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Article ; Online: Phytochemical investigation of

Ferreira, Miller Santos / Katchborian-Neto, Albert / Nicácio, Karen de Jesus / Santos, Mario F C / Dias, Danielle F / Chagas-Paula, Daniela A / Soares, Marisi G

Natural product research

2024 , Page(s) 1–7

Abstract: Endophytic fungi residing symbiotically in plant tissues are promising sources of bioactive natural products. This study explored the anti-inflammatory potential of an endophytic fungus isolated from the Brazilian medicinal ... ...

Abstract	Endophytic fungi residing symbiotically in plant tissues are promising sources of bioactive natural products. This study explored the anti-inflammatory potential of an endophytic fungus isolated from the Brazilian medicinal plant
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2024.2320733
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Article ; Online: Synthesis of lignin-based carbon/graphene oxide foam and its application as sensors for ammonia gas detection.

Rodrigues, Jéssica S / de S M de Freitas, Amanda / de Lima, Lucas F / Lopes, Henrique S M / Maciel, Cristiane C / Fré, Lucas V B V / Pires, Ariane A F / de Lima, Vitor H / Oliveira, Vinicius J R / de A Olivati, Clarissa / Ferreira, Marystela / Riul, Antonio / Botaro, Vagner R

International journal of biological macromolecules

2024 Volume 268, Issue Pt 2, Page(s) 131883

Abstract: The present study highlights the integration of lignin with graphene oxide (GO) and its reduced form (rGO) as a significant advancement within the bio-based products industry. Lignin-phenol-formaldehyde (LPF) resin is used as a carbon source in ... ...

Abstract	The present study highlights the integration of lignin with graphene oxide (GO) and its reduced form (rGO) as a significant advancement within the bio-based products industry. Lignin-phenol-formaldehyde (LPF) resin is used as a carbon source in polyurethane foams, with the addition of 1 %, 2 %, and 4 % of GO and rGO to produce carbon structures thus producing carbon foams (CFs). Two conversion routes are assessed: (i) direct addition with rGO solution, and (ii) GO reduction by heat treatment. Carbon foams are characterized by thermal, structural, and morphological analysis, alongside an assessment of their electrochemical behavior. The thermal decomposition of samples with GO is like those having rGO, indicating the effective removal of oxygen groups in GO by carbonization. The addition of GO and rGO significantly improved the electrochemical properties of CF, with the GO2% sensors displaying 39 % and 62 % larger electroactive area than control and rGO2% sensors, respectively. Furthermore, there is a significant electron transfer improvement in GO sensors, demonstrating a promising potential for ammonia detection. Detailed structural and performance analysis highlights the significant enhancement in electrochemical properties, paving the way for the development of advanced sensors for gas detection, particularly ammonia, with the prospective market demands for durable, simple, cost-effective, and efficient devices.
Language	English
Publishing date	2024-04-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131883
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Zs.B 2374: Show issues

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Book ; Online: Natural Additives in Food

Barros, Lillian / Ferreira, Isabel C.F.R.

2022

Keywords	Technology: general issues ; trisodium citrate ; microbial transglutaminase ; casein gels ; textural properties ; microstructures ; Urtica spp ; bioactive compounds ; antioxidant activity ; antimicrobial activity ; traditional medicine ; food industry ; animal breeding ; beta cyclodextrin ; ewe's milk ; cheese ; Manchego ; lipids ; cholesterol ; anthocyanin ; natural extract ; tetraethyl orthosilicate ; black carrot ; black rice flour ; anthocyanins ; low gluten muffins ; added value products ; soymilk ; enzyme modified soymilk ; skim milk ; rennet induced gelation ; rheological properties ; egg yolk ; cholesterol extraction ; granules extraction ; anionic chelating biopolymers ; ADME ; absorption ; chlorophylls ; chlorophyllin ; green colorant ; zinc-chlorophylls ; copper-chlorophyll ; coloring foodstuff ; natural colorants ; food colors ; pomelo peel ; essential oil ; anti-oxidant ; anti-melanogenic ; B16 melanoma cell ; oxygen-containing sulfur flavor molecules ; β-carotene ; bis(2-methyl-3-furyl) disulfide (BMFDS) ; oxidation products ; beetroot ; betalains ; semi-preparative RP-HPLC ; in vitro human gastrointestinal digestion ; ex vivo colon fermentation ; antioxidant ability ; malonildialdehyde ; extra virgin olive oil ; leaf addition ; Tunisian varieties ; phenolics ; tocopherols ; Prunus spinosa L. fruit epicarp ; wild fruit valorization ; cyanidin 3-rutinoside ; peonidin 3-rutinoside ; heat and ultrasound assisted extraction ; response surface methodology ; Ocimum basilicum var. purpurascens leaves ; red rubin basil ; Heat-Assisted Extraction ; extraction optimization ; polyphenols ; tiger nut ; by-products ; solvent extraction ; horchata de chufa ; triple TOF-LC-MS-MS ; Caenorhabditis elegans ; antioxidants ; bergenin ; stress resistance ; lifespan ; Huntington ; uxi ; Endopleura uchi ; Allium cepa red cv ; Citrus limon ; pickling ; volatiles ; SPME ; chemometrics ; byproducts ; food additives ; antimicrobial ; antioxidant ; colorants ; texturizing agents ; foaming capacity and emulsifiers
Language	0\|e
Size	1 electronic resource (290 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021619474
ISBN	9783036541051 ; 3036541055
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Synthesis of temporomandibular disorders management intervention outcomes for development of core outcome sets: A systematic review.

Ferreira, N R / Marto, C M / de Sousa, B M / Loureiro, M / Oliveira, A T / DosSantos, M F / Rodrigues, M J

Journal of oral rehabilitation

2024

Abstract: Introduction: The selection of appropriate outcomes in clinical trials and systematic reviews is a crucial factor in determining the results that are useful, reliable, and relevant for both patients and healthcare professionals. Clinicians and ... ...

Abstract	Introduction: The selection of appropriate outcomes in clinical trials and systematic reviews is a crucial factor in determining the results that are useful, reliable, and relevant for both patients and healthcare professionals. Clinicians and researchers have been encouraged to develop and apply core outcome sets (COS) to minimise the discrepancy between studies. Aim: This systematic review is the first phase of the COS development project for clinical trials in temporomandibular disorders (COS-TMD). It aims to identify and synthesise the outcomes used in the randomised controlled trials (RCT) that evaluated the effectiveness of interventions used in TMD management. Materials and methods: An electronic search was performed in several databases: MEDLINE (via PubMed), Scopus, Web of Science, Cochrane Library and EMBASE. The eligibility criteria comprised RCT that applied any intervention to treat temporomandibular joint disorders or masticatory muscle disorders. The identified outcomes were categorised according to domains of the Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (IMMPACT). Results: The electronic search resulted in 1606 studies. After removing duplicates and applying the eligibility criteria, 106 RCT were included. A total of 43 studies evaluated masticatory muscle disorders, 27 evaluated temporomandibular joint disorders, and 36 analysed mixed TMD. Conclusions: The evaluation showed significant variability in the types of outcomes and their measurement instruments. In addition, some domains such as physical and emotional functioning, participant ratings of global improvement and adverse events have been neglected when determining the effectiveness of treatments for TMD.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.13692
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Zs.A 991: Show issues

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Article ; Online: Integrative open workflow for confident annotation and molecular networking of metabolomics MSE/DIA data.

Katchborian-Neto, Albert / Alves, Matheus F / Bueno, Paula C P / de Jesus Nicácio, Karen / Ferreira, Miller S / Oliveira, Tiago B / Barbosa, Henrique / Murgu, Michael / de Paula Ladvocat, Ana C C / Dias, Danielle F / Soares, Marisi G / Lago, João H G / Chagas-Paula, Daniela A

Briefings in bioinformatics

2024 Volume 25, Issue 2

Abstract: Liquid chromatography coupled with high-resolution mass spectrometry data-independent acquisition (LC-HRMS/DIA), including MSE, enable comprehensive metabolomics analyses though they pose challenges for data processing with automatic annotation and ... ...

Abstract	Liquid chromatography coupled with high-resolution mass spectrometry data-independent acquisition (LC-HRMS/DIA), including MSE, enable comprehensive metabolomics analyses though they pose challenges for data processing with automatic annotation and molecular networking (MN) implementation. This motivated the present proposal, in which we introduce DIA-IntOpenStream, a new integrated workflow combining open-source software to streamline MSE data handling. It provides 'in-house' custom database construction, allows the conversion of raw MSE data to a universal format (.mzML) and leverages open software (MZmine 3 and MS-DIAL) all advantages for confident annotation and effective MN data interpretation. This pipeline significantly enhances the accessibility, reliability and reproducibility of complex MSE/DIA studies, overcoming previous limitations of proprietary software and non-universal MS data formats that restricted integrative analysis. We demonstrate the utility of DIA-IntOpenStream with two independent datasets: dataset 1 consists of new data from 60 plant extracts from the Ocotea genus; dataset 2 is a publicly available actinobacterial extract spiked with authentic standard for detailed comparative analysis with existing methods. This user-friendly pipeline enables broader adoption of cutting-edge MS tools and provides value to the scientific community. Overall, it holds promise for speeding up metabolite discoveries toward a more collaborative and open environment for research.
MeSH term(s)	Reproducibility of Results ; Workflow ; Metabolomics/methods ; Mass Spectrometry/methods ; Chromatography, Liquid/methods ; Software
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbae013
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Zs.A 6262: Show issues

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Article ; Online: Synthesis and photothermal performance of non-stoichiometric molybdenum oxide (MoO

Lima, Diane C A / Ferreira, Aldebarã F / Silva, Stterferson E / Alves, Severino / Sousa, Felipe L N / de Azevedo, Walter M

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 24, Page(s) 8353–8360

Abstract: This work reports the interaction of γ-rays with ... ...

Abstract	This work reports the interaction of γ-rays with MoO
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt00183k
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Article ; Online: Abdominal TRPV1 channel desensitization enhances stress-induced hyperthermia during social stress in rats.

Reis, T O / Noronha, S I S R / Lima, P M A / De Abreu, A R R / Mesquita, L B T / Ferreira, F I / Silva, F C / Chianca-Jr, D A / De Menezes, R C

Autonomic neuroscience : basic & clinical

2023 Volume 246, Page(s) 103073

Abstract: Aims: In rats, stress-induced hyperthermia caused by social interaction depends on brown adipose tissue (BAT) thermogenesis and peripheral vasoconstriction. However, the peripheral mechanisms responsible for regulating the level of hyperthermia during ... ...

Abstract	Aims: In rats, stress-induced hyperthermia caused by social interaction depends on brown adipose tissue (BAT) thermogenesis and peripheral vasoconstriction. However, the peripheral mechanisms responsible for regulating the level of hyperthermia during social stress are still unknown. The transient receptor potential vanilloid 1 (TRPV1) subfamily, expressed in sensory and visceral neurons, can serve as a thermoreceptor. Here, we tested the hypothesis that the abdominal TRPV1 is essential in regulating stress-induced hyperthermia during social stress. Main methods: Male Wistar rats received an intraperitoneal injection of Resiniferatoxin (RTX) - an ultra-potent capsaicin analog, (i.e., to desensitize the TRPV1 channels) or vehicle. Seven days later, we evaluated the effects of abdominal TRPV1 channels desensitization on core body temperature (CBT), brown adipose tissue (BAT) temperature, tail skin temperature, and heart rate (HR) of rats subjected to a social stress protocol. Key findings: We found abdominal TRPV1 desensitization increased CBT and BAT temperature but did not change tail skin temperature and HR during rest. However, under social stress, we found that abdominal TRPV1 desensitization heightened the increase in CBT and BAT caused by stress. Also, it abolished the increase in tail skin temperature that occurs during and after social stress. TRPV1 desensitization also delayed the HR recovery after the exposure to the social stress. Significance: These results show that abdominal TRPV1 channels desensitization heightens stress-induced hyperthermia, causing heat dissipation during and after social stress, enabling optimal thermal control during social encounters.
MeSH term(s)	Animals ; Male ; Rats ; Capsaicin/pharmacology ; Hyperthermia, Induced ; Rats, Sprague-Dawley ; Rats, Wistar ; TRPV Cation Channels/physiology
Chemical Substances	Capsaicin (S07O44R1ZM) ; TRPV Cation Channels ; Trpv1 protein, rat
Language	English
Publishing date	2023-01-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2023.103073
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Zs.A 1533: Show issues

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Article ; Online: The impact of COVID-19 on TB care in Brazil.

Neto, E R D / Matos, T S / Ferreira, A C Furtado / Bezerra-Santos, M / Junior, A G da Silva / do Carmo, R F / de Souza, C D F

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2023 Volume 27, Issue 12, Page(s) 941–943

MeSH term(s)	Humans ; COVID-19 ; Brazil/epidemiology ; Tuberculosis/therapy ; Tuberculosis/drug therapy ; Antitubercular Agents/therapeutic use
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2023-12-02
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.23.0300
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Zs.A 4776: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 261: Show issues

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Article ; Online: Synthesis and Application of a New Polymer with Imprinted Ions for the Preconcentration of Uranium in Natural Water Samples and Determination by Digital Imaging.

Felix, Caio S A / Chagas, Adriano V B / de Jesus, Rafael F / Barbosa, Willams T / Barbosa, Josiane D V / Ferreira, Sergio L C / Cerdà, Víctor

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 10

Abstract: This work proposes the synthesis of a new polymer with imprinted ions (IIP) for the pre-concentration of uranium in natural waters using digital imaging as a detection technique. The polymer was synthesized using 2-(5-bromo-2-pyridylazo)-5- ... ...

Abstract	This work proposes the synthesis of a new polymer with imprinted ions (IIP) for the pre-concentration of uranium in natural waters using digital imaging as a detection technique. The polymer was synthesized using 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (Br-PADAP) for complex formation, ethylene glycol dimethacrylate (EGDMA) as a crosslinking reagent, methacrylic acid (AMA) as functional monomer, and 2,2'-azobisisobutyronitrile as a radical initiator. The IIP was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy (FTIR). Uranium determination was performed using digital imaging (ID), and some experimental conditions (sample pH, eluent concentration, and sampling flow rate) were optimized using a two-level full factorial design and Doelhert response surface methodology. Thus, using the optimized conditions, the system allowed the determination of uranium with detection and quantification limits of 2.55 and 8.51 µg L
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28104065
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Zs.MO 81: Show issues

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Article: Titanium-Enriched Medium Promotes Environment-Induced Epigenetic Machinery Changes in Human Endothelial Cells.

Fernandes, Célio Júnior da C / da Silva, Rodrigo A Foganholi / Wood, Patrícia F / Ferreira, Marcel Rodrigues / de Almeida, Gerson S / de Moraes, Julia Ferreira / Bezerra, Fábio J / Zambuzzi, Willian F

Journal of functional biomaterials

2023 Volume 14, Issue 3

Abstract: It is important to understand whether endothelial cells are epigenetically affected by titanium-enriched media when angiogenesis is required during bone development and it is expected to be recapitulated during osseointegration of biomaterials. To better ...

Abstract	It is important to understand whether endothelial cells are epigenetically affected by titanium-enriched media when angiogenesis is required during bone development and it is expected to be recapitulated during osseointegration of biomaterials. To better address this issue, titanium-enriched medium was obtained from incubation of titanium discs for up to 24 h as recommended by ISO 10993-5:2016, and further used to expose human umbilical vein endothelial cells (HUVECs) for up to 72 h, when the samples were properly harvested to allow molecular analysis and epigenetics. In general, our data show an important repertoire of epigenetic players in endothelial cells responding to titanium, reinforcing protein related to the metabolism of acetyl and methyl groups, as follows: Histone deacetylases (HDACs) and NAD-dependent deacetylase sirtuin-1 (Sirt1), DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) methylcytosine dioxygenases, which in conjunction culminate in driving chromatin condensation and the methylation profile of DNA strands, respectively. Taking our data into consideration, HDAC6 emerges as important player of this environment-induced epigenetic mechanism in endothelial cells, while Sirt1 is required in response to stimulation of reactive oxygen species (ROS) production, as its modulation is relevant to vasculature surrounding implanted devices. Collectively, all these findings support the hypothesis that titanium keeps the surrounding microenvironment dynamically active and so affects the performance of endothelial cells by modulating epigenetics. Specifically, this study shows the relevance of HDAC6 as a player in this process, possibly correlated with the cytoskeleton rearrangement of those cells. Furthermore, as those enzymes are druggable, it opens new perspectives to consider the use of small molecules to modulate their activities as a biotechnological tool in order to improve angiogenesis and accelerate bone growth with benefits of a fast recovery time for patients.
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb14030131
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