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  1. Article ; Online: COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes.

    Muyayalo, Kahinho P / Huang, Dong-Hui / Zhao, Si-Jia / Xie, Ting / Mor, Gil / Liao, Ai-Hua

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2020  Volume 84, Issue 5, Page(s) e13304

    Abstract: Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and ... ...

    Abstract Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and even mortality due to their susceptibility to respiratory pathogens and their particular immunologic state. Several studies assessing SARS-CoV-2 infection during pregnancy reported adverse pregnancy outcomes in patients with severe conditions, including spontaneous abortion, preterm labor, fetal distress, cesarean section, preterm birth, neonatal asphyxia, neonatal pneumonia, stillbirth, and neonatal death. However, whether these complications are causally related to SARS-CoV-2 infection is not clear. Here, we reviewed the scientific evidence supporting the contributing role of Treg/Th17 cell imbalance in the uncontrolled systemic inflammation characterizing severe cases of COVID-19. Based on the recognized harmful effects of these CD4
    MeSH term(s) COVID-19/immunology ; COVID-19/transmission ; Female ; Humans ; Infectious Disease Transmission, Vertical ; Pandemics ; Pregnancy/immunology ; Pregnancy Complications, Infectious/immunology ; Pregnancy Outcome ; SARS-CoV-2/physiology ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
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  2. Article ; Online: Modulatory effect of intravenous immunoglobulin on Th17/Treg cell balance in women with unexplained recurrent spontaneous abortion.

    Muyayalo, Kahinho P / Li, Zhi-Hui / Mor, Gil / Liao, Ai-Hua

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2018  Volume 80, Issue 4, Page(s) e13018

    Abstract: Recurrent spontaneous abortion (RSA) is a growing problem worldwide. In a majority of cases, the cause remains unknown but there is increasing evidence that immunologic factors play an important role. Intravenous immunoglobulin (IVIg) therapy has been ... ...

    Abstract Recurrent spontaneous abortion (RSA) is a growing problem worldwide. In a majority of cases, the cause remains unknown but there is increasing evidence that immunologic factors play an important role. Intravenous immunoglobulin (IVIg) therapy has been proposed to have immune modulatory effects and therefore been applicable for the treatment of patients with RSA. Although its efficacy is still controversial, several recent studies suggest that IVIg treatment may improve pregnancy outcomes. CD4
    MeSH term(s) Abortion, Habitual/immunology ; Abortion, Habitual/therapy ; Adaptive Immunity/immunology ; CD4 Lymphocyte Count ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Immunotherapy/methods ; Pregnancy ; Pregnancy Outcome ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology
    Chemical Substances Immunoglobulins, Intravenous ; Immunologic Factors
    Language English
    Publishing date 2018-07-09
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: COVID‐19 and Treg/Th17 imbalance

    Muyayalo, Kahinho P. / Huang, Dong‐Hui / Zhao, Si‐Jia / Xie, Ting / Mor, Gil / Liao, Ai‐Hua

    American Journal of Reproductive Immunology ; ISSN 1046-7408 1600-0897

    Potential relationship to pregnancy outcomes

    2020  

    Keywords Obstetrics and Gynaecology ; Immunology ; Immunology and Allergy ; Reproductive Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/aji.13304
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes

    Muyayalo, Kahinho P / Huang, Dong-Hui / Zhao, Si-Jia / Xie, Ting / Mor, Gil / Liao, Ai-Hua

    Am J Reprod Immunol

    Abstract: Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and ... ...

    Abstract Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and even mortality due to their susceptibility to respiratory pathogens and their particular immunologic state. Several studies assessing SARS-CoV-2 infection during pregnancy reported adverse pregnancy outcomes in patients with severe conditions, including spontaneous abortion, preterm labor, fetal distress, cesarean section, preterm birth, neonatal asphyxia, neonatal pneumonia, stillbirth, and neonatal death. However, whether these complications are causally related to SARS-CoV-2 infection is not clear. Here, we reviewed the scientific evidence supporting the contributing role of Treg/Th17 cell imbalance in the uncontrolled systemic inflammation characterizing severe cases of COVID-19. Based on the recognized harmful effects of these CD4+ T-cell subset imbalances in pregnancy, we speculated that SARS-CoV-2 infection might lead to adverse pregnancy outcomes through the deregulation of otherwise tightly regulated Treg/Th17 ratios, and to subsequent uncontrolled systemic inflammation. Moreover, we discuss the possibility of vertical transmission of COVID-19 from infected mothers to their infants, which could also explain adverse perinatal outcomes. Rigorous monitoring of pregnancies and appropriate measures should be taken to prevent and treat early eventual maternal and perinatal complications.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #642280
    Database COVID19

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  5. Article ; Online: Immunological function of vitamin D during human pregnancy.

    Ji, Jin-Lu / Muyayalo, Kahinho P / Zhang, Yong-Hong / Hu, Xiao-Hui / Liao, Ai-Hua

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2017  Volume 78, Issue 2

    Abstract: The well-established classic role of vitamin D is implicated in the regulation of the balance between calcium and phosphorus. Furthermore, vitamin D is also involved in many non-classic physiological processes, mainly including the regulation of cell ... ...

    Abstract The well-established classic role of vitamin D is implicated in the regulation of the balance between calcium and phosphorus. Furthermore, vitamin D is also involved in many non-classic physiological processes, mainly including the regulation of cell proliferation, differentiation, apoptosis and immune function, participation in the inflammatory response and maintenance of genome stability function. During pregnancy, vitamin D receptor and its metabolic enzymes are expressed at the placenta and decidua, indicating the potential role in the mechanism of immunomodulation at the maternal-fetal interface. The insufficiency or deficiency of vitamin D may affect the mother directly and is related to specific pregnancy outcomes, such as preeclampsia, gestational diabetes, and recurrent miscarriage. This article reviews the effects of vitamin D on immune regulation during pregnancy.
    MeSH term(s) Animals ; Female ; Humans ; Pregnancy/immunology ; Pregnancy Complications/immunology ; Vitamin D/immunology ; Vitamin D/metabolism
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2017
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.12716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Galectin-9 Alleviates LPS-Induced Preeclampsia-Like Impairment in Rats via Switching Decidual Macrophage Polarization to M2 Subtype.

    Li, Zhi-Hui / Wang, Li-Ling / Liu, Hong / Muyayalo, Kahinho P / Huang, Xiao-Bo / Mor, Gil / Liao, Ai-Hua

    Frontiers in immunology

    2019  Volume 9, Page(s) 3142

    Abstract: Dysfunction of decidual macrophages (DMs) is considered a critical event in the pathogenesis of pre-eclampsia (PE). T cell immunoglobulin mucin 3 (Tim-3) is an important negative regulatory molecule that induces immune tolerance by interacting with its ... ...

    Abstract Dysfunction of decidual macrophages (DMs) is considered a critical event in the pathogenesis of pre-eclampsia (PE). T cell immunoglobulin mucin 3 (Tim-3) is an important negative regulatory molecule that induces immune tolerance by interacting with its ligand Galectin-9 (Gal-9) and thus modulating function of various immune cells, including macrophages. However, the regulatory effects of Tim-3/Gal-9 signaling on DMs polarization and its role in PE remain unclear. In this study, we established a PE-like rat model by administering 1.0 μg/kg lipopolysaccharide (LPS) to normal pregnant Sprague-Dawley rats via the tail vein at embryonic day 5 (E5). Apart from the pre-eclamptic manifestations, increased M1 subtype and decreased M2 subtype were observed at the maternal-fetal interface, as well as increased pro-inflammatory cytokines (TNF-α and IL-1β) and reduced anti-inflammatory cytokines (TGF-β and IL-10). Moreover, the expression of Tim-3 in DMs and that of Gal-9 at the maternal-fetal interface were reduced. After administration of recombinant Galectin-9 (rGal-9) protein, we found that liver and renal injuries and maternofetal placental functional deficiency, including inadequate trophoblast cells invasion, impaired spiral artery remodeling and fetal capillary development, were reversed. In addition, the polarization of DMs was inclined to M2 subtype, which was similar to the polarization of DMs in the control rats but contrary to the PE-like rats. Interestingly, at E9, the expression of Tim-3 in DMs and that of Gal-9 at the maternal-fetal interface were significantly increased in the rGal-9 protein intervention group. Taken together, our findings show that administration of rGal-9 protein can alleviate the PE-like rat manifestations induced by LPS. This finding may be related to the activation of the Tim-3/Gal-9 signaling pathway, which promotes DMs polarization dominantly shifting to M2 subtype. Moreover, upregulation of Tim-3 in DMs and Gal-9 at the maternal-fetal interface at E9 suggests that Tim-3/Gal-9 pathway may play some important roles in early pregnancy and even embryo development.
    MeSH term(s) Animals ; Blood Pressure ; Cytokines/metabolism ; Decidua/immunology ; Decidua/metabolism ; Disease Models, Animal ; Female ; Fluorescent Antibody Technique ; Galectins/genetics ; Galectins/metabolism ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Humans ; Hypertension ; Immunohistochemistry ; Inflammation Mediators/metabolism ; Kidney/immunology ; Kidney/metabolism ; Kidney/pathology ; Lipopolysaccharides/adverse effects ; Lipopolysaccharides/immunology ; Liver/immunology ; Liver/metabolism ; Liver/pathology ; Macrophage Activation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Maternal-Fetal Exchange/genetics ; Maternal-Fetal Exchange/immunology ; Models, Biological ; Placenta/immunology ; Placenta/metabolism ; Placenta/pathology ; Pre-Eclampsia/etiology ; Pre-Eclampsia/metabolism ; Pre-Eclampsia/physiopathology ; Pregnancy ; Proteinuria/immunology ; Proteinuria/metabolism ; Rats ; Signal Transduction
    Chemical Substances Cytokines ; Galectins ; Hepatitis A Virus Cellular Receptor 2 ; Inflammation Mediators ; Lipopolysaccharides ; galectin 9, rat
    Language English
    Publishing date 2019-01-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.03142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The roles of the PD-1/PD-L1 pathway at immunologically privileged sites.

    Wang, Li-Ling / Li, Zhi-Hui / Hu, Xiao-Hui / Muyayalo, Kahinho P / Zhang, Yong-Hong / Liao, Ai-Hua

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2017  Volume 78, Issue 2

    Abstract: The PD-1/PD-L1 pathway plays a vital role in the maintenance of peripheral tolerance, promoting the development and function of regulatory T cells, and maintaining the quiescence of autoreactive T cells. Abnormalities in this inhibitory pathway are ... ...

    Abstract The PD-1/PD-L1 pathway plays a vital role in the maintenance of peripheral tolerance, promoting the development and function of regulatory T cells, and maintaining the quiescence of autoreactive T cells. Abnormalities in this inhibitory pathway are involved in the pathogenesis of some disorders such as tumours, autoimmune diseases, pregnancy complications, and transplantation rejection. Immune privilege represents a special immunological condition, where foreign antigens can be tolerated and do not elicit an immune response. The anterior chamber of the eye, central nervous system, testis, pregnant uterus, and hair follicles are all regarded as immune-privileged sites in humans. Numerous studies show that the PD-1/PD-L1 pathway contributes to the maintenance of the immune-privileged microenvironment. In this review, we will mainly focus on the roles of the PD-1/PD-L1 pathway in the anterior chamber of the eye, brain and testis, as well as further investigations in testis.
    MeSH term(s) Animals ; B7-H1 Antigen/immunology ; Brain/immunology ; Eye/immunology ; Humans ; Male ; Programmed Cell Death 1 Receptor/immunology ; Testis/immunology
    Chemical Substances B7-H1 Antigen ; CD274 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2017
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.12710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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