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Article: The Persistency and Visibility of Synovial Fluid Crystals After at Least 10 Days in Refrigerator by Light and Polarized Microscopy.

Shenavandeh, Saeedeh

2023 Volume 57, Issue 8, Page(s) 1239–1242

Abstract: Introduction: Synovial fluid (SF) analysis is one of the most important tests used in approach to arthritis and is necessary for rheumatology fellowship training. It depends on the operator's experience and can be affected by handling, processing, ... ...

Abstract	Introduction: Synovial fluid (SF) analysis is one of the most important tests used in approach to arthritis and is necessary for rheumatology fellowship training. It depends on the operator's experience and can be affected by handling, processing, temperature, type of preservative, and time from aspiration to analysis. Therefore, we aimed to reevaluate the SF with positive results for crystals, after at least 10 days for the persistency and visibility of the crystals. Method: For 1 year, we reevaluated crystal positive synovial fluid samples after at least 10 days under light and polarized microscopy. The samples were sent in tubes without any preservative. After the first day of diagnosis of a crystal arthropathy, all the samples were kept in 4 °C refrigerator in a syringe without any preservative and then reevaluated. Results: 14 calcium pyrophosphate (CPP); 12 monosodium urate (MSU), 1 of which was combined CPP and MSU; and 1 post-methylprednisolone (Depomedrol) injection, steroid crystal arthropathy were found and reevaluated. In all reevaluated samples [between 10-24 (median:14 days)], the crystals were detectable again. Conclusion: Our results suggests that SF CPP, MSU and methylprednisolone crystals at 4 °C without preservation could be detectable after 10-24 days (median: 14, 15.5, and 10 days, respectively) under light and polarized microscopy. It seems that the samples evaluated in emergency settings without enough time and those sent from other centers or gathering samples for trainees can be kept to detect crystals at least 10 days for all and till 22 days (for CCP and MSU) after sampling.
Language	English
Publishing date	2023-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-00900-y
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Article ; Online: Does the use of nail cosmetics interfere with the reporting of nailfold capillaroscopy?

Shenavandeh, Saeedeh

Clinical rheumatology

2023 Volume 42, Issue 5, Page(s) 1307–1313

Abstract: Capillaroscopy is a non-invasive tool evaluating the nail-fold capillaries, especially in approach to Raynaud's phenomenon (RP) and scleroderma (SSc) spectrum of diseases. It was recommended that the patients should not use any cosmetic procedure ... ...

Abstract	Capillaroscopy is a non-invasive tool evaluating the nail-fold capillaries, especially in approach to Raynaud's phenomenon (RP) and scleroderma (SSc) spectrum of diseases. It was recommended that the patients should not use any cosmetic procedure involving the nailfold to avoid misinterpretations. Therefore, we aimed to find the problems of using or recent removal of the nail polishes/artificial nails/henna before doing capillaroscopy. During 10 years, we looked for all capillaroscopy reports and nail fold images of patients who referred for capillaroscopy and had used or recently removed nail polish/artificial nail/henna in order to find the presence of any artifacts or misinterpretations in reports. Sixty-three patients were identified that had used or removed the nail cosmetic during 10 days before capillaroscopy. In patients who used nail polish, removed their nail polish, used artificial nails, or removed the artificial nails, and those using henna, 16.2%, 36.4%, 3.8%, 0%, and 1.4% of nail folds showed some stains in the upper part of the nail fold area, respectively, that had no interference with the report due to their distinct color. However, few areas were covered with polish stains in patients who removed the polish recently. The presence of nail cosmetics including nail polishes, henna, and artificial nails at the time of capillaroscopy does not induce a significant misinterpretation in capillaroscopy. However, some colored stains which were mostly distinguishable from hemorrhages could be seen. The removal of them 10 days before the time of capillaroscopy did not decrease the cosmetic artifacts. Key Points • The presence of nail cosmetics including nail polishes, henna, and artificial nails at the time of capillaroscopy does not induce a significant misinterpretation in capillaroscopy. • The removal of nail polish 10 days before the time of capillaroscopy did not decrease the procedure artifacts. • The removal of nail polish 10 days before capillaroscopy increased the area of artifacts and coverage of the study background.
MeSH term(s)	Humans ; Nails/diagnostic imaging ; Nails/blood supply ; Microscopic Angioscopy ; Raynaud Disease/diagnostic imaging ; Cosmetics ; Capillaries/diagnostic imaging
Chemical Substances	Cosmetics ; lawsone (TLH4A6LV1W)
Language	English
Publishing date	2023-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-023-06503-0
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Zs.A 1740: Show issues

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Article: Scleroderma-overlap syndromes: capillaroscopy, laboratory, and clinical manifestations and follow-up compared to scleroderma patients.

Shenavandeh, Saeedeh / Azariyon, Zahra / Nazarinia, Mohammad Ali

Reumatologia

2024 Volume 61, Issue 6, Page(s) 448–459

Abstract: Introduction: Overlap syndrome (OS) is a group of systemic connective tissue diseases (CTDs) that meet the criteria of two or more CTDs. In this study, we evaluated clinical, laboratory, and capillaroscopic manifestations of patients with scleroderma OS ...

Abstract	Introduction: Overlap syndrome (OS) is a group of systemic connective tissue diseases (CTDs) that meet the criteria of two or more CTDs. In this study, we evaluated clinical, laboratory, and capillaroscopic manifestations of patients with scleroderma OS (SSc-OS) and its subgroups and follow-up progression compared to patients with limited SSc (LcSSc). Material and methods: In a 10-year cross-sectional study, we evaluated 135 adult patients (70 with SSc-OS and 65 with LcSSc) with the same skin score for their baseline and follow-up clinical, laboratory, high-resolution chest tomography (HRCT), echocardiography, and nailfold capillaroscopy data and compared them. Results: Of the 135 patients, 70 had SSc-OS, including 45 (64.3%) cases of SSc-SS (Sjögren's syndrome), 11 (15.7%) of SSc-RA (rheumatoid arthritis), 9 (12.9%) of SSc-myositis and 5 (1.7%) of SSc-SLE (systemic lupus erythematosus), and 65 had LcSSc. Lung and heart involvement and pulmonary arterial hypertension (PAH) did not differ between the two groups ( Conclusions: In SSc-OS patients, the most common subgroup was SSc-SS. Scleroderma OS was associated with lower major organ involvement and capillaroscopy progression than LcSSc. Major organ involvement in patients with SSc-OS was significantly lower than in LcSSc patients. In the follow-up, new DU was not seen in the SSc-OS with lower progression of lung involvement, skin score, and capillary damage.
Language	English
Publishing date	2024-01-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum/175508
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Article: Nailfold capillaroscopy changes with disease activity in patients with inflammatory myositis including overlap myositis, pure dermatomyositis, and pure polymyositis.

Shenavandeh, Saeedeh / Rashidi, Farideh

Reumatologia

2022 Volume 60, Issue 1, Page(s) 42–52

Abstract: Objectives: Nailfold capillaroscopy (NFC) is useful in the evaluation of connective tissue diseases. There are few capillaroscopy examinations in patients with idiopathic inflammatory myopathies (IIMs) using the 2017 European League Against Rheumatism/ ... ...

Abstract	Objectives: Nailfold capillaroscopy (NFC) is useful in the evaluation of connective tissue diseases. There are few capillaroscopy examinations in patients with idiopathic inflammatory myopathies (IIMs) using the 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification. We evaluated the clinical, laboratory, and NFC in patients with IIMs using 2 classifications. Material and methods: In this cross-sectional study, 150 patients with IIMs were selected based on the EULAR/ACR classification and the Troyanov and Senécal classification. Nailfold capillaroscopy, laboratory tests, clinical manifestations, and disease activity were evaluated. Results: The subgroups were as follows: 81 patient with dermatomyositis (DM), 25 with amyopathic dermatomyositis (ADM), 25 with juvenile dermatomyositis (JDM), 19 with polymyositis (PM),53 with pure DM, 11 with pure PM, and 51 with overlap myositis (OM). Eight (42%) patients with PM and 28 (34.5%) patients with DM were categorized as OM. The scleroderma pattern was the dominant capillaroscopy pattern in the DM (72.8%), JDM (72%), ADM (76%), pure DM (75.4%), and OM (78.4%) subgroups, respectively. In the DM, ADM, JDM, and OM subgroups, scleroderma pattern had an association with high skin Visual Analogue Scale (VAS) score ( Conclusions: The scleroderma pattern was the dominant capillaroscopy pattern in all groups except for PM and pure PM. Some of patients with PM could be categorized as OM. In the DM and pure DM subgroups, there was a significant association between global and skin activity and higher NFC score. Adding the NFC to the classification of IIM is probably helpful in more detailed classifications.
Language	English
Publishing date	2022-02-28
Publishing country	Poland
Document type	Journal Article
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum.2022.114109
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Article ; Online: Nailfold capillaroscopy changes with disease activity in patients with inflammatory myositis including overlap myositis, pure dermatomyositis, and pure polymyositis

Saeedeh Shenavandeh / Farideh Rashidi

Rheumatology, Vol 60, Iss 1, Pp 42-

2022 Volume 52

Keywords	inflammatory myositis ; overlap myositis ; nailfold capillaroscopy ; Medicine ; R
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Images: Dysphagia and Respiratory Distress Along With A Curvilinear Calcification in the Neck Brightens Up an Undiagnosed Case of Huge Carotid Artery Pseudoaneurysm Due to Takayasu Arteritis.

Ghoddusi Johari, Hamed / Shenavandeh, Saeedeh / Rasekhi, Alireza

ACR open rheumatology

2022 Volume 4, Issue 5, Page(s) 383–384

Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article
ISSN	2578-5745
ISSN (online)	2578-5745
DOI	10.1002/acr2.11389
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Article ; Online: Glomerulopathy in patients with dermatomyositis in early active disease

Saeedeh Shenavandeh / Mahsa TorabiJahromi / Sahand Mohammadzadeh

Rheumatology, Vol 60, Iss 3, Pp 200-

clinical, pathological and capillaroscopic manifestations, and response to treatment

2022 Volume 208

Keywords	dermatomyositis ; glomerulonephritis ; mesangioproliferative ; capillaroscopy ; Medicine ; R
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Glomerulopathy in patients with dermatomyositis in early active disease: clinical, pathological and capillaroscopic manifestations, and response to treatment.

Shenavandeh, Saeedeh / TorabiJahromi, Mahsa / Mohammadzadeh, Sahand

Reumatologia

2022 Volume 60, Issue 3, Page(s) 200–208

Abstract: Introduction: Idiopathic inflammatory myopathies (IIMs) are a group of systemic connective tissue diseases that present with muscular and extra-muscular manifestations. There are few reports on kidney involvement, especially in dermatomyositis (DM) ... ...

Abstract	Introduction: Idiopathic inflammatory myopathies (IIMs) are a group of systemic connective tissue diseases that present with muscular and extra-muscular manifestations. There are few reports on kidney involvement, especially in dermatomyositis (DM) patients. We evaluated the clinical, laboratory, capillaroscopy, and kidney pathology of patients with DM, who presented with proteinuria during the first year, and followed them for response to treatment. Material and methods: We evaluated 205 patients with proximal muscle weakness or high muscle enzymes, who referred to the nailfold capillaroscopy clinic from April 2010 to October 2021. Seventy-four patients fulfilled the New 2017 EULAR/ACR Classification Criteria for adult and juvenile IM with probability of ≥ 90% for DM with duration of ≤ 12 months and proteinuria > 350 mg/24 hours. All manifestations of patients with glomerulopathy and their kidney biopsies were reviewed, and they were followed for their treatment response. Results: From 74 patients with DM, 52 female and 22 male, median age 37 (19-65) years, and disease duration of median 4.5 (1-12) months, 2 (2.7%) patients (25- and 28-year-old male) had proteinuria. Their kidney biopsy showed mesangioproliferative glomerulonephritis (GN). There was no case of acute or chronic kidney damage or rhabdomyolysis. Both had high disease activity, high erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), abnormal capillaroscopy, and high anti-Ro positivity with good early response of their kidney function, muscle weakness, and laboratory tests after immunosuppressive treatment for 3-6 months. One patient had capillaroscopy follow-up, and all abnormalities were resolved in 8 fingers. One patient, due to poor follow-up, after 8 months had recurrence of his disease. Conclusions: We found mesangioproliferative GN as a rare extra-muscular manifestation in patients with DM in the active and early phase of the disease. Full immunosuppressive treatment showed early complete recovery in these patients.
Language	English
Publishing date	2022-07-13
Publishing country	Poland
Document type	Journal Article
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum.2022.117840
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Article ; Online: Comment on: Causes of Raynaud's phenomenon and the predictive laboratory and capillaroscopy features for the evolution to a definite connective tissue disease: reply.

Shenavandeh, Saeedeh / Ajri, Mehrnoush / Hamidi, Sahand

Rheumatology (Oxford, England)

2021 Volume 61, Issue 7, Page(s) e190–e191

MeSH term(s)	Connective Tissue Diseases/complications ; Humans ; Microscopic Angioscopy ; Raynaud Disease/etiology
Language	English
Publishing date	2021-11-05
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keab885
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Article ; Online: Association of Large Vessel Aneurysm/Pseudo-Aneurysm/Aortitis and Deep Vein Thrombosis in Patients with Behçet's Disease: A Case Report.

Shenavandeh, Saeedeh / Johari, Hamed Ghoddusi / Aflaki, Elham

Current rheumatology reviews

2021 Volume 18, Issue 1, Page(s) 83–87

Abstract: Background: Behçet's disease (BD) is a complex vasculitis with some vascular manifestations including venous thrombosis, arterial thrombosis/aneurysm/pseudoaneurysm, and co-associated venous thrombosis and arterial lesions. We present two patients with ... ...

Abstract	Background: Behçet's disease (BD) is a complex vasculitis with some vascular manifestations including venous thrombosis, arterial thrombosis/aneurysm/pseudoaneurysm, and co-associated venous thrombosis and arterial lesions. We present two patients with Behçet's disease came with progressive both arterial and venous involvement. Case presentation: The first patient was a young man with recurrent oral aphthosis and skin folliculitis and referred with complaint of new abdominal pain and 2 months severe headache. He had not referred to a physician due to COVID-19 pandemic until that time. In addition, he gradually developed a lower extremity edema and eventually was diagnosed with BD complicated with brain sagittal sinus vein thrombosis, abdominal aortic aneurysms and aortitis and deep vein thrombosis (DVT) of femoral vein. The second patient was a young woman with previous history of uveitis, DVT and recurrent oral and genital aphthosis presented with a large inguinal mass due to large iliac artery pseudoaneurysm impending to rupture, and after the operation, due to poor follow-up, developed a new femoral DVT. Conclusion: It seems the same inflammatory process is responsible for arterial and venous involvement in patients with BD, so it should be considered that involvement in one side (venous/arterial) can be a risk factor for the other side (venous/arterial) and early immunosuppressive treatment should always be considered to improve the prognosis.
MeSH term(s)	Aneurysm/complications ; Aneurysm/surgery ; Aneurysm, False/complications ; Aortitis/complications ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; COVID-19/complications ; Female ; Humans ; Male ; Pandemics ; Thrombosis/complications ; Venous Thrombosis/complications
Language	English
Publishing date	2021-09-17
Publishing country	United Arab Emirates
Document type	Case Reports
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397117666210920154400
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