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  1. Article ; Online: Extinguishing the fire in sickle cell anemia.

    Novelli, Enrico M

    Blood

    2022  Volume 139, Issue 17, Page(s) 2578–2580

    MeSH term(s) Anemia, Sickle Cell/complications ; Antibodies, Monoclonal, Humanized ; Child ; Double-Blind Method ; Humans ; Young Adult
    Chemical Substances Antibodies, Monoclonal, Humanized ; canakinumab (37CQ2C7X93)
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022015910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  2. Article: Warm autoimmune hemolytic anemia and hemophagocytic lymphohistiocytosis/macrophage activation syndrome occurring after COVID19 infection and administration of Casirivimab + Imdevimab (COVID19 monoclonal antibody).

    Swartz, Andrew W / Novelli, Enrico M

    Clinical case reports

    2024  Volume 12, Issue 2, Page(s) e8426

    Abstract: Warm Autoimmune Hemolytic Anemia (WAHA) is the most common form of autoimmune hemolysis and there is a growing body of evidence of an association between SARS-CoV-2 infection, WAHA and a hyperinflammatory state, including hemophagocytic ... ...

    Abstract Warm Autoimmune Hemolytic Anemia (WAHA) is the most common form of autoimmune hemolysis and there is a growing body of evidence of an association between SARS-CoV-2 infection, WAHA and a hyperinflammatory state, including hemophagocytic lymphohistiocytosis/macrophage activation syndrome. However, there is no literature to date of WAHA or hyperinflammatory state following administration of anti-SARS-CoV-2 monoclonal antibody treatment. This report documents a case of a patient with history of WAHA who developed brisk hemolysis and a hyperinflammatory state consistent with hemophagocytic lymphohistiocytosis/macrophage activation syndrome after COVID-19 infection and treatment with an anti-SARS-CoV-2 monoclonal antibody. He was successfully treated with multimodal treatment involving steroids, intravenous immunoglobulins, rituximab, anakinra, and vincristine with resolution of the hemolysis.
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: It's high time to turn the spotlight on HbSC disease.

    Oluwole, Olubusola / Novelli, Enrico M

    Blood advances

    2023  Volume 7, Issue 13, Page(s) 3320–3322

    MeSH term(s) Adult ; Humans ; Hydroxyurea
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023009993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7153: Show issues Location:
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  4. Article ; Online: Is CBD ready for prime time in sickle cell disease?

    Curtis, Susanna A / Novelli, Enrico M

    Blood

    2023  Volume 141, Issue 2, Page(s) 132–133

    MeSH term(s) Animals ; Mice ; Cannabidiol ; Hyperalgesia ; Anemia, Sickle Cell
    Chemical Substances Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 and SCA: an old friend comes to the rescue.

    Novelli, Enrico M

    Blood

    2020  Volume 135, Issue 22, Page(s) 1925–1926

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections ; Friends ; Humans ; Hydroxyurea ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Stroke
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020006442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 364: Show issues

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  7. Article ; Online: Editorial commentary: Sickle cell disease: Diagnosing the heart of the matter.

    Caughey, Melissa C / Novelli, Enrico M

    Trends in cardiovascular medicine

    2020  Volume 31, Issue 3, Page(s) 194–195

    MeSH term(s) Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/genetics ; Heart ; Humans
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2020.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3419: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Astrocytic mitochondrial frataxin-A promising target for ischemic brain injury.

    Hazra, Rimi / Novelli, Enrico M / Hu, Xiaoming

    CNS neuroscience & therapeutics

    2022  Volume 29, Issue 3, Page(s) 783–788

    Abstract: In the ischemic brain, hypoxia leads to mitochondrial dysfunction, insufficient energy production, and astrocyte activation. Yet, most studies investigating mitochondrial dysfunction in cerebral ischemia have focused exclusively on neurons. This review ... ...

    Abstract In the ischemic brain, hypoxia leads to mitochondrial dysfunction, insufficient energy production, and astrocyte activation. Yet, most studies investigating mitochondrial dysfunction in cerebral ischemia have focused exclusively on neurons. This review will highlight the importance of the morphological, molecular, and functional heterogeneity of astrocytes in their role in brain injuries and explore how activated astrocytes exhibit calcium imbalance, reactive oxygen species overproduction, and apoptosis. In addition, special focus will be given to the role of the mitochondrial protein frataxin in activated astrocytes during ischemia and its putative role in the pharmacological management of cerebral ischemia.
    MeSH term(s) Humans ; Astrocytes/metabolism ; Brain Injuries/drug therapy ; Brain Injuries/metabolism ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Mitochondria/physiology ; Mitochondrial Proteins/drug effects ; Mitochondrial Proteins/metabolism ; Frataxin
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.14068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4537: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Molecular mechanisms of hepatic dysfunction in sickle cell disease: lessons from Townes mouse model.

    Pradhan-Sundd, Tirthadipa / Kato, Gregory J / Novelli, Enrico M

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 2, Page(s) C494–C504

    Abstract: Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects ∼100,000 Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile inflammation, and hemolysis are the major pathophysiological pathways ... ...

    Abstract Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects ∼100,000 Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile inflammation, and hemolysis are the major pathophysiological pathways leading to liver injury in SCD. Although hepatic dysfunction affects up to 10%-40% of patients with SCD, therapeutic approaches to prevent liver injury in SCD are not known, and the molecular mechanisms promoting progressive liver injury in SCD remain poorly understood. Animal models have been beneficial in bridging the gap between preclinical and translational research in SCD. Recent advances in methodology have allowed the development of several humanized animal models to address various aspects of SCD-related liver diseases. This review provides an overview of current knowledge of the molecular mechanisms and potential therapeutic options of SCD-associated liver dysfunction using the Townes mouse model.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/drug therapy ; Anemia, Sickle Cell/genetics ; Animals ; Disease Models, Animal ; Erythrocytes/metabolism ; Hemolysis ; Humans ; Liver Diseases/genetics ; Mice
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00175.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  10. Article ; Online: Comprehensive assessment of cognitive function in adults with moderate and severe sickle cell disease.

    Portela, Gerard T / Butters, Meryl A / Brooks, Maria M / Candra, Leticia / Rosano, Caterina / Novelli, Enrico M

    American journal of hematology

    2022  Volume 97, Issue 9, Page(s) E344–E346

    MeSH term(s) Adult ; Anemia, Sickle Cell ; Cognition ; Humans
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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