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Article ; Online: Gender-specific insights into the irritable bowel syndrome pathophysiology. Focus on gut dysbiosis and permeability.

JohnBritto, Jerlin Stephy / Di Ciaula, Agostino / Noto, Antonino / Cassano, Velia / Sciacqua, Angela / Khalil, Mohamad / Portincasa, Piero / Bonfrate, Leonilde

European journal of internal medicine

2024

Abstract: Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder involving the brain-gut interaction. IBS is characterized by persistent abdominal pain and changes in bowel habits. IBS exerts significant impacts on quality of life ... ...

Abstract	Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder involving the brain-gut interaction. IBS is characterized by persistent abdominal pain and changes in bowel habits. IBS exerts significant impacts on quality of life and imposes huge economic costs. Global epidemiological data reveal variations in IBS prevalence, both globally and between genders, necessitating comprehensive studies to uncover potential societal and cultural influences. While the exact pathophysiology of IBS remains incompletely understood, the mechanism involves a dysregulation of the brain-gut axis, leading to disturbed intestinal motility, local inflammation, altered intestinal permeability, visceral sensitivity, and gut microbiota composition. We reviewed several gender-related pathophysiological aspects of IBS pathophysiology, by focusing on gut dysbiosis and intestinal permeability. This perspective paves the way to personalized and multidimensional clinical management of individuals with IBS.
Language	English
Publishing date	2024-03-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2024.03.011
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Article ; Online: Myocardial mechano-energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity.

Cefalo, Chiara Maria Assunta / Riccio, Alessia / Fiorentino, Teresa Vanessa / Succurro, Elena / Mannino, Gaia Chiara / Perticone, Maria / Sciacqua, Angela / Andreozzi, Francesco / Sesti, Giorgio

Obesity (Silver Spring, Md.)

2024 Volume 32, Issue 5, Page(s) 888–899

Abstract: Objective: Reduced myocardial mechano-energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with "metabolically healthy overweight" (MHOW) ...

Abstract	Objective: Reduced myocardial mechano-energetic efficiency (MEE) was associated with BMI. Subgroups of individuals with increased BMI but favorable cardiovascular risk profile were identified as individuals with "metabolically healthy overweight" (MHOW) and "metabolically healthy obesity" (MHO), respectively. We aim to investigate whether those with MHOW/MHO, defined as those having none of the components of metabolic syndrome, exhibit impaired MEE compared with their unhealthy counterparts. Methods: Myocardial MEE per gram of left ventricular mass (MEEi) was assessed by echocardiography in 2190 nondiabetic individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study who were divided, according to BMI and metabolic status, into groups of individuals with metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), MHOW, metabolically unhealthy overweight (MUOW), MHO, and metabolically unhealthy obesity (MUO). Results: After adjusting for age and sex, no differences in myocardial MEEi were observed among individuals with MHNW, MHOW, and MHO (p = 0.56). Myocardial MEEi was comparable among individuals with MUNW, MUOW, and MUO (p = 0.21). Individuals with MHNW, MHOW, and MHO displayed significantly higher myocardial MEEi compared with their unhealthy counterparts. Conclusions: Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.24006
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Appropriateness of direct oral anticoagulant prescribing in older subjects with atrial fibrillation discharged from acute medical wards.

De Vincentis, Antonio / Soraci, Luca / Arena, Elena / Sciacqua, Angela / Armentaro, Giuseppe / Aucella, Francesco / Corsonello, Andrea / Aucella, Filippo / Antonelli Incalzi, Raffaele

British journal of clinical pharmacology

2024 Volume 90, Issue 5, Page(s) 1231–1239

Abstract: Aims: Knowledge on the prescriptive practice of direct oral anticoagulants (DOACs) in older subjects with atrial fibrillation (AF) hospitalized in acute medical wards is limited. This study aimed to evaluate the prevalence and appropriateness of DOAC ... ...

Abstract	Aims: Knowledge on the prescriptive practice of direct oral anticoagulants (DOACs) in older subjects with atrial fibrillation (AF) hospitalized in acute medical wards is limited. This study aimed to evaluate the prevalence and appropriateness of DOAC prescriptions in hospitalized older subjects with AF, discharged from acute medical wards. Methods: We analysed a cohort of 609 subjects with AF, aged ≥65 years (mean age 85 years) enrolled from 39 geriatric and nephrology wards in Italy. DOAC prescriptive appropriateness was evaluated according to the summary of product characteristics (smPC), 2019 Beers and STOPP criteria, and drug-drug interactions (DDIs). Results: At hospital discharge, 33% of patients with AF were prescribed with DOAC, 26% with vitamin-K antagonist, while 41% did not receive any anticoagulant. Among subjects on DOAC therapy, 31% presented a violation of the smPC criteria (mainly underdosage-17%), while 48% and 18% presented a Beers/STOPP inappropriate prescription, or a DDI, respectively. Older age, lower body mass index (BMI), cancer and higher estimated glomerular filtration rate (eGFR) were independently associated with DOAC underdosage or missed prescription (age: adjusted odds ratio [aOR] 1.06, 95% confidence interval [95% CI] 1.00-1.12 for underdosage; eGFR: aOR 1.04, 95% CI 1.02-1.07 for underdosage; BMI: aOR 0.95, 95% CI 0.91-0.99 for missed prescription; cancer: aOR 1.93, 95% CI 1.19-3.13 for missed prescription). Conclusions: This study showed a suboptimal DOAC prescriptive practice in older in-patients, with frequent missed prescription and DOAC underdosage. Contrary to current recommendations, physicians appear overly concerned by bleeding risk in real-life older and frailer subjects. Strategies should be developed to promote appropriate DOAC prescription in the hospital setting.
MeSH term(s)	Humans ; Atrial Fibrillation/drug therapy ; Aged, 80 and over ; Aged ; Female ; Male ; Patient Discharge ; Inappropriate Prescribing/statistics & numerical data ; Inappropriate Prescribing/prevention & control ; Italy/epidemiology ; Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Drug Interactions ; Practice Patterns, Physicians'/statistics & numerical data ; Practice Patterns, Physicians'/standards ; Age Factors ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/therapeutic use ; Hospitalization/statistics & numerical data
Chemical Substances	Anticoagulants ; Factor Xa Inhibitors
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.16010
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Article ; Online: Correction to: Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register.

Succurro, Elena / Novella, Alessio / Nobili, Alessandro / Giofrè, Federica / Arturi, Franco / Sciacqua, Angela / Andreozzi, Francesco / Pietrangelo, Antonello / Sesti, Giorgio

Internal and emergency medicine

2023 Volume 18, Issue 5, Page(s) 1611

Language	English
Publishing date	2023-08-03
Publishing country	Italy
Document type	Published Erratum
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03361-1
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Zs.A 6673: Show issues

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Article ; Online: Association of sodium-glucose cotransporter 2 inhibitors with changes in comprehensive geriatric assessment in elderly diabetic patients with heart failure: Data from MAGIC-HF.

Armentaro, Giuseppe / Cassano, Velia / Condoleo, Valentino / Magurno, Marcello / Divino, Marcello / Pastura, Carlo Alberto / Miceli, Sofia / Maio, Raffaele / Arturi, Franco / Hribal, Marta Letizia / Brunetti, Antonio / Sesti, Giorgio / Rosano, Giuseppe Massimo Claudio / Sciacqua, Angela

European journal of heart failure

2024

Language	English
Publishing date	2024-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.3262
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Zs.A 5299: Show issues

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Article ; Online: Circadian Clock Desynchronization and Insulin Resistance.

Catalano, Federica / De Vito, Francesca / Cassano, Velia / Fiorentino, Teresa Vanessa / Sciacqua, Angela / Hribal, Marta Letizia

International journal of environmental research and public health

2022 Volume 20, Issue 1

Abstract: The circadian rhythm regulates biological processes that occur within 24 h in living organisms. It plays a fundamental role in maintaining biological functions and responds to several inputs, including food intake, light/dark cycle, sleep/wake cycle, and ...

Abstract	The circadian rhythm regulates biological processes that occur within 24 h in living organisms. It plays a fundamental role in maintaining biological functions and responds to several inputs, including food intake, light/dark cycle, sleep/wake cycle, and physical activity. The circadian timing system comprises a central clock located in the suprachiasmatic nucleus (SCN) and tissue-specific clocks in peripheral tissues. Several studies show that the desynchronization of central and peripheral clocks is associated with an increased incidence of insulin resistance (IR) and related diseases. In this review, we discuss the current knowledge of molecular and cellular mechanisms underlying the impact of circadian clock dysregulation on insulin action. We focus our attention on two possible mediators of this interaction: the phosphatases belonging to the pleckstrin homology leucine-rich repeat protein phosphatase family (PHLPP) family and the deacetylase Sirtuin1. We believe that literature data, herein summarized, suggest that a thorough change of life habits, with the return to synchronized food intake, physical activity, and rest, would doubtless halt the vicious cycle linking IR to dysregulated circadian rhythms. However, since such a comprehensive change may be incompatible with the demand of modern society, clarifying the pathways involved may, nonetheless, contribute to the identification of therapeutic targets that may be exploited to cure or prevent IR-related diseases.
MeSH term(s)	Humans ; Circadian Clocks/physiology ; Insulin Resistance ; Circadian Rhythm/physiology ; Suprachiasmatic Nucleus/metabolism ; Photoperiod
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010029
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Article ; Online: Clinical and Functional Effects of Inhaled Dual Therapy Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease: A Real-Life Study.

Pelaia, Corrado / Ferrante Bannera, Anna / Rotundo, Fioramante Lello / Tropea, Francesco Giuseppe / Armentaro, Giuseppe / Maglio, Angelantonio / Sciacqua, Angela / Vatrella, Alessandro / Pelaia, Girolamo

International journal of chronic obstructive pulmonary disease

2023 Volume 18, Page(s) 995–1002

Abstract: Background: The pharmacological association umeclidinium/vilanterol (UMEC/VI) allows to implement a very effective dual bronchodilation in chronic obstructive pulmonary disease (COPD), thus optimizing bronchodilating therapy.: Methods: The main ... ...

Abstract	Background: The pharmacological association umeclidinium/vilanterol (UMEC/VI) allows to implement a very effective dual bronchodilation in chronic obstructive pulmonary disease (COPD), thus optimizing bronchodilating therapy. Methods: The main purpose of our real-world observational study was to evaluate in COPD patients the effects of UMEC/VI on lung function and respiratory symptoms. Functional and clinical parameters were assessed at baseline, and after 52 weeks of treatment with this combined double inhaled therapy. Results: We enrolled 110 subjects suffering from COPD. A 12-month UMEC/VI treatment induced significant improvements in total lung capacity (TLC) (p < 0.05), and residual volume (RV) (p < 0.0001). Pulmonary deflation was paralleled by significant increases of forced expiratory volume in one second (FEV Conclusion: In conclusion, our study corroborates in a real-life context the effectiveness of UMEC/VI in COPD treatment. Indeed, our broad investigational strategy has allowed to better characterize the functional mechanisms underpinning the therapeutic properties of UMEC/VI association.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Bronchodilator Agents ; Treatment Outcome ; Muscarinic Antagonists ; Drug Combinations ; Administration, Inhalation ; Benzyl Alcohols ; Chlorobenzenes ; Quinuclidines ; Double-Blind Method
Chemical Substances	vilanterol (028LZY775B) ; GSK573719 ; Bronchodilator Agents ; Muscarinic Antagonists ; Drug Combinations ; Benzyl Alcohols ; Chlorobenzenes ; Quinuclidines
Language	English
Publishing date	2023-05-26
Publishing country	New Zealand
Document type	Observational Study ; Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S407238
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Article ; Online: Sex-based differences in the comprehensive geriatric assessment in elderly hospitalized patients with non-valvular atrial fibrillation.

Armentaro, Giuseppe / Pastori, Daniele / Castagna, Alberto / Condoleo, Valentino / Cassano, Velia / Pastura, Carlo Alberto / Francica, Mattea / Benincasa, Caterina / D'Alterio, Nicola / Arturi, Franco / Ruotolo, Giovanni / Sciacqua, Angela

European journal of internal medicine

2024

Abstract: Atrial fibrillation (AF) represents the most common supraventricular arrhythmia, with a prevalence of 1-3 % in the world population. Growing evidences show that AF plays an important role as a risk factor for the development of cognitive impairment (CoI) ...

Abstract	Atrial fibrillation (AF) represents the most common supraventricular arrhythmia, with a prevalence of 1-3 % in the world population. Growing evidences show that AF plays an important role as a risk factor for the development of cognitive impairment (CoI) and dementia, depression and functional limitation. The purpose of the study is to evaluate, in a large cohort of elderly hospitalized patients with nonvalvular AF (NVAF) on direct oral anticoagulants (DOACs) therapy, the prevalence of CoI, depression, and functional limitation, and to assess the different variables that may be detrimental or protective on the risk of CoI or functional limitation. 1004 elderly patients were enrolled, 384 men and 620 women, with a mean age of 84±7.1 years. The two groups were comparable for the main study variables, except for age, prevalence of hypertension and CKD, which were higher in women, while ischemic heart disease was higher in men. In addition, the two groups differed in the CHA
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2024.03.014
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Article: Effect of dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist on weight loss in subjects with obesity.

Zaffina, Isabella / Pelle, Maria Chiara / Armentaro, Giuseppe / Giofrè, Federica / Cassano, Velia / Sciacqua, Angela / Arturi, Franco

Frontiers in endocrinology

2023 Volume 14, Page(s) 1095753

Abstract: The occurrence of obesity is an increasing issue worldwide, especially in industrialized countries. Weight loss is important both to treat obesity and to prevent the development of complications. Currently, several drugs are used to treat obesity, but ... ...

Abstract	The occurrence of obesity is an increasing issue worldwide, especially in industrialized countries. Weight loss is important both to treat obesity and to prevent the development of complications. Currently, several drugs are used to treat obesity, but their efficacy is modest. Thus, new anti-obesity treatments are needed. Recently, there has been increased interest in the development of incretins that combine body-weight-lowering and glucose-lowering effects. Therefore, a new drug that simultaneously coactivates both the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R) has been developed. Tirzepatide, the first in this class, improves glycemic control by increasing insulin sensitivity and lipid metabolism as well as by reducing body weight. Combining the activation of the two receptors, greater improvement of β-cell function offers more effective treatment of diabetes and obesity with fewer adverse effects than selective GLP-1R agonists. In the present review, we discuss the progress in the use of GIPR and GLP-1R coagonists and review literature from
MeSH term(s)	Animals ; Humans ; Gastric Inhibitory Polypeptide/metabolism ; Glucagon-Like Peptide-1 Receptor/agonists ; Incretins ; Obesity/metabolism ; Weight Loss ; Glucose/therapeutic use
Chemical Substances	Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide-1 Receptor ; Incretins ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1095753
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Article: Mutual Effect Modification between Insulin Resistance and Endothelial Dysfunction in Predicting Incident Heart Failure in Hypertensives.

Perticone, Maria / Maio, Raffaele / Gigliotti, Simona / Shehaj, Ermal / Toscani, Alfredo Francesco / Capomolla, Antonella / Fabiani, Ginevra / Sciacqua, Angela / Perticone, Francesco

Biomedicines

2023 Volume 11, Issue 8

Abstract: Insulin resistance and endothelial dysfunction are associated with heart failure (HF). Our objective was to investigate whether endothelial dysfunction and insulin resistance are independent predictors of incident HF and if a possible interaction exists ... ...

Abstract	Insulin resistance and endothelial dysfunction are associated with heart failure (HF). Our objective was to investigate whether endothelial dysfunction and insulin resistance are independent predictors of incident HF and if a possible interaction exists between them. We enrolled 705 white never-treated hypertensives. Endothelium-dependent vasodilation was investigated by intra-arterial infusion of acetylcholine. During the follow-up [median: 117 months (range: 31-211)], we documented 223 new cases of HF (3.3 events/100 patient-years). We stratified the study population into progressors and non-progressors; progressors showed an older age and a higher prevalence of females, as well as higher mean values of baseline glucose, insulin, homeostasis model assessment (HOMA), creatinine, and high-sensitivity C-reactive protein (hs-CRP), whereas the estimated glomerular filtration rate (e-GFR) and endothelium-dependent vasodilation were lower. In the multiple Cox regression analysis, serum hs-CRP (HR = 1.362, (95% CI = 1.208-1.536), HOMA (HR = 1.293, 95% CI = 1.142-1.465), maximal acetylcholine (Ach)-stimulated forearm blood flow (FBF) (100% increment, HR = 0.807, 95% CI = 0.697-0.934), and e-GFR (10 mL/min/1.73 m
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082188
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