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  1. Article ; Online: COVID-19 and SIC (!).

    Nevzorov, Ilja / Tulamo, Riikka / Albäck, Anders / Lassila, Riitta

    Journal of vascular surgery

    2020  Volume 72, Issue 3, Page(s) 1148–1150

    MeSH term(s) Anticoagulants/administration & dosage ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/drug therapy ; Disseminated Intravascular Coagulation/etiology ; Disseminated Intravascular Coagulation/mortality ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Prognosis ; Prothrombin Time ; SARS-CoV-2 ; Sepsis/blood ; Sepsis/complications ; Sepsis/immunology ; Sepsis/virology ; Severity of Illness Index
    Chemical Substances Anticoagulants ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Letter
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2020.05.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1933: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: COVID-19 and SIC (!)

    Nevzorov, Ilja / Tulamo, Riikka / Albäck, Anders / Lassila, Riitta

    Journal of Vascular Surgery

    2020  Volume 72, Issue 3, Page(s) 1148–1150

    Keywords Surgery ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2020.05.047
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1933: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Article ; Online: Myosin-1C uses a novel phosphoinositide-dependent pathway for nuclear localization.

    Nevzorov, Ilja / Sidorenko, Ekaterina / Wang, Weihuan / Zhao, Hongxia / Vartiainen, Maria K

    EMBO reports

    2018  Volume 19, Issue 2, Page(s) 290–304

    Abstract: Accurate control of macromolecule transport between nucleus and cytoplasm underlines several essential biological processes, including gene expression. According to the canonical model, nuclear import of soluble proteins is based on nuclear localization ... ...

    Abstract Accurate control of macromolecule transport between nucleus and cytoplasm underlines several essential biological processes, including gene expression. According to the canonical model, nuclear import of soluble proteins is based on nuclear localization signals and transport factors. We challenge this view by showing that nuclear localization of the actin-dependent motor protein Myosin-1C (Myo1C) resembles the diffusion-retention mechanism utilized by inner nuclear membrane proteins. We show that Myo1C constantly shuttles in and out of the nucleus and that its nuclear localization does not require soluble factors, but is dependent on phosphoinositide binding. Nuclear import of Myo1C is preceded by its interaction with the endoplasmic reticulum, and phosphoinositide binding is specifically required for nuclear import, but not nuclear retention, of Myo1C. Our results therefore demonstrate, for the first time, that membrane association and binding to nuclear partners is sufficient to drive nuclear localization of also soluble proteins, opening new perspectives to evolution of cellular protein sorting mechanisms.
    MeSH term(s) Active Transport, Cell Nucleus ; Animals ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Cytoplasm/metabolism ; Gene Expression ; Genes, Reporter ; Humans ; Immunohistochemistry ; Mice ; Myosin Type I/chemistry ; Myosin Type I/genetics ; Myosin Type I/metabolism ; Nuclear Localization Signals/chemistry ; Phosphatidylinositols/metabolism ; Protein Binding ; Recombinant Fusion Proteins ; Signal Transduction
    Chemical Substances Chromatin ; Nuclear Localization Signals ; Phosphatidylinositols ; Recombinant Fusion Proteins ; Myosin Type I (EC 3.6.1.-)
    Language English
    Publishing date 2018-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201744296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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