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  1. Article ; Online: The mast cell: the comfortable third in recent CRS research.

    Giancaspro, Rossana / Cassano, Michele / Gelardi, Matteo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 12, Page(s) 5665–5666

    MeSH term(s) Humans ; Mast Cells/metabolism ; Eosinophil Cationic Protein/metabolism ; Peroxidase/metabolism ; Sinusitis/metabolism ; Rhinitis/metabolism
    Chemical Substances Eosinophil Cationic Protein (EC 3.1.27.-) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2023-08-14
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08177-5
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  2. Article ; Online: Ferning in Nasal Mucus.

    Gelardi, Matteo / Cassano, Michele

    The New England journal of medicine

    2021  Volume 384, Issue 24, Page(s) 2331

    MeSH term(s) Crystallization ; Humans ; Mucus/chemistry ; Nasal Mucosa
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm2034441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nasal cytology and histology in CRSwNP: Two sides of the same coin.

    Gelardi, Matteo / Giancaspro, Rossana / Cassano, Michele / Ribatti, Domenico

    Frontiers in medicine

    2023  Volume 10, Page(s) 1143351

    Abstract: Knowledge of chronic rhinosinusitis with nasal polyps (CRSwNP) has increased rapidly over the past decade. However, the study of the histological features of nasal polyps has not gone hand in hand with the study of the inflammatory mechanisms underlying ... ...

    Abstract Knowledge of chronic rhinosinusitis with nasal polyps (CRSwNP) has increased rapidly over the past decade. However, the study of the histological features of nasal polyps has not gone hand in hand with the study of the inflammatory mechanisms underlying CRSwNP. Indeed, precisely because they are benign neoformations, nasal polyps have not attracted the attention of pathologists over the years. Nasal cytology has shown that CRSwNP, generally defined as a Type-2 disease, is characterized not only by eosinophilic but also mast cell inflammation and, in particular, the most severe forms of CRSwNP are precisely characterized by a mixed eosinophilic-mast cell inflammation. Interestingly, mast cells cannot be visualized by histology due to limitations in staining and magnification, and therefore are not commonly described in histological reports of nasal polyps. However, immunohistochemistry can highlight these latter cells and specifically this technique has recently demonstrated that mast cells are located in the lamina propria of almost all types of polyps and in the epithelial level of the most severe forms. Unfortunately, the latter technique is not commonly carried out in clinical practice by virtue of the high cost and time burden. On the other hand, nasal cytology is an easy-to-apply and economic diagnostic tool, commonly practiced in rhinological setting, which can effectively fill the gap between histology and immunohistochemistry, allowing to non-invasively establish the endotype of nasal polyps and to highlight all cytotypes, including mast cells, that cannot be visualized by the other two techniques. The recent demonstration of the close correlation between mast cell intraepithelial infiltrate and CRSwNP severity paves the way for new therapeutic possibilities aimed at reducing not only eosinophilic infiltration but also mast cell infiltration.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1143351
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  4. Article ; Online: The nose: The silent zone of scientific research.

    Giancaspro, Rossana / Landi, Massimo / Cassano, Michele / Gelardi, Matteo

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 129, Issue 5, Page(s) 646

    MeSH term(s) Humans ; Nose
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.07.031
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  5. Article ; Online: Chronic rhinosinusitis with nasal polyps recurrence: Not only eosinophils and neutrophils.

    Gelardi, Matteo / Giancaspro, Rossana / Cassano, Michele

    American journal of otolaryngology

    2022  Volume 43, Issue 3, Page(s) 103447

    MeSH term(s) Chronic Disease ; Eosinophils ; Humans ; Nasal Polyps/complications ; Nasal Polyps/surgery ; Neutrophils ; Rhinitis ; Sinusitis
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2022.103447
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  6. Article: Chronic rhinosinusitis with nasal polyposis: the role of personalized and integrated medicine.

    Ciprandi, Giorgio / Gelardi, Matteo

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2021  Volume 91, Issue 3

    Abstract: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common disorder. From a clinical and immunopathological point of view, different phenotypes and endotypes have been identified. As asthma is frequent comorbidity, biological agents for treating ... ...

    Abstract Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common disorder. From a clinical and immunopathological point of view, different phenotypes and endotypes have been identified. As asthma is frequent comorbidity, biological agents for treating CRSwNP associated with asthma may be an attractive strategy. Biological agents have several mechanisms, such as antagonizing IgE, interleukin (IL) 4, IL-5, and IL-13. However, a workup is mandatory, mainly concerning pheno-endotyping. In this regard, clinical cytological grading (CCG) has been proposed as a useful tool to manage patients with CRSwNP as it allows us to define clinical and immunopathological phenotypes able to identify the ideal candidate for biologics. In particular, the mixed cellular pattern, such as eosinophils and mast cells, could be sensitive to anti-IL-4 agents. There is still a need for well-established indications, criteria of responsiveness, duration, and safety. Moreover, personalized medicine could be opportunely integrated and/or alternated with intranasal corticosteroids to prevent relevant adverse events.
    MeSH term(s) Asthma/drug therapy ; Asthma/epidemiology ; Chronic Disease ; Humans ; Nasal Polyps/complications ; Nasal Polyps/drug therapy ; Nasal Polyps/epidemiology ; Rhinitis/drug therapy ; Rhinitis/epidemiology ; Sinusitis/drug therapy ; Sinusitis/epidemiology
    Language English
    Publishing date 2021-03-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2021.1769
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  7. Article ; Online: Dupilumab's impact on nasal citology: Real life experience after 1 year of treatment.

    Gelardi, Matteo / Giancaspro, Rossana / Quaranta, Vitaliano Nicola / La Gatta, Emanuel / Ruzza, Annamaria / Cassano, Michele

    American journal of otolaryngology

    2024  Volume 45, Issue 4, Page(s) 104275

    Abstract: Background: Biologic agents are considered a new revolutionized therapy for severe and recurrent forms of CRSwNP which disease burden is not sufficiently controlled by conservative and/or surgical treatments. Recent Research has focused on evaluating ... ...

    Abstract Background: Biologic agents are considered a new revolutionized therapy for severe and recurrent forms of CRSwNP which disease burden is not sufficiently controlled by conservative and/or surgical treatments. Recent Research has focused on evaluating their real-life efficacy in CRSwNP, as only limited reports on real-life data are available. However, in most studies, the response to treatment is evaluated in terms of improvement in Nasal Polyp Score (NPS) or in Sino-Nasal Outcome test (SNOT-22) scores. However, both criteria do not consider nasal immunophlogosis, which can be easily assessed by nasal cytology. The aim of our study was to evaluate changings in the nasal inflammatory infiltrate of CRSwNP patients treated with Dupilumab for 12 months.
    Methods: 27 patients suffering from severe CRSwNP treated with Dupilumab were recruited. Nasal cytology findings, NPS, SNOT-22, ACT scores and blood eosinophil count at T0 (before treatment) and at T1 (after 1 year of treatment) were compared.
    Results: After 1 year of biological therapy with Dupilumab, NPS, SNOT-22 and, among the 17 asthmatic patients, ACT scores improved significantly. At T1, a statistically significant percentage of patients showed negative citology. Moreover, a significant reduction in the mast cell-eosinophilic pattern and an increase of neutrophils and bacteria was reported.
    Conclusions: The response to treatment can be considered both in the case of negative nasal cytology and in the case of the appearance of neutrophils and bacteria. In this context, eosinophils, the specific target of biological therapies, play a crucial role in regulating tissue homeostasis and, consequently, the nasal immunophlogosis.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104275
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  8. Article ; Online: When nasal cytology detects acute lymphoblastic leukaemia: New diagnostical implications.

    Gelardi, Matteo / Giancaspro, Rossana / Pecoraro, Pietro / Cassano, Michele

    Cytopathology : official journal of the British Society for Clinical Cytology

    2022  Volume 33, Issue 4, Page(s) 544–546

    MeSH term(s) Acute Disease ; Cytodiagnosis ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
    Language English
    Publishing date 2022-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034190-0
    ISSN 1365-2303 ; 0956-5507 ; 1350-4037
    ISSN (online) 1365-2303
    ISSN 0956-5507 ; 1350-4037
    DOI 10.1111/cyt.13109
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    Zs.A 2926: Show issues Location:
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  9. Article ; Online: Nasal cytology identifies healthy and damaged nasal epithelial cells - Reply.

    Ciprandi, Giorgio / Gelardi, Matteo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 1, Page(s) 148–149

    MeSH term(s) Epithelial Cells ; Nasal Cavity ; Virus Diseases
    Language English
    Publishing date 2020-03-19
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i1.9264
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  10. Article ; Online: Nasal cytology and histology in CRSwNP

    Matteo Gelardi / Rossana Giancaspro / Michele Cassano / Domenico Ribatti

    Frontiers in Medicine, Vol

    Two sides of the same coin

    2023  Volume 10

    Abstract: Knowledge of chronic rhinosinusitis with nasal polyps (CRSwNP) has increased rapidly over the past decade. However, the study of the histological features of nasal polyps has not gone hand in hand with the study of the inflammatory mechanisms underlying ... ...

    Abstract Knowledge of chronic rhinosinusitis with nasal polyps (CRSwNP) has increased rapidly over the past decade. However, the study of the histological features of nasal polyps has not gone hand in hand with the study of the inflammatory mechanisms underlying CRSwNP. Indeed, precisely because they are benign neoformations, nasal polyps have not attracted the attention of pathologists over the years. Nasal cytology has shown that CRSwNP, generally defined as a Type-2 disease, is characterized not only by eosinophilic but also mast cell inflammation and, in particular, the most severe forms of CRSwNP are precisely characterized by a mixed eosinophilic-mast cell inflammation. Interestingly, mast cells cannot be visualized by histology due to limitations in staining and magnification, and therefore are not commonly described in histological reports of nasal polyps. However, immunohistochemistry can highlight these latter cells and specifically this technique has recently demonstrated that mast cells are located in the lamina propria of almost all types of polyps and in the epithelial level of the most severe forms. Unfortunately, the latter technique is not commonly carried out in clinical practice by virtue of the high cost and time burden. On the other hand, nasal cytology is an easy-to-apply and economic diagnostic tool, commonly practiced in rhinological setting, which can effectively fill the gap between histology and immunohistochemistry, allowing to non-invasively establish the endotype of nasal polyps and to highlight all cytotypes, including mast cells, that cannot be visualized by the other two techniques. The recent demonstration of the close correlation between mast cell intraepithelial infiltrate and CRSwNP severity paves the way for new therapeutic possibilities aimed at reducing not only eosinophilic infiltration but also mast cell infiltration.
    Keywords CRSwNP ; nasal cytology ; histology ; mast cells ; eosinophils ; Medicine (General) ; R5-920
    Subject code 571
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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