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  1. Article ; Online: Metabolic Endotoxemia and Arterial Stiffness in Diabetes.

    Loffredo, Lorenzo / Violi, Francesco

    Circulation research

    2022  Volume 131, Issue 6, Page(s) 555–557

    MeSH term(s) Blood Pressure ; Diabetes Mellitus ; Endotoxemia ; Humans ; Hypertension ; Vascular Stiffness
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Radial artery pseudo-aneurysm detected with a portable handheld ultrasound device in a COVID-19 patient.

    Loffredo, Lorenzo / Pignatelli, Pasquale

    Kardiologia polska

    2022  Volume 81, Issue 1, Page(s) 66–67

    MeSH term(s) Humans ; Radial Artery/diagnostic imaging ; COVID-19 ; Aneurysm ; Ultrasonography
    Language English
    Publishing date 2022-09-15
    Publishing country Poland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of severe thrombocytopenia on bleeding in chronic liver disease after low risk surgical procedures: a meta-analysis.

    Loffredo, Lorenzo / Maggio, Enrico / Vestri, Anna Rita / Di Rocco, Arianna / Pignatelli, Pasquale / Violi, Francesco

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2024  

    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Letter
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2024.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6326: Show issues Location:
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  4. Article ; Online: COVID-19 and cardiovascular injury: A role for oxidative stress and antioxidant treatment?

    Loffredo, Lorenzo / Violi, Francesco

    International journal of cardiology

    2020  Volume 312, Page(s) 136

    MeSH term(s) Antioxidants/pharmacology ; Betacoronavirus/physiology ; COVID-19 ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Coronavirus Infections/complications ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Humans ; NADPH Oxidase 2/metabolism ; Oxidative Stress/drug effects ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Antioxidants ; NADPH Oxidase 2 (EC 1.6.3.-)
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2020.04.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1673: Show issues Location:
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  5. Article ; Online: Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis.

    Maggio, Enrico / Bocchini, Valeria Proietti / Carnevale, Roberto / Pignatelli, Pasquale / Violi, Francesco / Loffredo, Lorenzo

    Nutrition reviews

    2023  

    Abstract: Context: A previous study showed that vitamin E is effective in reducing the incidence of myocardial infarction only when it is taken in the absence of other antioxidants. It is unclear if it also reduces the incidence of stroke.: Objective: The aim ... ...

    Abstract Context: A previous study showed that vitamin E is effective in reducing the incidence of myocardial infarction only when it is taken in the absence of other antioxidants. It is unclear if it also reduces the incidence of stroke.
    Objective: The aim of this meta-analysis is to compare the effect of vitamin E supplementation alone or combined with other antioxidants on the incidence of stroke.
    Data sources: A search was performed in the following databases: PubMed, ISI Web of Science, SCOPUS, and Cochrane Library.
    Data extraction: Sixteen randomized controlled trials were selected to evaluate the effect of vitamin E supplementation on stroke.
    Data analysis: The range of vitamin E doses used was 33-800 IU. The follow-up period ranged from 6 months to 9.4 years. Compared with controls, when vitamin E was given alone it did not reduce the incidence of ischemic and hemorrhagic stroke. Conversely, compared with controls, supplementation of vitamin E with other antioxidants reduced ischemic stroke (random effects, RR: 0.91; 95% CI: 0.84-0.99; P = 0.02) but with a significant increase in hemorrhagic stroke (random effects, RR: 1.22; 95% CI: 1.0-1.48; P = 0.04).
    Conclusions: Supplementation with vitamin E alone is not associated with stroke reduction. Instead, supplementation of vitamin E with other antioxidants reduces the incidence of ischemic stroke but increases the risk of hemorrhagic stroke, cancelling any beneficial effect derived. Thus, vitamin E is not recommended in stroke prevention.
    Systematic review registration: PROSPERO registration no. CRD42022258259.
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82067-2
    ISSN 1753-4887 ; 0029-6643
    ISSN (online) 1753-4887
    ISSN 0029-6643
    DOI 10.1093/nutrit/nuad114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3388: Show issues Location:
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  6. Article ; Online: Full

    Loffredo, Lorenzo / Di Castelnuovo, Augusto / Chiariello, Giovanni Alfonso / Pignatelli, Pasquale / Violi, Francesco

    Haematologica

    2022  Volume 107, Issue 8, Page(s) 1933–1939

    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19 ; Heparin, Low-Molecular-Weight ; Humans ; Venous Thromboembolism
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight
    Language English
    Publishing date 2022-08-01
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.280652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 and cardiovascular injury

    Loffredo, Lorenzo / Violi, Francesco

    International Journal of Cardiology

    A role for oxidative stress and antioxidant treatment?

    2020  Volume 312, Page(s) 136

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2020.04.066
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Thrombopoietin receptor agonists and risk of portal vein thrombosis in patients with liver disease and thrombocytopenia: A meta-analysis.

    Loffredo, Lorenzo / Violi, Francesco

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2018  Volume 51, Issue 1, Page(s) 24–27

    Abstract: Background: Treatment of thrombocytopenia with thrombopoietin receptor agonists (TPORAs) seems to be associated with portal vein thrombosis (PVT) in patients with chronic liver disease (CLD). We performed a meta-analysis of the trials carried out in ... ...

    Abstract Background: Treatment of thrombocytopenia with thrombopoietin receptor agonists (TPORAs) seems to be associated with portal vein thrombosis (PVT) in patients with chronic liver disease (CLD). We performed a meta-analysis of the trials carried out in this clinical setting to assess if such association is detectable.
    Methods: We performed a meta-analysis with studies that compared the effect of TPORAS vs placebo in patients with CLD and thrombocytopenia.
    Results: Four studies, including 1953 patients, reported the incidence of PVT in patients with CLD and thrombocytopenia treated with TPORAs or placebo. No significant difference was found for incidence of PVT in patients treated with TPORAs compared with placebo (O.R.: 2.8; 95% C.I., 0.97-8.16; p = 0.055). A significant association between PVT and TPORAs was observed only in patients treated with eltrombopag (O.R.: 3.8; 95% C.I., 1.14-13.2; p = 0.03). Three studies, including 514 patients who were undergoing an elective invasive procedure, analyzed the incidence of PVT in TPORAs-treated patients with CLD and thrombocytopenia; no significant difference was found for incidence of PVT in patients treated with TPORAs compared with placebo (O.R.: 2.6; 95% C.I., 0.6-11.6; p = 0.212). A significant difference was found for incidence of arterial and venous thrombo-embolic events in CLD patients treated with eltrombopag compared with placebo-treated patients (O.R.: 3.4; 95% C.I., 1.5-7.7; p = 0.003).
    Conclusion: The results of this meta-analysis show that TPORAs are not associated with PVT in CLD patients even in the case of surgical procedure. PVT risk seems to be associated only with eltrombopag use.
    MeSH term(s) Chronic Disease ; Humans ; Liver Diseases/complications ; Liver Diseases/drug therapy ; Portal Vein ; Receptors, Thrombopoietin/agonists ; Receptors, Thrombopoietin/therapeutic use ; Risk Factors ; Thrombocytopenia/complications ; Thrombocytopenia/drug therapy ; Venous Thrombosis/etiology
    Chemical Substances Receptors, Thrombopoietin
    Language English
    Publishing date 2018-06-20
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2018.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1134: Show issues Location:
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  10. Article ; Online: Anticoagulation in patients with advanced liver disease: an open issue.

    Violi, Francesco / Loffredo, Lorenzo / Pastori, Daniele

    Internal and emergency medicine

    2020  Volume 16, Issue 1, Page(s) 61–71

    Abstract: Liver disease has been long considered as a risk factor for bleeding for the presence of prolongation of global tests of clotting activation and low platelet count. For this reason, the use of anticoagulants in patients with liver disease and an ... ...

    Abstract Liver disease has been long considered as a risk factor for bleeding for the presence of prolongation of global tests of clotting activation and low platelet count. For this reason, the use of anticoagulants in patients with liver disease and an indication to anticoagulation, such as atrial fibrillation of venous thrombosis, has been poorly considered. Furthermore, recent studies underscored the fact that patients with chronic liver disease may experience thrombosis in portal as well as systemic circulation and treatment with anticoagulants should be considered. The introduction of direct oral anticoagulants has increased therapeutic options for thromboprophylaxis; however, evidence on their safety and efficacy in specific populations, such as patients with liver disease, is still scarce and needs further investigation. Thus, atrial fibrillation patients with coexistent liver disease have been excluded from clinical trials with direct oral anticoagulants. Here, we provide an overview on mechanisms of thrombosis in patients with advanced chronic liver disease and a summary of evidence on the use of oral anticoagulants in patients with liver disease and portal vein thrombosis or atrial fibrillation.
    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Chronic Disease ; Hemorrhage/chemically induced ; Humans ; Liver Diseases/complications ; Portal Vein ; Risk Factors ; Stroke/prevention & control ; Venous Thrombosis/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-10-18
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02526-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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