Article ; Online: Serum Levels of Interleukins in Endometriosis Patients: A Systematic Review and Meta-analysis.
Journal of minimally invasive gynecology
2024 Volume 31, Issue 5, Page(s) 387–396.e11
Abstract: Objective: The aims of this systematic review and meta-analysis were to produce a comprehensive survey of the serum levels of interleukins (ILs) in untreated people with endometriosis compared with people without endometriosis.: Data sources: A ... ...
Abstract | Objective: The aims of this systematic review and meta-analysis were to produce a comprehensive survey of the serum levels of interleukins (ILs) in untreated people with endometriosis compared with people without endometriosis. Data sources: A systematic literature search of English language studies within Cinahl, Medline Complete, PubMed, and Scopus from inception to May 2023 was performed. Methods of study selection: We included studies that compared IL serum levels in people with endometriosis to those without endometriosis. Meta-analysis was performed on IL-1RA, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17A, IL-18, IL-23, and IL-37. Tabulation, integration, and results: The systematic search retrieved 651 studies, of which 77 underwent a full-text review. A total of 30 studies met inclusion criteria for the meta-analysis. IL-1Ra, IL-6, and IL-37 serum levels were 2.56 (95% CI 2.20-2.92, p <.001), 1.38 (95% CI 0.58-2.17, p <.001), and 1.77 (95% CI 1.33-2.20, p <.001) standard deviations higher in the patients with endometriosis compared with patients without endometriosis while IL-23 serum levels 0.40 (95% CI -0.73 to -0.07, p = .02) standard deviations lower, respectively. Conclusion: There is mounting evidence that ILs, especially IL-6, may be good candidates for unique noninvasive diagnostic tools and/or treatment pathways for endometriosis. |
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MeSH term(s) | Endometriosis/blood ; Humans ; Female ; Interleukins/blood ; Interleukin-6/blood ; Interleukin-23/blood ; Interleukin 1 Receptor Antagonist Protein/blood ; Interleukin-18/blood ; Interleukin-2/blood ; Interleukin-10/blood ; Interleukin-17/blood ; Interleukin-1beta/blood ; Interleukin-4/blood ; Interleukin-8/blood ; Interleukin-1/blood ; Interleukin-12/blood |
Chemical Substances | Interleukins ; Interleukin-6 ; Interleukin-23 ; IL37 protein, human ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-18 ; Interleukin-2 ; Interleukin-10 (130068-27-8) ; Interleukin-17 ; Interleukin-1beta ; IL6 protein, human ; Interleukin-4 (207137-56-2) ; Interleukin-8 ; IL10 protein, human ; Interleukin-1 ; Interleukin-12 (187348-17-0) ; IL4 protein, human |
Language | English |
Publishing date | 2024-02-29 |
Publishing country | United States |
Document type | Journal Article ; Systematic Review ; Meta-Analysis ; Review |
ZDB-ID | 2186934-0 |
ISSN | 1553-4669 ; 1553-4650 |
ISSN (online) | 1553-4669 |
ISSN | 1553-4650 |
DOI | 10.1016/j.jmig.2024.02.011 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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