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  1. Article ; Online: Mechanism-based interventions for ASD cannot be implemented using conventional trial designs.

    Sprengers, Jan J / Geertjens, Lisa / Bruining, Hilgo

    Autism research : official journal of the International Society for Autism Research

    2024  Volume 17, Issue 2, Page(s) 202–203

    MeSH term(s) Humans ; Autism Spectrum Disorder/therapy
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.3086
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  2. Article ; Online: Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial.

    van Andel, Dorinde M / Sprengers, Jan J / Königs, Marsh / de Jonge, Maretha V / Bruining, Hilgo

    Journal of autism and developmental disorders

    2023  Volume 54, Issue 3, Page(s) 894–904

    Abstract: We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (≤ 1 mg ...

    Abstract We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (≤ 1 mg twice-daily) in unmedicated children 7-15 years with ASD. Children with IQ ≥ 70 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to - 0.013,p = .034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to - 0.001,p = .042). This study offers perspectives to include neurocognitive tests in ASD trials.
    MeSH term(s) Child ; Humans ; Autism Spectrum Disorder/drug therapy ; Bumetanide/adverse effects ; Autistic Disorder ; Intention ; Linear Models
    Chemical Substances Bumetanide (0Y2S3XUQ5H)
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-022-05841-3
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    Zs.A 765: Show issues Location:
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  3. Article ; Online: Dr. Sprengers et al. Reply.

    Sprengers, Jan J / van Andel, Dorinde M / Bruining, Hilgo

    Journal of the American Academy of Child and Adolescent Psychiatry

    2021  Volume 60, Issue 8, Page(s) 938–939

    Abstract: Before we elaborate on the postulated discrepancies between our trial and previous bumetanide in autism spectrum disorder (ASD) trials, we would like to acknowledge the crucial pioneering work on the γ-aminobutyric acid (GABA) developmental sequence by ... ...

    Abstract Before we elaborate on the postulated discrepancies between our trial and previous bumetanide in autism spectrum disorder (ASD) trials, we would like to acknowledge the crucial pioneering work on the γ-aminobutyric acid (GABA) developmental sequence by Dr. Ben-Ari and colleagues. Chloride dysregulation and altered GABA polarity have been implicated in neurological and neurodevelopmental disorders, including some forms of ASD. Etiologies underlying ASD are profoundly heterogeneous, and an important challenge is to link the optimal treatment to individual patients. Indeed, ASD animal models indicate reversed GABA polarity as a treatment target in some,
    MeSH term(s) Animals ; Autism Spectrum Disorder ; Autistic Disorder ; Bumetanide/pharmacology ; Humans ; Neurodevelopmental Disorders ; gamma-Aminobutyric Acid
    Chemical Substances Bumetanide (0Y2S3XUQ5H) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2020.12.034
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  4. Article ; Online: COVID-19 and child and adolescent psychiatry: an unexpected blessing for part of our population?

    Bruining, Hilgo / Bartels, Meike / Polderman, Tinca J C / Popma, Arne

    European child & adolescent psychiatry

    2020  Volume 30, Issue 7, Page(s) 1139–1140

    Keywords covid19
    Language English
    Publishing date 2020-07-04
    Publishing country Germany
    Document type Letter
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-020-01578-5
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  5. Article ; Online: Corrigendum to "Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials" [Contemp. Clin. Trials Commun. 36 (2023)/ DOI: 10.1016/j.conctc.2023.101233].

    Hollander, Bibiche den / Rothuizen-Lindenschot, Marieke / Geertjens, Lisa / Vaz, Frédéric M / Brands, Marion M / Le, Hoang Lan / van Eeghen, Agnies M / van de Ven, Peter M / Cornel, Martina C / Jacobs, Bart A W / Bruining, Hilgo / van Karnebeek, Clara D

    Contemporary clinical trials communications

    2024  Volume 38, Page(s) 101264

    Abstract: This corrects the article DOI: 10.1016/j.conctc.2023.101233.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.conctc.2023.101233.].
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Published Erratum
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2024.101264
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  6. Article ; Online: Resting-state network organisation in children with traumatic brain injury.

    Botchway, Edith / Kooper, Cece C / Pouwels, Petra J W / Bruining, Hilgo / Engelen, Marc / Oosterlaan, Jaap / Königs, Marsh

    Cortex; a journal devoted to the study of the nervous system and behavior

    2022  Volume 154, Page(s) 89–104

    Abstract: Children with traumatic brain injury are at risk of neurocognitive and behavioural impairment. Although there is evidence for abnormal brain activity in resting-state networks after TBI, the role of resting-state network organisation in paediatric TBI ... ...

    Abstract Children with traumatic brain injury are at risk of neurocognitive and behavioural impairment. Although there is evidence for abnormal brain activity in resting-state networks after TBI, the role of resting-state network organisation in paediatric TBI outcome remains poorly understood. This study is the first to investigate the impact of paediatric TBI on resting-state network organisation using graph theory, and its relevance for functional outcome. Participants were 8-14 years and included children with (i) mild TBI and risk factors for complicated TBI (mild
    MeSH term(s) Brain ; Brain Injuries, Traumatic ; Child ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-06-04
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/j.cortex.2022.05.014
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    Zs.A 687: Show issues Location:
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  7. Article ; Online: Personalized medicine for rare neurogenetic disorders: can we make it happen?

    van Eeghen, Agnies M / Bruining, Hilgo / Wolf, Nicole I / Bergen, Arthur A / Houtkooper, Riekelt H / van Haelst, Mieke M / van Karnebeek, Clara D

    Cold Spring Harbor molecular case studies

    2022  Volume 8, Issue 2

    Abstract: Rare neurogenetic disorders are collectively common, affecting 3% of the population, and often manifest with complex multiorgan comorbidity. With advances in genetic, -omics, and computational analysis, more children can be diagnosed and at an earlier ... ...

    Abstract Rare neurogenetic disorders are collectively common, affecting 3% of the population, and often manifest with complex multiorgan comorbidity. With advances in genetic, -omics, and computational analysis, more children can be diagnosed and at an earlier age. Innovations in translational research facilitate the identification of treatment targets and development of disease-modifying drugs such as gene therapy, nutraceuticals, and drug repurposing. This increasingly allows targeted therapy to prevent the often devastating manifestations of rare neurogenetic disorders. In this perspective, successes in diagnosis, prevention, and treatment are discussed with a focus on inherited disorders of metabolism. Barriers for the identification, development, and implementation of rare disease-specific therapies are discussed. New methodologies, care networks, and collaborative frameworks are proposed to optimize the potential of personalized genomic medicine to decrease morbidity and improve lives of these vulnerable patients.
    MeSH term(s) Child ; Genomics ; Humans ; Precision Medicine/methods ; Rare Diseases/diagnosis ; Rare Diseases/genetics ; Rare Diseases/therapy ; Translational Research, Biomedical
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2835759-0
    ISSN 2373-2873 ; 2373-2873
    ISSN (online) 2373-2873
    ISSN 2373-2873
    DOI 10.1101/mcs.a006200
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  8. Article ; Online: Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions.

    Schulte, Joran T / Wierenga, Corette J / Bruining, Hilgo

    Neuroscience and biobehavioral reviews

    2018  Volume 90, Page(s) 260–271

    Abstract: Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic inhibition during and beyond brain development. This regulation is mainly dependent on the two co-transporters ... ...

    Abstract Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic inhibition during and beyond brain development. This regulation is mainly dependent on the two co-transporters K
    MeSH term(s) Animals ; Epilepsy/metabolism ; Hippocampus/metabolism ; Humans ; Mental Disorders/metabolism ; Neurons/metabolism ; Sodium-Potassium-Chloride Symporters/metabolism ; Symporters/metabolism
    Chemical Substances Sodium-Potassium-Chloride Symporters ; Symporters
    Language English
    Publishing date 2018-05-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2018.05.001
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  9. Article: COVID-19 and child and adolescent psychiatry: an unexpected blessing for part of our population?

    Bruining, Hilgo / Bartels, Meike / Polderman, Tinca J C / Popma, Arne

    Eur. child adolesc. psychiatry

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #629765
    Database COVID19

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  10. Article ; Online: On Benzodiazepines, Paradoxical Agitation, Hyperactive Delirium, and Chloride Homeostasis.

    Schieveld, Jan N M / Strik, Jacqueline J M H / Bruining, Hilgo

    Critical care medicine

    2018  Volume 46, Issue 9, Page(s) 1558–1559

    MeSH term(s) Benzodiazepines ; Child ; Critical Illness ; Delirium ; Homeostasis ; Humans ; Psychomotor Agitation
    Chemical Substances Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2018-09-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003231
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