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Article ; Online: Strategies to mitigate heating during radiofrequency ablation for atrial fibrillation.

Dhawan, Rahul / DeSimone, Christopher V

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2022 Volume 66, Issue 8, Page(s) 1769–1771

Language	English
Publishing date	2022-12-10
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-022-01443-2
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Article ; Online: Successful prediction of left bundle branch block-induced cardiomyopathy and treatment effect by artificial intelligence-enabled electrocardiogram.

Dhawan, Rahul / Omer, Mohamed / Carpenter, Caitlin / Friedman, Paul A / Liu, Xiaoke

Pacing and clinical electrophysiology : PACE

2024

Abstract: Background: Left bundle branch block (LBBB) induced cardiomyopathy is an increasingly recognized disease entity. However, no clinical testing has been shown to be able to predict such an occurrence.: Case report: A 70-year-old male with a prior ... ...

Abstract	Background: Left bundle branch block (LBBB) induced cardiomyopathy is an increasingly recognized disease entity. However, no clinical testing has been shown to be able to predict such an occurrence. Case report: A 70-year-old male with a prior history of LBBB with preserved ejection fraction (EF) and no other known cardiovascular conditions presented with presyncope, high-grade AV block, and heart failure with reduced EF (36%). His coronary angiogram was negative for any obstructive disease. No other known etiologies for cardiomyopathy were identified. Artificial intelligence-enabled ECGs performed 6 years prior to clinical presentation consistently predicted a high probability (up to 91%) of low EF. The patient successfully underwent left bundle branch area (LBBA) pacing with correction of the underlying LBBB. Subsequent AI ECGs showed a large drop in the probability of low EF immediately after LBBA pacing to 47% and then to 3% 2 months post procedure. His heart failure symptoms markedly improved and EF normalized to 54% at the same time. Conclusions: Artificial intelligence-enabled ECGS may help identify patients who are at risk of developing LBBB-induced cardiomyopathy and predict the response to LBBA pacing.
Language	English
Publishing date	2024-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14980
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Gastrointestinal treatment-related adverse events of combined immune checkpoint inhibitors: a meta-analysis.

Karna, Rahul / S Deliwala, Smit / Ramgopal, Balasubramanian / Asawa, Palash / Mishra, Rahul / P Mohan, Babu / Jayakrishnan, Thejus / Grover, Dheera / Kalra, Tanisha / Bhalla, Jaideep / Saraswati, Ushasi / K Gangwani, Manesh / Dhawan, Manish / G Adler, Douglas

Immunotherapy

2023 Volume 15, Issue 10, Page(s) 773–786

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/drug therapy ; Diarrhea ; Colon
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2023-0001
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Article: Case Report: ST-Elevation Myocardial Infarction Secondary to Acute Atherothrombotic Occlusion Treated With No Stent Strategy.

Dhawan, Rahul / Samant, Saurabhi / Gajanan, Ganesh / Chatzizisis, Yiannis S

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 834676

Abstract: Background: Intravascular imaging plays a vital role in the pathophysiology-based diagnosis and treatment of patients with ST-elevation myocardial infarction (STEMI). We present a case of STEMI due to plaque erosion, which was managed with a no stent ... ...

Abstract	Background: Intravascular imaging plays a vital role in the pathophysiology-based diagnosis and treatment of patients with ST-elevation myocardial infarction (STEMI). We present a case of STEMI due to plaque erosion, which was managed with a no stent approach. Case summary: A 43-year-old female with a history of tobacco abuse presented with an anterior STEMI. Coronary angiography revealed acute thrombotic occlusion of the left anterior descending artery with spontaneous recanalization. Intravascular imaging with optical coherence tomography (OCT) demonstrated plaque erosion as the underlying etiology for the acute thrombotic occlusion. A no stent strategy with aspiration thrombectomy and dual antiplatelet therapy was used to manage the patient given that there was no evidence of plaque rupture. Repeat coronary imaging was done at 2 months to assess the status of the lesion. Conclusion: A 43-year-old female with STEMI due to plaque erosion was successfully managed only by thrombus aspiration and not by angioplasty and stent placement. Individualized treatment approaches in patients with acute coronary syndromes, can not only achieve optimal management goals but also avoid unnecessary complications associated with interventions. This case illustrates how intracoronary imaging and pathophysiology-guided treatment can dramatically change management. In this young patient, STEMI was managed purely by thrombus aspiration. Intravascular imaging obviated the need for stent placement possibly preventing stent-related complications including restenosis and thrombosis.
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.834676
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Article ; Online: Professional Challenges for United States Hematology/Oncology Trainees during COVID-19.

Banerjee, Rahul / Kareff, Samuel A / Leyfman, Yan / Dhawan, Natasha / Hammons, Lindsay R / Desai, Aakash / Tsang, Mazie / Velazquez, Ana I / Nizam, Amanda

Cancer investigation

2023 Volume 41, Issue 6, Page(s) 539–547

Abstract: COVID-19 has been devastating for patients with cancer. In this commentary, we chronicle the pandemic's downstream impacts on United States hematology/oncology trainees in terms of professional development and career advancement. These include loss of ... ...

Abstract	COVID-19 has been devastating for patients with cancer. In this commentary, we chronicle the pandemic's downstream impacts on United States hematology/oncology trainees in terms of professional development and career advancement. These include loss of access to clinical electives and protocol workshops, delays in research approval and execution, mentor shortages due to academic burnout, and obstacles with career transitions (most notably the post-fellowship job search). While certain silver linings from the pandemic have undoubtedly emerged, continued progress against COVID-19 will be essential to fully overcome the professional challenges it has created for the future hematology/oncology workforce.
MeSH term(s)	Humans ; United States/epidemiology ; COVID-19/epidemiology ; Medical Oncology ; Fellowships and Scholarships ; Hematology ; Pandemics
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2023.2199216
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Article: Arrhythmia-Induced Cardiomyopathy: Prevalent, Under-recognized, Reversible.

Dhawan, Rahul / Gopinathannair, Rakesh

Journal of atrial fibrillation

2017 Volume 10, Issue 3, Page(s) 1776

Abstract: Arrhythmia-induced cardiomyopathy (AIC) is a clinical condition in which a persistent tachyarrhythmia or frequent ectopy contribute to ventricular dysfunction leading to systolic heart failure. AIC can be partially or completely corrected with adequate ... ...

Abstract	Arrhythmia-induced cardiomyopathy (AIC) is a clinical condition in which a persistent tachyarrhythmia or frequent ectopy contribute to ventricular dysfunction leading to systolic heart failure. AIC can be partially or completely corrected with adequate treatment of the culprit arrhythmia. Several molecular and cellular alterations by which tachyarrhythmias lead to cardiomyopathy have been identified. AIC can affect children and adults, can be clinically silent in the form of asymptomatic tachycardia with cardiomyopathy, or can present with manifest heart failure. A high index of suspicion for AIC and aggressive treatment of the culprit arrhythmia can result in resolution of heart failure symptoms and improvement in cardiac function. Recurrent arrhythmia, following recovery from the index episode, can hasten the left ventricular dysfunction and result in HF, suggesting persistent adverse remodeling despite recovery of left ventricular function. Several aspects of AIC, such as predisposing factors, early diagnosis, preventive measures to avoid adverse remodeling, and long-term prognosis, remain unclear, and need further research.
Language	English
Publishing date	2017-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2451936-4
ISSN	1941-6911
ISSN	1941-6911
DOI	10.4022/jafib.1776
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Article ; Online: Assessment of Choroidal Thickness in Acute Central Serous Chorioretinopathy Using Swept Source Optical Coherence Tomography

Arjun Bamel / Parag K Shah / Rahul Bharadwaj / Aeshvarya Dhawan / Anupam Singh

Journal of Clinical and Diagnostic Research, Vol 16, Iss 9, Pp 5-

A Case-control study

2022 Volume 8

Abstract: Introduction: Central Serous Chorioretinopathy (CSCR) is a disease characterised by localised Neurosensory Detachment (NSD) with or without focal Pigment Epithelial Detachments (PED) and altered Retinal Pigment Epithelium (RPE). Since, CSCR being a ... ...

Abstract	Introduction: Central Serous Chorioretinopathy (CSCR) is a disease characterised by localised Neurosensory Detachment (NSD) with or without focal Pigment Epithelial Detachments (PED) and altered Retinal Pigment Epithelium (RPE). Since, CSCR being a pachychoroid entity the visualisation and evaluation of choroidal vessels have shown that vascular layers are altered in the disease process. Aim: To assess Subfoveal Choroidal Thickness (SFCT), in acute CSCR patients in both affected and fellow unaffected eyes using Swept Source Optical Coherence Tomography (SS-OCT), and to compare these with age-matched control group. Materials and Methods: This was a hospital-based case-control study, conducted between July 2018 to May 2019 at Outpatient Department (OPD) of Aravind Eye Hospital, Coimbatore, India. Total of 41 patients and 41 controls from OPD were included. Uncorrected Visual Acuity (UCVA) and Best Corrected Visual Acuity (BCVA) were measured on Snellen’s chart. After pupil dilatation, posterior segment evaluation with slit lamp bio microscopy using a 90D lens and documentation with fundus photograph were done. All subjects were examined using SSOCT which was done for both the eyes. Descriptive analysis such as mean, standard deviation and percentage were used to exhibit the clinical parameters. Independent t-test analysis was more suitable for this data. All the statistical tests were examined with 5% (p-value≤0.05) level of significance. Results: The age (mean±SD) of cases and controls were 38.44±6.14 years and 37.21±2.72 years, respectively. The mean SFCT of affected and unaffected fellow eye of cases were 465.39±60.02 μm and 407.12±57.29 μm respectively, (p-value<0.001). The mean SFCT of affected eyes of cases and control group eyes were 465.39±60.02 μm and 267.5±34.40 μm respectively, (p-value<0.001). Conclusion: The choroid was significantly thicker in affected as well as unaffected eye of CSCR patient. This implies that the CSCR affect the choroidal thickness in both affected as well as unaffected eye ...
Keywords	bullous retinal detachment ; pachychoroid ; pigment epithelial detachment ; Medicine ; R
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Phonetic Word Embeddings

Sharma, Rahul / Dhawan, Kunal / Pailla, Balakrishna

2021

Abstract: This work presents a novel methodology for calculating the phonetic similarity between words taking motivation from the human perception of sounds. This metric is employed to learn a continuous vector embedding space that groups similar sounding words ... ...

Abstract	This work presents a novel methodology for calculating the phonetic similarity between words taking motivation from the human perception of sounds. This metric is employed to learn a continuous vector embedding space that groups similar sounding words together and can be used for various downstream computational phonology tasks. The efficacy of the method is presented for two different languages (English, Hindi) and performance gains over previous reported works are discussed on established tests for predicting phonetic similarity. To address limited benchmarking mechanisms in this field, we also introduce a heterographic pun dataset based evaluation methodology to compare the effectiveness of acoustic similarity algorithms. Further, a visualization of the embedding space is presented with a discussion on the various possible use-cases of this novel algorithm. An open-source implementation is also shared to aid reproducibility and enable adoption in related tasks.
Keywords	Computer Science - Computation and Language
Subject code	410
Publishing date	2021-09-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Two Limitations of Subcutaneous Implantable Cardioverter Defibrillator in the Same Patient Warranting Its Explant.

Dhawan, Rahul / Ahmad, Mansoor / Jhand, Aravdeep / Kanwal, Sumera / Jamil, Adeel / Khan, Faris

The American journal of case reports

2021 Volume 22, Page(s) e928983

Abstract: BACKGROUND A subcutaneous implantable cardioverter defibrillator (S-ICD) is preferred over a transvenous implantable cardioverter defibrillator (TV-ICD) in selected cases owing to a lower rate of lead-related complications such as infections and venous ... ...

Abstract	BACKGROUND A subcutaneous implantable cardioverter defibrillator (S-ICD) is preferred over a transvenous implantable cardioverter defibrillator (TV-ICD) in selected cases owing to a lower rate of lead-related complications such as infections and venous thrombosis. However, the S-ICD has its own limitations, including inappropriate shocks due to oversensed events, and the inability to treat ventricular tachycardia (VT) below a heart rate of 170 beats per minutes (bpm). We present a patient case which showed manifestations of both of these limitations, warranting explant of the device. CASE REPORT A 50-year-old man with a history of nonischemic cardiomyopathy and VT had a S-ICD placed at an outside facility. However, he continued to have VT despite on anti-arrhythmic drugs and required recurrent S-ICD shocks. Device interrogation showed that he was intermittently receiving appropriate shocks for slower VT (with a heart rate ranging from 150 bpm to 160 bpm) due to oversensing of T waves. However, treatment was delayed for other VT episodes owing to appropriate sensing and the patient's heart rate being below the lowest detection zone for S-ICD. Due to slower VT cycle length and frequent oversensed events, the S-ICD was ultimately replaced by a TV-ICD system. CONCLUSIONS This case report emphasizes the importance of S-ICD pre-implant vector screening and the need for paying attention to VT cycle length to prevent inappropriate device shocks and/or delayed therapies.
MeSH term(s)	Arrhythmias, Cardiac ; Defibrillators, Implantable/adverse effects ; Electric Countershock ; Humans ; Male ; Middle Aged ; Tachycardia, Ventricular/therapy ; Treatment Outcome
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.928983
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Article ; Online: A 37-Year-Old Woman with Hypertrophic Cardiomyopathy with a Dual-Chamber Implantable Cardioverter-Defibrillator Requiring Percutaneous Transvenous Lead Extraction and Multidisciplinary Management.

Dhawan, Rahul / Khan, Faris / Samant, Saurabhi / Asawaeer, Majid / Merritt Genore, HelenMari / Erickson, Christopher C

The American journal of case reports

2021 Volume 22, Page(s) e932073

Abstract: BACKGROUND Percutaneous transvenous lead extraction (TLE) of cardiac implantable electronic devices can be performed with a high success rate. However, TLE has its limitations and challenges. Recognizing the challenges at an early stage during the ... ...

Abstract	BACKGROUND Percutaneous transvenous lead extraction (TLE) of cardiac implantable electronic devices can be performed with a high success rate. However, TLE has its limitations and challenges. Recognizing the challenges at an early stage during the procedure is vital for appropriate patient management. We present a challenging case of implantable cardioverter-defibrillator (ICD) lead extraction in which we aborted TLE in favor of elective surgical extraction (SE). This potentially prevented a major catastrophic complication of vascular tear, which would have required an emergent thoracotomy. CASE REPORT A 37-year-old woman with history of hypertrophic cardiomyopathy had a primary prevention dual-chamber ICD implant in 2001 and underwent right ventricular ICD lead revision in 2009 due to lead fracture. In 2019, she was again found to have right ventricular ICD lead malfunction. TLE was attempted, but no meaningful progression could be made despite using multiple extraction tools. Therefore, TLE was aborted in favor of SE. During elective SE, significant adhesions were noted, and the innominate vein was completely avulsed during removal of the leads, requiring venous reconstruction by the vascular surgery team. After SE and vascular reconstruction, an epicardial ICD system was placed, and the patient had an uneventful postoperative recovery. CONCLUSIONS This case report highlights the limitations of TLE and the importance of recognizing them in a timely manner. In all challenging cases, conversion to elective SE should be considered to avoid potential injuries warranting emergent surgical repair.
MeSH term(s)	Adult ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/therapy ; Defibrillators, Implantable/adverse effects ; Device Removal ; Female ; Humans ; Tissue Adhesions ; Treatment Outcome
Language	English
Publishing date	2021-10-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.932073
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