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Article ; Online: Sirtuin modulators: past, present, and future perspectives.

Fiorentino, Francesco / Mautone, Nicola / Menna, Martina / D'Acunzo, Francesca / Mai, Antonello / Rotili, Dante

Future medicinal chemistry

2022 Volume 14, Issue 12, Page(s) 915–939

Abstract: Sirtuins are ... ...

Abstract	Sirtuins are NAD
MeSH term(s)	Animals ; Gene Expression Regulation ; Mammals ; Neoplasms/drug therapy ; Protein Isoforms/metabolism ; Sirtuins
Chemical Substances	Protein Isoforms ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Journal Article ; Review
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2022-0031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Could Insect Products Provide a Safe and Sustainable Feed Alternative for the Poultry Industry? A Comprehensive Review

Ayman Khalifah / Sara Abdalla / Mai Rageb / Lucianna Maruccio / Francesca Ciani / Karim El-Sabrout

Animals, Vol 13, Iss 1534, p

2023 Volume 1534

Abstract: The planet is home to more than 2000 species of edible insects, some of which have been consumed as food for many years. Recently, edible insect products have been gradually increasing in several countries, such as Italy and Egypt, as novel feed ... ...

Abstract	The planet is home to more than 2000 species of edible insects, some of which have been consumed as food for many years. Recently, edible insect products have been gradually increasing in several countries, such as Italy and Egypt, as novel feed resources for humans and animals due to their availability, potential economic benefits, and high nutritive value. The insect industry can provide a new solution for livestock nutrition and offer many additional advantages, but there are obstacles to overcome, such as some nutritional organizations that forbid its usage. Nevertheless, previous research indicates that different insect species could be used safely as nutraceuticals in poultry farming to improve broiler growth performance (>3%) and layer egg production (>5%). Among these species, there are various products and extracts that can be used in poultry nutrition in a sustainable manner. This review provides an outline of insect composition, nutrient values, application in poultry feed, safety, and guidelines, and finally, the future perspectives of insects as an alternative feed source in poultry diets.
Keywords	edible insect products ; egg production ; growth ; gut health ; immunity ; meat quality ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anticancer evaluation of new organometallic ruthenium(ii) flavone complexes.

Khater, Mai / Brazier, John A / Greco, Francesca / Osborn, Helen M I

RSC medicinal chemistry

2022 Volume 14, Issue 2, Page(s) 253–267

Abstract: Targeting multiple malignancy features such as angiogenesis, proliferation and metastasis with one molecule is an effective strategy in developing potent anticancer agents. Ruthenium metal complexation to bioactive scaffolds is reported to enhance their ... ...

Abstract	Targeting multiple malignancy features such as angiogenesis, proliferation and metastasis with one molecule is an effective strategy in developing potent anticancer agents. Ruthenium metal complexation to bioactive scaffolds is reported to enhance their biological activities. Herein, we evaluate the impact of Ru chelation on the pharmacological activities of two bioactive flavones (1 and 2) as anticancer candidates. The novel Ru complexes (1Ru and 2Ru) caused a loss of their parent molecules' antiangiogenic activities in an endothelial cell tube formation assay. 1Ru enhanced the antiproliferative and antimigratory activities of its 4-oxoflavone 1 on MCF-7 breast cancer cells (IC
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d2md00304j
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Article ; Online: COVID-19 and cardiovascular diseases.

Mai, Francesca / Del Pinto, Rita / Ferri, Claudio

Journal of cardiology

2020 Volume 76, Issue 5, Page(s) 453–458

Abstract: Infection by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the second pandemic of the XXI century after influenza A in 2009. As of mid-June 2020, more than 4,40,000 fatal cases of SARS-CoV-2-related disease (COVID-19) ...

Abstract	Infection by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the second pandemic of the XXI century after influenza A in 2009. As of mid-June 2020, more than 4,40,000 fatal cases of SARS-CoV-2-related disease (COVID-19) have occurred worldwide. Besides its prominent expression at the level of the respiratory apparatus, COVID-19 is also characterized by a substantial degree of cardiovascular involvement, both in terms of deterioration of pre-existing conditions, and as the effect of inflammation-facilitated acute events. They include ischemic/inflammatory heart disease, ventricular arrhythmias, conduction disturbances, thrombotic events at the level of the lungs, and systemic activation of the coagulation cascade, configuring the scenario of disseminated intravascular coagulation. Herein, we summarize the main COVID-19 features of relevance for the clinicians in the cardiovascular field. The rationale, concerns, and possible side effects of specific therapeutic measures, including anticoagulants, renin-angiotensin-aldosterone system inhibitors, and anti-inflammatory/antiviral medications applied to the treatment of COVID-19 are also discussed.
MeSH term(s)	Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/virology ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/physiopathology ; Renin-Angiotensin System ; SARS-CoV-2 ; Thrombosis/virology ; COVID-19 Drug Treatment
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Anticoagulants ; Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-07-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2020.07.013
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Article ; Online: COVID-19 and cardiovascular diseases

Mai, Francesca / Del Pinto, Rita / Ferri, Claudio

Journal of Cardiology

2020 Volume 76, Issue 5, Page(s) 453–458

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2020.07.013
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 1794: Show issues

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Article ; Online: Could Insect Products Provide a Safe and Sustainable Feed Alternative for the Poultry Industry? A Comprehensive Review

Khalifah, Ayman / Abdalla, Sara / Rageb, Mai / Maruccio, Lucianna / Ciani, Francesca / El-Sabrout, Karim

Animals. 2023 May 03, v. 13, no. 9

2023

Abstract	The planet is home to more than 2000 species of edible insects, some of which have been consumed as food for many years. Recently, edible insect products have been gradually increasing in several countries, such as Italy and Egypt, as novel feed resources for humans and animals due to their availability, potential economic benefits, and high nutritive value. The insect industry can provide a new solution for livestock nutrition and offer many additional advantages, but there are obstacles to overcome, such as some nutritional organizations that forbid its usage. Nevertheless, previous research indicates that different insect species could be used safely as nutraceuticals in poultry farming to improve broiler growth performance (>3%) and layer egg production (>5%). Among these species, there are various products and extracts that can be used in poultry nutrition in a sustainable manner. This review provides an outline of insect composition, nutrient values, application in poultry feed, safety, and guidelines, and finally, the future perspectives of insects as an alternative feed source in poultry diets.
Keywords	dietary supplements ; edible insects ; egg production ; growth performance ; livestock nutrition ; nutritive value ; poultry ; poultry feed ; poultry industry ; poultry nutrition ; Egypt ; Italy
Language	English
Dates of publication	2023-0503
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13091534
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Early epilepsy surgery for non drug-resistant patients.

Pelliccia, Veronica / Deleo, Francesco / Gozzo, Francesca / Giovannelli, Ginevra / Mai, Roberto / Cossu, Massimo / Tassi, Laura

Epilepsy & behavior reports

2022 Volume 19, Page(s) 100542

Abstract: The aim of epilepsy treatment is to achieve seizure freedom. Surgery is often still considered a late option when pharmacological treatments have failed and epilepsy has become drug-resistant. We analyse the clinical features and surgical outcome in ... ...

Abstract	The aim of epilepsy treatment is to achieve seizure freedom. Surgery is often still considered a late option when pharmacological treatments have failed and epilepsy has become drug-resistant. We analyse the clinical features and surgical outcome in patients who underwent surgery without experiencing drug-resistance comparing with those observed in patients who became drug-resistant. Two-hundred and fifty patients with symptomatic focal epilepsy (12.1% of patients who underwent surgery at the "Claudio Munari" Epilepsy Surgery Center) were selected on the basis of initial period of seizure freedom and followed-up for at least 12 months. Patients were divided into two groups: those who underwent surgery during the initial period of seizure freedom (n = 74), and those who underwent surgery after an initial seizure-free period followed by drug-resistance (n = 176). Outcomes were significantly better in non-drug-resistant patients (p < 0.001), all of whom had Engel class Ia or Ic. In the drug-resistant group, 136 patients (77.3%) had class Ia or Ic. The median post-operative follow-up was respectively 75.0 and 84.0 months. Epilepsy surgery is a successful treatment, especially for non-drug-resistant patients with focal epilepsy with structural etiology. The timing of surgery affects the outcomes, and "early" surgery should be preferred to prevent likely drug-resistance and to improve prognosis.
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article
ISSN	2589-9864
ISSN (online)	2589-9864
DOI	10.1016/j.ebr.2022.100542
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Article: Could Insect Products Provide a Safe and Sustainable Feed Alternative for the Poultry Industry? A Comprehensive Review.

Khalifah, Ayman / Abdalla, Sara / Rageb, Mai / Maruccio, Lucianna / Ciani, Francesca / El-Sabrout, Karim

Animals : an open access journal from MDPI

2023 Volume 13, Issue 9

Abstract	The planet is home to more than 2000 species of edible insects, some of which have been consumed as food for many years. Recently, edible insect products have been gradually increasing in several countries, such as Italy and Egypt, as novel feed resources for humans and animals due to their availability, potential economic benefits, and high nutritive value. The insect industry can provide a new solution for livestock nutrition and offer many additional advantages, but there are obstacles to overcome, such as some nutritional organizations that forbid its usage. Nevertheless, previous research indicates that different insect species could be used safely as nutraceuticals in poultry farming to improve broiler growth performance (>3%) and layer egg production (>5%). Among these species, there are various products and extracts that can be used in poultry nutrition in a sustainable manner. This review provides an outline of insect composition, nutrient values, application in poultry feed, safety, and guidelines, and finally, the future perspectives of insects as an alternative feed source in poultry diets.
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13091534
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Article ; Online: Prandial state and biological sex modulate clinically relevant efflux transporters to different extents in Wistar and Sprague Dawley rats.

Gavins, Francesca K H / Dou, Liu / Qin, Yujia / Madla, Christine M / Murdan, Sudaxshina / Basit, Abdul W / Mai, Yang / Orlu, Mine

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 160, Page(s) 114329

Abstract: P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 (MRP2) are clinically relevant efflux transporters implicated in the oral absorption of many food and drug substrates. Here, we hypothesised ... ...

Abstract	P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 (MRP2) are clinically relevant efflux transporters implicated in the oral absorption of many food and drug substrates. Here, we hypothesised that food intake could influence protein and mRNA intestinal expression of P-gp/abcb1a, BCRP/abcg2, and MRP2/abcc2 differently in male and female Wistar and Sprague Dawley rats. To test this hypothesis, we used enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR) to quantify the protein and mRNA intestinal expression of these transporters, respectively. Our study found food and sex differences in P-gp expression, whereby in the fed state P-gp expression decreased in male Wistar rats, but P-gp expression increased in females. In the fed state, BCRP expression increased in both male and female Wistar rats, compared with the fasted state. In contrast, no sex differences or food effect differences were seen in Sprague Dawley rats for P-gp and BCRP expression. On the other hand, in the fed state, MRP2 expression was higher in male and female Wistar and Sprague Dawley rats when compared with the fasted state. Sex differences were also observed in the fasted state. Overall, significant strain differences were reported for P-gp, BCRP and MRP2 expression. Strong to moderate positive linear correlations were found between ELISA and PCR quantification methods. ELISA may be more useful than PCR as it reports protein expression as opposed to transcript expression. Researchers must consider the influence of sex, strain and feeding status in preclinical studies of P-gp, BCRP and MRP2 drug substrates.
MeSH term(s)	Rats ; Male ; Female ; Animals ; Rats, Sprague-Dawley ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Rats, Wistar ; Neoplasm Proteins/metabolism ; Membrane Transport Proteins ; ATP Binding Cassette Transporter, Subfamily B ; Multidrug Resistance-Associated Protein 2 ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; RNA, Messenger/genetics ; Multidrug Resistance-Associated Proteins/genetics
Chemical Substances	ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Neoplasm Proteins ; Membrane Transport Proteins ; ATP Binding Cassette Transporter, Subfamily B ; Multidrug Resistance-Associated Protein 2 ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; RNA, Messenger ; Multidrug Resistance-Associated Proteins
Language	English
Publishing date	2023-01-31
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114329
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Ud II Zs.198: Show issues

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Article ; Online: Chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: Role of BDNF signaling in the infralimbic cortex.

Sadighi, Mina / Mai, Lingling / Xu, Yifan / Boillot, Morgane / Targa, Giorgia / Mottarlini, Francesca / Brambilla, Paolo / Gass, Peter / Caffino, Lucia / Fumagalli, Fabio / Homberg, Judith R

Journal of affective disorders

2024 Volume 351, Page(s) 128–142

Abstract: Background: Bipolar disorder (BD) is a highly burdensome psychiatric disorder characterized by alternating states of mania and depression. A major challenge in the clinic is the switch from depression to mania, which is often observed in female BD ... ...

Abstract	Background: Bipolar disorder (BD) is a highly burdensome psychiatric disorder characterized by alternating states of mania and depression. A major challenge in the clinic is the switch from depression to mania, which is often observed in female BD patients during antidepressant treatment such as imipramine. However, the underlying neural basis is unclear. Methods: To investigate the potential neuronal pathways, serotonin transporter knockout (SERT KO) rats, an experimental model of female BD patients, were subjected to a battery of behavioral tests under chronic treatment of the antidepressant imipramine. In addition, the expression of brain-derived neurotrophic factor (BDNF) and its downstream signaling was examined in the prefrontal cortex. Results: Chronic exposure to imipramine reduced anxiety and sociability and problem-solving capacity, and increased thigmotaxis and day/night activity in all animals, but specifically in female SERT KO rats, compared to female wild-type (WT) rats. Further, we found an activation of BDNF-TrkB-Akt pathway signaling in the infralimbic, but not prelimbic, cortex after chronic imipramine treatment in SERT KO, but not WT, rats. Limitations: Repeated testing behaviors could potentially affect the results. Additionally, the imipramine induced changes in behavior and in the BDNF system were measured in separate animals. Conclusions: Our study indicates that female SERT KO rats, which mirror the female BD patients with the 5-HTTLPR s-allele, are at higher risk of a switch to mania-like behaviors under imipramine treatment. Activation of the BDNF-TrkB-Akt pathway in the infralimbic cortex might contribute to this phenotype, but causal evidence remains to be provided.
MeSH term(s)	Humans ; Rats ; Female ; Animals ; Imipramine/pharmacology ; Imipramine/therapeutic use ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Mania/metabolism ; Depression ; Proto-Oncogene Proteins c-akt/metabolism ; Antidepressive Agents/pharmacology ; Hippocampus/metabolism
Chemical Substances	Imipramine (OGG85SX4E4) ; Brain-Derived Neurotrophic Factor ; Serotonin Plasma Membrane Transport Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Antidepressive Agents
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.186
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Zs.A 1485: Show issues

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