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  1. Article ; Online: Children of frontline coronavirus disease-2019 warriors: our observations.

    Dubey, Souvik / Dubey, Mahua Jana / Ghosh, Ritwik / Chatterjee, Subhankar

    The Journal of pediatrics

    2020  Volume 224, Page(s) 188–189

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.05.026
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  2. Article: Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral?

    Dubey, Souvik / Dubey, Mahua Jana / Ghosh, Ritwik / Mukherjee, Debaleena / Pandit, Alak / Benito-León, Julián

    The Egyptian journal of neurology, psychiatry and neurosurgery

    2022  Volume 58

    Abstract: Neurodegenerative dementias such as the behavioral variant of frontotemporal dementia, Alzheimer's disease, and Parkinson's disease dementia are linked to various behavioral and psychological abnormalities. Whether these abnormalities precede, coincide ... ...

    Abstract Neurodegenerative dementias such as the behavioral variant of frontotemporal dementia, Alzheimer's disease, and Parkinson's disease dementia are linked to various behavioral and psychological abnormalities. Whether these abnormalities precede, coincide or follow the onset of cognitive symptoms is still controversial in existing literature, with trajectories available so far dependent on types of dementia. The authors aim to review the different kinds of premorbid behavioral symptoms/personality traits associated with an increased risk of developing specific types of neurodegenerative dementia. Neuroticism has been associated with an increased risk of Alzheimer's disease and late-onset behavioral abnormalities with the behavioral variant of frontotemporal dementia. The presence of obsessive-compulsive spectrum disorders in Parkinson's disease dementia is also not rare. Analyzing this evidence, we propose "behavioral biomarkers" as neuroticism in Alzheimer's disease, late-onset behavioral abnormalities in behavioral variant of frontotemporal dementia, and obsessive-compulsive traits in Parkinson's disease dementia. These noninvasive behavioral biomarkers will be of immense help, particularly in developing countries, and will prevent the need for costlier investigations and aid in therapeutic strategies.
    Language English
    Publishing date 2022-09-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686351-0
    ISSN 1687-8329 ; 1110-1083
    ISSN (online) 1687-8329
    ISSN 1110-1083
    DOI 10.1186/s41983-022-00538-x
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  3. Article ; Online: Metronidazole-Induced Toxic Neuropathy With the "Boomerang" Sign: A Case Report.

    Ghosh, Ritwik / Chatterjee, Subhankar / Dubey, Mahua Jana / Dubey, Souvik / Benito-León, Julián

    Clinical neuropharmacology

    2022  Volume 45, Issue 2, Page(s) 35–38

    Abstract: Background: Metronidazole has been used to treat a broad range of infections over the decades, and its safety profile has been presumably well studied. However, neurological severe adverse events after prescription and nonprescription use of ... ...

    Abstract Background: Metronidazole has been used to treat a broad range of infections over the decades, and its safety profile has been presumably well studied. However, neurological severe adverse events after prescription and nonprescription use of metronidazole is well recognized but underdiagnosed.
    Case presentation: We report the case of a 48-year-old Indian man who presented with unremitting symptoms of peripheral neuropathy along with a silent callosal lesion in the splenium ("boomerang" sign). Because he had visited 3 neurologists previously, there were many targeted and nontargeted investigations, which failed to reach an etiological diagnosis and hence to provide relief. The patient was questioned about a potential neurotoxin exposure, and at that point, he said that he had been taking metronidazole for a long time, without any supervision, as an over-the-counter remedy for self-diagnosed "chronic amebiasis." On stopping metronidazole, he recovered gradually. In the sixth month of follow-up, brain magnetic resonance imaging showed disappearance of the callosal lesion and significant improvement in the nerve conduction studies.
    Conclusions: Clinicians should keep metronidazole toxicity in mind while dealing with a case of cytotoxic lesion of the corpus callosum with splenium involvement and peripheral neuropathy.
    MeSH term(s) Brain Diseases/chemically induced ; Corpus Callosum ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Metronidazole/adverse effects ; Middle Aged ; Peripheral Nervous System Diseases/chemically induced ; Polyneuropathies
    Chemical Substances Metronidazole (140QMO216E)
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 199293-4
    ISSN 1537-162X ; 0362-5664
    ISSN (online) 1537-162X
    ISSN 0362-5664
    DOI 10.1097/WNF.0000000000000497
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  6. Article: Psychosocial Basis of Human Sufferings and Poverty in Patients with Neurological and Psychiatric Disorders.

    Dubey, Souvik / Ghosh, Ritwik / Dubey, Mahua Jana / Das, Shambaditya / Chakraborty, Arka Prava / Santra, Arindam / Dutta, Ajitava / Roy, Dipayan / Pandit, Alak / Roy, Biman Kanti / Das, Gautam / Benito-León, Julián

    Medical research archives

    2023  Volume 11, Issue 5

    Abstract: Neurological disorders and psychiatric ailments often lead to cognitive disabilities and low attainment of education, pivoting misconceptions, myths, and misbeliefs. Poverty and low educational attainment are intriguingly associated with poor awareness ... ...

    Abstract Neurological disorders and psychiatric ailments often lead to cognitive disabilities and low attainment of education, pivoting misconceptions, myths, and misbeliefs. Poverty and low educational attainment are intriguingly associated with poor awareness and perception of these diseases that add to the suffering. Poverty goes parallel with a low level of education and is intricately associated with neuropsychiatric ailments, which have the potential to spread transgenerationally. Robust education policies, proper government rules and regulations against the spread of disease-related myths and misconceptions, uplifting medical education in its true sense, voices against consanguinity, and programs to raise scientific perception about diseases can help to throw light at the end of this dark tunnel. In this article, the authors intend to 1) decipher the potential psychosocial basis of human suffering and poverty in patients with neurological and psychiatric disorders, and 2) discuss the apropos way-outs that would potentially mitigate suffering, and alleviate the economic burden and cognitive disabilities of families with neuropsychiatric diseases.
    Language English
    Publishing date 2023-05-20
    Publishing country United States
    Document type Journal Article
    ISSN 2375-1916
    ISSN 2375-1916
    DOI 10.18103/mra.v11i5.3919
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  7. Article ; Online: The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia.

    Dubey, Souvik / Das, Shambaditya / Ghosh, Ritwik / Dubey, Mahua Jana / Chakraborty, Arka Prava / Roy, Dipayan / Das, Gautam / Dutta, Ajitava / Santra, Arindam / Sengupta, Samya / Benito-León, Julián

    Journal of Alzheimer's disease reports

    2023  Volume 7, Issue 1, Page(s) 119–128

    Abstract: Background: Cognitive postscripts of COVID-19, codenamed as 'cognitive COVID' or 'brain fog,' characterized by multidomain cognitive impairments, are now being reckoned as the most devastating sequelae of COVID-19. However, the impact on the already ... ...

    Abstract Background: Cognitive postscripts of COVID-19, codenamed as 'cognitive COVID' or 'brain fog,' characterized by multidomain cognitive impairments, are now being reckoned as the most devastating sequelae of COVID-19. However, the impact on the already demented brain has not been studied.
    Objective: We aimed to assess the cognitive functioning and neuroimaging following SARS-CoV-2 infection in patients with pre-existing dementia.
    Methods: Fourteen COVID-19 survivors with pre-existing dementia (four with Alzheimer's disease, five with vascular dementia, three with Parkinson's disease dementia, and two with the behavioral variant of frontotemporal dementia) were recruited. All these patients had detailed cognitive and neuroimaging evaluations within three months before suffering from COVID-19 and one year later.
    Results: Of the 14 patients, ten required hospitalization. All developed or increased white matter hyperintensities that mimicked multiple sclerosis and small vessel disease. There was a significant increase in fatigue (
    Conclusion: The rapid progression of dementia, the addition of further impairments/deterioration of cognitive abilities, and the increase or new appearance of white matter lesion burden suggest that previously compromised brains have little defense to withstand a new insult (i.e., 'second hit' like infection/dysregulated immune response, and inflammation). 'Brain fog' is an ambiguous terminology without specific attribution to the spectrum of post-COVID-19 cognitive sequelae. We propose a new codename, i.e. 'FADE-IN MEMORY' (i.e., Fatigue, decreased Fluency, Attention deficit, Depression, Executive dysfunction, slowed INformation processing speed, and subcortical MEMORY impairment).
    Language English
    Publishing date 2023-02-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-220090
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  8. Article: COVID-19 Pandemic, Personality and Geriatric Population: Proposed Pragmatism.

    Dubey, Souvik / Sengupta, Samya / Ghosh, Ritwik / Dubey, Mahua Jana / Chatterjee, Subham / Das, Gautam / Roy, Dipayan / Ray, Biman Kanti / Benito-León, Julián

    Journal of patient experience

    2021  Volume 8, Page(s) 23743735211059051

    Abstract: The elderly population is a sensitive and delicate cohort of society who is being compelled to bear the significant smoulders of disruptive social behavior of humankind amidst the COVID-19 pandemic. Our aim for this review was (1) to find out the root of ...

    Abstract The elderly population is a sensitive and delicate cohort of society who is being compelled to bear the significant smoulders of disruptive social behavior of humankind amidst the COVID-19 pandemic. Our aim for this review was (1) to find out the root of disruption of societal integrity and self-centeredness by analyzing the spokes of HEXACO; (2) to delineate their possible relationships with the formation of Neuroticism and eventually Psychopathy, which have endangered human civilization the most in this pandemic; and (3) to search for the potential ways to get rid of these dark times. The constellation of different negative human behaviors probably originate from the negative deflection of components of the HEXACO model of personality towards the genesis of the dark triad. COVID-19 pandemic and upsurge of the dark triad in the form of Neuroticism, Narcissism and Machiavellianism potentially portend major mental health threats. Cultivation and practice of positive emotions and triumph of honesty, humility and humanity are imperative to save the mankind from the savagery of this pandemic.
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2857285-3
    ISSN 2374-3743 ; 2374-3735
    ISSN (online) 2374-3743
    ISSN 2374-3735
    DOI 10.1177/23743735211059051
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  9. Article ; Online: Bilateral thalamic changes in anti-NMDAR encephalitis presenting with hemichorea and dystonia and acute transient psychotic disorder.

    Dubey, Souvik / Ghosh, Ritwik / Dubey, Mahua Jana / Sengupta, Samya / Benito-León, Julián / Ray, Biman Kanti

    Journal of neuroimmunology

    2020  Volume 347, Page(s) 577329

    Abstract: Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is one of the most common causes of autoimmune encephalitis. Both movement disorders and neuropsychiatric manifestations are considered core features of anti-NMDAR encephalitis. Strong clinical ...

    Abstract Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is one of the most common causes of autoimmune encephalitis. Both movement disorders and neuropsychiatric manifestations are considered core features of anti-NMDAR encephalitis. Strong clinical suspicion, along with NMDAR antibody positivity in paired sample of serum and cerebrospinal fluid, with supportive MRI changes clinch diagnosis in majority. We herein report a case of a middle-aged woman with subacute behavioral abnormalities, which were so severe that forced her to attempt suicide. Hemichorea and dystonia, which appeared later in course, are not previously reported movement disorders in combination in anti-NMDAR encephalitis. Further, magnetic resonance imaging showed bilateral thalamic hyperintensities with diffusion restriction, which are in turn not described in this entity. After amalgamation of history, especially the presence of neuropsychiatric symptoms, clinical features, physical examination, and investigations, the diagnosis of anti-NMDAR encephalitis could be established. Our case not only highlights that the combination of hemichorea and dystonia can be features of anti-NMDAR encephalitis, but adds novelty by bilateral symmetric thalamic changes.
    MeSH term(s) Acute Disease ; Adult ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnostic imaging ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/drug therapy ; Chorea/complications ; Chorea/diagnostic imaging ; Chorea/drug therapy ; Dystonia/complications ; Dystonia/diagnostic imaging ; Dystonia/drug therapy ; Female ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Psychotic Disorders/complications ; Psychotic Disorders/diagnostic imaging ; Psychotic Disorders/drug therapy ; Thalamus/diagnostic imaging
    Chemical Substances Immunoglobulins, Intravenous
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2020.577329
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  10. Article ; Online: COVID-19 and addiction.

    Dubey, Mahua Jana / Ghosh, Ritwik / Chatterjee, Subham / Biswas, Payel / Chatterjee, Subhankar / Dubey, Souvik

    Diabetes & metabolic syndrome

    2020  Volume 14, Issue 5, Page(s) 817–823

    Abstract: Background and aims: 2019-coronavirus disease (COVID-19) is causing insurmountable psychosocial impact on the whole mankind. Marginalized community, particularly those with substance use disorders (SUD), are particularly vulnerable to contract the ... ...

    Abstract Background and aims: 2019-coronavirus disease (COVID-19) is causing insurmountable psychosocial impact on the whole mankind. Marginalized community, particularly those with substance use disorders (SUD), are particularly vulnerable to contract the infection and also likely to suffer from greater psychosocial burden. This article analyses the intricate bi-directional relationship between COVID-19 and addiction.
    Methods: Pubmed and Google Scholar are searched with the following key terms- "COVID-19", "SARS-CoV2", "Pandemic", "Addiction", "Opioid", "Alcohol", "Smoking", "Addiction Psychiatry", "Deaddiction", "Substance use disorders", "Behavioral addiction". Few newspaper reports related to COVID-19 and addiction have also been added as per context.
    Results: People with SUD are at greater risk of worse COVID-19 outcome. There is surge of addictive behaviors (both new and relapse) including behavioral addiction in this period. Withdrawal emergencies and death are also being increasingly reported. Addicted people are especially facing difficulties in accessing the healthcare services which are making them prone to procure drugs by illegal means.
    Conclusion: COVID-19 and addiction are the two pandemics which are on the verge of collision causing major public health threat. While every effort must be taken to make the public aware of deleterious effects of SUD on COVID-19 prognosis, the resumption of deaddiction services and easier accessibility of prescription drugs are needs of the hour.
    MeSH term(s) Behavior, Addictive/complications ; Behavior, Addictive/epidemiology ; Behavior, Addictive/psychology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Delivery of Health Care/methods ; Delivery of Health Care/organization & administration ; Delivery of Health Care/trends ; Health Services Accessibility/organization & administration ; Health Services Accessibility/standards ; Health Services Accessibility/trends ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Prognosis ; SARS-CoV-2 ; Social Marginalization/psychology ; Substance-Related Disorders/complications ; Substance-Related Disorders/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.06.008
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