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  1. Article ; Online: Beyond the liver: The role of neurotensin in nonalcoholic fatty liver disease.

    Barchetta, Ilaria

    Journal of internal medicine

    2023  Volume 294, Issue 3, Page(s) 245–247

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Neurotensin
    Chemical Substances Neurotensin (39379-15-2)
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.44: Show issues Location:
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  2. Article ; Online: Neurotensin: Linking metabolism and cardiovascular disease.

    Barchetta, Ilaria / Cavallo, Maria Gisella

    Atherosclerosis

    2024  , Page(s) 117514

    Language English
    Publishing date 2024-03-08
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2024.117514
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  3. Article ; Online: Reply to Li and colleagues.

    Souza, Matheus / Diaz, Ivanna / Barchetta, Ilaria / Mantovani, Alessandro

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 44, Issue 1, Page(s) 265

    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15788
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    Zs.A 1632: Show issues Location:
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  4. Article ; Online: Gastrointestinal cancers in lean individuals with non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    Souza, Matheus / Diaz, Ivanna / Barchetta, Ilaria / Mantovani, Alessandro

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 44, Issue 1, Page(s) 6–14

    Abstract: Background & aims: Obesity and non-alcoholic fatty liver disease (NAFLD) are known risk factors for gastrointestinal (GI) cancers. However, GI carcinogenesis in lean NAFLD patients remains unclear. This systematic review and meta-analysis aims to ... ...

    Abstract Background & aims: Obesity and non-alcoholic fatty liver disease (NAFLD) are known risk factors for gastrointestinal (GI) cancers. However, GI carcinogenesis in lean NAFLD patients remains unclear. This systematic review and meta-analysis aims to investigate the association between lean NAFLD and GI cancer risk.
    Methods: PubMed, Embase and Cochrane Library databases were systematically searched (from inception date to April 2023) for cohort studies assessing GI cancers in lean (body mass index [BMI] < 25 kg/m
    Results: Eight studies with 56,745 NAFLD individuals (11% were lean) and 704 cases of incident GI cancers were included. Lean NAFLD was associated with higher risk of hepatic (RR 1.77, 95% CI 1.15-2.73), pancreatic (RR 1.97, 95% CI 1.01-3.86) and colorectal cancers (RR 1.53, 95% CI 1.12-2.09), compared to non-lean NAFLD. No significant differences were observed for oesophagus, gastric, biliary and small intestine cancers.
    Conclusions: This study shows that lean NAFLD patients have an increased risk of liver, pancreatic and colorectal cancers compared to non-lean NAFLD patients, emphasizing the need to explore tailored cancer prevention strategies for this specific patient group. Further research is required to explore the mechanisms underlying the association between lean NAFLD and specific GI cancers.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Risk Factors ; Gastrointestinal Neoplasms/epidemiology ; Gastrointestinal Neoplasms/complications ; Colorectal Neoplasms/complications
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15763
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    Zs.A 1632: Show issues Location:
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  5. Article: Could vitamin d supplementation benefit patients with chronic liver disease?

    Barchetta, Ilaria

    Gastroenterology & hepatology

    2014  Volume 8, Issue 11, Page(s) 755–757

    Language English
    Publishing date 2014-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
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    Zs.MO 517: Show issues

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  6. Article: Dipeptidyl Peptidase 4 (DPP4) as A Novel Adipokine: Role in Metabolism and Fat Homeostasis.

    Barchetta, Ilaria / Cimini, Flavia Agata / Dule, Sara / Cavallo, Maria Gisella

    Biomedicines

    2022  Volume 10, Issue 9

    Abstract: Dipeptidyl peptidase 4 (DPP4) is a molecule implicated in the regulation of metabolic homeostasis and inflammatory processes, and it exerts its main action through its enzymatic activity. DPP4 represents the enzyme most involved in the catabolism of ... ...

    Abstract Dipeptidyl peptidase 4 (DPP4) is a molecule implicated in the regulation of metabolic homeostasis and inflammatory processes, and it exerts its main action through its enzymatic activity. DPP4 represents the enzyme most involved in the catabolism of incretin hormones; thus, its activity impacts appetite, energy balance, and the fine regulation of glucose homeostasis. Indeed, DPP4 inhibitors represent a class of antidiabetic agents widely used for the treatment of Type 2 diabetes mellitus (T2DM). DPP4 also acts as an adipokine and is mainly secreted by the adipose tissue, mostly from mature adipocytes of the visceral compartment, where it exerts autocrine and paracrine activities. DPP4 can disrupt insulin signaling within the adipocyte and in other target cells and tissues, where it also favors the development of a proinflammatory environment. This is likely at the basis of the presence of elevated circulating DPP4 levels in several metabolic diseases. In this review, we summarize the most recent evidence of the role of the DPP4 as an adipokine-regulating glucose/insulin metabolism and fat homeostasis, with a particular focus on clinical outcomes associated with its increased secretion in the presence of adipose tissue accumulation and dysfunction.
    Language English
    Publishing date 2022-09-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10092306
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  7. Article ; Online: New Insights in the Control of Fat Homeostasis: The Role of Neurotensin.

    Barchetta, Ilaria / Baroni, Marco Giorgio / Melander, Olle / Cavallo, Maria Gisella

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Neurotensin (NT) is a small peptide with pleiotropic functions, exerting its primary actions by controlling food intake and energy balance. The first evidence of an involvement of NT in metabolism came from studies on the central nervous system and brain ...

    Abstract Neurotensin (NT) is a small peptide with pleiotropic functions, exerting its primary actions by controlling food intake and energy balance. The first evidence of an involvement of NT in metabolism came from studies on the central nervous system and brain circuits, where NT acts as a neurotransmitter, producing different effects in relation to the specific region involved. Moreover, newer interesting chapters on peripheral NT and metabolism have emerged since the first studies on the NT-mediated regulation of gut lipid absorption and fat homeostasis. Intriguingly, NT enhances fat absorption from the gut lumen in the presence of food with a high fat content, and this action may explain the strong association between high circulating levels of pro-NT, the NT stable precursor, and the increased incidence of metabolic disorders, cardiovascular diseases, and cancer observed in large population studies. This review aims to provide a synthetic overview of the main regulatory effects of NT on several biological pathways, particularly those involving energy balance, and will focus on new evidence on the role of NT in controlling fat homeostasis, thus influencing the risk of unfavorable cardio-metabolic outcomes and overall mortality in humans.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Fats/metabolism ; Homeostasis/physiology ; Humans ; Metabolic Diseases/metabolism ; Neurotensin/metabolism
    Chemical Substances Biomarkers ; Fats ; Neurotensin (39379-15-2)
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042209
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  8. Article ; Online: COVID-19 and diabetes: Is this association driven by the DPP4 receptor? Potential clinical and therapeutic implications.

    Barchetta, Ilaria / Cavallo, Maria Gisella / Baroni, Marco Giorgio

    Diabetes research and clinical practice

    2020  Volume 163, Page(s) 108165

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Dipeptidyl Peptidase 4 ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2020.108165
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    Zs.A 2047: Show issues Location:
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  9. Article ; Online: Technological Support to Intensive Insulin Therapy by a Novel Smartphone Application in Young Adults With Type 1 Diabetes: One Center's Experience.

    Barchetta, Ilaria / Cavallo, Maria Gisella

    Journal of diabetes science and technology

    2018  Volume 13, Issue 1, Page(s) 148–149

    MeSH term(s) Adult ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/methods ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Female ; Humans ; Hypoglycemia/blood ; Hypoglycemia/drug therapy ; Insulin/therapeutic use ; Male ; Middle Aged ; Mobile Applications ; Patient Compliance ; Psychological Distress ; Smartphone ; Surveys and Questionnaires
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2018-10-07
    Publishing country United States
    Document type Letter
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/1932296818803937
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  10. Article ; Online: New Insights in the Control of Fat Homeostasis

    Ilaria Barchetta / Marco Giorgio Baroni / Olle Melander / Maria Gisella Cavallo

    International Journal of Molecular Sciences, Vol 23, Iss 2209, p

    The Role of Neurotensin

    2022  Volume 2209

    Abstract: Neurotensin (NT) is a small peptide with pleiotropic functions, exerting its primary actions by controlling food intake and energy balance. The first evidence of an involvement of NT in metabolism came from studies on the central nervous system and brain ...

    Abstract Neurotensin (NT) is a small peptide with pleiotropic functions, exerting its primary actions by controlling food intake and energy balance. The first evidence of an involvement of NT in metabolism came from studies on the central nervous system and brain circuits, where NT acts as a neurotransmitter, producing different effects in relation to the specific region involved. Moreover, newer interesting chapters on peripheral NT and metabolism have emerged since the first studies on the NT-mediated regulation of gut lipid absorption and fat homeostasis. Intriguingly, NT enhances fat absorption from the gut lumen in the presence of food with a high fat content, and this action may explain the strong association between high circulating levels of pro-NT, the NT stable precursor, and the increased incidence of metabolic disorders, cardiovascular diseases, and cancer observed in large population studies. This review aims to provide a synthetic overview of the main regulatory effects of NT on several biological pathways, particularly those involving energy balance, and will focus on new evidence on the role of NT in controlling fat homeostasis, thus influencing the risk of unfavorable cardio–metabolic outcomes and overall mortality in humans.
    Keywords neurotensin ; gut peptides ; gastrointestinal hormones ; obesity ; NAFLD ; fatty liver ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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