LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 36

Search options

  1. Article ; Online: COVID-19 and Health Disparities: the Reality of "the Great Equalizer".

    Mein, Stephen A

    Journal of general internal medicine

    2020  Volume 35, Issue 8, Page(s) 2439–2440

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Coronavirus Infections/ethnology ; Coronavirus Infections/mortality ; Coronavirus Infections/prevention & control ; Health Services Accessibility/standards ; Health Status Disparities ; Healthcare Disparities/organization & administration ; Humans ; Minority Health/statistics & numerical data ; Needs Assessment ; Pandemics/prevention & control ; Pneumonia, Viral/ethnology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Socioeconomic Factors ; United States/epidemiology ; Vulnerable Populations/ethnology
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05880-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: COVID-19 and Health Disparities

    Mein, Stephen A

    Journal of General Internal Medicine

    the Reality of “the Great Equalizer”

    2020  Volume 35, Issue 8, Page(s) 2439–2440

    Keywords Internal Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05880-5
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Prenatal Air Pollution and Child Lung Function: The Impossible Search for a Vulnerable Trimester.

    Rice, Mary B / Mein, Stephen A

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 1, Page(s) 15–16

    MeSH term(s) Air Pollution ; Child ; Cohort Studies ; Female ; Humans ; Pregnancy ; Pregnancy Trimesters
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202003-0764ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: COVID-19 Pandemic: A Wake-Up Call for Clean Air.

    Mein, Stephen A / Annesi-Maesano, Isabella / Rice, Mary B

    Annals of the American Thoracic Society

    2021  Volume 18, Issue 9, Page(s) 1450–1455

    MeSH term(s) COVID-19 ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202012-1542VP
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Sugar, Sodium, and Water: A Recipe for Disaster.

    Mein, Stephen A / Schwartzstein, Richard M / Richards, Jeremy B

    Annals of the American Thoracic Society

    2020  Volume 17, Issue 8, Page(s) 1016–1020

    MeSH term(s) Adenocarcinoma/drug therapy ; Antineoplastic Agents/adverse effects ; Blood Glucose/metabolism ; Colorectal Neoplasms/drug therapy ; Diabetic Ketoacidosis/etiology ; Diabetic Ketoacidosis/therapy ; Female ; Humans ; Hypernatremia/etiology ; Hypernatremia/therapy ; Middle Aged ; Osmolar Concentration ; Sodium/blood ; Vomiting/etiology
    Chemical Substances Antineoplastic Agents ; Blood Glucose ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Clinical Conference ; Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202004-360CC
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Health Care Access and Cardiovascular Risk Factor Management Among Working-Age US Adults During the Pandemic.

    Marinacci, Lucas X / Bartlett, Victoria / Zheng, ZhaoNian / Mein, Stephen / Wadhera, Rishi K

    Circulation. Cardiovascular quality and outcomes

    2023  Volume 16, Issue 12, Page(s) e010516

    Abstract: Background: Low-income working-age US adults disproportionately experienced health care disruptions at the onset of the coronavirus disease 2019 pandemic. Little is known about how health care access and cardiovascular risk factor management changed as ... ...

    Abstract Background: Low-income working-age US adults disproportionately experienced health care disruptions at the onset of the coronavirus disease 2019 pandemic. Little is known about how health care access and cardiovascular risk factor management changed as the pandemic went on or if patterns differed by state Medicaid expansion status.
    Methods: Cross-sectional data from the behavioral risk factor surveillance system were used to compare self-reported measures of health care access and cardiovascular risk factor management among US adults aged 18 to 64 years in 2021 (pandemic) to 2019 (prepandemic) using multivariable Poisson regression models. We assessed differential changes between low-income (<138% federal poverty level) and high-income (>400% federal poverty level) working-age adults by including an interaction term for income group and year. We then evaluated changes among low-income adults in Medicaid expansion versus nonexpansion states using a similar approach.
    Results: The unweighted study population included 80 767 low-income and 184 136 high-income adults. Low-income adults experienced improvements in insurance coverage (relative risk [RR], 1.10 [95% CI, 1.08-1.12]), access to a provider (RR, 1.12 [95% CI, 1.09-1.14]), and ability to afford care (RR, 1.07 [95% CI, 1.05-1.09]) in 2021 compared with 2019. While these measures also improved for high-income adults, gains in coverage and ability to afford care were more pronounced among low-income adults. However, routine visits (RR, 0.96 [95% CI, 0.94-0.98]) and cholesterol testing (RR, 0.93 [95% CI, 0.91-0.96]) decreased for low-income adults, while diabetes screening (RR, 1.01 [95% CI, 0.95-1.08]) remained stable. Treatment for hypertension (RR, 1.05 [95% CI, 1.02-1.08]) increased, and diabetes-focused visits and insulin use remained stable. These patterns were similar for high-income adults. Across most outcomes, there were no differential changes between low-income adults residing in Medicaid expansion versus nonexpansion states.
    Conclusions: In this national study of working-age adults in the United States, measures of health care access improved for low- and high-income adults in 2021. However, routine outpatient visits and cardiovascular risk factor screening did not return to prepandemic levels, while risk factor treatment remained stable. As many coronavirus disease-era safety net policies come to an end, targeted strategies are needed to protect health care access and improve cardiovascular risk factor screening for working-age adults.
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Patient Protection and Affordable Care Act ; Pandemics ; Cross-Sectional Studies ; Risk Factors ; Medicaid ; Health Services Accessibility ; Diabetes Mellitus ; Insurance Coverage ; Heart Disease Risk Factors
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.123.010516
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6744: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Lifetime Exposure to Traffic-related Pollution and Lung Function in Early Adolescence.

    Mein, Stephen A / Nurhussien, Lina / Rifas-Shiman, Sheryl L / Luttmann-Gibson, Heike / Sordillo, Joanne E / Oken, Emily / Gold, Diane R / Rice, Mary B

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 10, Page(s) 1776–1779

    MeSH term(s) Adolescent ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Environmental Exposure/adverse effects ; Humans ; Lung ; Traffic-Related Pollution ; Vehicle Emissions/analysis ; Vehicle Emissions/toxicity
    Chemical Substances Air Pollutants ; Vehicle Emissions
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202112-1352RL
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Routine Use of Tenecteplase for Thrombolysis in Acute Ischemic Stroke.

    Zhong, Cathy S / Beharry, James / Salazar, Daniel / Smith, Kelly / Withington, Stephen / Campbell, Bruce C V / Wilson, Duncan / Le Heron, Campbell / Mason, Deborah / Duncan, Roderick / Reimers, Jon / Mein-Smith, Frances / Diprose, William K / Barber, P Alan / Ranta, Annemarei / Fink, John N / Wu, Teddy Y

    Stroke

    2021  Volume 52, Issue 3, Page(s) 1087–1090

    Abstract: Background and purpose: In ischemic stroke, intravenous tenecteplase is noninferior to alteplase in selected patients and has some practical advantages. Several stroke centers in New Zealand changed to routine off-label intravenous tenecteplase due to ... ...

    Abstract Background and purpose: In ischemic stroke, intravenous tenecteplase is noninferior to alteplase in selected patients and has some practical advantages. Several stroke centers in New Zealand changed to routine off-label intravenous tenecteplase due to improved early recanalization in large vessel occlusion, inconsistent access to thrombectomy within stroke networks, and for consistency in treatment protocols between patients with and without large vessel occlusion. We report the feasibility and safety outcomes in tenecteplase-treated patients.
    Methods: We performed a retrospective analysis of consecutive patients thrombolyzed with intravenous tenecteplase at 1 comprehensive and 2 regional stroke centers from July 14, 2018, to February 29, 2020. We report the baseline clinical characteristics, rates of symptomatic intracranial hemorrhage, and angioedema. These were then compared with patient outcomes with those treated with intravenous alteplase at 2 other comprehensive stroke centers. Multivariable mixed-effects logistic regression models were performed assessing the association of tenecteplase with symptomatic intracranial hemorrhage and independent outcome (modified Rankin Scale score, 0-2) at day 90.
    Results: There were 165 patients treated with tenecteplase and 254 with alteplase. Age (75 versus 74 years), sex (56% versus 60% male), National Institutes of Health Stroke Scale scores (8 versus 10), median door-to-needle times (47 versus 48 minutes), or onset-to-needle time (129 versus 130 minutes) were similar between the groups. Symptomatic intracranial hemorrhage occurred in 3 (1.8% [95% CI, 0.4-5.3]) tenecteplase patients compared with 7 (2.7% [95% CI, 1.1-5.7]) alteplase patients (
    Conclusions: Routine use of tenecteplase for stroke thrombolysis was feasible and had comparable safety profile and outcome to alteplase.
    MeSH term(s) Administration, Intravenous ; Aged ; Aged, 80 and over ; Angioedema/epidemiology ; Angioedema/etiology ; Feasibility Studies ; Female ; Fibrinolytic Agents/adverse effects ; Fibrinolytic Agents/therapeutic use ; Humans ; Intracranial Hemorrhages/epidemiology ; Intracranial Hemorrhages/etiology ; Ischemic Stroke/drug therapy ; Male ; Middle Aged ; Retrospective Studies ; Tenecteplase/adverse effects ; Tenecteplase/therapeutic use ; Thrombolytic Therapy/adverse effects ; Time-to-Treatment ; Tissue Plasminogen Activator/adverse effects ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Tenecteplase (WGD229O42W)
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.030859
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

    Carbajosa, Guillermo / Malki, Karim / Lawless, Nathan / Wang, Hong / Ryder, John W / Wozniak, Eva / Wood, Kristie / Mein, Charles A / Dobson, Richard J B / Collier, David A / O'Neill, Michael J / Hodges, Angela K / Newhouse, Stephen J

    Neurobiology of aging

    2018  Volume 69, Page(s) 151–166

    Abstract: Rare heterozygous coding variants in the triggering receptor expressed in myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the loss ...

    Abstract Rare heterozygous coding variants in the triggering receptor expressed in myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the loss of Trem2 in mouse brain to better understand its role in disease using differential expression and coexpression network analysis of Trem2 knockout and wild-type mice. We generated RNA-Seq data from cortex and hippocampus sampled at 4 and 8 months. Using brain cell-type markers and ontology enrichment, we found subnetworks with cell type and/or functional identity. We primarily discovered changes in an endothelial gene-enriched subnetwork at 4 months, including a shift toward a more central role for the amyloid precursor protein gene, coupled with widespread disruption of other cell-type subnetworks, including a subnetwork with neuronal identity. We reveal an unexpected potential role of Trem2 in the homeostasis of endothelial cells that goes beyond its known functions as a microglial receptor and signaling hub, suggesting an underlying link between immune response and vascular disease in dementia.
    MeSH term(s) Animals ; Cerebral Cortex/metabolism ; Endothelial Cells/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Gene Regulatory Networks ; Hippocampus/metabolism ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice, Knockout ; Microglia/metabolism ; Neurons/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Sequence Analysis, RNA
    Chemical Substances Membrane Glycoproteins ; Receptors, Immunologic ; Trem2 protein, mouse
    Language English
    Publishing date 2018-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2018.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1685: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 10: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top