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Article ; Online: A Conversation with Dr. Ludmila Prokunina-Olsson.

Prokunina-Olsson, Ludmila

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2022 Volume 42, Issue 9, Page(s) 462–466

Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2022.29043.lup
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Article ; Online: Call for Special Issue Papers:

Prokunina-Olsson, Ludmila

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2021 Volume 42, Issue 11, Page(s) 551–552

MeSH term(s)	Interferons ; Antiviral Agents
Chemical Substances	Interferons (9008-11-1) ; Antiviral Agents
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2022.29044.cfp
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Article ; Online: The Interferon-Lambda Family Celebrates 20 Years of Scientific Discovery.

Donnelly, Raymond P / Prokunina-Olsson, Ludmila

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2023 Volume 43, Issue 9, Page(s) 359–362

Abstract: ... et al., 2003; Sheppard et al., 2003) and 10 years since the subsequent discovery of IFN-λ4 (Prokunina ... Olsson et al., 2013). The IFN-λ family (type III IFNs) includes 4 members: IFN-λ1, 2, 3, and 4, and all 4 ...

Abstract	It has now been 20 years since the original discovery of the interferon λ (IFN-λ) family (Kotenko et al., 2003; Sheppard et al., 2003) and 10 years since the subsequent discovery of IFN-λ4 (Prokunina-Olsson et al., 2013). The IFN-λ family (type III IFNs) includes 4 members: IFN-λ1, 2, 3, and 4, and all 4 of these proteins signal through the same heterodimeric receptor complex: IFN-λR1 plus IL-10R2. Throughout the past 20 years, much has been learned about the IFN-λ family and the important role of these cytokines in antiviral responses against viruses such as hepatitis C virus, influenza A virus, and SARS-CoV-2. This special issue of the
MeSH term(s)	Humans ; Interferon Lambda ; COVID-19 ; SARS-CoV-2 ; Interferons ; Cytokines
Chemical Substances	Interferon Lambda ; Interferons (9008-11-1) ; Cytokines
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2023.0122
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Article ; Online: Genetics of the Human Interferon Lambda Region.

Prokunina-Olsson, Ludmila

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2019 Volume 39, Issue 10, Page(s) 599–608

Abstract: Humans are polymorphic in their ability to produce type-III interferons. Most individuals of African ancestry are genetically capable of generating all 4 type-III interferons (IFN-λ1, 2, 3, and 4), whereas the majority of individuals of European and ... ...

Abstract	Humans are polymorphic in their ability to produce type-III interferons. Most individuals of African ancestry are genetically capable of generating all 4 type-III interferons (IFN-λ1, 2, 3, and 4), whereas the majority of individuals of European and Asian ancestry lack IFN-λ4 and thus can generate only IFN-λ1, 2, and 3. All 4 type-III IFNs are encoded by genes located within a ∼55 kb genomic region on human chromosome 19. Although IFN-λ4 appears to be important in animals, genetic alterations acquired in the Hominidae lineage, and particularly in humans, resulted in the elimination of IFN-λ4 or restriction of its activity, suggesting that IFN-λ4 function might be detrimental to human health. Genetic variants within the
MeSH term(s)	Animals ; Chromosomes, Human, Pair 9/genetics ; Chromosomes, Human, Pair 9/metabolism ; Genetic Loci ; Genetic Variation ; Hepacivirus/metabolism ; Hepatitis C/genetics ; Hepatitis C/metabolism ; Hepatitis C/pathology ; Humans ; Interferons/genetics ; Interferons/metabolism
Chemical Substances	interferon type III ; Interferons (9008-11-1)
Language	English
Publishing date	2019-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2019.0043
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Article ; Online: Genetics Helps to Find Synergy for Immune Checkpoint and Targeted Combination Therapies.

Prokunina-Olsson, Ludmila

Cancer research

2019 Volume 79, Issue 21, Page(s) 5476–5478

Abstract: Checkpoint inhibitors, including anti-PD-L1 therapy, emerged as a treatment option for many cancer types, albeit with limited response rates. Combinations of immune-based and -targeted therapies are needed to achieve synergistic antitumor effects and ... ...

Abstract	Checkpoint inhibitors, including anti-PD-L1 therapy, emerged as a treatment option for many cancer types, albeit with limited response rates. Combinations of immune-based and -targeted therapies are needed to achieve synergistic antitumor effects and provide much needed treatment personalization and improved response. Genetic alterations can be used as molecular drug targets and as biomarkers to select patients for specific therapies and their combinations. Fukumoto and colleagues present a promising example of this approach for the treatment of ovarian cancer with inactivating ARID1A mutations using a combination of the checkpoint and histone deacetylase inhibitors.
MeSH term(s)	Combined Modality Therapy ; DNA-Binding Proteins ; Female ; Histone Deacetylase 6 ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Nuclear Proteins ; Ovarian Neoplasms ; Programmed Cell Death 1 Receptor ; Transcription Factors
Chemical Substances	ARID1A protein, human ; DNA-Binding Proteins ; Nuclear Proteins ; Programmed Cell Death 1 Receptor ; Transcription Factors ; HDAC6 protein, human (EC 3.5.1.98) ; Histone Deacetylase 6 (EC 3.5.1.98)
Language	English
Publishing date	2019-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-19-2528
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Article ; Online: When the Smoke Clears m

Banday, A Rouf / Papenberg, Brenen W / Prokunina-Olsson, Ludmila

Cancer research

2020 Volume 80, Issue 13, Page(s) 2718–2719

Abstract: Long noncoding RNAs (lncRNA) have been implicated in many diseases, including cancer. Although these disease-associated effects have been mostly attributed to the ability of lncRNAs to function as regulatory noncoding transcripts, there is growing ... ...

Abstract	Long noncoding RNAs (lncRNA) have been implicated in many diseases, including cancer. Although these disease-associated effects have been mostly attributed to the ability of lncRNAs to function as regulatory noncoding transcripts, there is growing evidence that lncRNAs may also encode functional micropeptides. In the current issue of
MeSH term(s)	Cigarette Smoking ; Esophageal Neoplasms ; Esophageal Squamous Cell Carcinoma ; Humans ; Male ; RNA, Long Noncoding/genetics ; Smoke ; Y Chromosome
Chemical Substances	RNA, Long Noncoding ; Smoke
Language	English
Publishing date	2020-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-20-0961
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Article ; Online: It Takes Two (Genomes) to Cancer: Paired Viral and Host Transcriptome Analysis Provides New Insights about EBV Carcinogenicity.

Mbulaiteye, Sam M / Prokunina-Olsson, Ludmila

Cancer research

2019 Volume 79, Issue 23, Page(s) 5917–5919

Abstract: The discovery of Epstein-Barr virus (EBV) in 1964 gave birth to the field of viral oncology. Despite significant scientific and clinical developments in research on several other viruses discovered and linked to cancer risk much later, our understanding ... ...

Abstract	The discovery of Epstein-Barr virus (EBV) in 1964 gave birth to the field of viral oncology. Despite significant scientific and clinical developments in research on several other viruses discovered and linked to cancer risk much later, our understanding of EBV as a carcinogen and a possible target for therapeutic interventions remains limited. In this issue of
MeSH term(s)	Epstein-Barr Virus Infections/genetics ; Gene Expression Profiling ; Genome, Viral ; Herpesvirus 4, Human ; Humans ; Neoplasms
Language	English
Publishing date	2019-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-19-2996
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Article ; Online: The IFN-λ4 Conundrum: When a Good Interferon Goes Bad.

Onabajo, Olusegun O / Muchmore, Brian / Prokunina-Olsson, Ludmila

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2019 Volume 39, Issue 10, Page(s) 636–641

Abstract: Since its discovery in 2013, interferon lambda 4 (IFN-λ4) has received a reputation as a paradoxical type III IFN. Difficulties in detecting IFN-λ4, especially in secreted form even led to questions about its existence. However, the genetic ability to ... ...

Abstract	Since its discovery in 2013, interferon lambda 4 (IFN-λ4) has received a reputation as a paradoxical type III IFN. Difficulties in detecting IFN-λ4, especially in secreted form even led to questions about its existence. However, the genetic ability to generate IFN-λ4, determined by the presence of the rs368234815-ΔG allele, is the strongest predictor of impaired clearance of hepatitis C virus (HCV) infection in humans. Significant modulation of IFN-λ4 activity by a genetic variant (P70S) supports IFN-λ4, and not other type III IFNs encoded in the same genomic locus, as the primary functional cause of the association with HCV clearance. Although the ability to produce IFN-λ4 is associated with decreased HCV clearance, the recombinant IFN-λ4 is active against HCV and other viruses. These observations present an apparent conundrum-when and how does a presumably good IFN, with anti-HCV activity, interfere with the ability to clear HCV? In this review, we discuss findings that suggest potential mechanisms for explaining this conundrum.
MeSH term(s)	Hepacivirus/genetics ; Hepacivirus/metabolism ; Hepatitis C/genetics ; Hepatitis C/metabolism ; Hepatitis C/pathology ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; Polymorphism, Genetic
Chemical Substances	IFNL4 protein, human ; Interleukins
Language	English
Publishing date	2019-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2019.0044
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Article ; Online: What makes the hepatitis C virus evolve?

O'Brien, Thomas R / Hartmann, Rune / Prokunina-Olsson, Ludmila

eLife

2019 Volume 8

Abstract: Polymorphisms in ... ...

Abstract	Polymorphisms in the
MeSH term(s)	Antiviral Agents ; Genotype ; Hepacivirus ; Interferons ; Interleukins
Chemical Substances	Antiviral Agents ; Interleukins ; Interferons (9008-11-1)
Language	English
Publishing date	2019-09-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.50148
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Article ; Online: Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors.

Gonzalez, Nicole / Rao, Nina / Dean, Michael / Lee, Donghyuk / Hurson, Amber N / Baris, Dalsu / Schwenn, Molly / Johnson, Alison / Prokunina-Olsson, Ludmila / Friesen, Melissa C / Zhu, Bin / Rothman, Nathaniel / Silverman, Debra T / Koutros, Stella

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2023 Volume 32, Issue 6, Page(s) 840–847

Abstract: Background: Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and ... ...

Abstract	Background: Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors. Methods: Targeted sequencing was conducted in bladder tumors from the New England Bladder Cancer Study. Using data on 797 cases and 1,418 controls, two-stage polytomous logistic regression was used to evaluate etiologic heterogeneity between bladder cancer subtypes and quantitative, lifetime estimates of respirable elemental carbon (REC), a surrogate for diesel exposure. Poisson regression was used to evaluate associations between REC and mutational signatures. Results: We observed significant heterogeneity in the diesel-bladder cancer risk relationship, with a strong positive association among cases with high-grade, nonmuscle invasive TP53-mutated tumors compared with controls [ORTop Tertile vs.Unexposed, 4.8; 95% confidence interval (CI), 2.2-10.5; Ptrend < 0.001; Pheterogeneity = 0.002]. In muscle-invasive tumors, we observed a positive association between diesel exposure and the nitro-PAH signatures of 1,6-dintropyrene (RR, 1.93; 95% CI, 1.28-2.92) and 3-nitrobenzoic acid (RR, 1.97; 95% CI, 1.33-2.92). Conclusions: The relationship between diesel exhaust and bladder cancer was heterogeneous based on the presence of TP53 mutations in tumors, further supporting the link between PAH exposure and TP53 mutations in carcinogenesis. Future studies that can identify nitro-PAH signatures in exposed tumors are warranted to add human data supporting the link between diesel and bladder cancer. Impact: This study provides additional insight into the etiology and possible mechanisms related to diesel exhaust-induced bladder cancer.
MeSH term(s)	Humans ; Vehicle Emissions/toxicity ; Polycyclic Aromatic Hydrocarbons/toxicity ; Nitrates ; Urinary Bladder Neoplasms/chemically induced ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/genetics ; Mutation ; Carcinogenesis
Chemical Substances	Vehicle Emissions ; Polycyclic Aromatic Hydrocarbons ; Nitrates
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-22-1208
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