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  1. Article ; Online: COVID-19 and stroke: Red flags for secondary movement disorders?

    Victorino, Daniella Balduino / Guimarães-Marques, Marcia / Nejm, Mariana / Scorza, Fulvio Alexandre / Scorza, Carla Alessandra

    eNeurologicalSci

    2020  Volume 21, Page(s) 100289

    Abstract: Hypercoagulability may predispose COVID-19 patients to thromboembolic complications.•Movement disorders may develop as complications of vascular events and infections.•Health professionals should be vigilant for abnormal movements in COVID-19 patients. ...

    Abstract •Hypercoagulability may predispose COVID-19 patients to thromboembolic complications.•Movement disorders may develop as complications of vascular events and infections.•Health professionals should be vigilant for abnormal movements in COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-11-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2838045-9
    ISSN 2405-6502 ; 2405-6502
    ISSN (online) 2405-6502
    ISSN 2405-6502
    DOI 10.1016/j.ensci.2020.100289
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  2. Article ; Online: COVID-19 and Parkinson's Disease: Are We Dealing with Short-term Impacts or Something Worse?

    Victorino, Daniella Balduino / Guimarães-Marques, Marcia / Nejm, Mariana / Scorza, Fulvio Alexandre / Scorza, Carla Alessandra

    Journal of Parkinson's disease

    2020  Volume 10, Issue 3, Page(s) 899–902

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Memory, Short-Term ; Pandemics ; Parkinson Disease/epidemiology ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-202073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6964: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: "Mozart effect" for Parkinson's disease: music as medicine.

    Victorino, Daniella Balduino / Scorza, Carla Alessandra / Fiorini, Ana Claudia / Finsterer, Josef / Scorza, Fulvio Alexandre

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2020  Volume 42, Issue 1, Page(s) 319–320

    MeSH term(s) Auditory Perception ; Gait ; Humans ; Medicine ; Music ; Parkinson Disease/therapy
    Language English
    Publishing date 2020-06-30
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-020-04537-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
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  4. Article: Repurposing GLP-1 Receptor Agonists for Parkinson's Disease: Current Evidence and Future Opportunities.

    Victorino, Daniella Balduino / Nejm, Mariana / Guimarães-Marques, Marcia / Scorza, Fulvio Alexandre / Scorza, Carla Alessandra

    Pharmaceutical medicine

    2021  Volume 35, Issue 1, Page(s) 11–19

    Abstract: The global burden of chronic disorders such as Parkinson's disease (PD) has rapidly increased over recent decades. Despite an increasing understanding of PD pathophysiology, there are no effective therapies capable of stopping or slowing the progression ... ...

    Abstract The global burden of chronic disorders such as Parkinson's disease (PD) has rapidly increased over recent decades. Despite an increasing understanding of PD pathophysiology, there are no effective therapies capable of stopping or slowing the progression of this neurological condition. It has been suggested that type 2 diabetes mellitus (T2DM) may be a risk factor for PD and comorbid T2DM may worsen PD symptoms, as well as accelerate neurodegeneration. In fact, the similar pathological mechanisms shared by PD and T2DM have inspired several studies on the therapeutic potential of T2DM drugs against PD, among which glucagon-like peptide-1 receptor (GLP-1R) agonists are promising candidates. Here, we highlight the mechanisms linking T2DM and PD, as well as the links between insulin resistance (IR) and PD patients' risk of developing cognitive deficits. We also briefly review the effects of GLP-1R agonists on PD and discuss how the successful use of these substances in preclinical models of PD has paved the way for PD clinical trials. We further discuss how recent evidence on the beneficial effects of dulaglutide on cognitive function of T2DM patients may have important implications for PD drug repurposing.
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Drug Repositioning ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents/therapeutic use ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Parkinson Disease/epidemiology ; Pharmaceutical Preparations
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-01-07
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415165-8
    ISSN 1179-1993 ; 1178-2595
    ISSN (online) 1179-1993
    ISSN 1178-2595
    DOI 10.1007/s40290-020-00374-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2034: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Pharmacological Signature and Target Specificity of Inhibitory Circuits Formed by Martinotti Cells in the Mouse Barrel Cortex.

    Donato, Cristina / Balduino Victorino, Daniella / Cabezas, Carolina / Aguirre, Andrea / Lourenço, Joana / Potier, Marie-Claude / Zorrilla de San Martin, Javier / Bacci, Alberto

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 43, Issue 1, Page(s) 14–27

    Abstract: In the neocortex, fast synaptic inhibition orchestrates both spontaneous and sensory-evoked activity. GABAergic interneurons (INs) inhibit pyramidal neurons (PNs) directly, modulating their output activity and thus contributing to balance cortical ... ...

    Abstract In the neocortex, fast synaptic inhibition orchestrates both spontaneous and sensory-evoked activity. GABAergic interneurons (INs) inhibit pyramidal neurons (PNs) directly, modulating their output activity and thus contributing to balance cortical networks. Moreover, several IN subtypes also inhibit other INs, forming specific disinhibitory circuits, which play crucial roles in several cognitive functions. Here, we studied a subpopulation of somatostatin-positive INs, the Martinotti cells (MCs) in layer 2/3 of the mouse barrel cortex (both sexes). MCs inhibit the distal portion of PN apical dendrites, thus controlling dendrite electrogenesis and synaptic integration. Yet, it is poorly understood whether MCs inhibit other elements of the cortical circuits, and the connectivity properties with non-PN targets are unknown. We found that MCs have a strong preference for PN dendrites, but they also considerably connect with parvalbumin-positive, vasoactive intestinal peptide-expressing, and layer 1 (L1) INs. Remarkably, GABAergic synapses from MCs exhibited clear cell type-specific short-term plasticity. Moreover, whereas the biophysical properties of MC-PN synapses were consistent with distal dendritic inhibition, MC-IN synapses exhibited characteristics of fast perisomatic inhibition. Finally, MC-PN connections used α5-containing GABA
    MeSH term(s) Female ; Male ; Animals ; Vasoactive Intestinal Peptide/metabolism ; Parvalbumins/metabolism ; Neurons ; Pyramidal Cells/physiology ; Interneurons/physiology ; Somatostatin/metabolism ; Synapses/physiology ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Vasoactive Intestinal Peptide (37221-79-7) ; Parvalbumins ; Somatostatin (51110-01-1) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1661-21.2022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: COVID-19 and stroke

    Victorino, Daniella Balduino / Guimarães-Marques, Marcia / Nejm, Mariana / Scorza, Fulvio Alexandre / Scorza, Carla Alessandra

    eNeurologicalSci

    red flags for secondary movement disorders?

    2020  , Page(s) 100289

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2838045-9
    ISSN 2405-6502
    ISSN 2405-6502
    DOI 10.1016/j.ensci.2020.100289
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test.

    Bocca Nejm, Mariana / Victorino, Daniella Balduino / Guimarães-Marques, Marcia Jonathas / Scorza, Carla Alessandra / Finsterer, Josef / Scorza, Fulvio Alexandre / Cysneiros, Roberta Monterazzo

    Epileptic disorders : international epilepsy journal with videotape

    2021  Volume 23, Issue 3, Page(s) 476–484

    Abstract: Objective: Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy.: Methods: We investigated the ... ...

    Abstract Objective: Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy.
    Methods: We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test.
    Results: Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials.
    Significance: Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.
    MeSH term(s) Animals ; Dietary Supplements ; Epilepsy ; Epilepsy, Temporal Lobe/chemically induced ; Epilepsy, Temporal Lobe/drug therapy ; Fish Oils/pharmacology ; Morris Water Maze Test ; Pilocarpine/toxicity ; Rats ; Spatial Memory
    Chemical Substances Fish Oils ; Pilocarpine (01MI4Q9DI3)
    Language English
    Publishing date 2021-06-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1684/epd.2021.1289
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5740: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 252: Show issues
    Zs.MN 11: Show issues

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  8. Article ; Online: Domperidone in Parkinson's disease: a valuable controversy, but unnecessary panic.

    Victorino, Daniella Balduino / Nejm, Mariana Bocca / Guimarães-Marques, Marcia Jonathas / Scorza, Carla Alessandra / Fiorini, Ana Claudia / Finsterer, Josef / Scorza, Fulvio Alexandre

    Family practice

    2020  Volume 37, Issue 5, Page(s) 723–724

    MeSH term(s) Aged ; Cohort Studies ; Domperidone ; Humans ; Parkinson Disease/drug therapy ; Potentially Inappropriate Medication List
    Chemical Substances Domperidone (5587267Z69)
    Language English
    Publishing date 2020-05-29
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605939-9
    ISSN 1460-2229 ; 0263-2136
    ISSN (online) 1460-2229
    ISSN 0263-2136
    DOI 10.1093/fampra/cmaa054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2021: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.

    Postic, Guillaume / Solarz, Jean / Loubière, Cécile / Kandiah, Janany / Sawmynaden, Jaysen / Adam, Frederic / Vilaire, Marie / Léger, Thibaut / Camadro, Jean-Michel / Victorino, Daniella Balduino / Potier, Marie-Claude / Bun, Eric / Moroy, Gautier / Kauskot, Alexandre / Christophe, Olivier / Janel, Nathalie

    Journal of cellular and molecular medicine

    2023  Volume 27, Issue 15, Page(s) 2228–2238

    Abstract: Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate thrombocytopenia. In case of Down syndrome, thrombocytopenia is not associated with bleeding, and it ... ...

    Abstract Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate thrombocytopenia. In case of Down syndrome, thrombocytopenia is not associated with bleeding, and it remains poorly characterized regarding molecular mechanisms. We investigated the effects of overexpression of Dyrk1A, an important factor contributing to some major Down syndrome phenotypes, on platelet number and bleeding in mice. Mice overexpressing Dyrk1A have a decrease in platelet number by 20%. However, bleeding time was found to be reduced by 50%. The thrombocytopenia and the decreased bleeding time observed were not associated to an abnormal platelet receptors expression, to a defect of platelet activation by ADP, thrombin or convulxin, to the presence of activated platelets in the circulation or to an abnormal half-life of the platelets. To propose molecular mechanisms explaining this discrepancy, we performed a network analysis of Dyrk1A interactome and demonstrated that Dyrk1A, fibronectin and fibrinogen interact indirectly through two distinct clusters of proteins. Moreover, in mice overexpressing Dyrk1A, increased plasma fibronectin and fibrinogen levels were found, linked to an increase of the hepatic fibrinogen production. Our results indicate that overexpression of Dyrk1A in mice induces decreased bleeding consistent with increased plasma fibronectin and fibrinogen levels, revealing a new role of Dyrk1A depending on its indirect interaction with these two proteins.
    MeSH term(s) Animals ; Humans ; Mice ; Blood Platelets/metabolism ; Down Syndrome/metabolism ; Fibrinogen/metabolism ; Fibronectins/metabolism ; Hemorrhage/metabolism ; Thrombocytopenia/metabolism ; Dyrk Kinases
    Chemical Substances Fibrinogen (9001-32-5) ; Fibronectins
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: COVID-19 and Parkinson's Disease: Are We Dealing with Short-term Impacts or Something Worse?

    Victorino, Daniella Balduino / Guimarães-Marques, Marcia / Nejm, Mariana / Scorza, Fulvio Alexandre / Scorza, Carla Alessandra

    Journal of Parkinson's disease (Online)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32390643
    Database COVID19

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