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  1. Article ; Online: A genetic insight into vitamin D binding protein and COVID-19.

    Alshahawey, Mona

    Medical hypotheses

    2021  Volume 149, Page(s) 110531

    Abstract: It's since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A "pandemic"; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been ... ...

    Abstract It's since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A "pandemic"; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes [1]. As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I'd believe that vitamin D binding protein (DBP) is maybe also involved. A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.
    MeSH term(s) Alleles ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Immune System ; Pandemics ; Polymorphism, Genetic ; Risk Factors ; SARS-CoV-2 ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin D-Binding Protein/genetics
    Chemical Substances Vitamin D-Binding Protein ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2021.110531
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  2. Article: COVID-19 and Vitamin D deficiency; the two pandemics. Are they correlated?

    Alshahawey, Mona

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    2020  Volume 91, Issue 5-6, Page(s) 383–384

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Vitamin D ; Vitamin D Deficiency/epidemiology
    Chemical Substances Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000671
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  4. Article ; Online: COVID-19 and Vitamin D deficiency; the two pandemics. Are they correlated?

    Alshahawey, Mona

    International Journal for Vitamin and Nutrition Research

    2020  , Page(s) 1–2

    Keywords Nutrition and Dietetics ; Medicine (miscellaneous) ; Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
    Language English
    Publisher Hogrefe Publishing Group
    Publishing country de
    Document type Article ; Online
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000671
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  5. Article ; Online: Sex-mediated effects of ACE2 and TMPRSS2 on the incidence and severity of COVID-19; The need for genetic implementation.

    Alshahawey, Mona / Raslan, Mohamed / Sabri, Nagwa

    Current research in translational medicine

    2020  Volume 68, Issue 4, Page(s) 149–150

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/genetics ; Female ; Humans ; Male ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/genetics ; Polymorphism, Genetic/genetics ; SARS-CoV-2 ; Serine Endopeptidases/genetics ; Sex Factors
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-09-06
    Publishing country France
    Document type Letter
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2020.08.002
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  6. Article: Sex-mediated effects of ACE2 and TMPRSS2 on the incidence and severity of COVID-19; The need for genetic implementation

    Alshahawey, Mona / Raslan, Mohamed / Sabri, Nagwa

    Curr Res Transl Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #745937
    Database COVID19

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  7. Article: The impact of cholecalciferol on markers of vascular calcification in hemodialysis patients: A randomized placebo controlled study

    Alshahawey, Mona / El borolossy, Radwa / El Wakeel, Lamia / Elsaid, Tamer / Sabri, Nagwa Ali

    The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2021 Feb. 08, v. 31, no. 2

    2021  

    Abstract: Vascular calcification is an independent risk factor for cardiovascular diseases and all-cause mortality in end stage renal disease, and particularly in hemodialysis patients. Vitamin D deficiency has been shown to be associated with vascular ... ...

    Abstract Vascular calcification is an independent risk factor for cardiovascular diseases and all-cause mortality in end stage renal disease, and particularly in hemodialysis patients. Vitamin D deficiency has been shown to be associated with vascular calcification among this category of patients. Cholecalciferol or vitamin D3; the native inactivated 25-hydroxy vitamin D [25(OH)D], has been proposed to have a good impact on vascular calcification and vitamin D deficiency. However, clinical data is still limited.A prospective, randomized, placebo-controlled study was carried out to evaluate the effect of oral cholecalciferol on vascular calcification and 25(OH)D levels in hemodialysis patients. A total of sixty eligible hemodialysis patients were randomly assigned to either a treatment group (Oral 200.000IU Cholecalciferol per month) or a placebo group, for 3 months. Serum 25-hydroxy vitamin D (25(OH)D), fetuin-A, fibroblast growth factor (FGF-23), osteoprotegerin (OPG), calcium, phosphorus, their product (CaXP) and intact parathyroid hormone (iPTH) levels, were all assessed at baseline and at the end of the study. ClinicalTrials.gov registration number: NCT03602430. Cholecalciferol significantly increased serum levels of 25(OH)D and fetuin-A in the treatment group (p-value < 0.001), while no significant difference was observed in the placebo group. Cholecalciferol administration showed no effect on either FGF-23 or OPG. None of the treatment group patients experienced any adverse effects.Cholecalciferol was shown to be an effective, tolerable, inexpensive pharmacotherapeutic option to overcome vitamin D deficiency, with a possible modulating effect on fetuin-A, among hemodialysis patients.NCT03602430.
    Keywords blood serum ; calcification ; calcium ; cardiovascular diseases ; cholecalciferol ; fibroblast growth factors ; hemodialysis ; kidney diseases ; metabolism ; mortality ; parathyroid hormone ; patients ; phosphorus ; placebos ; risk factors ; vitamin D deficiency
    Language English
    Dates of publication 2021-0208
    Size p. 626-633.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2020.09.014
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Sex-mediated effects of ACE2 and TMPRSS2 on the incidence and severity of COVID-19; The need for genetic implementation

    Alshahawey, Mona / Raslan, Mohamed / Sabri, Nagwa

    Current Research in Translational Medicine

    2020  Volume 68, Issue 4, Page(s) 149–150

    Keywords General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2452-3186
    DOI 10.1016/j.retram.2020.08.002
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  9. Article ; Online: Effect of febuxostat on oxidative stress in hemodialysis patients with endothelial dysfunction: a randomized, placebo-controlled, double-blinded study.

    Alshahawey, Mona / Shaheen, Sara M / Elsaid, Tamer / Sabri, Nagwa Ali

    International urology and nephrology

    2019  Volume 51, Issue 9, Page(s) 1649–1657

    Abstract: Purpose: Oxidative stress, which is most likely a key mediator in the development of cardiovascular disease, is implicated in the progression and deterioration of chronic kidney disease. Patients on hemodialysis exhibit the excessive generation of ... ...

    Abstract Purpose: Oxidative stress, which is most likely a key mediator in the development of cardiovascular disease, is implicated in the progression and deterioration of chronic kidney disease. Patients on hemodialysis exhibit the excessive generation of oxidative stressors, which may also be responsible for the endothelial dysfunction prevalent in these patients. Febuxostat, an inhibitor of xanthine oxidase enzyme, is emerging as a novel drug in the amelioration of oxidative stress status. However, studies regarding its effect among hemodialysis patients are still lacking.
    Methods: This prospective, block-randomized, double-blinded, placebo-controlled study was carried out to assess the effect of oral 40 mg febuxostat on oxidative stress in hemodialysis patients. In total, fifty-seven eligible patients were randomly assigned to either a drug group or a placebo group for the 2-month study period. Serum malondialdehyde (MDA) and serum superoxide dismutase (SOD) were assessed at baseline and at the end of the study. A correlation analysis between previously reported serum asymmetric dimethylarginine (ADMA), serum MDA and serum SOD was performed.
    Results: Febuxostat significantly decreased the serum MDA and significantly increased the serum SOD, while no significant results were observed in the placebo group. A highly positive correlation between the MDA levels and ADMA levels at baseline was noticed in both groups, while there was a highly negative correlation between the SOD levels and ADMA levels at baseline in both groups. A positive correlation between the change in ADMA levels and MDA levels from baseline was observed only in the drug group.
    Conclusion: Febuxostat appears to have a direct ameliorating effect on oxidative stress in hemodialysis patients with endothelial dysfunction.
    MeSH term(s) Adult ; Double-Blind Method ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Febuxostat/pharmacology ; Febuxostat/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Oxidative Stress/drug effects ; Prospective Studies ; Renal Dialysis
    Chemical Substances Febuxostat (101V0R1N2E)
    Language English
    Publishing date 2019-08-01
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-019-02243-w
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    Zs.A 733: Show issues Location:
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  10. Article ; Online: The impact of cholecalciferol on markers of vascular calcification in hemodialysis patients: A randomized placebo controlled study.

    Alshahawey, Mona / El Borolossy, Radwa / El Wakeel, Lamia / Elsaid, Tamer / Sabri, Nagwa Ali

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2020  Volume 31, Issue 2, Page(s) 626–633

    Abstract: Background and aim: Vascular calcification is an independent risk factor for cardiovascular diseases and all-cause mortality in end stage renal disease, and particularly in hemodialysis patients. Vitamin D deficiency has been shown to be associated with ...

    Abstract Background and aim: Vascular calcification is an independent risk factor for cardiovascular diseases and all-cause mortality in end stage renal disease, and particularly in hemodialysis patients. Vitamin D deficiency has been shown to be associated with vascular calcification among this category of patients. Cholecalciferol or vitamin D3; the native inactivated 25-hydroxy vitamin D [25(OH)D], has been proposed to have a good impact on vascular calcification and vitamin D deficiency. However, clinical data is still limited.
    Methods and results: A prospective, randomized, placebo-controlled study was carried out to evaluate the effect of oral cholecalciferol on vascular calcification and 25(OH)D levels in hemodialysis patients. A total of sixty eligible hemodialysis patients were randomly assigned to either a treatment group (Oral 200.000IU Cholecalciferol per month) or a placebo group, for 3 months. Serum 25-hydroxy vitamin D (25(OH)D), fetuin-A, fibroblast growth factor (FGF-23), osteoprotegerin (OPG), calcium, phosphorus, their product (CaXP) and intact parathyroid hormone (iPTH) levels, were all assessed at baseline and at the end of the study. ClinicalTrials.gov registration number: NCT03602430. Cholecalciferol significantly increased serum levels of 25(OH)D and fetuin-A in the treatment group (p-value < 0.001), while no significant difference was observed in the placebo group. Cholecalciferol administration showed no effect on either FGF-23 or OPG. None of the treatment group patients experienced any adverse effects.
    Conclusion: Cholecalciferol was shown to be an effective, tolerable, inexpensive pharmacotherapeutic option to overcome vitamin D deficiency, with a possible modulating effect on fetuin-A, among hemodialysis patients. CLINICALTRIALS.
    Gov registration number: NCT03602430.
    MeSH term(s) Adult ; Biomarkers/blood ; Cholecalciferol/adverse effects ; Cholecalciferol/therapeutic use ; Egypt ; Female ; Humans ; Kidney Diseases/blood ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis/adverse effects ; Single-Blind Method ; Time Factors ; Treatment Outcome ; Vascular Calcification/blood ; Vascular Calcification/diagnosis ; Vascular Calcification/etiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy ; Vitamins/adverse effects ; Vitamins/therapeutic use ; alpha-2-HS-Glycoprotein/metabolism
    Chemical Substances AHSG protein, human ; Biomarkers ; Vitamins ; alpha-2-HS-Glycoprotein ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2020-09-21
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2020.09.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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