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  1. Article: Effects of Early Initiation of Polymyxin B Hemoperfusion Therapy in Patients with Cancer with Refractory Septic Shock.

    Lee, Jae Hoon / Han, Won Ho / Im, Hyun-Jae / Kim, Jee Hee

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Case Report: Needle Penetrated in the Back Skin Presenting As a Conical Papule.

    Kim, Dong Chan / Han, Hee Jeong / Kwon, Soo Hyun / Choi, Jee Woong

    Annals of dermatology

    2023  Volume 35, Issue Suppl 1, Page(s) S148–S149

    Language English
    Publishing date 2023-10-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.21.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long-Term Changes in Adipose Tissue in the Newly Formed Bone Induced by Recombinant Human BMP-2 In Vivo.

    Jee, Hyouk-Keun / Jeon, Woo-Young / Kwak, Han-Wool / Seok, Hyun

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 1

    Abstract: Recombinant human bone morphogenetic protein-2 (rhBMP-2) induces osteogenesis and adipogenesis in bone scaffolds. We evaluated rhBMP-2-induced long-term changes in adipose tissue in the newly formed bone in different scaffolds forms. Bovine bone ... ...

    Abstract Recombinant human bone morphogenetic protein-2 (rhBMP-2) induces osteogenesis and adipogenesis in bone scaffolds. We evaluated rhBMP-2-induced long-term changes in adipose tissue in the newly formed bone in different scaffolds forms. Bovine bone particles and blocks were grafted along with rhBMP-2 in the subperiosteal space of a rat calvarial bone, and the formation of new bone and adipose tissue were evaluated at 6 and 16 weeks after the surgery. The bone mineral density (BMD) and trabecular thickness (TbTh) of the 16w particle group were significantly higher than those of the 6w particle group (p = 0.018 and 0.012, respectively). The BMD and TbTh gradually increased in the particle group from weeks 6 to 16. The average adipose tissue volume (ATV) of the 6w particle group was higher than that of the 16w particle group, although the difference was not significant (p > 0.05), and it decreased gradually. There were no significant changes in the bone volume (BV) and BMD between the 6w and 16w block groups. Histological analysis revealed favorable new bone regeneration in all groups. Adipose tissue was formed between the bone particles and at the center in the particle and block groups, respectively. The adipose tissue space decreased, and the proportion of new bone increased in the 16w particle group compared to that in the 6w group. To summarize, in the particle group, the adipose tissue decreased in a time-dependent manner, BMD and TbTh increased, and new bone formation increased from 6 to 16 weeks. These results suggest that rhBMP-2 effectively induces new bone formation in the long term in particle bone scaffolds.
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8010033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of Water Amount Intake before Scuba Diving on the Risk of Decompression Sickness.

    Han, Kil-Hyung / Hyun, Gwang-Suk / Jee, Yong-Seok / Park, Jung-Min

    International journal of environmental research and public health

    2021  Volume 18, Issue 14

    Abstract: Background and ... ...

    Abstract Background and objective
    MeSH term(s) Decompression Sickness/epidemiology ; Decompression Sickness/etiology ; Decompression Sickness/prevention & control ; Diving ; Drinking ; Humans ; Ultrasonography, Doppler ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2021-07-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18147601
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  5. Article: Delirium After Traumatic Brain Injury: Prediction by Location and Size of Brain Lesion.

    Han, Soo Jeong / Suh, Jee Hyun / Lee, Ja Young / Kim, Soo Jin

    Annals of rehabilitation medicine

    2023  Volume 47, Issue 3, Page(s) 214–221

    Abstract: Objective: To examine (1) the location of brain lesion that would predict post-traumatic delirium and (2) the association between volume of brain lesion and occurrence of delirium in patients with traumatic brain injury (TBI).: Methods: A ... ...

    Abstract Objective: To examine (1) the location of brain lesion that would predict post-traumatic delirium and (2) the association between volume of brain lesion and occurrence of delirium in patients with traumatic brain injury (TBI).
    Methods: A retrospective study was conducted by reviewing medical records of 68 TBI patients, categorized into two groups: the delirious group (n=38) and non-delirious group (n=30). The location and volume of TBI were investigated with the 3D Slicer software.
    Results: The TBI region in the delirious group mainly involved the frontal or temporal lobe (p=0.038). All 36 delirious patients had brain injury on the right side (p=0.046). The volume of hemorrhage in the delirious group was larger by about 95 mL compared to the non-delirious group, but this difference was not statistically significant (p=0.382).
    Conclusion: Patients with delirium after TBI had significantly different injury site and side, but not lesion size compared to patients without delirium.
    Language English
    Publishing date 2023-06-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2659431-6
    ISSN 2234-0653 ; 2234-0645
    ISSN (online) 2234-0653
    ISSN 2234-0645
    DOI 10.5535/arm.23008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Transcranial direct current stimulation combined with amantadine in repetitive mild traumatic brain injury in rats.

    Han, Soo Jeong / Park, Gahee / Suh, Jee Hyun

    BMC neuroscience

    2022  Volume 23, Issue 1, Page(s) 76

    Abstract: Background: Balance and memory deficits are common in patients with repetitive mild traumatic brain injury (mTBI).: Objective: To investigate the combined effects of amantadine and transcranial direct current stimulation (tDCS) on balance and memory ... ...

    Abstract Background: Balance and memory deficits are common in patients with repetitive mild traumatic brain injury (mTBI).
    Objective: To investigate the combined effects of amantadine and transcranial direct current stimulation (tDCS) on balance and memory in repetitive mTBI rat models.
    Methods: In this prospective animal study, 40 repetitive mTBI rats were randomly assigned to four groups: tDCS, amantadine, combination of amantadine and anodal tDCS, and control. The tDCS group received four sessions of anodal tDCS for four consecutive days. The amantadine group received four intraperitoneal injections of amantadine for four consecutive days. The combination group received four intraperitoneal injections of amantadine and anodal tDCS for four consecutive days. Motor-evoked potential (MEP), rotarod test, and novel object test results were evaluated before mTBI, before treatment, and after treatment.
    Results: All groups showed significant improvements in the rotarod and novel object tests, particularly the combination group. The combination group showed a significant improvements in duration (p < 0.01) and maximal speed in the rotarod test (p < 0.01), as well as an improvement in novel object ratio (p = 0.05) and MEP amplitude (p = 0.05) after treatment. The combination group exhibited a significant increase in novel object ratio compared to the tDCS group (p = 0.04). The GFAP integral intensity of the left motor cortex and hippocampus was the lowest in the combination group.
    Conclusion: Combination treatment with amantadine and tDCS had positive effects on balance and memory recovery after repetitive mTBI in rats. Therefore, we expect that the combination of amantadine and tDCS may be a treatment option for patients with repetitive mTBIs.
    Language English
    Publishing date 2022-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041344-0
    ISSN 1471-2202 ; 1471-2202
    ISSN (online) 1471-2202
    ISSN 1471-2202
    DOI 10.1186/s12868-022-00763-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex.

    Cho, Ji Hyeon / Chae, Chang Woo / Lim, Jae Ryong / Jung, Young Hyun / Han, Su Jong / Yoon, Jee Hyeon / Park, Ji Yong / Han, Ho Jae

    Autophagy

    2024  , Page(s) 1–18

    Abstract: Damaged mitochondria accumulation in diabetes is one of the main features that contribute to increased incidence of cognitive impairment by inducing apoptosis. Butyrate is a major metabolite produced by microbiota that has neuroprotective effects by ... ...

    Abstract Damaged mitochondria accumulation in diabetes is one of the main features that contribute to increased incidence of cognitive impairment by inducing apoptosis. Butyrate is a major metabolite produced by microbiota that has neuroprotective effects by regulating mitochondrial function. However, detailed mechanisms underlying how butyrate can regulate neuronal mitophagy remain unclear. Here, we examined the regulatory effects of sodium butyrate (NaB) on high glucose-induced mitophagy dysregulation, neuronal apoptosis, and cognitive impairment and its underlying mechanisms in human-induced pluripotent stem cell-derived neurons, SH-SY5Ys, and streptozotocin (STZ)-induced diabetic mice. In our results, diabetic mice showed gut-microbiota dysbiosis, especially a decreased number of butyrate-producing bacteria and reduced NaB plasma concentration. NaB ameliorated high glucose-induced neuronal mitochondrial dysfunction by recovering PRKN/Parkin-mediated mitophagy. High glucose-induced reactive oxygen species (ROS) and -inhibited PRKAA/AMPKα stimulated the RELA/p65-HDAC8 complex, which downregulated PRKN protein expression by binding to the
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2024.2323785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness.

    Yoon, Seo Yeon / Lee, Sang Chul / Suh, Jee Hyun / Yang, Seung Nam / Han, Kyungdo / Kim, Yong Wook

    NPJ Parkinson's disease

    2024  Volume 10, Issue 1, Page(s) 17

    Abstract: We aimed to investigate the association of various mental illnesses, including depression, bipolar disorder, schizophrenia, insomnia, and anxiety, with the risk of early-onset Parkinson's disease (EOPD) (age <50 years) and compare it with that of late- ... ...

    Abstract We aimed to investigate the association of various mental illnesses, including depression, bipolar disorder, schizophrenia, insomnia, and anxiety, with the risk of early-onset Parkinson's disease (EOPD) (age <50 years) and compare it with that of late-onset PD (LOPD) (age ≥50 years). This nationwide cohort study enrolled 9,920,522 people who underwent a national health screening examination in 2009, and followed up until 31 December 2018. There was a significantly increased risk of EOPD and LOPD in individuals with mental illness, and EOPD showed a stronger association than LOPD (EOPD, hazard ratio (HR) = 3.11, 95% CI: 2.61‒3.72; LOPD, HR = 1.70, 95% CI: 1.66‒1.74; p for interaction <0.0001). Our results suggest that people with mental illnesses aged < 50 years are at a higher risk of PD than those aged ≥50 years. Future studies are warranted to elucidate the pathomechanism of EOPD in relation to mental illness.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-023-00621-x
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  9. Article ; Online: Comprehensive Understanding for Application in Korean Patients with Type 2 Diabetes Mellitus of the Consensus Statement on Carbohydrate-Restricted Diets by Korean Diabetes Association, Korean Society for the Study of Obesity, and Korean Society of Hypertension.

    Choi, Jong Han / Kang, Jee-Hyun / Chon, Suk

    Diabetes & metabolism journal

    2022  Volume 46, Issue 3, Page(s) 377–390

    Abstract: The Joint Committee of the Korean Diabetes Association, the Korean Society for the Study of Obesity, and the Korean Society of Hypertension announced a consensus statement on carbohydrate-restricted diets and intermittent fasting, representing an ... ...

    Abstract The Joint Committee of the Korean Diabetes Association, the Korean Society for the Study of Obesity, and the Korean Society of Hypertension announced a consensus statement on carbohydrate-restricted diets and intermittent fasting, representing an emerging and popular dietary pattern. In this statement, we recommend moderately-low-carbohydrate or low-carbohydrate diets, not a very-low-carbohydrate diet, for patients with type 2 diabetes mellitus. These diets can be considered a dietary regimen to improve glycemic control and reduce body weight in adults with type 2 diabetes mellitus. This review provides the detailed results of a meta-analysis and systematic literature review on the potential harms and benefits of carbohydrate-restricted diets in patients with diabetes. We expect that this review will help experts and patients by fostering an in-depth understanding and appropriate application of carbohydrate-restricted diets in the comprehensive management of diabetes.
    MeSH term(s) Adult ; Diabetes Mellitus, Type 2 ; Diet, Carbohydrate-Restricted ; Humans ; Hypertension ; Obesity ; Republic of Korea/epidemiology
    Language English
    Publishing date 2022-05-25
    Publishing country Korea (South)
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2022.0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Delirium After Traumatic Brain Injury

    Soo Jeong Han / Jee Hyun Suh / Ja Young Lee / Soo Jin Kim

    Annals of Rehabilitation Medicine, Vol 47, Iss 3, Pp 214-

    Prediction by Location and Size of Brain Lesion

    2023  Volume 221

    Abstract: Objective To examine (1) the location of brain lesion that would predict post-traumatic delirium and (2) the association between volume of brain lesion and occurrence of delirium in patients with traumatic brain injury (TBI). Methods A retrospective ... ...

    Abstract Objective To examine (1) the location of brain lesion that would predict post-traumatic delirium and (2) the association between volume of brain lesion and occurrence of delirium in patients with traumatic brain injury (TBI). Methods A retrospective study was conducted by reviewing medical records of 68 TBI patients, categorized into two groups: the delirious group (n=38) and non-delirious group (n=30). The location and volume of TBI were investigated with the 3D Slicer software. Results The TBI region in the delirious group mainly involved the frontal or temporal lobe (p=0.038). All 36 delirious patients had brain injury on the right side (p=0.046). The volume of hemorrhage in the delirious group was larger by about 95 mL compared to the non-delirious group, but this difference was not statistically significant (p=0.382). Conclusion Patients with delirium after TBI had significantly different injury site and side, but not lesion size compared to patients without delirium.
    Keywords traumatic brain injury ; delirium ; intracranial hemorrhages ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Korean Academy of Rehabilitation Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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