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  1. Article ; Online: Regulating the Regulators: Epigenetic Modulation of Regulatory T Cells in Pulmonary Hypertension.

    Farha, Samar / Aldred, Micheala A

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 8, Page(s) 834–836

    MeSH term(s) Humans ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/pathology ; Pulmonary Arterial Hypertension ; T-Lymphocytes, Regulatory ; Familial Primary Pulmonary Hypertension ; Epigenesis, Genetic
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1456ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 and pulmonary hypertension.

    Farha, Samar

    Cleveland Clinic journal of medicine

    2020  

    Abstract: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by pulmonary arterial remodeling and vasoconstriction leading to elevated pulmonary artery pressure and, ultimately, right heart failure. So far, few cases of COVID-19 disease in ... ...

    Abstract Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by pulmonary arterial remodeling and vasoconstriction leading to elevated pulmonary artery pressure and, ultimately, right heart failure. So far, few cases of COVID-19 disease in patients with PH have been reported. Caution is warranted in interpreting this observation as data are evolving and several factors may influence the number of reported cases of PH and COVID-19. Social distancing and quarantine could play a role, especially for patients with chronic diseases who might be more vigilant of their potential for respiratory infection. In addition, PH is a rare disease, and because testing is not universal, we could be underestimating the number of cases. Other hypothetical factors to consider are the underlying pathophysiology of PH and the medications used to treat PH and their implications in COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87a.ccc021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: COVID-19 and pulmonary hypertension

    Farha, Samar

    Clevel. clin. j. med

    Abstract: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by pulmonary arterial remodeling and vasoconstriction leading to elevated pulmonary artery pressure and, ultimately, right heart failure. So far, few cases of COVID-19 disease in ... ...

    Abstract Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by pulmonary arterial remodeling and vasoconstriction leading to elevated pulmonary artery pressure and, ultimately, right heart failure. So far, few cases of COVID-19 disease in patients with PH have been reported. Caution is warranted in interpreting this observation as data are evolving and several factors may influence the number of reported cases of PH and COVID-19. Social distancing and quarantine could play a role, especially for patients with chronic diseases who might be more vigilant of their potential for respiratory infection. In addition, PH is a rare disease, and because testing is not universal, we could be underestimating the number of cases. Other hypothetical factors to consider are the underlying pathophysiology of PH and the medications used to treat PH and their implications in COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #248833
    Database COVID19

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  4. Article ; Online: Hematopoietic stem cells and extramedullary hematopoiesis in the lungs.

    Reichard, Andrew / Wanner, Nicholas / Farha, Samar / Asosingh, Kewal

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2023  Volume 103, Issue 12, Page(s) 967–977

    Abstract: Hematopoietic stem cells are key players in hematopoiesis as the body maintains a physiologic steady state, and the signaling pathways and control mechanisms of these dynamic cells are implicated in processes from inflammation to cancer. Although the ... ...

    Abstract Hematopoietic stem cells are key players in hematopoiesis as the body maintains a physiologic steady state, and the signaling pathways and control mechanisms of these dynamic cells are implicated in processes from inflammation to cancer. Although the bone marrow is commonly regarded as the site of hematopoiesis and hematopoietic stem cell residence, these cells also circulate in the blood and reside in extramedullary tissues, including the lungs. Flow cytometry is an invaluable tool in evaluating hematopoietic stem cells, revealing their phenotypes and relative abundances in both healthy and diseased states. This review outlines current protocols and cell markers used in flow cytometric analysis of hematopoietic stem and progenitor cell populations. Specific niches within the bone marrow are discussed, as are metabolic processes that contribute to stem cell self-renewal and differentiation, as well as the role of hematopoietic stem cells outside of the bone marrow at physiologic steady state. Finally, pulmonary extramedullary hematopoiesis and its associated disease states are outlined. Hematopoiesis in the lungs is a new and emerging concept, and discovering ways in which the study of lung-resident hematopoietic stem cells can be translated from murine models to patients will impact clinical treatment.
    MeSH term(s) Humans ; Animals ; Mice ; Hematopoiesis, Extramedullary ; Hematopoietic Stem Cells/metabolism ; Hematopoiesis ; Bone Marrow/metabolism ; Lung
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24804
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  5. Article: Corticosteroid treatment for persistent pulmonary infiltrates following COVID-19 infection: Clearing the fog?

    Ntiamoah, Prince / Biehl, Michelle / Ruesch, Victoria / Mehta, Atul C / Farha, Samar

    Annals of thoracic medicine

    2024  Volume 19, Issue 1, Page(s) 74–80

    Abstract: Background: Systemic corticosteroids have been shown to improve outcomes in severe coronavirus disease 2019 (COVID-19) pneumonia; however, their role in post-COVID-19 persistent lung abnormalities is not well defined. Here, we describe our experience ... ...

    Abstract Background: Systemic corticosteroids have been shown to improve outcomes in severe coronavirus disease 2019 (COVID-19) pneumonia; however, their role in post-COVID-19 persistent lung abnormalities is not well defined. Here, we describe our experience with corticosteroids in patients with persistent lung infiltrates following COVID-19 infection.
    Research question: What is the efficacy of systemic corticosteroids in improving lung function and radiological abnormalities in patients following COVID-19 pneumonia?
    Study design and methods: This is a single-center retrospective study evaluating patients with persistent respiratory symptoms and abnormal chest computed tomography findings. Patients were divided into two groups based on treatment with corticosteroids: "steroid group" and "nonsteroid group." Clinical data were collected from the electronic medical records.
    Results: Between March 2020 and December 2021, 227 patients were seen in the post-COVID-19 pulmonary clinic, of which 75 were included in this study. The mean age was 56 years, 63% were female, and 75% were white. The main physiologic deficit was reduced Diffusing capacity of the Lungs for Carbon Monoxide (DLCO) at 72% (±22). On chest imaging, the most common findings were ground-glass opacities (91%) and consolidation (29%). Thirty patients received corticosteroid (steroid group) and 45 did not (nonsteroid group). Patients treated with corticosteroids had lower DLCO (DLCO [%]: steroid group 63 ± 17, nonsteroid group 78 ± 23;
    Conclusion: The use of systemic corticosteroids in patients with persistent respiratory symptoms and radiological abnormalities post-COVID-19 was associated with significant improvement in pulmonary function testing and imaging. Prospective studies are needed to confirm whether these findings are the effect of corticosteroid therapy or disease evolution over time.
    Language English
    Publishing date 2024-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/atm.atm_121_23
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  6. Article ; Online: COVID-19 and Pulmonary Arterial Hypertension: Early Data and Many Questions.

    Farha, Samar / Heresi, Gustavo A

    Annals of the American Thoracic Society

    2020  Volume 17, Issue 12, Page(s) 1528–1530

    MeSH term(s) COVID-19 ; Humans ; Hypertension, Pulmonary ; Incidence ; Pandemics ; Patients ; Pulmonary Arterial Hypertension ; SARS-CoV-2 ; Surveys and Questionnaires
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202008-1014ED
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  7. Article ; Online: A qualitative assessment of anabolic-androgenic steroid use among gym users in Jordan: motives, perception, and safety.

    Izzat, Nawal / Abu-Farha, Rana / Harahsheh, Mea'ad M / Thiab, Samar

    International journal of legal medicine

    2023  Volume 137, Issue 5, Page(s) 1421–1430

    Abstract: Background: Over the years, the use of anabolic-androgenic steroids (AAS) has become widespread among athletes and bodybuilders. The prevalence of their use has been estimated at around 20 to 50% globally. Unfortunately, many athletes do not have the ... ...

    Abstract Background: Over the years, the use of anabolic-androgenic steroids (AAS) has become widespread among athletes and bodybuilders. The prevalence of their use has been estimated at around 20 to 50% globally. Unfortunately, many athletes do not have the proper knowledge about the effects of these banned substances Thus, this study aims to qualitatively assess Jordanian gym users' AAS intentions, perceptions, and safety.
    Methods: Twenty male Jordanian anabolic steroid users were interviewed using in-depth interviews as part of a qualitative study evaluating the motivations, perceptions, and safety of AAS among gym users.
    Results: The findings of this study indicate that the desire to compete in bodybuilding contests was the primary motivation for participants to use AAS. The study participants mentioned using a combination of oral and injectable medications. Gym coaches and trainers were also identified as an essential source of information for AAS use. A very limited number of AAS users were getting their information from healthcare providers, and most of them have experienced some of these medications side effects but are still willing to continue the use of AAS to get what they need in terms of their physical appearance or for winning competitions.
    Conclusion: There is an urgent need for structured awareness campaigns targeting gyms and fitness clubs' members to increase their knowledge about the side effects and health risks associated with the use of AAS. In addition, sports governing bodies should have stricter measures to tackle this problem and discourage athletes from using such products.
    MeSH term(s) Humans ; Male ; Motivation ; Jordan ; Anabolic Androgenic Steroids ; Anabolic Agents/adverse effects ; Testosterone Congeners/adverse effects ; Exercise ; Steroids/pharmacology ; Perception
    Chemical Substances Anabolic Androgenic Steroids ; Anabolic Agents ; Testosterone Congeners ; Steroids
    Language English
    Publishing date 2023-06-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-023-03046-6
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  8. Article: An evaluation of pharmacists' general attitudes, knowledge, and phobias regarding medications that include corticosteroids: a cross-sectional study.

    Barakat, Muna / Thiab, Samar / Farha, Rana Abu / Alshweiki, Anas O / Thaher, Roa'a / Alsughaier, Asem / Malaeb, Diana

    Journal of pharmaceutical health care and sciences

    2024  Volume 10, Issue 1, Page(s) 8

    Abstract: Background: Corticosteroid-containing medications are widely accessible in various forms, including topical, injectable, and inhaled formulations. Due to uncertain safety profiles, healthcare providers, including pharmacists, often express apprehension ... ...

    Abstract Background: Corticosteroid-containing medications are widely accessible in various forms, including topical, injectable, and inhaled formulations. Due to uncertain safety profiles, healthcare providers, including pharmacists, often express apprehension when dispensing these drugs. This cross-sectional study assesses the knowledge, attitudes, and phobia of Jordanian pharmacists regarding corticosteroid-containing medications.
    Methods: Conducted through a self-administered online questionnaire.
    Results: the study reveals that dermatological conditions and respiratory disorders are the primary indications for prescribing corticosteroid-containing drugs. The most reported side effects among pharmacists' patients include increased appetite, diabetes, and skin thinning. Pharmacists generally exhibit acceptable knowledge, with a median score of 9.0 out of 11.0 (IQR = 3.0). Over two-thirds of pharmacists (69.9%) achieve a high knowledge score (Bloom's cut-off point ≥ 8.8). However, only 55.7% are aware that corticosteroids may induce mood changes. High phobia scores, particularly concerning increased blood pressure and osteoporosis risks, indicate pharmacist reservations in corticosteroid dispensing. Interestingly, pharmacists in rural areas display lower knowledge scores, while those working outside community pharmacies exhibit lower phobia scores compared to their counterparts in urban areas and community pharmacies, respectively.
    Conclusion: Despite generally good knowledge levels, the study underscores high phobia scores among Jordanian pharmacists regarding corticosteroid dispensing, particularly due to concerns about blood pressure elevation and osteoporosis risks. This suggests a potential need for targeted educational interventions and support systems to enhance pharmacist confidence and optimize corticosteroid usage while minimizing associated risks.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809913-8
    ISSN 2055-0294
    ISSN 2055-0294
    DOI 10.1186/s40780-024-00329-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In reply: Rapidly progressive pleural effusion.

    Zoumot, Zaid / Farha, Samar / Wahla, Ali

    Cleveland Clinic journal of medicine

    2019  Volume 86, Issue 4, Page(s) 236

    MeSH term(s) Humans ; Pleural Effusion
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.86c.04002
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  10. Article ; Online: Rapidly progressive pleural effusion.

    Zoumot, Zaid / Wahla, Ali S / Farha, Samar

    Cleveland Clinic journal of medicine

    2019  Volume 86, Issue 1, Page(s) 21–27

    MeSH term(s) Adult ; Disease Progression ; Humans ; Male ; Pleural Effusion/diagnosis ; Pleural Effusion/physiopathology
    Language English
    Publishing date 2019-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.86a.18067
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