex Work.

Budhwani, Henna / Hearld, Kristine R / Butame, Seyram A / Naar, Sylvie / Tapia, Leandro / Paulino-Ramírez, Robert

AIDS patient care and STDs

2021 Volume 35, Issue 12, Page(s) 488–494

Abstract: Exposure to stigma, violence, sex work, and substance use are associated with increased HIV risk, but relationships between these factors have not been fully elucidated among transgender women whose data are often aggregated with men who have sex with ... ...

Abstract	Exposure to stigma, violence, sex work, and substance use are associated with increased HIV risk, but relationships between these factors have not been fully elucidated among transgender women whose data are often aggregated with men who have sex with men and other sexual and gender minorities. Considering this gap, we aimed to identify a serologically confirmed HIV estimate for transgender women and examine the relationships between stigma, sex work, substance use, and HIV among a national sample of transgender women in Dominican Republic. We analyzed biomarkers and self-report data from the third wave of Dominican Republic's Encuesta de Vigilancia y Comportamiento con Vinculación Serológica, employing logistic and negative binomial regression to estimate models (
MeSH term(s)	Dominican Republic/epidemiology ; Female ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Sex Work ; Sexual and Gender Minorities ; Social Stigma ; Transgender Persons
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1326868-5
ISSN	1557-7449 ; 0893-5068 ; 1087-2914
ISSN (online)	1557-7449
ISSN	0893-5068 ; 1087-2914
DOI	10.1089/apc.2021.0127
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2328: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality

Rojas, Macarena / Prado, Yolanda / Tapia, Pablo / Carreño, Leandro J. / Cabello-Verrugio, Claudio / Simon, Felipe

Antioxidants. 2022 Dec. 15, v. 11, no. 12

2022

Abstract	During systemic inflammation, reactive oxygen species (ROS) are generated in the bloodstream, producing large amounts of oxidized HDL (oxHDL). OxHDL loses the vascular protective features of native HDL, acquiring detrimental actions. Systemic inflammation promotes endothelial fibrosis, characterized by adhesion protein downregulation and fibrotic-specific gene upregulation, disrupting endothelial monolayer integrity. Severe systemic inflammatory conditions, as found in critically ill patients in the intensive care unit (ICU), exhibit endothelial hyperpermeability, hypotension, and organ hypoperfusion, promoting organ dysfunction and increased mortality. Because endothelial fibrosis disturbs the endothelium, it is proposed that it is the cellular and molecular origin of endothelial hyperpermeability and the subsequent deleterious consequences. However, whether oxHDL is involved in this process is unknown. The aim of this study was to investigate the fibrotic effect of oxHDL on the endothelium, to elucidate the underlying molecular and cellular mechanism, and to determine its effects on vascular permeability, blood pressure, and mortality. The results showed that oxHDL induces endothelial fibrosis through the LOX-1/NOX-2/ROS/NF-κB pathway, TGF-β secretion, and ALK-5/Smad activation. OxHDL-treated rats showed endothelial hyperpermeability, hypotension, and an enhanced risk of death and mortality, which was prevented using an ALK-5 inhibitor and antioxidant diet consumption. Additionally, the ICU patients showed fibrotic endothelial cells, and the resuscitation fluid volume administered correlated with the plasma oxHDL levels associated with an elevated risk of death and mortality. We conclude that oxHDL generates endothelial fibrosis, impacting blood pressure regulation and survival.
Keywords	adhesion ; blood flow ; blood pressure ; death ; diet ; endothelium ; fibrosis ; genes ; high density lipoprotein ; hypotension ; inflammation ; mortality ; oxidation ; permeability ; reactive oxygen species ; risk ; secretion
Language	English
Dates of publication	2022-1215
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11122469
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Clima e incidencia de la Malaria durante períodos inter e intra-epidémicos en el Gran Santo Domingo, República Dominicana

Leandro Tapia / Cesar Arredondo- Abreu / Nicole Mrvos / Carlos Ruiz-Matuk / Robert Paulino-Ramírez

Ciencia y Salud, Vol 5, Iss

2021 Volume 1

Abstract: El cambio climático tiene importantes implicaciones de salud pública, las cuales se incrementan en la malaria. En zonas donde nunca antes se había identificado las diferentes especies de Plasmodium se convirtió en realidad. Por consiguiente, la ... ...

Abstract	El cambio climático tiene importantes implicaciones de salud pública, las cuales se incrementan en la malaria. En zonas donde nunca antes se había identificado las diferentes especies de Plasmodium se convirtió en realidad. Por consiguiente, la comprensión de la relación entre esta enfermedad y el clima se ha convertido en una prioridad de salud global. En este estudio extrajimos los casos reportados de malaria y los informes climáticos de bases de datos de información pública entre 2012 y 2018. Mediante análisis de regresión confrontamos los casos de malaria semanales con promedios climáticos de semana de retraso. Durante los períodos inter-epidémicos la humedad relativa (b = .1101, p <0.001) y la temperatura media (b = 0.118, p < 0.001) fueron predictores significativos de incidencia de malaria. Sin embargo, durante los períodos intra-epidémicos, estos predictores se comportan de manera diferente: humedad relativa (b = -0.265, p<0.05) y temperatura media (b = -1.47, p<0.001). La temperatura media y la humedad relativa impulsan la incidencia de malaria en Santo Domingo. Estas dos variables pueden servir de predictores para futuros brotes en regiones de alta incidencia poblacional.
Keywords	malaria ; variable climática ; temperatura ; análisis de correlación ; República Dominicana ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Language	Spanish
Publishing date	2021-02-01T00:00:00Z
Publisher	Instituto Tecnológico de Santo Domingo (INTEC)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transmisión del virus del dengue y su relación con factores climáticos durante los períodos intra e interepidémicos en Santo Domingo, República Dominicana

Leandro Tapia / Cesar Arredondo- Abreu / Miguel Delgadillo / Carlos Ruiz-Matuk / Robert Paulino-Ramírez

Ciencia y Salud, Vol 5, Iss

2021 Volume 2

Abstract: Antecedentes: Aedes spp. y la dinámica del virus del dengue está altamente influenciada por factores ambientales. Una relación detallada entre el clima y la enfermedad en los períodos inter e intra-epidémicos podrían beneficiar la vigilancia del dengue ... ...

Abstract	Antecedentes: Aedes spp. y la dinámica del virus del dengue está altamente influenciada por factores ambientales. Una relación detallada entre el clima y la enfermedad en los períodos inter e intra-epidémicos podrían beneficiar la vigilancia del dengue para optimizar la preparación y las políticas adecuadas de control de vectores. Métodos: se analizaron los informes de casos de dengue y las variables climáticas en Santo Domingo, República Dominicana, para determinar la correlación del período 2012-2018 y los diferentes tiempos de retraso. Se llevó a cabo un análisis de regresión de dichas variables para comprender mejor las relaciones entre las tasas de incidencia del dengue y los cambios climáticos. Resultados: durante los brotes epidémicos, la temperatura (r = 0.73, p <0.001) y la humedad relativa (r = -0.22, p = 0.009) se correlacionan significativamente con la incidencia del dengue con un retraso de 9 semanas, el análisis de regresión muestra que la temperatura media (b = 62.401, p < 0.001), precipitación (b = 2.810, p <0.001) y humedad relativa (b = -5.462, p = 0.025) fueron predictores significativos. Durante los períodos inter-epidémico, la temperatura (r = 0.23, p <0.001) tuvo una correlación significativa con la incidencia del dengue con un retraso de 7 semanas, la humedad relativa (b = 1.454, p <0.05) y la temperatura media (b = 5.14, p <0.01) son predictores significativos de la cantidad de casos de dengue. La precipitación no se correlacionó significativamente con la incidencia del dengue. Conclusiones: existe una relación no lineal entre los factores climáticos y la incidencia del dengue. La infección por dengue depende del clima, y la temperatura parece jugar un papel importante en los factores climáticos.
Keywords	dengue ; variables climáticas ; incidencia ; temperatura ; análisis de correlación ; República Dominicana ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Language	Spanish
Publishing date	2021-06-01T00:00:00Z
Publisher	Instituto Tecnológico de Santo Domingo (INTEC)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Seroprevalence of Specific Antibodies against SARS-CoV-2 from Hotspot Communities in the Dominican Republic.

Paulino-Ramirez, Robert / Báez, Amado Alejandro / Vallejo Degaudenzi, Alejandro / Tapia, Leandro

The American journal of tropical medicine and hygiene

2020 Volume 103, Issue 6, Page(s) 2343–2346

Abstract: Seroprevalence surveys are of utmost importance to assess the proportion of a population that has developed antibodies against a newly introduced virus and could therefore potentially exhibit immunologic protection against subsequent infection. This ... ...

Abstract	Seroprevalence surveys are of utmost importance to assess the proportion of a population that has developed antibodies against a newly introduced virus and could therefore potentially exhibit immunologic protection against subsequent infection. This study aims to understand the distribution of IgM and IgG antibodies in the Dominican Republic. We surveyed a total of 12,897 participants between April and June 2020 in 10 provinces of the Dominican Republic. Survey efforts in emerging hotspots yielded a positivity for all participants of anti-SARS-CoV-2 IgM of 3.8% and IgG of 5.4%, indicating that the pathogen was in circulation before the identification of those particular communities as hotspots. We found important age differences between participants who participated in the serological study where a higher mean age is associated IgM positivity and a lower age with IgG positivity. Our results highlight the need for strategies that involve community-based seroprevalence monitoring. These should preclude syndromic case identification. Also, the higher mean age of IgM-positive participants suggests that strategies based on syndromic surveillance could identify hotspots at later phases, based on the number of cases detected at the healthcare center, as such community-based seroprevalence monitoring may be an effective intervention for future outbreaks.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/transmission ; Child ; Child, Preschool ; Dominican Republic/epidemiology ; Epidemiological Monitoring ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/immunology ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Keywords	covid19
Language	English
Publishing date	2020-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0907
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.61: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic

Mary E. Petrone / Rebecca Earnest / José Lourenço / Moritz U. G. Kraemer / Robert Paulino-Ramirez / Nathan D. Grubaugh / Leandro Tapia

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 12

Abstract: Dengue is endemic in the Dominican Republic, and causes regular outbreaks, whereas Zika and chikungunya are emerging infections in the area. Here, the authors show that outbreaks of the emerging infections could not be predicted by seasonal dengue ... ...

Abstract	Dengue is endemic in the Dominican Republic, and causes regular outbreaks, whereas Zika and chikungunya are emerging infections in the area. Here, the authors show that outbreaks of the emerging infections could not be predicted by seasonal dengue dynamics.
Keywords	Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED